E Frank

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Simultaneous evaluation of the harms and benefits of treatments in randomized clinical trials: demonstration of a new approach
    E Frank
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychol Med 42:865-73. 2012
  2. ncbi Validity and reliability of the Structured Clinical Interview for the Trauma and Loss Spectrum (SCI-TALS)
    Liliana Dell'Osso
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Italy
    Clin Pract Epidemiol Ment Health 4:2. 2008
  3. ncbi Predictors and moderators of time to remission of major depression with interpersonal psychotherapy and SSRI pharmacotherapy
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychol Med 41:151-62. 2011
  4. ncbi Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder
    Ellen Frank
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 9:325-32. 2007
  5. ncbi Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Trials 5:253-61. 2008
  6. ncbi The importance of routine for preventing recurrence in bipolar disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 163:981-5. 2006
  7. ncbi The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1559-65. 2008
  8. ncbi Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:761-7. 2007
  9. ncbi Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:996-1004. 2005
  10. ncbi Antidepressants and psychotherapy: a clinical research review
    Ellen Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic PA 15213, USA
    Dialogues Clin Neurosci 7:263-72. 2005

Research Grants

  1. A Novel Therapy for Depression with Co-Occurring Panic
    Ellen Frank; Fiscal Year: 2003
  2. Depression: The Search for Treatment-Relevant Phenotypes
    Ellen Frank; Fiscal Year: 2009

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. ncbi Simultaneous evaluation of the harms and benefits of treatments in randomized clinical trials: demonstration of a new approach
    E Frank
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychol Med 42:865-73. 2012
    ..Particularly in mental health, however, there is a lack of a single objective, reliable measure of outcome that is sensitive to crucial individual differences among patients...
  2. ncbi Validity and reliability of the Structured Clinical Interview for the Trauma and Loss Spectrum (SCI-TALS)
    Liliana Dell'Osso
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, University of Pisa, Italy
    Clin Pract Epidemiol Ment Health 4:2. 2008
    ..An additional condition of complicated grief (CG), well described in the literature, is triggered by bereavement...
  3. ncbi Predictors and moderators of time to remission of major depression with interpersonal psychotherapy and SSRI pharmacotherapy
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychol Med 41:151-62. 2011
    ..We sought to determine whether measures of spectrum psychopathology are useful in deciding which patients with unipolar depression should receive pharmacotherapy versus depression-specific psychotherapy...
  4. ncbi Interpersonal and social rhythm therapy: an intervention addressing rhythm dysregulation in bipolar disorder
    Ellen Frank
    University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Dialogues Clin Neurosci 9:325-32. 2007
    ..Using a case example, the authors describe how IPSRT is implemented in a clinical setting, detailing the therapeutic methods and processes involved...
  5. ncbi Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Trials 5:253-61. 2008
    ..A multi-site clinical trial that includes psychotherapy as one of the treatments presents numerous challenges related to cross-site consistency and communication...
  6. ncbi The importance of routine for preventing recurrence in bipolar disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 163:981-5. 2006
  7. ncbi The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1559-65. 2008
    ..The authors describe the effect of acute treatment with interpersonal and social rhythm therapy on occupational functioning over a period of approximately 2.5 years...
  8. ncbi Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:761-7. 2007
    ..The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment...
  9. ncbi Two-year outcomes for interpersonal and social rhythm therapy in individuals with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:996-1004. 2005
    ..Recent investigations have demonstrated benefits from the addition of psychoeducation or psychotherapy to pharmacotherapy in this population...
  10. ncbi Antidepressants and psychotherapy: a clinical research review
    Ellen Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic PA 15213, USA
    Dialogues Clin Neurosci 7:263-72. 2005
    ..There is a clear need for more information about the relative efficacy of pharmacotherapy-psychotherapy combinations or sequences versus either pharmacotherapy or psychotherapy provided as monotherapies...
  11. ncbi Interpersonal and social rhythm therapy: a means of improving depression and preventing relapse in bipolar disorder
    Ellen Frank
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Clin Psychol 63:463-73. 2007
    ..The article concludes with a case example that further illustrates the basic therapeutic methods and processes of IPSRT...
  12. ncbi High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 153:1418-22. 1996
    ..Twenty-eight patients (17.7%) received inpatient care at some point during acute-phase treatment...
  13. ncbi Influence of panic-agoraphobic spectrum symptoms on treatment response in patients with recurrent major depression
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 157:1101-7. 2000
    ..The authors tested the hypothesis that a lifetime history of panic-agoraphobic spectrum symptoms predicts a poorer response to depression treatment...
  14. ncbi Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 154:958-62. 1997
    ..This study was conducted to identify which elderly patients with remitted recurrent major depression remain well with maintenance interpersonal psychotherapy after discontinuation of active antidepressant medication (nortriptyline)...
  15. ncbi Temporal profiles of the course of depression during treatment. Predictors of pathways toward recovery in the elderly
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
    Arch Gen Psychiatry 54:1016-24. 1997
    ..Whether patients vary in their pathways toward those outcomes--and the extent to which such variation can be anticipated by patient characteristics prior to treatment--has not been empirically examined...
  16. ncbi Latent structure of EEG sleep variables in depressed and control subjects: descriptions and clinical correlates
    D J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Psychiatry Res 79:105-22. 1998
    ..Multivariate statistical techniques decrease the risk of Type I and Type II errors when using a large number of collinear sleep measures, and can clarify conceptual issues related to sleep and depression...
  17. ncbi Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 156:202-8. 1999
    ..The authors tested the hypothesis that nortriptyline and interpersonal psychotherapy, alone and in combination, are superior to placebo in achieving remission of bereavement-related major depressive episodes...
  18. ncbi Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years
    C F Reynolds
    The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 281:39-45. 1999
    ..Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability...
  19. ncbi Treatment-emergent suicidal ideation during 4 months of acute management of unipolar major depression with SSRI pharmacotherapy or interpersonal psychotherapy in a randomized clinical trial
    P Rucci
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Depress Anxiety 28:303-9. 2011
    ....
  20. ncbi Natural history and preventative treatment of recurrent mood disorders
    E Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pennsylvania 15213 2593, USA
    Annu Rev Med 50:453-68. 1999
    ..Finally, the chapter describes recent advances in the treatment of bipolar disorder...
  21. ncbi Panic-agoraphobic spectrum: reliability and validity of assessment instruments
    M K Shear
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:59-66. 2001
    ..We conclude that PAS can be reliably assessed, and that it describes a valid, coherent constellation of features associated with DSM IV Panic Disorder, but providing additional important clinical information...
  22. ncbi Sleep and treatment response in depression: new findings using power spectral analysis
    D J Buysse
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, E 1127 WPIC, Pittsburgh, PA 15213, USA
    Psychiatry Res 103:51-67. 2001
    ..Quantitative REMs may provide a more direct measure of brainstem function and dysfunction during REM sleep than quantitative sleep EEG measures...
  23. ncbi Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Psychiatry Res 95:109-18. 2000
    ..These preliminary findings suggest that chronic lithium treatment may decrease the levels of both cytosolic PKC alpha isozyme and membrane PIP(2) in platelets of bipolar disorder patients...
  24. ncbi Initial recovery patterns may predict which maintenance therapies for depression will keep older adults well
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 65:155-66. 2001
    ..Patients' temporal patterns of acute treatment response may predict who requires which maintenance therapy to remain well...
  25. ncbi Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Psychopharmacology (Berl) 149:12-6. 2000
    ..In vitro and in vivo animal studies suggest that the intracellular phosphatidylinositol (PI) pathway is an important target for the effects of lithium...
  26. ncbi Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  27. ncbi Decreased pituitary volume in patients with bipolar disorder
    R B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 50:271-80. 2001
    ..Our findings suggest that detectable abnormalities in pituitary size are present in patients with bipolar disorder, which may reflect a dysfunctional HPA axis...
  28. ncbi Comparative outcomes among the problem areas of interpersonal psychotherapy for depression
    J C Levenson
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 27:434-40. 2010
    ..Moreover, we sought to understand how the patient characteristics and interpersonal problems most closely linked to the onset of a patient's current depression contributed to IPT success...
  29. ncbi PET imaging of serotonin 1A receptor binding in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Biol Psychiatry 46:1375-87. 1999
    ..PET imaging using the 5HT1A receptor radioligand, [11C]WAY-100635, may clarify the clinical conditions under which 5HT1A receptor binding potential (BP) is abnormal in depression...
  30. ncbi Tolerability of combined treatment with lithium and paroxetine in patients with bipolar disorder and depression
    A Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
    J Clin Psychopharmacol 21:474-8. 2001
    ..Clinicians should be aware of the possible development of a serotonin syndrome among patients in whom paroxetine is added to ongoing lithium treatment...
  31. ncbi MRI study of posterior fossa structures and brain ventricles in bipolar patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:313-22. 2001
    ..However, there were suggestions that abnormalities in cerebellum, vermis, and lateral ventricle sizes may be present in familial cases of the disorder, which should be further examined in future studies with larger patient samples...
  32. ncbi Subjective health measures and acute treatment outcomes in geriatric depression
    E J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 16:1149-55. 2001
    ..However, successful treatment for depression has been associated with improvement in self-rated health and other health measures...
  33. ncbi Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:1177-81. 1999
    ..This study compared the long-term efficacy of two fixed plasma levels of nortriptyline in preventing or delaying recurrence of major depression in elderly patients and in minimizing residual depressive symptoms and somatic complaints...
  34. ncbi Differential effects of age on brain gray matter in bipolar patients and healthy individuals
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychobiology 43:242-7. 2001
    ....
  35. ncbi Anatomical MRI study of basal ganglia in bipolar disorder patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:65-80. 2001
    ....
  36. ncbi Interpersonal psychotherapy for depression with panic spectrum symptoms: a pilot study
    Jill M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Depress Anxiety 21:140-2. 2005
    ..A newly adapted psychosocial treatment for depression with lifetime panic spectrum symptoms was evaluated in an open pilot study...
  37. ncbi Prevalence and clinical correlates of medical comorbidities in patients with bipolar I disorder: analysis of acute-phase data from a randomized controlled trial
    Wesley K Thompson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15260, USA
    J Clin Psychiatry 67:783-8. 2006
    ..We studied the relationship between number of medical comorbidities in patients with bipolar I disorder and their demographic and clinical characteristics...
  38. ncbi Personality pathology and outcome in recurrently depressed women over 2 years of maintenance interpersonal psychotherapy
    J M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychol Med 34:659-69. 2004
    ..Future maintenance treatment trials are needed to clarify the relationship between episodic mood disorder and personality function over time...
  39. ncbi Anxiety as a predictor of response to interpersonal psychotherapy for recurrent major depression: an exploratory investigation
    U Feske
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pennsylvania, USA
    Depress Anxiety 8:135-41. 1998
    ..Our findings strengthen existing evidence that concomitant anxiety can adversely affect the outcome of interpersonal therapy for depression...
  40. ncbi MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals
    S C Caetano
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-3282, USA
    Psychiatry Res 108:161-8. 2001
    ..Although functional abnormalities in the thalamus are likely to be implicated in the pathophysiology of mood disorders, no abnormalities in thalamic size appear present in bipolar or unipolar individuals...
  41. ncbi Competence of depressed patients for consent to research
    P S Appelbaum
    Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Psychiatry 156:1380-4. 1999
    ..This study used a new instrument for assessing depressed patients' capacities to consent to research and examined their performance, including the relation between severity of depression and extent of impairment...
  42. ncbi Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modality
    E Frank
    Department of Psychiatry, University of Pittsburgh 15213, USA
    J Abnorm Psychol 108:579-87. 1999
    ..This finding, consistent with the authors' philosophy that bipolar patients benefit from stable routines, suggests that disruptions in the psychosocial treatment plan contribute to worse outcomes...
  43. ncbi Prevalence of obesity and weight change during treatment in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:528-33. 2002
    ....
  44. ncbi The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorder
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States University Center for Social and Urban Research, Pittsburgh, PA, United States
    Psychiatry Res 168:67-77. 2009
    ..It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics...
  45. ncbi Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Psychiatry 159:466-8. 2002
    ..CONCLUSIONS: Treatment of late-life depression with nortriptyline and psychotherapy is more likely to maintain social adjustment than treatment with either alone. Combination therapy improves not only duration but quality of wellness...
  46. ncbi Randomized, placebo-controlled trial of fluoxetine for acute treatment of minor depressive disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Am J Psychiatry 161:1864-71. 2004
    ..Minor depressive disorder is both common and associated with significant psychosocial impairment. This study examined antidepressant treatment efficacy in a large group of patients with minor depressive disorder...
  47. ncbi Gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression
    P Rucci
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 150:907-13. 2009
    ..These results should be considered tentative pending replication in other samples...
  48. ncbi Nocturnal penile tumescence in healthy 20- to 59-year-olds: a revisit
    C F Reynolds
    Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 12:368-73. 1989
    ..Maximum buckling force and maximum erectile fullness showed stability across the four decades of the Pittsburgh sample...
  49. ncbi Traumatic grief treatment: a pilot study
    M K Shear
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Am J Psychiatry 158:1506-8. 2001
    ..The effects of a treatment program targeting debilitating grief symptoms were tested in a pilot study...
  50. ncbi Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:437-43. 2001
    ..Future studies should examine a possible role for this methodology in investigations of lithium refractoriness and prediction of treatment outcome in bipolar patients...
  51. ncbi Reliability and validity of the Panic Disorder Severity Scale: replication and extension
    M K Shear
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:293-6. 2001
    ..The purpose of this paper is to confirm reliability and validity, to provide an estimate of a cut-score discriminating the presence or absence of current DSM-IV Panic Disorder, and to determine the factor structure of the instrument...
  52. ncbi The development of study exit criteria for evaluating antimanic compounds
    E Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 62:421-5. 2001
    ..We sought a method that would be safer, more economical, and less sensitive to nonspecific factors in the clinical environment while still allowing unambiguous assessment of efficacy...
  53. ncbi Do nocturnal penile tumescence recordings alter electroencephalographic sleep?
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 10:486-90. 1987
    ....
  54. ncbi Adjunctive antipsychotic use in bipolar patients: an open 6-month prospective study following an acute episode
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Affect Disord 56:1-8. 1999
    ..We examined the use of adjunctive antipsychotics in the treatment of bipolar patients...
  55. ncbi Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..Future studies examining the relationship between specific symptomatic dimensions of MDD and OFC volumes could be especially informative...
  56. ncbi Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late-Life and Mid-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..RESULTS: Older-old patients responded as quickly and successfully as the young- and middle-old. CONCLUSIONS: Major depression in the very old can be treated as successfully as in early old age...
  57. ncbi Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  58. ncbi The interaction of drug- and psychotherapy in the long-term treatment of depression
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 62:131-7. 2001
    ..This paper reviews key findings in recurrent depression with respect to long-term treatment. Particular attention is paid to the combination treatment of psychotherapy and antidepressant drugs...
  59. ncbi Increased platelet membrane phosphatidylinositol-4,5-bisphosphate in drug-free depressed bipolar patients
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Neurosci Lett 299:150-2. 2001
    ....
  60. ncbi Are buckling force measurements reliable in nocturnal penile tumescence studies?
    E A Nofzinger
    Sleep and Chronobiology Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 16:156-62. 1993
    ....
  61. ncbi A controlled evaluation of monthly maintenance interpersonal psychotherapy in late-life depression with varying levels of cognitive function
    Kristen Carreira
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 23:1110-3. 2008
    ..To evaluate the effect of maintenance Interpersonal Psychotherapy (IPT) on recurrence rates and time to recurrence of major depression in elderly patients with varying levels of cognitive function...
  62. ncbi Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapy
    Paola Rucci
    Department of Psychiatry, Western Psychiatric Institite and Clinic, 3811 O'Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 159:1160-4. 2002
    ..CONCLUSIONS: A treatment program in a maximally supportive clinical environment can significantly reduce suicidal behavior in high-risk patients with bipolar I disorder...
  63. ncbi Clinical indicators for the use of antidepressants in the treatment of bipolar I depression
    A Fagiolini
    Department of Psychiatry University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 4:277-82. 2002
    ..Larger, prospective, and controlled studies are needed to verify our results and to identify additional indicators for a mood stabilizer and antidepressant combination treatment strategy...
  64. ncbi Self-reported cognitive problems predict employment trajectory in patients with bipolar I disorder
    A M Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States
    J Affect Disord 124:324-8. 2010
    ..Cognitive impairment in bipolar disorder has been associated with poor functional outcomes. We examined the relation of self-reported cognitive problems to employment trajectory in patients diagnosed with bipolar I disorder...
  65. ncbi Comparison of severe life stress in depressed mothers and non-mothers: do children matter?
    U Feske
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 13:109-17. 2001
    ..Our findings suggest that comprehensive treatment for mothers with major depression needs to address their parenting style and any psychological problems experienced by their children...
  66. ncbi The structure of lifetime panic-agoraphobic spectrum
    P Rucci
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 43:366-79. 2009
    ..Future perspectives might include the use of these factors to select homogeneous subgroups of patients for brain-imaging studies and to contribute to elucidating the causes and pathophysiology of panic disorder at molecular level...
  67. ncbi Interpersonal psychotherapy for late-life depression: past, present, and future
    M D Miller
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    J Psychother Pract Res 10:231-8. 2001
    ..In addition, preliminary results using IPT combined with paroxetine in depressed elders reveals no difference in remission rates between cognitively intact and cognitively impaired depressed elders...
  68. ncbi Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:382-90. 2009
    ..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder...
  69. ncbi Sensitivity to change and predictive validity of the MOODS-SR questionnaire, last-month version
    Mario Miniati
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychother Psychosom 78:116-24. 2009
    ....
  70. ncbi Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  71. ncbi Progress in the psychotherapy of mood disorders: studies from the Western Psychiatric Institute and Clinic
    E Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA
    Epidemiol Psichiatr Soc 10:245-52. 2001
    ..Administered in concert with the new medications advances in pharmacology have produced, disorder-specific psychosocial treatments have further improved the prognosis and course of bipolar and unipolar disorder...
  72. ncbi Comorbidity of depression and anxiety disorders in later life
    E J Lenze
    Intervention Research Centers in Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:86-93. 2001
    ..We also recommend directions for future research in the area of psychiatric comorbidity in late life...
  73. ncbi Treatment recommendations versus treatment realities: recognizing the rift and understanding the consequences
    E Frank
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Penn 15213, USA
    J Clin Psychiatry 62:10-5. 2001
    ..Long-term treatment of depression in clinical practice settings may benefit from a closer approximation to the conditions found in clinical trial settings...
  74. ncbi Types of stressors that increase susceptibility to the common cold in healthy adults
    S Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Health Psychol 17:214-23. 1998
    ....
  75. ncbi Effect of different recruitment sources on the composition of a bipolar disorder case registry
    S H Scholle
    Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA
    Soc Psychiatry Psychiatr Epidemiol 35:220-7. 2000
    ..Conducting research on low-prevalence conditions presents an ongoing challenge for clinical and services researchers. Recruitment through health professionals versus other forms of self-referral may affect study group composition...
  76. ncbi Indirect self-destructive behavior and overt suicidality in patients with complicated grief
    Katalin Szanto
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 67:233-9. 2006
    ..Therefore, we examined suicidal behavior and its correlates in 149 patients who signed informed consent statements to participate in a National Institute of Mental Health-funded treatment study of complicated grief...
  77. ncbi Association between illicit drug and alcohol use and first manic episode
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Pharmacol Biochem Behav 86:395-400. 2007
    ....
  78. ncbi Treating complicated grief: effects on sleep quality
    Anne Germain
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Behav Sleep Med 4:152-63. 2006
    ..Given that sleep disturbance is a risk factor for poor health outcomes, adjunctive sleep interventions may be necessary to enhance CGT outcomes...
  79. ncbi Treating complicated grief and substance use disorders: a pilot study
    Allan Zuckoff
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213 2393, USA
    J Subst Abuse Treat 30:205-11. 2006
    ..Study limitations notwithstanding, complicated grief and substance use treatment appears to be a promising intervention that merits further research...
  80. ncbi Clinical presentation and treatment outcome of African Americans with complicated grief
    Mario Cruz
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychiatr Serv 58:700-2. 2007
    ..This study sought to examine whether ethnic differences occur in the presentation of patients with complicated grief or their treatment outcome...
  81. ncbi Hypothyroidism in patients with bipolar I disorder treated primarily with lithium
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
    Epidemiol Psichiatr Soc 15:123-7. 2006
    ..This study evaluated the frequency and clinical significance of abnormal Thyroid Stimulating Hormone (TSH) and Free Thyroxine Index (FTI) in patients with bipolar I disorder treated primarily with lithium...
  82. ncbi Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 9:462-7. 2007
    ..We examine the structure of mood and anxiety spectrum features in patients with BD I to identify subtypes with similar profiles...
  83. ncbi Chronotype and body composition in bipolar disorder
    Isabella Soreca
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Chronobiol Int 26:780-8. 2009
    ..Evening chronotype could be a proxy for as yet unknown specific causes of the high rate of obesity and obesity-related diseases in bipolar disorder...
  84. ncbi Effect of age, weight, and CYP2C19 genotype on escitalopram exposure
    Yuyan Jin
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Pharmacol 50:62-72. 2010
    ..These variables may affect patient tolerance of this antidepressant and may provide important information in the effort to tailor treatments to patients' individual needs...
  85. ncbi Prefrontal cortical and striatal activity to happy and fear faces in bipolar disorder is associated with comorbid substance abuse and eating disorder
    Stefanie Hassel
    University of Pittsburgh, School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    J Affect Disord 118:19-27. 2009
    ....
  86. ncbi Psychotherapy as monotherapy for the treatment of bipolar II depression: a proof of concept study
    Holly A Swartz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Bipolar Disord 11:89-94. 2009
    ..We conducted a proof of concept study to determine the feasibility of using an individual psychotherapy, Interpersonal and Social Rhythm Therapy (IPSRT), as monotherapy for the acute treatment of bipolar II depression...
  87. ncbi Brief interpersonal psychotherapy for depressed mothers whose children are receiving psychiatric treatment
    Holly A Swartz
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Am J Psychiatry 165:1155-62. 2008
    ....
  88. ncbi Emotional and cardiovascular reactivity to a child-focused interpersonal stressor among depressed mothers of psychiatrically ill children
    Jill M Cyranowski
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Depress Anxiety 26:110-6. 2009
    ..This effect may become particularly pronounced when depressed mothers are parenting a psychiatrically ill child...
  89. ncbi Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence
    Danielle M Novick
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 12:1-9. 2010
    ..To date, there has been no comprehensive review of the published prevalence data for attempted suicide in BPII...
  90. ncbi Sudden gains in interpersonal psychotherapy for depression
    Morgen A R Kelly
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Behav Res Ther 45:2563-72. 2007
    ..The lack of impact of sudden gains on eventual outcome is discussed in terms of potentially disparate emphases and mechanisms of change between IPT and cognitive-behavioral therapy (CBT)...
  91. ncbi Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
    ..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
  92. ncbi Metabolic syndrome in bipolar disorder: findings from the Bipolar Disorder Center for Pennsylvanians
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    Bipolar Disord 7:424-30. 2005
    ..This study sought to evaluate the presence of the metabolic syndrome in a group of 171 patients with bipolar disorder who were consecutively recruited in the Bipolar Disorder Center for Pennsylvanians...
  93. ncbi Correlates of remission in primary care patients treated for minor depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Gen Hosp Psychiatry 24:12-9. 2002
    ..46) of being a patient in the VA system. The remaining variables associated with higher probability of remission appear to reflect social advantage and lower severity or complexity of illness...
  94. ncbi Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression
    Mark D Sullivan
    Department of Psychiatry, University of Washington, Seattle 98195, USA
    J Am Board Fam Pract 16:22-31. 2003
    ..It is clearly not necessary for patients to believe that their dysthymia or minor depression is biological to respond to antidepressant medication...
  95. ncbi Suicide attempts and ideation in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Clin Psychiatry 65:509-14. 2004
    ..Suicidal thinking and behavior are common in individuals with bipolar disorder...
  96. ncbi Development and preliminary testing of the General 5-Spectrum Measure (GSM-V)
    Paola Rucci
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, Pennsylvania 15213-2593, USA
    Depress Anxiety 18:109-17. 2003
    ..Additionally, it could provide a better characterization of patients with a syndromal level Axis-I disorder, who might require specific treatment strategies targeted to co-occurring subsyndromal conditions...
  97. ncbi Slower treatment response in bipolar depression predicted by lower pretreatment thyroid function
    Daniel P Cole
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Am J Psychiatry 159:116-21. 2002
    ..It remains to be seen whether pharmacological enhancement of thyroid function will facilitate recovery from bipolar depression...
  98. ncbi Relationship of birth cohort and early age at onset of illness in a bipolar disorder case registry
    K N Roy Chengappa
    Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213 2593, USA
    Am J Psychiatry 160:1636-42. 2003
    ..Utilizing data from a previously characterized registry of subjects with bipolar illness, the authors examined age at onset of the first illness episode in cohorts of subjects born from 1900 through 1939 and from 1940 through 1959...
  99. ncbi Beyond the question of placebo controls: ethical issues in psychopharmacological drug studies
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 171:19-26. 2003
    ..This review, although not exhaustive, highlights an array of ethical issues that arose from discussions within the NIMH Human Subjects Research Council Workgroup...
  100. ncbi 2002 Robert Ader New Investigator award. Relationship of cardiovascular reactivity, stressful life events, and multiple sclerosis disease activity
    Kurt D Ackerman
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Behav Immun 17:141-51. 2003
    ..These results are consistent with the hypothesis that stress is a potential trigger of MS disease activity and suggest that autonomic tone and stress reactivity may play a role in the development of stress-related exacerbations...
  101. ncbi The value of maintenance interpersonal psychotherapy (IPT) in older adults with different IPT foci
    Mark D Miller
    Intervention Research Center for Late Life Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 11:97-102. 2003
    ....

Research Grants7

  1. A Novel Therapy for Depression with Co-Occurring Panic
    Ellen Frank; Fiscal Year: 2003
    ....
  2. Depression: The Search for Treatment-Relevant Phenotypes
    Ellen Frank; Fiscal Year: 2009
    ..Signal detection analysis will be used to determine which combination of spectrum assessment scores and other clinical variables describe the profile of patients likely to stabilize or relapse with each of the treatments. ..