E Frank

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Computerized adaptive measurement of depression: a simulation study
    William Gardner
    Pediatrics, Children s Research Institute and Ohio State University, Columbus, OH, USA
    BMC Psychiatry 4:13. 2004
  2. ncbi request reprint Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modality
    E Frank
    Department of Psychiatry, University of Pittsburgh 15213, USA
    J Abnorm Psychol 108:579-87. 1999
  3. ncbi request reprint Natural history and preventative treatment of recurrent mood disorders
    E Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pennsylvania 15213 2593, USA
    Annu Rev Med 50:453-68. 1999
  4. pmc Association between illicit drug and alcohol use and first manic episode
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Pharmacol Biochem Behav 86:395-400. 2007
  5. ncbi request reprint Beyond the question of placebo controls: ethical issues in psychopharmacological drug studies
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 171:19-26. 2003
  6. ncbi request reprint The development of study exit criteria for evaluating antimanic compounds
    E Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 62:421-5. 2001
  7. ncbi request reprint Influence of panic-agoraphobic spectrum symptoms on treatment response in patients with recurrent major depression
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 157:1101-7. 2000
  8. ncbi request reprint Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:905-11. 2002
  9. ncbi request reprint Progress in the psychotherapy of mood disorders: studies from the Western Psychiatric Institute and Clinic
    E Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA
    Epidemiol Psichiatr Soc 10:245-52. 2001
  10. ncbi request reprint Cross-cultural validity of the structured clinical interview for panic-agoraphobic spectrum
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Soc Psychiatry Psychiatr Epidemiol 40:283-90. 2005

Collaborators

Detail Information

Publications146 found, 100 shown here

  1. pmc Computerized adaptive measurement of depression: a simulation study
    William Gardner
    Pediatrics, Children s Research Institute and Ohio State University, Columbus, OH, USA
    BMC Psychiatry 4:13. 2004
    ..We developed a computerized adaptive version of the Beck Depression Inventory (BDI). We examined its efficiency and its usefulness in identifying Major Depressive Episodes (MDE) and in measuring depression severity...
  2. ncbi request reprint Adjunctive psychotherapy for bipolar disorder: effects of changing treatment modality
    E Frank
    Department of Psychiatry, University of Pittsburgh 15213, USA
    J Abnorm Psychol 108:579-87. 1999
    ..This finding, consistent with the authors' philosophy that bipolar patients benefit from stable routines, suggests that disruptions in the psychosocial treatment plan contribute to worse outcomes...
  3. ncbi request reprint Natural history and preventative treatment of recurrent mood disorders
    E Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pennsylvania 15213 2593, USA
    Annu Rev Med 50:453-68. 1999
    ..Finally, the chapter describes recent advances in the treatment of bipolar disorder...
  4. pmc Association between illicit drug and alcohol use and first manic episode
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Pharmacol Biochem Behav 86:395-400. 2007
    ....
  5. ncbi request reprint Beyond the question of placebo controls: ethical issues in psychopharmacological drug studies
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychopharmacology (Berl) 171:19-26. 2003
    ..This review, although not exhaustive, highlights an array of ethical issues that arose from discussions within the NIMH Human Subjects Research Council Workgroup...
  6. ncbi request reprint The development of study exit criteria for evaluating antimanic compounds
    E Frank
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 62:421-5. 2001
    ..We sought a method that would be safer, more economical, and less sensitive to nonspecific factors in the clinical environment while still allowing unambiguous assessment of efficacy...
  7. ncbi request reprint Influence of panic-agoraphobic spectrum symptoms on treatment response in patients with recurrent major depression
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 157:1101-7. 2000
    ..The authors tested the hypothesis that a lifetime history of panic-agoraphobic spectrum symptoms predicts a poorer response to depression treatment...
  8. ncbi request reprint Clinical significance of lifetime panic spectrum symptoms in the treatment of patients with bipolar I disorder
    Ellen Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 59:905-11. 2002
    ..We hypothesized that lifetime panic spectrum features would be associated with higher levels of suicidal ideation and a poorer response to acute treatment of the index mood episode in this patient population...
  9. ncbi request reprint Progress in the psychotherapy of mood disorders: studies from the Western Psychiatric Institute and Clinic
    E Frank
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA, USA
    Epidemiol Psichiatr Soc 10:245-52. 2001
    ..Administered in concert with the new medications advances in pharmacology have produced, disorder-specific psychosocial treatments have further improved the prognosis and course of bipolar and unipolar disorder...
  10. ncbi request reprint Cross-cultural validity of the structured clinical interview for panic-agoraphobic spectrum
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Soc Psychiatry Psychiatr Epidemiol 40:283-90. 2005
    ....
  11. ncbi request reprint Treatment recommendations versus treatment realities: recognizing the rift and understanding the consequences
    E Frank
    Department of Psychiatry, School of Medicine, University of Pittsburgh, Penn 15213, USA
    J Clin Psychiatry 62:10-5. 2001
    ..Long-term treatment of depression in clinical practice settings may benefit from a closer approximation to the conditions found in clinical trial settings...
  12. ncbi request reprint Correlates of remission in primary care patients treated for minor depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, Pittsburgh, PA, USA
    Gen Hosp Psychiatry 24:12-9. 2002
    ..46) of being a patient in the VA system. The remaining variables associated with higher probability of remission appear to reflect social advantage and lower severity or complexity of illness...
  13. ncbi request reprint High relapse rate after discontinuation of adjunctive medication for elderly patients with recurrent major depression
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Late Life Mood Disorders, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, PA 15213, USA
    Am J Psychiatry 153:1418-22. 1996
    ..Twenty-eight patients (17.7%) received inpatient care at some point during acute-phase treatment...
  14. ncbi request reprint Which elderly patients with remitted depression remain well with continued interpersonal psychotherapy after discontinuation of antidepressant medication?
    C F Reynolds
    Mental Health Clinical Research Center for the Study of Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Psychiatry 154:958-62. 1997
    ..This study was conducted to identify which elderly patients with remitted recurrent major depression remain well with maintenance interpersonal psychotherapy after discontinuation of active antidepressant medication (nortriptyline)...
  15. ncbi request reprint Temporal profiles of the course of depression during treatment. Predictors of pathways toward recovery in the elderly
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA, USA
    Arch Gen Psychiatry 54:1016-24. 1997
    ..Whether patients vary in their pathways toward those outcomes--and the extent to which such variation can be anticipated by patient characteristics prior to treatment--has not been empirically examined...
  16. pmc The structure of lifetime manic-hypomanic spectrum
    G B Cassano
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, School of Medicine, University of Pisa, Italy
    J Affect Disord 112:59-70. 2009
    ..The aim of the present study is to examine the structure of mania/hypomania using 68 items of the MOODS-SR that explore cognitive, mood and energy/activity features associated with mania/hypomania...
  17. ncbi request reprint Treatment of bereavement-related major depressive episodes in later life: a controlled study of acute and continuation treatment with nortriptyline and interpersonal psychotherapy
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213, USA
    Am J Psychiatry 156:202-8. 1999
    ..The authors tested the hypothesis that nortriptyline and interpersonal psychotherapy, alone and in combination, are superior to placebo in achieving remission of bereavement-related major depressive episodes...
  18. ncbi request reprint Nortriptyline and interpersonal psychotherapy as maintenance therapies for recurrent major depression: a randomized controlled trial in patients older than 59 years
    C F Reynolds
    The Mental Health Clinical Research Centers for Late and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh Medical Center, PA 15213, USA
    JAMA 281:39-45. 1999
    ..Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability...
  19. ncbi request reprint Panic-agoraphobic spectrum: reliability and validity of assessment instruments
    M K Shear
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:59-66. 2001
    ..We conclude that PAS can be reliably assessed, and that it describes a valid, coherent constellation of features associated with DSM IV Panic Disorder, but providing additional important clinical information...
  20. pmc Predictors and moderators of time to remission of major depression with interpersonal psychotherapy and SSRI pharmacotherapy
    E Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Psychol Med 41:151-62. 2011
    ..We sought to determine whether measures of spectrum psychopathology are useful in deciding which patients with unipolar depression should receive pharmacotherapy versus depression-specific psychotherapy...
  21. ncbi request reprint Latent structure of EEG sleep variables in depressed and control subjects: descriptions and clinical correlates
    D J Buysse
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Psychiatry Res 79:105-22. 1998
    ..Multivariate statistical techniques decrease the risk of Type I and Type II errors when using a large number of collinear sleep measures, and can clarify conceptual issues related to sleep and depression...
  22. pmc Treatment-emergent suicidal ideation during 4 months of acute management of unipolar major depression with SSRI pharmacotherapy or interpersonal psychotherapy in a randomized clinical trial
    P Rucci
    Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Depress Anxiety 28:303-9. 2011
    ....
  23. doi request reprint The structure of lifetime panic-agoraphobic spectrum
    P Rucci
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 43:366-79. 2009
    ..Future perspectives might include the use of these factors to select homogeneous subgroups of patients for brain-imaging studies and to contribute to elucidating the causes and pathophysiology of panic disorder at molecular level...
  24. ncbi request reprint Effects of lithium on platelet membrane phosphoinositides in bipolar disorder patients: a pilot study
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    Psychopharmacology (Berl) 149:12-6. 2000
    ..In vitro and in vivo animal studies suggest that the intracellular phosphatidylinositol (PI) pathway is an important target for the effects of lithium...
  25. pmc Does psychomotor retardation define a clinically relevant phenotype of unipolar depression?
    S Calugi
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, School of Medicine, University of Pisa, Italy
    J Affect Disord 129:296-300. 2011
    ..The aim of this study was to assess the clinical correlates of psychomotor retardation endorsed at any time during the patients' lifetime (LPR)...
  26. ncbi request reprint Concurrent measures of protein kinase C and phosphoinositides in lithium-treated bipolar patients and healthy individuals: a preliminary study
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213
    Psychiatry Res 95:109-18. 2000
    ..These preliminary findings suggest that chronic lithium treatment may decrease the levels of both cytosolic PKC alpha isozyme and membrane PIP(2) in platelets of bipolar disorder patients...
  27. ncbi request reprint Personality pathology and outcome in recurrently depressed women over 2 years of maintenance interpersonal psychotherapy
    J M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Psychol Med 34:659-69. 2004
    ..By maintenance treatment we refer to long-term treatment provided to prevent depression recurrence among remitted patients...
  28. pmc Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy?
    Alexandre Y Dombrovski
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 25:1060-6. 2008
    ..We therefore examined the impact of persistent symptoms, including mood, insomnia, and anxiety symptoms, on time to recurrence in women receiving maintenance interpersonal psychotherapy (IPT-M) for recurrent depression...
  29. doi request reprint Comparative outcomes among the problem areas of interpersonal psychotherapy for depression
    J C Levenson
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 27:434-40. 2010
    ..Moreover, we sought to understand how the patient characteristics and interpersonal problems most closely linked to the onset of a patient's current depression contributed to IPT success...
  30. ncbi request reprint Tolerability of combined treatment with lithium and paroxetine in patients with bipolar disorder and depression
    A Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
    J Clin Psychopharmacol 21:474-8. 2001
    ..Clinicians should be aware of the possible development of a serotonin syndrome among patients in whom paroxetine is added to ongoing lithium treatment...
  31. ncbi request reprint Sleep and treatment response in depression: new findings using power spectral analysis
    D J Buysse
    Department of Psychiatry, University of Pittsburgh, 3811 O Hara Street, E 1127 WPIC, Pittsburgh, PA 15213, USA
    Psychiatry Res 103:51-67. 2001
    ..Quantitative REMs may provide a more direct measure of brainstem function and dysfunction during REM sleep than quantitative sleep EEG measures...
  32. ncbi request reprint Decreased pituitary volume in patients with bipolar disorder
    R B Sassi
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 50:271-80. 2001
    ..Our findings suggest that detectable abnormalities in pituitary size are present in patients with bipolar disorder, which may reflect a dysfunctional HPA axis...
  33. ncbi request reprint Initial recovery patterns may predict which maintenance therapies for depression will keep older adults well
    M A Dew
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 65:155-66. 2001
    ..Patients' temporal patterns of acute treatment response may predict who requires which maintenance therapy to remain well...
  34. ncbi request reprint PET imaging of serotonin 1A receptor binding in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Biol Psychiatry 46:1375-87. 1999
    ..PET imaging using the 5HT1A receptor radioligand, [11C]WAY-100635, may clarify the clinical conditions under which 5HT1A receptor binding potential (BP) is abnormal in depression...
  35. ncbi request reprint Differential effects of age on brain gray matter in bipolar patients and healthy individuals
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Neuropsychobiology 43:242-7. 2001
    ....
  36. ncbi request reprint MRI study of posterior fossa structures and brain ventricles in bipolar patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:313-22. 2001
    ..However, there were suggestions that abnormalities in cerebellum, vermis, and lateral ventricle sizes may be present in familial cases of the disorder, which should be further examined in future studies with larger patient samples...
  37. ncbi request reprint Three-year outcomes of maintenance nortriptyline treatment in late-life depression: a study of two fixed plasma levels
    C F Reynolds
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    Am J Psychiatry 156:1177-81. 1999
    ..This study compared the long-term efficacy of two fixed plasma levels of nortriptyline in preventing or delaying recurrence of major depression in elderly patients and in minimizing residual depressive symptoms and somatic complaints...
  38. pmc The factor structure of lifetime depressive spectrum in patients with unipolar depression
    G B Cassano
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, School of Medicine, University of Pisa, Italy
    J Affect Disord 115:87-99. 2009
    ..By examining data from a large number of items covering the range of depressive symptoms, the aim of the present study is to contribute to the identification of the structure of depression on a lifetime perspective...
  39. ncbi request reprint Anatomical MRI study of basal ganglia in bipolar disorder patients
    P Brambilla
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara St, Pittsburgh, PA 15213, USA
    Psychiatry Res 106:65-80. 2001
    ....
  40. ncbi request reprint Interpersonal psychotherapy for depression with panic spectrum symptoms: a pilot study
    Jill M Cyranowski
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Depress Anxiety 21:140-2. 2005
    ..A newly adapted psychosocial treatment for depression with lifetime panic spectrum symptoms was evaluated in an open pilot study...
  41. ncbi request reprint Prevalence and clinical correlates of medical comorbidities in patients with bipolar I disorder: analysis of acute-phase data from a randomized controlled trial
    Wesley K Thompson
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15260, USA
    J Clin Psychiatry 67:783-8. 2006
    ..We studied the relationship between number of medical comorbidities in patients with bipolar I disorder and their demographic and clinical characteristics...
  42. pmc Simultaneous evaluation of the harms and benefits of treatments in randomized clinical trials: demonstration of a new approach
    E Frank
    University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychol Med 42:865-73. 2012
    ..Particularly in mental health, however, there is a lack of a single objective, reliable measure of outcome that is sensitive to crucial individual differences among patients...
  43. pmc Clinical characteristics and treatment outcome of depression in patients with and without a history of emotional and physical abuse
    M Miniati
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, School of Medicine, University of Pisa, Italy
    J Psychiatr Res 44:302-9. 2010
    ..The present study suggests that patients with a history of EPA show a subtype of depression characterized by poor treatment response and more severe neurovegetative and psychomotor symptoms...
  44. ncbi request reprint Subjective health measures and acute treatment outcomes in geriatric depression
    E J Lenze
    The Intervention Research Center in Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA
    Int J Geriatr Psychiatry 16:1149-55. 2001
    ..However, successful treatment for depression has been associated with improvement in self-rated health and other health measures...
  45. ncbi request reprint Anxiety as a predictor of response to interpersonal psychotherapy for recurrent major depression: an exploratory investigation
    U Feske
    Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, Pennsylvania, USA
    Depress Anxiety 8:135-41. 1998
    ..Our findings strengthen existing evidence that concomitant anxiety can adversely affect the outcome of interpersonal therapy for depression...
  46. ncbi request reprint Do nocturnal penile tumescence recordings alter electroencephalographic sleep?
    M E Thase
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 10:486-90. 1987
    ....
  47. ncbi request reprint Competence of depressed patients for consent to research
    P S Appelbaum
    Department of Psychiatry, University of Massachusetts Medical School, Worcester 01655, USA
    Am J Psychiatry 156:1380-4. 1999
    ..This study used a new instrument for assessing depressed patients' capacities to consent to research and examined their performance, including the relation between severity of depression and extent of impairment...
  48. ncbi request reprint Traumatic grief treatment: a pilot study
    M K Shear
    Department of Psychiatry, University of Pittsburgh Medical Center, PA, USA
    Am J Psychiatry 158:1506-8. 2001
    ..The effects of a treatment program targeting debilitating grief symptoms were tested in a pilot study...
  49. ncbi request reprint MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals
    S C Caetano
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213-3282, USA
    Psychiatry Res 108:161-8. 2001
    ..Although functional abnormalities in the thalamus are likely to be implicated in the pathophysiology of mood disorders, no abnormalities in thalamic size appear present in bipolar or unipolar individuals...
  50. ncbi request reprint Prevalence of obesity and weight change during treatment in patients with bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:528-33. 2002
    ..Individuals with bipolar disorder tend to be overweight, and their treatment may exacerbate obesity and increase the risk of concurrent medical disease in this population...
  51. ncbi request reprint Randomized, placebo-controlled trial of fluoxetine for acute treatment of minor depressive disorder
    Lewis L Judd
    Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0603, USA
    Am J Psychiatry 161:1864-71. 2004
    ..Minor depressive disorder is both common and associated with significant psychosocial impairment. This study examined antidepressant treatment efficacy in a large group of patients with minor depressive disorder...
  52. pmc The Mood Disorder Burden Index: a scale for assessing the burden of caregivers to adults with unipolar or bipolar disorder
    Lynn M Martire
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States University Center for Social and Urban Research, Pittsburgh, PA, United States
    Psychiatry Res 168:67-77. 2009
    ..It will be important for future research to administer the MDBI to caregivers of middle-aged and older patients as well as those receiving treatment through inpatient settings or community outpatient clinics...
  53. ncbi request reprint Combined pharmacotherapy and psychotherapy as maintenance treatment for late-life depression: effects on social adjustment
    Eric J Lenze
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Psychiatry 159:466-8. 2002
    ..The authors hypothesized that elderly patients recovering from depression would have better social adjustment with medication and interpersonal psychotherapy than with medication or psychotherapy alone...
  54. ncbi request reprint Brain lithium concentrations in bipolar disorder patients: preliminary (7)Li magnetic resonance studies at 3 T
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Biol Psychiatry 49:437-43. 2001
    ..Future studies should examine a possible role for this methodology in investigations of lithium refractoriness and prediction of treatment outcome in bipolar patients...
  55. ncbi request reprint Adjunctive antipsychotic use in bipolar patients: an open 6-month prospective study following an acute episode
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213, USA
    J Affect Disord 56:1-8. 1999
    ..We examined the use of adjunctive antipsychotics in the treatment of bipolar patients...
  56. ncbi request reprint Nocturnal penile tumescence in healthy 20- to 59-year-olds: a revisit
    C F Reynolds
    Sleep Evaluation Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pennsylvania 15213
    Sleep 12:368-73. 1989
    ..Maximum buckling force and maximum erectile fullness showed stability across the four decades of the Pittsburgh sample...
  57. ncbi request reprint Reliability and validity of the Panic Disorder Severity Scale: replication and extension
    M K Shear
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Psychiatr Res 35:293-6. 2001
    ..The purpose of this paper is to confirm reliability and validity, to provide an estimate of a cut-score discriminating the presence or absence of current DSM-IV Panic Disorder, and to determine the factor structure of the instrument...
  58. pmc Medical burden in late-life bipolar and major depressive disorders
    Ariel G Gildengers
    Intervention Research Center for Late Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, The Center for Health Equity Research and Promotion, VA Pittsburgh Healthcare System, Pittsburgh, PA, USA
    Am J Geriatr Psychiatry 16:194-200. 2008
    ..The authors compare medical burden in elderly patients with bipolar disorder with that in those with major depressive disorder...
  59. ncbi request reprint Anatomic evaluation of the orbitofrontal cortex in major depressive disorder
    Acioly L T Lacerda
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Biol Psychiatry 55:353-8. 2004
    ..This study examined the OFC and its subdivisions in patients with MDD and matched healthy control subjects...
  60. ncbi request reprint Course and rate of antidepressant response in the very old
    Ariel G Gildengers
    The Intervention Research Centers for Late Life and Mid Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Affect Disord 69:177-84. 2002
    ..The authors examined elderly patients with major depression to determine the relationship of current age to treatment response course and success rate...
  61. pmc Differences between unipolar depression and bipolar II depression in women
    C P B Rastelli
    Department of Psychiatry, University of Pittsburgh, School of Medicine, PA 15213, United States
    J Affect Disord 150:1120-4. 2013
    ..We examined symptoms and clinical features of MDE in women with UD and BPII to compare presentations of the two disorders in women...
  62. ncbi request reprint Increased platelet membrane phosphatidylinositol-4,5-bisphosphate in drug-free depressed bipolar patients
    J C Soares
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Neurosci Lett 299:150-2. 2001
    ....
  63. pmc Genetic segregation analysis of early-onset recurrent unipolar depression
    M L Marazita
    Cleft Palate Craniofacial Center, School of Dental Medicine, University of Pittsburgh, PA 15261, USA
    Am J Hum Genet 61:1370-8. 1997
    ..Under the broad-definition assumption, the best-fitting model is a Mendelian codominant major locus with significant residual parental and spousal effects...
  64. ncbi request reprint Are buckling force measurements reliable in nocturnal penile tumescence studies?
    E A Nofzinger
    Sleep and Chronobiology Center, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213
    Sleep 16:156-62. 1993
    ....
  65. pmc Gender moderates the relationship between mania spectrum and serotonin transporter polymorphisms in depression
    P Rucci
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Med Genet B Neuropsychiatr Genet 150:907-13. 2009
    ..These results should be considered tentative pending replication in other samples...
  66. ncbi request reprint The interaction of drug- and psychotherapy in the long-term treatment of depression
    D J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    J Affect Disord 62:131-7. 2001
    ..This paper reviews key findings in recurrent depression with respect to long-term treatment. Particular attention is paid to the combination treatment of psychotherapy and antidepressant drugs...
  67. ncbi request reprint Clinical indicators for the use of antidepressants in the treatment of bipolar I depression
    A Fagiolini
    Department of Psychiatry University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 4:277-82. 2002
    ..Our objective was to evaluate the clinical and demographic differences between patients who remitted on a mood stabilizer alone and patients who subsequently required an adjunctive antidepressant to achieve stabilization...
  68. ncbi request reprint Comorbidity of depression and anxiety disorders in later life
    E J Lenze
    Intervention Research Centers in Late-Life Mood Disorders, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 14:86-93. 2001
    ..We also recommend directions for future research in the area of psychiatric comorbidity in late life...
  69. pmc Interpersonal psychotherapy for late-life depression: past, present, and future
    M D Miller
    Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA
    J Psychother Pract Res 10:231-8. 2001
    ..In addition, preliminary results using IPT combined with paroxetine in depressed elders reveals no difference in remission rates between cognitively intact and cognitively impaired depressed elders...
  70. pmc A controlled evaluation of monthly maintenance interpersonal psychotherapy in late-life depression with varying levels of cognitive function
    Kristen Carreira
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Int J Geriatr Psychiatry 23:1110-3. 2008
    ..To evaluate the effect of maintenance Interpersonal Psychotherapy (IPT) on recurrence rates and time to recurrence of major depression in elderly patients with varying levels of cognitive function...
  71. ncbi request reprint Suicide attempts in patients with bipolar I disorder during acute and maintenance phases of intensive treatment with pharmacotherapy and adjunctive psychotherapy
    Paola Rucci
    Department of Psychiatry, Western Psychiatric Institite and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Am J Psychiatry 159:1160-4. 2002
    ..Lifetime rates of suicide attempts among patients with bipolar I disorder were compared to rates during a 2-year period of intensive treatment with pharmacotherapy and with one of two adjunctive psychosocial interventions...
  72. pmc Sleep duration is associated with dyslipidemia in patients with bipolar disorder in clinical remission
    I Soreca
    University of Pittsburgh, School of Medicine, Department of Psychiatry, USA
    J Affect Disord 141:484-7. 2012
    ..Our hypothesis is that disturbances in the sleep-wake cycle are an important and under-recognized pathway through which affective disorders lead to increased cardiovascular risk...
  73. pmc Heterogeneity of amygdala response in major depressive disorder: the impact of lifetime subthreshold mania
    J C Fournier
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Psychol Med 43:293-302. 2013
    ..We aimed to examine whether individual differences in amygdala activity to emotionally salient stimuli were related to heterogeneity in lifetime levels of depressive and subthreshold manic symptoms among adults with MDD...
  74. ncbi request reprint Types of stressors that increase susceptibility to the common cold in healthy adults
    S Cohen
    Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Health Psychol 17:214-23. 1998
    ....
  75. pmc Self-reported cognitive problems predict employment trajectory in patients with bipolar I disorder
    A M Gilbert
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, United States
    J Affect Disord 124:324-8. 2010
    ..Cognitive impairment in bipolar disorder has been associated with poor functional outcomes. We examined the relation of self-reported cognitive problems to employment trajectory in patients diagnosed with bipolar I disorder...
  76. ncbi request reprint Comparison of severe life stress in depressed mothers and non-mothers: do children matter?
    U Feske
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania, USA
    Depress Anxiety 13:109-17. 2001
    ..Our findings suggest that comprehensive treatment for mothers with major depression needs to address their parenting style and any psychological problems experienced by their children...
  77. doi request reprint Sensitivity to change and predictive validity of the MOODS-SR questionnaire, last-month version
    Mario Miniati
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Psychother Psychosom 78:116-24. 2009
    ....
  78. pmc Enhancing outcomes in patients with bipolar disorder: results from the Bipolar Disorder Center for Pennsylvanians Study
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA
    Bipolar Disord 11:382-90. 2009
    ..We investigated whether SCBD and ECI + SCBD are able to improve outcomes and reduce health disparities for young and elderly individuals, African Americans, and rural residents with bipolar disorder...
  79. pmc Predicting 6-week treatment response to escitalopram pharmacotherapy in late-life major depressive disorder
    Ramin Saghafi
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, USA
    Int J Geriatr Psychiatry 22:1141-6. 2007
    ..This study aims to characterize sociodemographic, clinical, and neuropsychologic correlates of full, partial, and non-response to escitalopram monotherapy of unipolar MDD in later life...
  80. ncbi request reprint Serotonin type-1A receptor imaging in depression
    W C Drevets
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Nucl Med Biol 27:499-507. 2000
    ....
  81. ncbi request reprint Effect of different recruitment sources on the composition of a bipolar disorder case registry
    S H Scholle
    Department of Psychiatry, University of Pittsburgh, Pennsylvania, USA
    Soc Psychiatry Psychiatr Epidemiol 35:220-7. 2000
    ..Conducting research on low-prevalence conditions presents an ongoing challenge for clinical and services researchers. Recruitment through health professionals versus other forms of self-referral may affect study group composition...
  82. ncbi request reprint Psychotherapy for bipolar depression: a phase-specific treatment strategy?
    H A Swartz
    Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, PA, USA
    Bipolar Disord 3:11-22. 2001
    ..Pharmacologic strategies for bipolar depression are often inadequate. We therefore review the literature on the role of psychotherapy as an adjunct to medication in the treatment of bipolar depression...
  83. pmc Psychotherapy as monotherapy for the treatment of bipolar II depression: a proof of concept study
    Holly A Swartz
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA
    Bipolar Disord 11:89-94. 2009
    ..We conducted a proof of concept study to determine the feasibility of using an individual psychotherapy, Interpersonal and Social Rhythm Therapy (IPSRT), as monotherapy for the acute treatment of bipolar II depression...
  84. pmc Addressing the challenges of a cross-national investigation: lessons from the Pittsburgh-Pisa study of treatment-relevant phenotypes of unipolar depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Clin Trials 5:253-61. 2008
    ..A multi-site clinical trial that includes psychotherapy as one of the treatments presents numerous challenges related to cross-site consistency and communication...
  85. ncbi request reprint Obesity as a correlate of outcome in patients with bipolar I disorder
    Andrea Fagiolini
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 160:112-7. 2003
    ....
  86. ncbi request reprint The value of maintenance interpersonal psychotherapy (IPT) in older adults with different IPT foci
    Mark D Miller
    Intervention Research Center for Late Life Mood Disorders, University of Pittsburgh School of Medicine, PA, USA
    Am J Geriatr Psychiatry 11:97-102. 2003
    ....
  87. ncbi request reprint Patient beliefs predict response to paroxetine among primary care patients with dysthymia and minor depression
    Mark D Sullivan
    Department of Psychiatry, University of Washington, Seattle 98195, USA
    J Am Board Fam Pract 16:22-31. 2003
    ..Dysthymia and minor depression are common problems in primary care, but it is not known how patient health beliefs shape response to antidepressant treatment of these less severe forms of depression...
  88. pmc Sudden gains in interpersonal psychotherapy for depression
    Morgen A R Kelly
    Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Behav Res Ther 45:2563-72. 2007
    ..The lack of impact of sudden gains on eventual outcome is discussed in terms of potentially disparate emphases and mechanisms of change between IPT and cognitive-behavioral therapy (CBT)...
  89. ncbi request reprint Slower treatment response in bipolar depression predicted by lower pretreatment thyroid function
    Daniel P Cole
    Department of Psychiatry, University of Pittsburgh School of Medicine, USA
    Am J Psychiatry 159:116-21. 2002
    ..It was hypothesized that subjects with lower thyroid function, even within the normal range, would have a poorer response to initial treatment...
  90. pmc Mood and anxiety spectrum as a means to identify clinically relevant subtypes of bipolar I disorder
    Andrea Fagiolini
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Bipolar Disord 9:462-7. 2007
    ..We examine the structure of mood and anxiety spectrum features in patients with BD I to identify subtypes with similar profiles...
  91. ncbi request reprint 2002 Robert Ader New Investigator award. Relationship of cardiovascular reactivity, stressful life events, and multiple sclerosis disease activity
    Kurt D Ackerman
    Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Brain Behav Immun 17:141-51. 2003
    ..These results are consistent with the hypothesis that stress is a potential trigger of MS disease activity and suggest that autonomic tone and stress reactivity may play a role in the development of stress-related exacerbations...
  92. pmc Randomized trial of weekly, twice-monthly, and monthly interpersonal psychotherapy as maintenance treatment for women with recurrent depression
    Ellen Frank
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 164:761-7. 2007
    ..The authors sought to determine whether a greater frequency of interpersonal psychotherapy (IPT) sessions during maintenance treatment has a greater prophylactic effect than a previously validated once-a-month treatment...
  93. ncbi request reprint The panic-agoraphobic spectrum: development, description, and clinical significance
    M Katherine Shear
    Western Psychiatric Institute and Clinic, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
    Psychiatr Clin North Am 25:739-56. 2002
    ..Such an approach holds some promise for progress in studies of neurobiologic basis of panic and may be useful in further efforts to overcome the nagging problem of the ambiguous boundaries of DSM diagnostic categories [53]...
  94. pmc Emotional and cardiovascular reactivity to a child-focused interpersonal stressor among depressed mothers of psychiatrically ill children
    Jill M Cyranowski
    Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Depress Anxiety 26:110-6. 2009
    ..This effect may become particularly pronounced when depressed mothers are parenting a psychiatrically ill child...
  95. pmc The role of interpersonal and social rhythm therapy in improving occupational functioning in patients with bipolar I disorder
    Ellen Frank
    Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 165:1559-65. 2008
    ..The authors describe the effect of acute treatment with interpersonal and social rhythm therapy on occupational functioning over a period of approximately 2.5 years...
  96. doi request reprint Suicide attempts in bipolar I and bipolar II disorder: a review and meta-analysis of the evidence
    Danielle M Novick
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Bipolar Disord 12:1-9. 2010
    ..To date, there has been no comprehensive review of the published prevalence data for attempted suicide in BPII...
  97. pmc Effect of age, weight, and CYP2C19 genotype on escitalopram exposure
    Yuyan Jin
    Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    J Clin Pharmacol 50:62-72. 2010
    ..These variables may affect patient tolerance of this antidepressant and may provide important information in the effort to tailor treatments to patients' individual needs...
  98. pmc Bipolar disorder center for Pennsylvanians: implementing an effectiveness trial to improve treatment for at-risk patients
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Psychiatr Serv 60:888-97. 2009
    ..This report highlights the methods used to recruit, screen, and enroll a cohort of difficult-to-recruit individuals with bipolar disorder...
  99. ncbi request reprint Demographic and clinical characteristics of individuals in a bipolar disorder case registry
    David J Kupfer
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, PA 15213, USA
    J Clin Psychiatry 63:120-5. 2002
    ....
  100. doi request reprint Chronotype and body composition in bipolar disorder
    Isabella Soreca
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Chronobiol Int 26:780-8. 2009
    ..Evening chronotype could be a proxy for as yet unknown specific causes of the high rate of obesity and obesity-related diseases in bipolar disorder...
  101. ncbi request reprint A descriptive analysis of minor depression
    Mark Hyman Rapaport
    Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, 92037, USA
    Am J Psychiatry 159:637-43. 2002
    ..The authors provide a detailed clinical description of minor depression: its symptoms, level of disability, stability, and relationship to patient and family history of major depressive disorder...