Matthew B Francis


Affiliation: University of California
Country: USA


  1. Slack C, Finbloom J, Jeong K, Bruns C, Wemmer D, Pines A, et al. Rotaxane probes for protease detection by 129Xe hyperCEST NMR. Chem Commun (Camb). 2017;53:1076-1079 pubmed publisher
    ..Upon cleavage of the rotaxane by MMP-2, CB6 became accessible for 129Xe@CB6 interactions, leading to protease-responsive hyperCEST activation. ..
  2. Kwant R, Jaffe J, Palmere P, Francis M. Controlled levels of protein modification through a chromatography-mediated bioconjugation. Chem Sci. 2015;6:2596-2601 pubmed publisher
    ..We demonstrate the use of this method in the construction of a protein-templated light-harvesting mimic, a type of system which has historically been difficult to make in a well-defined manner. ..
  3. Finbloom J, Aanei I, Bernard J, Klass S, Elledge S, Han K, et al. Evaluation of Three Morphologically Distinct Virus-Like Particles as Nanocarriers for Convection-Enhanced Drug Delivery to Glioblastoma. Nanomaterials (Basel). 2018;8: pubmed publisher
    ..Overall, this study underscores the potential of nanoscale chemotherapeutic CED using virus-like particles and illustrates the need for further studies into how the overall morphology of VLPs influences their drug delivery properties. ..
  4. Furst A, Klass S, Francis M. DNA Hybridization to Control Cellular Interactions. Trends Biochem Sci. 2018;: pubmed publisher
    ..Improvement of methods to control the interactions between cells provides powerful tools to test hypotheses about intercellular interactions, nutrient transfer, and complex diseases. ..
  5. Hartman E, Jakobson C, Favor A, Lobba M, Alvarez Benedicto E, Francis M, et al. Quantitative characterization of all single amino acid variants of a viral capsid-based drug delivery vehicle. Nat Commun. 2018;9:1385 pubmed publisher
    ..In addition to providing a mutability blueprint for virus-like particles, SyMAPS can be readily applied to other self-assembling proteins. ..
  6. Elsohly A, Netirojjanakul C, Francis M. Antibody Modification of p-Aminophenylalanine-Containing Proteins. Methods Mol Biol. 2018;1798:195-201 pubmed publisher
    ..This technique provides a modular framework to easily prepare antibody-MS2 conjugates in an efficient manner, even at low concentrations of the reacting biomolecules. ..
  7. Aanei I, Glasgow J, Capehart S, Francis M. Encapsulation of Negatively Charged Cargo in MS2 Viral Capsids. Methods Mol Biol. 2018;1776:303-317 pubmed publisher
  8. Aanei I, Francis M. Dual Surface Modification of Genome-Free MS2 Capsids for Delivery Applications. Methods Mol Biol. 2018;1776:629-642 pubmed publisher
    ..These constructs have found applications in nanomaterial fabrication and as delivery vehicles with therapeutic potential. Importantly, the dual-modification strategies described herein could be extended to other VLP systems. ..
  9. Finbloom J, Francis M. Supramolecular strategies for protein immobilization and modification. Curr Opin Chem Biol. 2018;46:91-98 pubmed publisher
    ..These examples of supramolecular chemical biology present opportunities to advance a wide range of applications, including proteomics and drug delivery. ..

More Information


  1. Finbloom J, Slack C, Bruns C, Jeong K, Wemmer D, Pines A, et al. Rotaxane-mediated suppression and activation of cucurbit[6]uril for molecular detection by (129)Xe hyperCEST NMR. Chem Commun (Camb). 2016;52:3119-22 pubmed publisher
    ..This contrast-upon-activation (129)Xe NMR platform allows for modular synthesis and can be expanded to applications in detection and disease imaging. ..
  2. Rosen C, Kwant R, MacDonald J, Rao M, Francis M. Capture and Recycling of Sortase?A through Site-Specific Labeling with Lithocholic Acid. Angew Chem Int Ed Engl. 2016;55:8585-9 pubmed publisher
    ..Capture and recycling of the LA-Pro-SrtA?7M conjugate was achieved using ?CD-modified sepharose resin. The LA-Pro-SrtA?7M conjugate retained full enzymatic activity, even after multiple rounds of recycling. ..
  3. Sangsuwan R, Obermeyer A, Tachachartvanich P, Palaniappan K, Francis M. Direct detection of nitrotyrosine-containing proteins using an aniline-based oxidative coupling strategy. Chem Commun (Camb). 2016;52:10036-9 pubmed publisher
    ..Following this, an oxidative coupling reaction is used to attach anilines bearing fluorescence reporters or affinity probes. Features of this approach include fast reaction times, pmol-level sensitivity, and excellent chemoselectivity. ..
  4. Smith M, Francis M. Methods for Generating Microbial Cocultures that Grow in the Absence of Fixed Carbon or Nitrogen. Methods Mol Biol. 2018;1772:45-60 pubmed publisher
    ..The methods we used to develop this coculture are described in detail in the following chapter, including notes detailing some of our additional observations or thoughts on this system. ..