Nora Franceschini

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Genetics, ancestry, and hypertension: implications for targeted antihypertensive therapies
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, 137 E Franklin St, Suite 306, Chapel Hill, NC, USA
    Curr Hypertens Rep 16:461. 2014
  2. pmc Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599, USA
    Am J Hum Genet 93:545-54. 2013
  3. pmc Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study
    N Franceschini
    Department of Epidemiology, University of North Carolina, 137 E Franklin St, Suite 306 CB No 8050, Chapel Hill, NC 27599 8050, USA
    Diabetologia 56:2194-202. 2013
  4. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
  5. pmc Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
    Megan D Fesinmeyer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    BMC Med Genet 14:6. 2013
  6. pmc Discovery and fine mapping of serum protein loci through transethnic meta-analysis
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Hum Genet 91:744-53. 2012
  7. pmc The association of genetic variants of type 2 diabetes with kidney function
    Nora Franceschini
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Kidney Int 82:220-5. 2012
  8. pmc Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genet 9:90. 2008
  9. doi request reprint Cystatin C and preeclampsia: a case control study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514 3628, USA
    Ren Fail 30:89-95. 2008
  10. pmc The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Hypertens 22:552-8. 2009

Detail Information

Publications58

  1. ncbi request reprint Genetics, ancestry, and hypertension: implications for targeted antihypertensive therapies
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, 137 E Franklin St, Suite 306, Chapel Hill, NC, USA
    Curr Hypertens Rep 16:461. 2014
    ..There is still much work that remains to be done to identify genes both for efficacy and adverse events of antihypertensive medications. ..
  2. pmc Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599, USA
    Am J Hum Genet 93:545-54. 2013
    ....
  3. pmc Epidemiology and genetic determinants of progressive deterioration of glycaemia in American Indians: the Strong Heart Family Study
    N Franceschini
    Department of Epidemiology, University of North Carolina, 137 E Franklin St, Suite 306 CB No 8050, Chapel Hill, NC 27599 8050, USA
    Diabetologia 56:2194-202. 2013
    ..The underlying mechanisms leading to progression to type 2 diabetes are not fully understood and genetic tools may help to identify important pathways of glycaemic deterioration...
  4. pmc Reproductive aging-associated common genetic variants and the risk of breast cancer
    Chunyan He
    Department of Public Health, Indiana University School of Medicine, 980 West Walnut Street, R3 C241, Indianapolis, IN 46202, USA
    Breast Cancer Res 14:R54. 2012
    ..Recent genome-wide association studies have identified several novel genetic loci associated with these two traits. However, the association between these loci and breast cancer risk is unknown...
  5. pmc Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study
    Megan D Fesinmeyer
    Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    BMC Med Genet 14:6. 2013
    ..Although smoking behavior is known to affect body mass index (BMI), the potential for smoking to influence genetic associations with BMI is largely unexplored...
  6. pmc Discovery and fine mapping of serum protein loci through transethnic meta-analysis
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Hum Genet 91:744-53. 2012
    ....
  7. pmc The association of genetic variants of type 2 diabetes with kidney function
    Nora Franceschini
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Kidney Int 82:220-5. 2012
    ..Our findings suggest a shared genetic risk for type 2 diabetes and its kidney complications, and a potential role for WFS1 in early-onset diabetic nephropathy in American Indian populations...
  8. pmc Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genet 9:90. 2008
    ..1.4)...
  9. doi request reprint Cystatin C and preeclampsia: a case control study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514 3628, USA
    Ren Fail 30:89-95. 2008
    ..Increased plasma levels of cystatin C were independently associated with preeclampsia. Further studies are required to assess the role of cystatin C levels in preeclampsia severity and maternal and fetal outcomes...
  10. pmc The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Hypertens 22:552-8. 2009
    ..The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease...
  11. pmc The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
    Hum Genet 127:295-301. 2010
    ..Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians...
  12. pmc Orthostatic hypotension and incident chronic kidney disease: the atherosclerosis risk in communities study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
    Hypertension 56:1054-9. 2010
    ..These findings suggest that orthostatic hypotension increases the risk of chronic kidney disease in middle-aged persons, but race effects vary by choice of chronic kidney disease definition...
  13. pmc Recent findings in the genetics of blood pressure and hypertension traits
    Nora Franceschini
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Hypertens 24:392-400. 2011
    ..The impact of public health-relevant contexts such as diet, physical activity, psychosocial factors, and aging has not been examined for most common variants associated with BP...
  14. pmc Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Chapel Hill, 137 E Franklin St, Suite 306 CB 8050, Chapel Hill, NC 27514, USA
    Circ Cardiovasc Genet 2:396-401. 2009
    ..Accounting for the genetic interaction of these factors may help to identify common BP susceptibility alleles...
  15. pmc Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 East Franklin Street, Suite 306, CB 8050, Chapel Hill, North Carolina 27514, USA
    BMC Proc 1:S85. 2007
    ..Similar results were found in analysis of 12 transcripts, that had co-localized QTLs in the 13q34 region. Principal-component analyses did not improve the ability to identify chromosomal regions of co-localized gene expressions...
  16. ncbi request reprint A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514 3628, USA
    Hypertension 48:266-70. 2006
    ..8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes...
  17. ncbi request reprint Immunosuppression, hepatitis C infection, and acute renal failure in HIV-infected patients
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
    J Acquir Immune Defic Syndr 42:368-72. 2006
    ..Low CD4 cell counts predict HIV-related morbidity and mortality and may be associated with acute renal failure (ARF)...
  18. pmc Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Hypertens 21:194-9. 2008
    ..Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components...
  19. pmc Linkage analysis of glomerular filtration rate in American Indians
    Amy K Mottl
    UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7155, USA
    Kidney Int 74:1185-91. 2008
    ..This evidence for linkage of a quantitative trait locus influencing estimated glomerular filtration rate to a region of chromosome 12p in a large cohort of American Indians will be worth studying in more detail in the future...
  20. pmc Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
    Adrienne Tin
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    J Hum Genet 58:461-6. 2013
    ..However, careful attention must be paid to the correlation of systematic errors and inconsistent associations when different biomarkers or methods are used to measure the quantitative trait. ..
  21. pmc Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study
    Kari E North
    Department of Epidemiology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, 137 E Franklin St, Chapel Hill, NC 27599 8050, USA
    Eur J Gastroenterol Hepatol 24:9-16. 2012
    ....
  22. ncbi request reprint Maternal urine albumin excretion and pregnancy outcome
    Nora Franceschini
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7155, USA
    Am J Kidney Dis 45:1010-8. 2005
    ..The relationship between increased urine albumin excretion (albuminuria), a marker of endothelial dysfunction, and preterm birth has not been fully evaluated...
  23. pmc Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Diabetes 58:285-9. 2009
    ..Moreover, few studies have investigated the effects of TCF7L2 on type 2 diabetes in the context of metabolic risk factors of type 2 diabetes...
  24. pmc Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Acta Diabetol 47:199-207. 2010
    ..These results may suggest a new pathway in the pathogenesis of type 2 diabetes that involves pancreatic beta-cell damage and apoptosis...
  25. pmc Generalization of associations of kidney-related genetic loci to American Indians
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, Missouri Breaks Industries Research, Inc, Timber Lake, South Dakota, Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Bethesda, Maryland, MedStar Health Research Institute, Hyattsville, Maryland, Georgetown and Howard Universities Center for Clinical and Translational Science, Washington, DC
    Clin J Am Soc Nephrol 9:150-8. 2014
    ..Recent studies have identified several loci associated with kidney traits, but their relevance in American Indians is unknown...
  26. pmc Comparison of genome-wide variation between Malawians and African ancestry HapMap populations
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    J Hum Genet 55:366-74. 2010
    ..Five SNPs within the lactase gene (LCT) had substantially different allele frequencies between the Malawi population and Maasai in Kenyawa, Kenya (rs3769013, rs730005, rs3769012, rs2304370; P-values <1 x 10(-33))...
  27. ncbi request reprint Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Diabetes 56:137-42. 2007
    ..2) female subjects. Our findings overlap with several other linkage reports of insulin-related traits and demonstrate the importance of considering complex context-dependent interactions in the search for insulin-related genes...
  28. ncbi request reprint Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American Indians
    V Saroja Voruganti
    1 Department of Nutrition and Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA 2 Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA
    Eur J Hum Genet 22:938-43. 2014
    ..In summary, the association of polymorphisms in the uric acid transporter gene with SUA levels extends to a new population of American Indians. ..
  29. ncbi request reprint Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol
    Leslie A Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Am J Hum Genet 94:233-45. 2014
    ..In conclusion, this large whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL-C and provides unique insight into the design and analysis of similar experiments...
  30. pmc Orthostatic hypotension as a risk factor for incident heart failure: the atherosclerosis risk in communities study
    Christine D Jones
    Department of Social Medicine, University of North Carolina Preventive Medicine Residency Program, Chapel Hill, NC 27599 7240, USA
    Hypertension 59:913-8. 2012
    ..This association may be partially mediated through hypertension. Orthostatic measures may enhance risk stratification for future heart failure development...
  31. ncbi request reprint Incidence and etiology of acute renal failure among ambulatory HIV-infected patients
    Nora Franceschini
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Kidney Int 67:1526-31. 2005
    ..Its incidence and causes have not been studied since the introduction of highly active antiretroviral therapy (HAART) in HIV ambulatory patients...
  32. pmc Imputation of coding variants in African Americans: better performance using data from the exome sequencing project
    Qing Duan
    Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
    Bioinformatics 29:2744-9. 2013
    ..We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2's two-panel combination...
  33. pmc Genome-wide association study of age at menarche in African-American women
    Ellen W Demerath
    Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
    Hum Mol Genet 22:3329-46. 2013
    ..The findings provide the first evidence of cross-ethnic generalization of menarche loci identified to date, and suggest a number of novel biological links to menarche timing in AA women. ..
  34. pmc Association of adiposity genetic variants with menarche timing in 92,105 women of European descent
    Lindsay Fernández-Rhodes
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 137 East Franklin Street, Suite 306, Campus Box 8050, Chapel Hill, NC 27514 8050, USA
    Am J Epidemiol 178:451-60. 2013
    ..These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development. ..
  35. pmc APOL1 variants associate with increased risk of CKD among African Americans
    Meredith C Foster
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    J Am Soc Nephrol 24:1484-91. 2013
    ..22, 95% CI=1.01 to 4.84). In conclusion, APOL1 risk variants are risk factors for the development of CKD and progression from CKD to ESRD among African Americans in the general population...
  36. ncbi request reprint NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
    Genet Med 8:63-75. 2006
    ..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted...
  37. pmc Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9212. 2010
    ..Placental expression of CCR5 may be influenced by such polymorphisms as well as other in vivo regulatory factors...
  38. ncbi request reprint Genetic variants in nicotinic acetylcholine receptor genes jointly contribute to kidney function in American Indians: the Strong Heart Family Study
    Yun Zhu
    aTulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana bRush Alzheimer s Disease Center and Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois cTexas Biomedical Research Institute, San Antonio, Texas dMedStar Health Research Institute, Hyattsville, Maryland eUniversity of North Carolina at Chapel Hill, Chapel Hill, North Carolina fCenter for American Indian Health Research, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma, USA
    J Hypertens 32:1042-8; discussion 1049. 2014
    ..Whereas each single variant may only exert a small effect, the joint contribution of multiple variants to the risk of disease could be substantial...
  39. pmc The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study
    Mariaelisa Graff
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 62:1763-7. 2013
    ..Future research should compare and contrast our findings with results using longitudinal data...
  40. pmc Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function
    Dana B Hancock
    Behavioral Health Epidemiology Program, Research Triangle Institute International, Research Triangle Park, North Carolina, USA
    PLoS Genet 8:e1003098. 2012
    ..Our findings demonstrated that joint testing of SNP and SNP-by-environment interaction identified novel loci associated with complex traits that are missed when considering only the genetic main effects...
  41. pmc A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium
    Anne B Newman
    Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Avenue, Suite 500, University of Pittsburgh, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 65:478-87. 2010
    ..Genome-wide association studies (GWAS) may yield insights into longevity...
  42. pmc Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study
    Nora Franceschini
    Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Circ Cardiovasc Genet 4:661-72. 2011
    ..The association of 13 published CHD SNPs was examined in 5 ancestry groups of 4 large US prospective cohorts...
  43. ncbi request reprint Cinacalcet HCl: a calcimimetic agent for the management of primary and secondary hyperparathyroidism
    Nora Franceschini
    University of North Carolina, School of Medicine, Division of Nephrology and Hypertension, CB 7155, 348 MacNider Building, Chapel Hill, NC 27599 7155, USA
    Expert Opin Investig Drugs 12:1413-21. 2003
    ..This drug has a favourable pharmacokinetic profile compared to its precursors and will prove useful as an additional/alternative agent in patients with primary and secondary HPT...
  44. pmc Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained
    Ying Wu
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Genet 9:e1003379. 2013
    ..In conclusion, trans-ethnic high-density genotyping and analysis confirm the presence of allelic heterogeneity, allow the identification of population-specific variants, and limit the number of candidate SNPs for functional studies...
  45. pmc Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
    Kira C Taylor
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genet 14:33. 2013
    ..Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study...
  46. pmc Heritability and preliminary genome-wide linkage analysis of arsenic metabolites in urine
    Maria Tellez-Plaza
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
    Environ Health Perspect 121:345-51. 2013
    ..Arsenic (III) methyltransferase (AS3MT) has been related to urine arsenic metabolites in association studies. Other genes might also play roles in arsenic metabolism and excretion...
  47. pmc Longitudinal age-dependent effect on systolic blood pressure
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S87. 2009
    ..The value of the 2-df test for screening genetic interaction effects could not be established in this study...
  48. pmc Change in estimated GFR associates with coronary heart disease and mortality
    Kunihiro Matsushita
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Welch Center for Prevention, Epidemiology, and Clinical Research, 2024 E Monument Street, Baltimore, MD 21287, USA
    J Am Soc Nephrol 20:2617-24. 2009
    ..In conclusion, a steeper than average decline in eGFR associates with a higher risk for CHD and all-cause mortality. Increases in eGFR among participants with chronic kidney disease associate with similar increased risks...
  49. pmc Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
    Yu Yan
    Department of Epidemiology, University of North Carolina, 2101 McGavran Greenberg Hall, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S118. 2009
    ..The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level...
  50. pmc Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    Dana B Hancock
    Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA
    Nat Genet 42:45-52. 2010
    ..Our findings may offer insights into pulmonary function and pathogenesis of chronic lung disease...
  51. ncbi request reprint Prevention and treatment strategies for glucocorticoid-induced osteoporotic fractures
    Margaret Gourlay
    Department of Family Medicine, University of North Carolina, Chapel Hill, Manning Drive, CB 7595, Chapel Hill, NC 27599 7595, USA
    Clin Rheumatol 26:144-53. 2007
    ....
  52. ncbi request reprint N-acetylcysteine for the prevention of radiocontrast induced nephropathy: a meta-analysis of prospective controlled trials
    Abhijit V Kshirsagar
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Am Soc Nephrol 15:761-9. 2004
    ..Identified patient and study characteristics may be responsible for some, but not all, of this inconsistency. A large, randomized, placebo-controlled trial, a pooled analysis of patient-level data, or both may resolve this issue...
  53. ncbi request reprint Calcimimetics and the treatment of primary and secondary hyperparathyroidism
    Melanie S Joy
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Ann Pharmacother 38:1871-80. 2004
    ..To review the mechanism of action, development, and clinical application of the calcimimetic compounds being investigated for the treatment of primary and secondary hyperparathyroidism (HPT)...
  54. ncbi request reprint Primum non nocere: Should adults with idiopathic FSGS receive steroids?
    Nora Franceschini
    Division of Nephrology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Semin Nephrol 23:229-33. 2003
    ..Recommendations regarding a specific subset of patients who may benefit from steroid treatment are discussed. The controversies regarding steroids in idiopathic FSGS will only be resolved with data from controlled clinical trials...
  55. ncbi request reprint Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Infect Dis 40:1559-85. 2005
  56. pmc Suppression of HIV-1 replication by antiretroviral therapy improves renal function in persons with low CD4 cell counts and chronic kidney disease
    Robert C Kalayjian
    Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA
    AIDS 22:481-7. 2008
    ..To examine the association between changes in glomerular filtration rates (GFR) and antiretroviral therapy (ART)-mediated suppression of plasma HIV-1 viremia...
  57. ncbi request reprint Summary of Genetic Analysis Workshop 15: Group 9 linkage analysis of the CEPH expression data
    Ellen M Wijsman
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Genet Epidemiol 31:S75-85. 2007
    ..Finally, there were computational and analytic challenges in working with a large public data set, along with need for more data documentation...