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Genomes and Genes | Nora FranceschiniSummaryAffiliation: University of North Carolina Country: USA Publications
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Publications
Maternal urine albumin excretion and pregnancy outcomeNora Franceschini
Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7155, USA
Am J Kidney Dis 45:1010-8. 2005..The relationship between increased urine albumin excretion (albuminuria), a marker of endothelial dysfunction, and preterm birth has not been fully evaluated...- Incidence and etiology of acute renal failure among ambulatory HIV-infected patientsNora Franceschini
Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Kidney Int 67:1526-31. 2005..Its incidence and causes have not been studied since the introduction of highly active antiretroviral therapy (HAART) in HIV ambulatory patients... 
The association of genetic variants of type 2 diabetes with kidney functionNora Franceschini
University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Kidney Int 82:220-5. 2012..Our findings suggest a shared genetic risk for type 2 diabetes and its kidney complications, and a potential role for WFS1 in early-onset diabetic nephropathy in American Indian populations...
Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
BMC Med Genet 9:90. 2008..1.4)...- Linkage analysis of glomerular filtration rate in American IndiansAmy K Mottl
UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7155, USA
Kidney Int 74:1185-91. 2008..This evidence for linkage of a quantitative trait locus influencing estimated glomerular filtration rate to a region of chromosome 12p in a large cohort of American Indians will be worth studying in more detail in the future... - The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
Hum Genet 127:295-301. 2010..Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians... - Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart studyKari E North
Department of Epidemiology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, 137 E Franklin St, Chapel Hill, NC 27599 8050, USA
Eur J Gastroenterol Hepatol 24:9-16. 2012.... - Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource studyErvin R Fox
Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
Hum Mol Genet 20:2273-84. 2011..More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity... - Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, University of North Carolina Chapel Hill, 137 E Franklin St, Suite 306 CB 8050, Chapel Hill, NC 27514, USA
Circ Cardiovasc Genet 2:396-401. 2009..Accounting for the genetic interaction of these factors may help to identify common BP susceptibility alleles... - Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populationsKari E North
Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
Acta Diabetol 47:199-207. 2010..These results may suggest a new pathway in the pathogenesis of type 2 diabetes that involves pancreatic beta-cell damage and apoptosis... - Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart StudyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Am J Hypertens 21:194-9. 2008..Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components... - The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities studyNora Franceschini
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Am J Hypertens 22:552-8. 2009..The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease... - Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortiumXiaofeng Zhu
Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
Hum Mol Genet 20:2285-95. 2011..Our study highlights that admixture mapping analysis can help identify genetic variants missed by genome-wide association studies because of drastically reduced number of tests in the whole genome... - Orthostatic hypotension and incident chronic kidney disease: the atherosclerosis risk in communities studyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
Hypertension 56:1054-9. 2010..These findings suggest that orthostatic hypotension increases the risk of chronic kidney disease in middle-aged persons, but race effects vary by choice of chronic kidney disease definition... - Comparison of genome-wide variation between Malawians and African ancestry HapMap populationsBonnie R Joubert
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
J Hum Genet 55:366-74. 2010..Five SNPs within the lactase gene (LCT) had substantially different allele frequencies between the Malawi population and Maasai in Kenyawa, Kenya (rs3769013, rs730005, rs3769012, rs2304370; P-values <1 x 10(-33))... - The effects of HIV type-1 viral suppression and non-viral factors on quantitative proteinuria in the highly active antiretroviral therapy eraSamir K Gupta
Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Antivir Ther 14:543-9. 2009..Proteinuria is associated with progressive renal disease and overall mortality in HIV-infected patients; however, the prevalence and correlates of quantitative proteinuria in the highly active antiretroviral therapy era are unknown... - Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities studyYu Yan
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
Diabetes 58:285-9. 2009..Moreover, few studies have investigated the effects of TCF7L2 on type 2 diabetes in the context of metabolic risk factors of type 2 diabetes... - Orthostatic hypotension as a risk factor for incident heart failure: the atherosclerosis risk in communities studyChristine D Jones
Department of Social Medicine, University of North Carolina Preventive Medicine Residency Program, Chapel Hill, NC 27599 7240, USA
Hypertension 59:913-8. 2012..This association may be partially mediated through hypertension. Orthostatic measures may enhance risk stratification for future heart failure development... - Immunosuppression, hepatitis C infection, and acute renal failure in HIV-infected patientsNora Franceschini
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
J Acquir Immune Defic Syndr 42:368-72. 2006..Low CD4 cell counts predict HIV-related morbidity and mortality and may be associated with acute renal failure (ARF)... - Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in MalawiBonnie R Joubert
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
PLoS ONE 5:e9212. 2010..Placental expression of CCR5 may be influenced by such polymorphisms as well as other in vivo regulatory factors... - Suppression of HIV-1 replication by antiretroviral therapy improves renal function in persons with low CD4 cell counts and chronic kidney diseaseRobert C Kalayjian
Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA
AIDS 22:481-7. 2008..To examine the association between changes in glomerular filtration rates (GFR) and antiretroviral therapy (ART)-mediated suppression of plasma HIV-1 viremia... - Recent findings in the genetics of blood pressure and hypertension traitsNora Franceschini
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Am J Hypertens 24:392-400. 2011..The impact of public health-relevant contexts such as diet, physical activity, psychosocial factors, and aging has not been examined for most common variants associated with BP... - Prevention and treatment strategies for glucocorticoid-induced osteoporotic fracturesMargaret Gourlay
Department of Family Medicine, University of North Carolina, Chapel Hill, Manning Drive, CB 7595, Chapel Hill, NC 27599 7595, USA
Clin Rheumatol 26:144-53. 2007.... - Calcimimetics and the treatment of primary and secondary hyperparathyroidismMelanie S Joy
Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
Ann Pharmacother 38:1871-80. 2004..To review the mechanism of action, development, and clinical application of the calcimimetic compounds being investigated for the treatment of primary and secondary hyperparathyroidism (HPT)... - N-acetylcysteine for the prevention of radiocontrast induced nephropathy: a meta-analysis of prospective controlled trialsAbhijit V Kshirsagar
Division of Nephrology and Hypertension, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
J Am Soc Nephrol 15:761-9. 2004..Identified patient and study characteristics may be responsible for some, but not all, of this inconsistency. A large, randomized, placebo-controlled trial, a pooled analysis of patient-level data, or both may resolve this issue... - Cinacalcet HCl: a calcimimetic agent for the management of primary and secondary hyperparathyroidismNora Franceschini
University of North Carolina, School of Medicine, Division of Nephrology and Hypertension, CB 7155, 348 MacNider Building, Chapel Hill, NC 27599 7155, USA
Expert Opin Investig Drugs 12:1413-21. 2003..This drug has a favourable pharmacokinetic profile compared to its precursors and will prove useful as an additional/alternative agent in patients with primary and secondary HPT... - Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE studyNora Franceschini
Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
Circ Cardiovasc Genet 4:661-72. 2011..The association of 13 published CHD SNPs was examined in 5 ancestry groups of 4 large US prospective cohorts... - Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN studyKari E North
Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
Diabetes 56:137-42. 2007..2) female subjects. Our findings overlap with several other linkage reports of insulin-related traits and demonstrate the importance of considering complex context-dependent interactions in the search for insulin-related genes... - Longitudinal age-dependent effect on systolic blood pressureBonnie R Joubert
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, North Carolina 27599, USA
BMC Proc 3:S87. 2009..The value of the 2-df test for screening genetic interaction effects could not be established in this study... - NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE reviewNora Franceschini
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
Genet Med 8:63-75. 2006..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted... - Discovery and fine mapping of serum protein loci through transethnic meta-analysisNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
Am J Hum Genet 91:744-53. 2012.... - Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring CohortYu Yan
Department of Epidemiology, University of North Carolina, 2101 McGavran Greenberg Hall, Chapel Hill, North Carolina 27599, USA
BMC Proc 3:S118. 2009..The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level... - Cystatin C and preeclampsia: a case control studyNora Franceschini
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514 3628, USA
Ren Fail 30:89-95. 2008..Increased plasma levels of cystatin C were independently associated with preeclampsia. Further studies are required to assess the role of cystatin C levels in preeclampsia severity and maternal and fetal outcomes... - Summary of Genetic Analysis Workshop 15: Group 9 linkage analysis of the CEPH expression dataEllen M Wijsman
Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
Genet Epidemiol 31:S75-85. 2007..Finally, there were computational and analytic challenges in working with a large public data set, along with need for more data documentation... - Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of AmericaSamir K Gupta
Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
Clin Infect Dis 40:1559-85. 2005 - Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traitsNora Franceschini
Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 East Franklin Street, Suite 306, CB 8050, Chapel Hill, North Carolina 27514, USA
BMC Proc 1:S85. 2007..Similar results were found in analysis of 12 transcripts, that had co-localized QTLs in the 13q34 region. Principal-component analyses did not improve the ability to identify chromosomal regions of co-localized gene expressions... - A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family StudyNora Franceschini
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514 3628, USA
Hypertension 48:266-70. 2006..8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes... - Primum non nocere: Should adults with idiopathic FSGS receive steroids?Nora Franceschini
Division of Nephrology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Semin Nephrol 23:229-33. 2003..Recommendations regarding a specific subset of patients who may benefit from steroid treatment are discussed. The controversies regarding steroids in idiopathic FSGS will only be resolved with data from controlled clinical trials...