Nora Franceschini

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Incidence and etiology of acute renal failure among ambulatory HIV-infected patients
    Nora Franceschini
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Kidney Int 67:1526-31. 2005
  2. ncbi Maternal urine albumin excretion and pregnancy outcome
    Nora Franceschini
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7155, USA
    Am J Kidney Dis 45:1010-8. 2005
  3. pmc The association of genetic variants of type 2 diabetes with kidney function
    Nora Franceschini
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Kidney Int 82:220-5. 2012
  4. pmc Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genet 9:90. 2008
  5. pmc The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
    Hum Genet 127:295-301. 2010
  6. pmc Linkage analysis of glomerular filtration rate in American Indians
    Amy K Mottl
    UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7155, USA
    Kidney Int 74:1185-91. 2008
  7. pmc Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study
    Kari E North
    Department of Epidemiology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, 137 E Franklin St, Chapel Hill, NC 27599 8050, USA
    Eur J Gastroenterol Hepatol 24:9-16. 2012
  8. pmc Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Chapel Hill, 137 E Franklin St, Suite 306 CB 8050, Chapel Hill, NC 27514, USA
    Circ Cardiovasc Genet 2:396-401. 2009
  9. pmc Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Acta Diabetol 47:199-207. 2010
  10. pmc Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
    Ervin R Fox
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Hum Mol Genet 20:2273-84. 2011

Detail Information

Publications46

  1. ncbi Incidence and etiology of acute renal failure among ambulatory HIV-infected patients
    Nora Franceschini
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Kidney Int 67:1526-31. 2005
    ..Its incidence and causes have not been studied since the introduction of highly active antiretroviral therapy (HAART) in HIV ambulatory patients...
  2. ncbi Maternal urine albumin excretion and pregnancy outcome
    Nora Franceschini
    Department of Medicine, School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7155, USA
    Am J Kidney Dis 45:1010-8. 2005
    ..The relationship between increased urine albumin excretion (albuminuria), a marker of endothelial dysfunction, and preterm birth has not been fully evaluated...
  3. pmc The association of genetic variants of type 2 diabetes with kidney function
    Nora Franceschini
    University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Kidney Int 82:220-5. 2012
    ..Our findings suggest a shared genetic risk for type 2 diabetes and its kidney complications, and a potential role for WFS1 in early-onset diabetic nephropathy in American Indian populations...
  4. pmc Diabetes-specific genetic effects on obesity traits in American Indian populations: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    BMC Med Genet 9:90. 2008
    ..1.4)...
  5. pmc The association of the MYH9 gene and kidney outcomes in American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
    Hum Genet 127:295-301. 2010
    ..Identification of the actual functional genetic variation responsible for the associations seen in African-Americans will likely help to clarify the lack of replication of this gene in our population of American Indians...
  6. pmc Linkage analysis of glomerular filtration rate in American Indians
    Amy K Mottl
    UNC Kidney Center, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7155, USA
    Kidney Int 74:1185-91. 2008
    ..This evidence for linkage of a quantitative trait locus influencing estimated glomerular filtration rate to a region of chromosome 12p in a large cohort of American Indians will be worth studying in more detail in the future...
  7. pmc Sex and race differences in the prevalence of fatty liver disease as measured by computed tomography liver attenuation in European American and African American participants of the NHLBI family heart study
    Kari E North
    Department of Epidemiology, Carolina Center for Genome Sciences, University of North Carolina Chapel Hill, 137 E Franklin St, Chapel Hill, NC 27599 8050, USA
    Eur J Gastroenterol Hepatol 24:9-16. 2012
    ....
  8. pmc Social- and behavioral-specific genetic effects on blood pressure traits: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Chapel Hill, 137 E Franklin St, Suite 306 CB 8050, Chapel Hill, NC 27514, USA
    Circ Cardiovasc Genet 2:396-401. 2009
    ..Accounting for the genetic interaction of these factors may help to identify common BP susceptibility alleles...
  9. pmc Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations
    Kari E North
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Acta Diabetol 47:199-207. 2010
    ..These results may suggest a new pathway in the pathogenesis of type 2 diabetes that involves pancreatic beta-cell damage and apoptosis...
  10. pmc Association of genetic variation with systolic and diastolic blood pressure among African Americans: the Candidate Gene Association Resource study
    Ervin R Fox
    Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA
    Hum Mol Genet 20:2273-84. 2011
    ..More broadly, this work supports that notion that blood pressure among AAs is a trait with genetic underpinnings but also with significant complexity...
  11. pmc Generalization of associations of kidney-related genetic Loci to american indians
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, Department of Genetics, Texas Biomedical Research Institute, San Antonio, Texas, Center for American Indian Health Research, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, Missouri Breaks Industries Research, Inc, Timber Lake, South Dakota, Epidemiology and Biometry Program, National Heart, Lung, and Blood Institute, Bethesda, Maryland, MedStar Health Research Institute, Hyattsville, Maryland, Georgetown and Howard Universities Center for Clinical and Translational Science, Washington, DC
    Clin J Am Soc Nephrol 9:150-8. 2014
    ..Recent studies have identified several loci associated with kidney traits, but their relevance in American Indians is unknown...
  12. pmc Genome-wide linkage analysis of pulse pressure in American Indians: the Strong Heart Study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Am J Hypertens 21:194-9. 2008
    ..Pulse pressure, a measure of central arterial stiffness and a predictor of cardiovascular mortality, has known genetic components...
  13. pmc The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Am J Hypertens 22:552-8. 2009
    ..The checkpoint 2 gene (CHEK2) is an important transducer in DNA damage signaling pathways in response to injury, and therefore, CHEK2 variants may affect susceptibility to kidney disease...
  14. pmc Discovery and fine mapping of serum protein loci through transethnic meta-analysis
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Hum Genet 91:744-53. 2012
    ....
  15. pmc Combined admixture mapping and association analysis identifies a novel blood pressure genetic locus on 5p13: contributions from the CARe consortium
    Xiaofeng Zhu
    Department of Epidemiology and Biostatistics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA
    Hum Mol Genet 20:2285-95. 2011
    ..Our study highlights that admixture mapping analysis can help identify genetic variants missed by genome-wide association studies because of drastically reduced number of tests in the whole genome...
  16. pmc The effects of HIV type-1 viral suppression and non-viral factors on quantitative proteinuria in the highly active antiretroviral therapy era
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Antivir Ther 14:543-9. 2009
    ..Proteinuria is associated with progressive renal disease and overall mortality in HIV-infected patients; however, the prevalence and correlates of quantitative proteinuria in the highly active antiretroviral therapy era are unknown...
  17. pmc Comparison of genome-wide variation between Malawians and African ancestry HapMap populations
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC 27599, USA
    J Hum Genet 55:366-74. 2010
    ..Five SNPs within the lactase gene (LCT) had substantially different allele frequencies between the Malawi population and Maasai in Kenyawa, Kenya (rs3769013, rs730005, rs3769012, rs2304370; P-values <1 x 10(-33))...
  18. pmc Orthostatic hypotension and incident chronic kidney disease: the atherosclerosis risk in communities study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27514, USA
    Hypertension 56:1054-9. 2010
    ..These findings suggest that orthostatic hypotension increases the risk of chronic kidney disease in middle-aged persons, but race effects vary by choice of chronic kidney disease definition...
  19. pmc Transcription factor 7-like 2 (TCF7L2) polymorphism and context-specific risk of type 2 diabetes in African American and Caucasian adults: the Atherosclerosis Risk in Communities study
    Yu Yan
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA
    Diabetes 58:285-9. 2009
    ..Moreover, few studies have investigated the effects of TCF7L2 on type 2 diabetes in the context of metabolic risk factors of type 2 diabetes...
  20. pmc Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations
    Nora Franceschini
    Department of Epidemiology, University of North Carolina at Chapel Hill, NC 27599, USA
    Am J Hum Genet 93:545-54. 2013
    ....
  21. pmc The influence of obesity-related single nucleotide polymorphisms on BMI across the life course: the PAGE study
    Mariaelisa Graff
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Diabetes 62:1763-7. 2013
    ..Future research should compare and contrast our findings with results using longitudinal data...
  22. pmc Orthostatic hypotension as a risk factor for incident heart failure: the atherosclerosis risk in communities study
    Christine D Jones
    Department of Social Medicine, University of North Carolina Preventive Medicine Residency Program, Chapel Hill, NC 27599 7240, USA
    Hypertension 59:913-8. 2012
    ..This association may be partially mediated through hypertension. Orthostatic measures may enhance risk stratification for future heart failure development...
  23. ncbi Immunosuppression, hepatitis C infection, and acute renal failure in HIV-infected patients
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514, USA
    J Acquir Immune Defic Syndr 42:368-72. 2006
    ..Low CD4 cell counts predict HIV-related morbidity and mortality and may be associated with acute renal failure (ARF)...
  24. pmc Regulation of CCR5 expression in human placenta: insights from a study of mother-to-child transmission of HIV in Malawi
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 5:e9212. 2010
    ..Placental expression of CCR5 may be influenced by such polymorphisms as well as other in vivo regulatory factors...
  25. pmc Association of adiposity genetic variants with menarche timing in 92,105 women of European descent
    Lindsay Fernández-Rhodes
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, 137 East Franklin Street, Suite 306, Campus Box 8050, Chapel Hill, NC 27514 8050, USA
    Am J Epidemiol 178:451-60. 2013
    ..These findings suggest complex genetic relationships between menarche and overall obesity, and to a lesser extent central obesity, in normal processes of growth and development. ..
  26. pmc Investigation of gene-by-sex interactions for lipid traits in diverse populations from the population architecture using genomics and epidemiology study
    Kira C Taylor
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    BMC Genet 14:33. 2013
    ..Here, we investigated whether GWAS-identified SNPs for lipid traits exhibited heterogeneity by sex in the Population Architecture using Genomics and Epidemiology (PAGE) study...
  27. pmc Suppression of HIV-1 replication by antiretroviral therapy improves renal function in persons with low CD4 cell counts and chronic kidney disease
    Robert C Kalayjian
    Department of Medicine, MetroHealth Medical Center, Cleveland, Ohio, USA
    AIDS 22:481-7. 2008
    ..To examine the association between changes in glomerular filtration rates (GFR) and antiretroviral therapy (ART)-mediated suppression of plasma HIV-1 viremia...
  28. pmc Recent findings in the genetics of blood pressure and hypertension traits
    Nora Franceschini
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Am J Hypertens 24:392-400. 2011
    ..The impact of public health-relevant contexts such as diet, physical activity, psychosocial factors, and aging has not been examined for most common variants associated with BP...
  29. ncbi Prevention and treatment strategies for glucocorticoid-induced osteoporotic fractures
    Margaret Gourlay
    Department of Family Medicine, University of North Carolina, Chapel Hill, Manning Drive, CB 7595, Chapel Hill, NC 27599 7595, USA
    Clin Rheumatol 26:144-53. 2007
    ....
  30. ncbi N-acetylcysteine for the prevention of radiocontrast induced nephropathy: a meta-analysis of prospective controlled trials
    Abhijit V Kshirsagar
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Am Soc Nephrol 15:761-9. 2004
    ..Identified patient and study characteristics may be responsible for some, but not all, of this inconsistency. A large, randomized, placebo-controlled trial, a pooled analysis of patient-level data, or both may resolve this issue...
  31. ncbi Cinacalcet HCl: a calcimimetic agent for the management of primary and secondary hyperparathyroidism
    Nora Franceschini
    University of North Carolina, School of Medicine, Division of Nephrology and Hypertension, CB 7155, 348 MacNider Building, Chapel Hill, NC 27599 7155, USA
    Expert Opin Investig Drugs 12:1413-21. 2003
    ..This drug has a favourable pharmacokinetic profile compared to its precursors and will prove useful as an additional/alternative agent in patients with primary and secondary HPT...
  32. ncbi Calcimimetics and the treatment of primary and secondary hyperparathyroidism
    Melanie S Joy
    Division of Nephrology and Hypertension, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Ann Pharmacother 38:1871-80. 2004
    ..To review the mechanism of action, development, and clinical application of the calcimimetic compounds being investigated for the treatment of primary and secondary hyperparathyroidism (HPT)...
  33. pmc Trans-ethnic fine-mapping of lipid loci identifies population-specific signals and allelic heterogeneity that increases the trait variance explained
    Ying Wu
    Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS Genet 9:e1003379. 2013
    ..In conclusion, trans-ethnic high-density genotyping and analysis confirm the presence of allelic heterogeneity, allow the identification of population-specific variants, and limit the number of candidate SNPs for functional studies...
  34. pmc Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study
    Nora Franceschini
    Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Circ Cardiovasc Genet 4:661-72. 2011
    ..The association of 13 published CHD SNPs was examined in 5 ancestry groups of 4 large US prospective cohorts...
  35. ncbi Genotype-by-sex interaction on fasting insulin concentration: the HyperGEN study
    Kari E North
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 E Franklin St, Suite 306, Chapel Hill, NC 27514, USA
    Diabetes 56:137-42. 2007
    ..2) female subjects. Our findings overlap with several other linkage reports of insulin-related traits and demonstrate the importance of considering complex context-dependent interactions in the search for insulin-related genes...
  36. pmc Longitudinal age-dependent effect on systolic blood pressure
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S87. 2009
    ..The value of the 2-df test for screening genetic interaction effects could not be established in this study...
  37. ncbi NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27514 3628, USA
    Genet Med 8:63-75. 2006
    ..Nevertheless, the available data suggest that large epidemiological case-control studies to examine the association between NPHS2 variants and nephrotic syndrome are warranted...
  38. pmc Imputation of coding variants in African Americans: better performance using data from the exome sequencing project
    Qing Duan
    Department of Genetics and Department of Computer Science, University of North Carolina, Chapel Hill, NC 27599, USA, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA, Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Biostatistics and Center for Statistical Genetics, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA, Renaissance Computing Institute, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Statistics and Department of Genetics, Rutgers University, Piscataway, NJ 08854, USA, Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA, Department of Epidemiology, University of Washington, Seattle, WA 98195, USA, Division of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA, Department of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, Division of Cardiology, George Washington University School of Medicine and Health Sciences, Washington, DC 20037, USA, Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, France
    Bioinformatics 29:2744-9. 2013
    ..We recommend using haplotypes from Exome Sequencing Project alone or concatenation of the two panels over quality score-based post-imputation selection or IMPUTE2's two-panel combination...
  39. doi Cystatin C and preeclampsia: a case control study
    Nora Franceschini
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514 3628, USA
    Ren Fail 30:89-95. 2008
    ..Increased plasma levels of cystatin C were independently associated with preeclampsia. Further studies are required to assess the role of cystatin C levels in preeclampsia severity and maternal and fetal outcomes...
  40. ncbi Summary of Genetic Analysis Workshop 15: Group 9 linkage analysis of the CEPH expression data
    Ellen M Wijsman
    Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Genet Epidemiol 31:S75-85. 2007
    ..Finally, there were computational and analytic challenges in working with a large public data set, along with need for more data documentation...
  41. pmc Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
    Yu Yan
    Department of Epidemiology, University of North Carolina, 2101 McGavran Greenberg Hall, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S118. 2009
    ..The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level...
  42. ncbi Guidelines for the management of chronic kidney disease in HIV-infected patients: recommendations of the HIV Medicine Association of the Infectious Diseases Society of America
    Samir K Gupta
    Division of Infectious Diseases, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    Clin Infect Dis 40:1559-85. 2005
  43. pmc Comparison of strategies for identification of regulatory quantitative trait loci of transcript expression traits
    Nora Franceschini
    Department of Epidemiology, University of North Carolina Chapel Hill, Bank of America Center, 137 East Franklin Street, Suite 306, CB 8050, Chapel Hill, North Carolina 27514, USA
    BMC Proc 1:S85. 2007
    ..Similar results were found in analysis of 12 transcripts, that had co-localized QTLs in the 13q34 region. Principal-component analyses did not improve the ability to identify chromosomal regions of co-localized gene expressions...
  44. ncbi A quantitative trait loci-specific gene-by-sex interaction on systolic blood pressure among American Indians: the Strong Heart Family Study
    Nora Franceschini
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Bank of America Center, Chapel Hill, NC 27514 3628, USA
    Hypertension 48:266-70. 2006
    ..8 in women). Accounting for interaction with sex improved our ability to detect QTLs and demonstrated the importance of considering genotype-by-sex interaction in our search for blood pressure genes...
  45. ncbi Primum non nocere: Should adults with idiopathic FSGS receive steroids?
    Nora Franceschini
    Division of Nephrology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Semin Nephrol 23:229-33. 2003
    ..Recommendations regarding a specific subset of patients who may benefit from steroid treatment are discussed. The controversies regarding steroids in idiopathic FSGS will only be resolved with data from controlled clinical trials...