Research Topics
| M D FrameSummaryAffiliation: University of Rochester Country: USA Publications
| Collaborators
|
Detail Information
Publications
Increased flow precedes remote arteriolar dilations for some microapplied agonistsM D Frame
Department of Anesthesiology, Biomedical Engineering Program, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Am J Physiol Heart Circ Physiol 278:H1186-95. 2000..Papaverine had no remote effects. This study suggests that, although remote responses to some agonists are induced by primary signals to dilate, additionally, network changes in flow can stimulate extensive remote changes in diameter...- Localized adenovirus-mediated gene transfer into vascular smooth muscle in the hamster cheek pouchM D Frame
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Microcirculation 8:403-13. 2001..Our purpose was to develop a method for adenovirus delivery to the hamster cheek pouch to experimentally target gene transfer in tissue used for microvascular studies... - Diminished arteriolar responses in nitrate tolerance involve ROS and angiotensin IIMary D Frame
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
Am J Physiol Heart Circ Physiol 282:H2377-85. 2002..In summary, terminal arterioles are affected by nitrates to a greater extent than the arcade arterioles that feed them, in a process dependent on angiotensin II and ROS... - Network vascular communication initiated by increases in tissue adenosineR J Rivers
Department of Anesthesiology, Biomedical Engineering Program, University of Rochester, Rochester, NY, USA
J Vasc Res 36:193-200. 1999..Thus, increases in tissue adenosine may be critical for vascular communication of metabolic demands without regard to the specific blood flow path... - Flow-induced cytoskeletal changes in endothelial cells growing on curved surfacesM D Frame
Department of Anesthesiology, University of Rochester, NY 14642, USA Molly
Microcirculation 7:419-27. 2000..Our purpose was to investigate the effect of the shape of the growth surface (curved versus flat) on flow-induced F-actin organization in endothelial cells... - Shear stress gradient over endothelial cells in a curved microchannel systemM D Frame
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, NY 14642, USA
Biorheology 35:245-61. 1998..The wall shear stress gradient over the nucleus was 2-fold greater in the radial versus axial directions, and was sensitive to lateral versus midline positioned nuclei... - Technique for using video microscopy and indicator dilution for repeated measurements of cardiac output in small animalsR J Rivers
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, New York 14642, USA
Anesthesiology 94:489-95. 2001..2 +/- 0.5 ml/100 g body weight, within the normal range for hamsters. CONCLUSIONS: Fluorescent dye dilution and video microscopy can be used to repeatedly determine cardiac output or blood volume in small animals... - Mechanisms initiating integrin-stimulated flow recruitment in arteriolar networksMary D Frame
Department of Biomedical Engineering, Stony Brook University, HSC T18 030, Stony Brook, NY 11794 8181, USA
J Appl Physiol 102:2279-87. 2007.... - Initiation of remote microvascular preconditioning requires K(ATP) channel activityLauren Mabanta
Dept. of Biomedical Engineering, SUNY Stony Brook, Stony Brook, New York 11794, USA
Am J Physiol Heart Circ Physiol 290:H264-71. 2006..RMP was blocked during SNP, but not during DZ, stimulation. Thus stimulation of the RMP response requires mitochondrial K(ATP) channel activity after stimulation by nitric oxide donors... - Ligand-independent activation of vascular endothelial growth factor receptor 2 by fluid shear stress regulates activation of endothelial nitric oxide synthaseZheng Gen Jin
Center for Cardiovascular Research and Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
Circ Res 93:354-63. 2003..Finally, we show that inhibiting VEGFR2 kinase significantly reduces flow-mediated NO-dependent arteriolar dilation in vivo. These data identify VEGFR2 as a key mechanotransducer that activates eNOS in response to blood flow... - Arteriolar flow recruitment with vitronectin receptor stimulation linked to remote wall shear stressRandall J Fox
Department of Anesthesiology, Center for Cardiovascular Research, School of Medicine and Dentistry, University of Rochester, Rochester, NY 14642, USA
Microvasc Res 64:414-24. 2002..In contrast, NO alone initiates flow recruitment to the entire network, along multiple parallel flow paths... - Regulation of flow and wall shear stress in arteriolar networks of the hamster cheek pouchRandall J Fox
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
J Appl Physiol 92:2080-8. 2002..With SNP, diameter change correlated with the baseline (before SNP) shear stress conditions... - Remote microvascular preconditioning alters specific vasoactive responsesMary D Frame
Department of Biomedical Engineering, Stony Brook University, Stony Brook, NY 11794 8181, USA
Microcirculation 14:739-51. 2007..The goal of this study was to further characterize RMP and to investigate the extent to which RMP altered local vasoactive responses...