Janusz Frackowiak

Summary

Affiliation: University at Albany
Country: USA

Publications

  1. ncbi Extracellular deposits of A beta produced in cultures of Alzheimer disease brain vascular smooth muscle cells
    Janusz Frackowiak
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    J Neuropathol Exp Neurol 64:82-90. 2005
  2. ncbi The effect of oxidative stress on amyloid precursor protein processing in cells engaged in beta-amyloidosis is related to apolipoprotein E genotype
    Bozena Mazur-Kolecka
    New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Neurobiology, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    Acta Neuropathol 108:287-94. 2004
  3. doi Sera from children with autism alter proliferation of human neuronal progenitor cells exposed to oxidation
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    Neurotox Res 16:87-95. 2009
  4. pmc Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 70:36-50. 2011
  5. pmc The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 116:391-407. 2008
  6. ncbi Induction of vascular amyloidosis-beta by oxidative stress depends on APOE genotype
    Bozena Mazur-Kolecka
    New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Neurobiology, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 27:804-14. 2006
  7. doi Formation of amyloid-beta oligomers in brain vascular smooth muscle cells transiently exposed to iron-induced oxidative stress
    Janusz Frackowiak
    NYS Institute for Basic Research in Developmental Disabilities IBRDD, 1050 Forest Hill Rd, Staten Island, NY, 10314, USA
    Acta Neuropathol 117:557-67. 2009
  8. doi Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    J Neurosci Res 90:999-1010. 2012
  9. ncbi Altered development of neuronal progenitor cells after stimulation with autistic blood sera
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    Brain Res 1168:11-20. 2007
  10. pmc Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e35414. 2012

Detail Information

Publications20

  1. ncbi Extracellular deposits of A beta produced in cultures of Alzheimer disease brain vascular smooth muscle cells
    Janusz Frackowiak
    NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    J Neuropathol Exp Neurol 64:82-90. 2005
    ..This is a valuable system to study the effects of various potential amyloidogenic factors on formation of extracellular Abeta deposits...
  2. ncbi The effect of oxidative stress on amyloid precursor protein processing in cells engaged in beta-amyloidosis is related to apolipoprotein E genotype
    Bozena Mazur-Kolecka
    New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Neurobiology, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    Acta Neuropathol 108:287-94. 2004
    ..We hypothesize that the altered processing of APP in SMCs locally exposed to oxidative stress facilitates cellular deposition of Abeta and contribute to the increased risk of development of beta-amyloidosis in epsilon4/epsilon4 carriers...
  3. doi Sera from children with autism alter proliferation of human neuronal progenitor cells exposed to oxidation
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    Neurotox Res 16:87-95. 2009
    ..These results suggest that altered response of NPCs to oxidative stress may play a role in the etiology of autism...
  4. pmc Link between DYRK1A overexpression and several-fold enhancement of neurofibrillary degeneration with 3-repeat tau protein in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 70:36-50. 2011
    ..These data support the hypothesis that phosphorylation of ASF by overexpressed DYRK1A may contribute to alternative splicing of exon 10, increased expression of 3R tau, and early onset of neurofibrillary degeneration in DS...
  5. pmc The role of overexpressed DYRK1A protein in the early onset of neurofibrillary degeneration in Down syndrome
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Acta Neuropathol 116:391-407. 2008
    ....
  6. ncbi Induction of vascular amyloidosis-beta by oxidative stress depends on APOE genotype
    Bozena Mazur-Kolecka
    New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Neurobiology, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 27:804-14. 2006
    ..The greater susceptibility of epsilon4 carriers to Fe(2+) ions may result in an increased risk of beta-amyloidosis...
  7. doi Formation of amyloid-beta oligomers in brain vascular smooth muscle cells transiently exposed to iron-induced oxidative stress
    Janusz Frackowiak
    NYS Institute for Basic Research in Developmental Disabilities IBRDD, 1050 Forest Hill Rd, Staten Island, NY, 10314, USA
    Acta Neuropathol 117:557-67. 2009
    ..The data suggest that transient increases in local availability of iron in brain blood vessel walls in vivo, e.g., after microhemorrhages, may trigger Abeta oligomerization...
  8. doi Effect of DYRK1A activity inhibition on development of neuronal progenitors isolated from Ts65Dn mice
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, USA
    J Neurosci Res 90:999-1010. 2012
    ..This study suggests that pharmacological normalization of DYRK1A activity may have a potential role in DS therapy...
  9. ncbi Altered development of neuronal progenitor cells after stimulation with autistic blood sera
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    Brain Res 1168:11-20. 2007
    ..Further studies in this cell culture model may explain some of the cellular alterations described in autistic patients...
  10. pmc Abnormal intracellular accumulation and extracellular Aβ deposition in idiopathic and Dup15q11.2-q13 autism spectrum disorders
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York, United States of America
    PLoS ONE 7:e35414. 2012
    ..It has been shown that amyloid ß (Aβ), a product of proteolytic cleavage of the amyloid β precursor protein (APP), accumulates in neuronal cytoplasm in non-affected individuals in a cell type-specific amount...
  11. ncbi The effect of oxidative stress on accumulation of apolipoprotein E3 and E4 in a cell culture model of beta-amyloid angiopathy (CAA)
    Bozena Mazur-Kolecka
    Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    Brain Res 983:48-57. 2003
    ..The higher cellular accumulation of apoE4 than apoE3 in SMCs exposed to oxidative stress may facilitate development of beta-amyloid angiopathy that is more frequent in epsilon 4/ epsilon 4 carriers...
  12. ncbi Secretion and accumulation of Abeta by brain vascular smooth muscle cells from AbetaPP-Swedish transgenic mice
    Janusz Frackowiak
    NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    J Neuropathol Exp Neurol 62:685-96. 2003
    ..Vascular muscle cells from Tg2576 mice appear to be a valuable model of the intracellular accumulation of Abeta. We suggest that vascular muscle cells may be involved in the production of cerebrovascular amyloid in Tg2576 mice...
  13. ncbi Lysosomal deposition of Abeta in cultures of brain vascular smooth muscle cells is enhanced by iron
    Janusz Frackowiak
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    Brain Res 1002:67-75. 2004
    ..The data suggest that iron may be the factor that triggers vascular amyloidosis. Lysosomal accumulation of APP and Abeta initiates deposition of amyloid in blood vessels in Tg2576 mice...
  14. ncbi TGFbeta1 enhances formation of cellular Abeta/apoE deposits in vascular myocytes
    Bozena Mazur-Kolecka
    Department of Pathological Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 24:355-64. 2003
    ..The results suggest that the concomitant presence of apoE and TGFbeta1 can trigger vascular beta-amyloidosis by inducing intracellular formation of stable Abeta/apoE deposits...
  15. pmc Intracellular distribution of differentially phosphorylated dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A)
    Wojciech Kaczmarski
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, Staten Island, New York
    J Neurosci Res 92:162-73. 2014
    ..This study supports the hypothesis that intracellular distribution and compartment-specific functions of DYRK1A may depend on its phosphorylation pattern...
  16. pmc Intraneuronal Abeta immunoreactivity is not a predictor of brain amyloidosis-beta or neurofibrillary degeneration
    Jerzy Wegiel
    Department of Developmental Neurobiology, NYS Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY, 10314, USA
    Acta Neuropathol 113:389-402. 2007
    ....
  17. ncbi Neprilysin protects human neuronal progenitor cells against impaired development caused by amyloid-beta peptide
    Bozena Mazur-Kolecka
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Brain Res 1124:10-8. 2006
    ..This finding suggests that neprilysin could facilitate neuroreplacement therapy with HNPCs in treatment of neurodegenerative diseases...
  18. ncbi Oxidative protein damage in cells engaged in beta-amyloidosis is related to apoE genotype
    Bozena Mazur-Kolecka
    New York State Institute for Basic Research in Developmental Disabilities, Department of Pathological Neurobiology, 1050 Forest Hill Rd, Staten Island, NY 10314, USA
    Neuroreport 13:465-8. 2002
    ..We hypothesize that the damage caused by oxidation in epsilon4/epsilon4 carriers facilitates development of beta-amyloidosis...
  19. ncbi Cell type- and brain structure-specific patterns of distribution of minibrain kinase in human brain
    Jerzy Wegiel
    Department of Developmental Neurobiology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Brain Res 1010:69-80. 2004
    ..Differences in the topography and the amount of Mnb/Dyrk1A in neurons, astrocytes, and ependymal and endothelial cells appear to reflect cell type- and brain structure-specific patterns in trafficking and utilization of Mnb/Dyrk1A...
  20. ncbi Cerebral amyloid angiopathy plays a direct role in the pathogenesis of Alzheimer's disease. Pro-CAA position statement
    James A R Nicoll
    Clinical Neurosciences, University of Southampton, Southampton General Hospital, Mailpoint 813, Southampton, SO 16 6YD, UK
    Neurobiol Aging 25:589-97; discussion 603-4. 2004
    ..Increased concentration of soluble Abeta leads to the formation of insoluble Abeta plaques, other features of AD pathology, and dementia...