Jonathan H Fox

Summary

Affiliation: University of Wyoming
Country: USA

Publications

  1. pmc Iron accumulates in Huntington's disease neurons: protection by deferoxamine
    Jianfang Chen
    Department of Veterinary Sciences and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming, United States of America
    PLoS ONE 8:e77023. 2013
  2. pmc The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
    Jonathan H Fox
    MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Charlestown, MA, USA
    Mol Neurodegener 5:26. 2010
  3. pmc Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein
    Jonathan H Fox
    Department of Veterinary Science and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming 82070, USA
    J Biol Chem 286:18320-30. 2011
  4. doi request reprint Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model
    Zhen Lu
    Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA Neuroscience Graduate Program, University of Wyoming, Laramie, WY 82070, USA
    Neurobiol Dis 71:34-42. 2014
  5. pmc Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease
    Kiersten L Berggren
    Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Road, Laramie, WY 82070, USA Electronic address
    Redox Biol 4:363-74. 2015

Collaborators

  • Steven Hersch
  • Jianfang Chen
  • Ashley I Bush
  • Irene Volitakis
  • Kiersten L Berggren
  • Zhen Lu
  • Eileen Marks
  • Liset Vargas
  • Jonathan Miller
  • Bryan Dugas
  • Erin McAllum
  • Lindsay Dodds
  • Amber Lothian
  • Blaine Roberts
  • Merl Raisbeck
  • Vanita Chopra
  • Robert A Cherny
  • Jenna Moline
  • Lorraine Barrows
  • Linh Q Lam
  • James A Duce
  • Barry Lai
  • Zhaojie Zhang

Detail Information

Publications5

  1. pmc Iron accumulates in Huntington's disease neurons: protection by deferoxamine
    Jianfang Chen
    Department of Veterinary Sciences and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming, United States of America
    PLoS ONE 8:e77023. 2013
    ..These findings, together with protection by deferoxamine, support a potentiating role of neuronal iron accumulation in HD. ..
  2. pmc The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
    Jonathan H Fox
    MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Charlestown, MA, USA
    Mol Neurodegener 5:26. 2010
    ..In this study, we evaluated the mTOR kinase inhibitor and macroautophagy promoting drug everolimus in the R6/2 mouse model of HD...
  3. pmc Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein
    Jonathan H Fox
    Department of Veterinary Science and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming 82070, USA
    J Biol Chem 286:18320-30. 2011
    ..These findings show that inhibiting formation of oxidation-dependent huntingtin oligomers, or promoting their dissolution, may have protective effects in HD by decreasing the burden of soluble mutant huntingtin...
  4. doi request reprint Altered selenium status in Huntington's disease: neuroprotection by selenite in the N171-82Q mouse model
    Zhen Lu
    Department of Veterinary Sciences, University of Wyoming, Laramie, WY 82070, USA Neuroscience Graduate Program, University of Wyoming, Laramie, WY 82070, USA
    Neurobiol Dis 71:34-42. 2014
    ..Modification of selenium metabolism results in beneficial effects in mouse HD and thus may represent a therapeutic strategy. ..
  5. pmc Neonatal iron supplementation potentiates oxidative stress, energetic dysfunction and neurodegeneration in the R6/2 mouse model of Huntington's disease
    Kiersten L Berggren
    Department of Veterinary Sciences, University of Wyoming, 1174 Snowy Range Road, Laramie, WY 82070, USA Electronic address
    Redox Biol 4:363-74. 2015
    ..Findings indicate that elevated neonatal iron intake potentiates mouse HD and promotes oxidative stress and energetic dysfunction in brain. Neonatal-infant dietary iron intake level may be an environmental modifier of human HD. ..