- The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's diseaseJonathan H Fox
MassGeneral Institute for Neurodegenerative Disease and Harvard Medical School, Charlestown, MA, USA
Mol Neurodegener 5:26. 2010..In this study, we evaluated the mTOR kinase inhibitor and macroautophagy promoting drug everolimus in the R6/2 mouse model of HD...
- Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble proteinJonathan H Fox
Department of Veterinary Science and Neuroscience Graduate Program, University of Wyoming, Laramie, Wyoming 82070, USA
J Biol Chem 286:18320-30. 2011..These findings show that inhibiting formation of oxidation-dependent huntingtin oligomers, or promoting their dissolution, may have protective effects in HD by decreasing the burden of soluble mutant huntingtin...