Research Topics
| Ira J FoxSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Detail Information
Publications
Transplantation into and inside the liverIra J Fox
Department of Surgery, 983285 University of Nebraska Medical Center, Omaha, NE 68198-3285, USA
Hepatology 36:249-51. 2002- Hepatocyte transplantationIra J Fox
Department of Surgery, Organ Transplant Program, 983285, University of Nebraska Medical Center, Omaha NE 68198-3285, USA
J Hepatol 40:878-86. 2004 - Hepatocyte transplantationIra J Fox
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
Am J Transplant 4:7-13. 2004.... - Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrowJia Lin Zhang
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA
Transplantation 80:362-9. 2005.... - Prolonged survival of porcine hepatocytes in cynomolgus monkeysHideo Nagata
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
Gastroenterology 132:321-9. 2007..As a prelude to clinical application, we tested the feasibility of hepatocyte xenotransplantation in nonhuman primates... - Competitive equality of donor cells expressing a disparate MHC antigen following stem cell-enriched bone marrow transplantationJia-Lin Zhang
Departments of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA
Transplantation 79:1332-7. 2005..These results may have relevance to understanding long-term gene expression after hematopoietic stem cell based gene therapy... - Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantationHideo Nagata
Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA
Gastroenterology 124:422-31. 2003.... 
The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosisLiping Liu
Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
Hepatology 55:1529-39. 2012....- Route of hepatocyte delivery affects hepatocyte engraftment in the spleenHideo Nagata
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
Transplantation 76:732-4. 2003..The route of hepatocyte delivery may influence hepatocyte engraftment and explain the disparity in efficacy of hepatocyte transplantation between the laboratory and clinic... 
Heart xenograft survival with chimeric pig donors and modest immune suppressionWilliam E Beschorner
Department of Surgery, Transplantation Section, University Nebraska Medical Center, Omaha, NE 68198 3285, USA
Ann Surg 237:265-72. 2003..The clinical use of pig organ xenografts is currently precluded by severe acute rejection, which resists standard immune suppression...- Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantationJean F Botha
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3285, USA
Liver Int 27:758-63. 2007..This study examines the impact of donor liver macrovesicular steatosis on recurrence of hepatitis C virus (HCV) disease after liver transplantation... - Isolated hepatocyte transplantation in an infant with a severe urea cycle disorderSimon P Horslen
Section of Pediatric Gastroenterology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
Pediatrics 111:1262-7. 2003.... - Long-term transgene expression and survival of transgene-expressing grafts following lentivirus transduction of bone marrow side population cellsJai-lin Zhang
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198-3285, USA
Transplantation 79:882-8. 2005..Transplantation of a relatively small number of transduced SP cells led to prolonged transgene mRNA expression and antigen-specific survival of grafts expressing the foreign MHC transgene... - Radiolabeled constructs for evaluation of the asialoglycoprotein receptor status and hepatic functional reservesMichio Abe
University of Nebraska Medical Center, Departments of Radiation Oncology and Surgery, J Bruce Henriksen Laboratories for Cancer Research, Omaha, Nebraska 68198, USA
Bioconjug Chem 14:997-1006. 2003..These differences in rates of liver uptake and clearance of catabolized radiolabeled AF can be used to determine functional activity of liver and transplanted hepatocytes... - Induction of chimerism in mice using human MHC class I-mismatched Hoechst 33342 side population donor stem cellsJohn D Jackson
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
Cell Transplant 11:779-85. 2002..Therefore, SP cells may be useful for establishing mixed chimerism, which may induce immunologic nonresponsiveness to donor antigens in solid organ transplantation... - Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytesJin Cai
Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
Hepatology 36:386-94. 2002..Further investigation is warranted regarding the mechanisms of loss of mass or function of the transplanted hepatocytes over time and how the relatively few engrafted hepatocytes can ameliorate liver decompensation in cirrhosis... - Hepatocyte transplantationSimon P Horslen
1 Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198-3285, USA
Transplantation 77:1481-6. 2004..The potential of isolated hepatocyte transplantation remains largely untapped and awaits alternate sources of cells for transplantation other than those from discarded human cadaveric livers... - A whole-organ regenerative medicine approach for liver replacementAlejandro Soto-Gutierrez
Transplantation Section, Department of Surgery, Children s Hospital of Pittsburgh, Center for Innovative Regenerative Therapies, University of Pittsburgh, Pennsylvania, USA
Tissue Eng Part C Methods 17:677-86. 2011..The present study investigates a new, minimally disruptive method for whole-organ liver decellularization and three different cell reseeding strategies to engineer functional liver tissue... - Isolated liver transplantation in infants with end-stage liver disease associated with short bowel syndromeSimon P Horslen
Department of Pediatrics, University of Nebraska, Omaha, Nebraska 68198 3285, USA
Ann Surg 235:435-9. 2002..To evaluate experience with isolated orthotopic liver transplantation in children with liver failure associated with short bowel syndrome (SBS)... - Differentiation and transplantation of human embryonic stem cell-derived hepatocytesHesham Basma
Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
Gastroenterology 136:990-9. 2009..Embryonic stem cells are pluripotent, potentially can differentiate into any cell type, and therefore could be developed as a source of human hepatocytes... - Omeprozole therapy in pediatric patients after liver and intestinal transplantationStuart S Kaufman
Joint Section of Pediatric Gastroenterology and Nutrition, Departments of Pediatrics, University of Nebraska Medical Center and Creighton University, Omaha, Nebraska, USA
J Pediatr Gastroenterol Nutr 34:194-8. 2002..A dosage of 0.5 mg/kg every 12 hours is sufficient for most patients, but dosing every 6 to 8 hours is required to assure maximal acid suppression in all... - Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn ratYujo Kawashita
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA
J Hepatol 49:99-106. 2008.... - Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytesAlejandro Soto-Gutierrez
Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Nat Biotechnol 24:1412-9. 2006..After functioning in the BAL, ES cell-derived hepatocytes developed characteristics nearly identical to those of primary hepatocytes... - Intrasplenic hepatocyte transplantation prolonged the survival in Nagase analbuminemic rats with liver failure induced by common bile duct ligationMasahiro Ito
Department of Surgery, Fujita Health University, Toyoake, Aichi, Japan
Cell Transplant 16:547-53. 2007..This study indicates that hepatocytes can be transplanted to temporarily provide life-supporting liver-specific metabolic function and prolong the survival in recipient rats with liver failure induced by CBDL... - To be or not to be: generation of hepatocytes from cells outside the liverIra J Fox
Gastroenterology 134:878-81. 2008 - Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in miceJorge D Rivas Carrillo
Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama, Japan
Diabetes 56:1259-67. 2007..Following isolation and transplantation, islets are susceptible to apoptosis, which limits their function and probably long-term islet graft survival... - Immortalized hepatocytes using human artificial chromosomeMasahiro Ito
Department of Surgery, Fujita Health University, Toyaoke City, Aichi, Japan
Cell Transplant 17:165-71. 2008..In further experiments, this cell line will be used for transplantable cells or artificial organ using HAC. These results represent an important step toward the development of immortalized hepatocytes... - Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cellsElena V Mashalova
Department of Microbiology and Immunology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
Hepatology 45:755-66. 2007..CONCLUSION: AdE3 gene products prevent hepatocyte allograft rejection mainly by protecting the cells from the effector limb of the host immune response and could be used as a tool to facilitate allogeneic hepatocyte transplantation... - Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell linesAlejandro Soto Gutierrez
Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Nat Protoc 2:347-56. 2007..The sorted cells produce albumin in culture and metabolize ammonia, lidocaine and diazepam at approximately two-thirds the rate of primary mouse hepatocytes... - Instant hepatic differentiation of human embryonic stem cells using activin A and a deleted variant of HGFYong Chen
Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700-8558, Japan
Cell Transplant 15:865-71. 2006..We developed an efficient method to differentiate KhES-1 cells into hepatocyte-like cells in vitro using 50 ng/ml of activin A and 500 ng/ml of dHGF...