Ira J Fox

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Transplantation into and inside the liver
    Ira J Fox
    Department of Surgery, 983285 University of Nebraska Medical Center, Omaha, NE 68198 3285, USA
    Hepatology 36:249-51. 2002
  2. ncbi request reprint Hepatocyte transplantation
    Ira J Fox
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Am J Transplant 4:7-13. 2004
  3. ncbi request reprint Hepatocyte transplantation
    Ira J Fox
    Department of Surgery, Organ Transplant Program, 983285, University of Nebraska Medical Center, Omaha NE 68198 3285, USA
    J Hepatol 40:878-86. 2004
  4. ncbi request reprint Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow
    Jia Lin Zhang
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
    Transplantation 80:362-9. 2005
  5. ncbi request reprint Prolonged survival of porcine hepatocytes in cynomolgus monkeys
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Gastroenterology 132:321-9. 2007
  6. ncbi request reprint Competitive equality of donor cells expressing a disparate MHC antigen following stem cell-enriched bone marrow transplantation
    Jia Lin Zhang
    Departments of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
    Transplantation 79:1332-7. 2005
  7. ncbi request reprint Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA
    Gastroenterology 124:422-31. 2003
  8. pmc The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis
    Liping Liu
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Hepatology 55:1529-39. 2012
  9. ncbi request reprint Route of hepatocyte delivery affects hepatocyte engraftment in the spleen
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Transplantation 76:732-4. 2003
  10. pmc A nonhuman primate model of human radiation-induced venocclusive liver disease and hepatocyte injury
    Govardhana Rao Yannam
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska
    Int J Radiat Oncol Biol Phys 88:404-11. 2014

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Transplantation into and inside the liver
    Ira J Fox
    Department of Surgery, 983285 University of Nebraska Medical Center, Omaha, NE 68198 3285, USA
    Hepatology 36:249-51. 2002
  2. ncbi request reprint Hepatocyte transplantation
    Ira J Fox
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Am J Transplant 4:7-13. 2004
    ....
  3. ncbi request reprint Hepatocyte transplantation
    Ira J Fox
    Department of Surgery, Organ Transplant Program, 983285, University of Nebraska Medical Center, Omaha NE 68198 3285, USA
    J Hepatol 40:878-86. 2004
  4. ncbi request reprint Tolerance by selective in vivo expansion of foreign major histocompatibility complex-transduced autologous bone marrow
    Jia Lin Zhang
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
    Transplantation 80:362-9. 2005
    ..Selective expansion of transduced hematopoietic stem cells has been accomplished by incorporating the dihydrofolate reductase (DHFR) gene into the gene transfer vector...
  5. ncbi request reprint Prolonged survival of porcine hepatocytes in cynomolgus monkeys
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Gastroenterology 132:321-9. 2007
    ..As a prelude to clinical application, we tested the feasibility of hepatocyte xenotransplantation in nonhuman primates...
  6. ncbi request reprint Competitive equality of donor cells expressing a disparate MHC antigen following stem cell-enriched bone marrow transplantation
    Jia Lin Zhang
    Departments of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
    Transplantation 79:1332-7. 2005
    ..The competitive disadvantage associated with engraftment of donor cells expressing foreign MHC antigens is thought to result from a defect in engraftment secondary to donor-host incompatibility or immunologic resistance by the host...
  7. ncbi request reprint Treatment of cirrhosis and liver failure in rats by hepatocyte xenotransplantation
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha 68198, USA
    Gastroenterology 124:422-31. 2003
    ..The use of porcine hepatocytes might address this problem; however, xenogeneic hepatocytes are thought to be functionally incompatible across species and susceptible to irreversible rejection...
  8. pmc The microenvironment in hepatocyte regeneration and function in rats with advanced cirrhosis
    Liping Liu
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE, USA
    Hepatology 55:1529-39. 2012
    ..Both, however, recovered more than 2 months after transplantation, indicating that either mature hepatocytes or a subpopulation of adult stem cells are capable of full recovery in severe cirrhosis...
  9. ncbi request reprint Route of hepatocyte delivery affects hepatocyte engraftment in the spleen
    Hideo Nagata
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Transplantation 76:732-4. 2003
    ..The route of hepatocyte delivery may influence hepatocyte engraftment and explain the disparity in efficacy of hepatocyte transplantation between the laboratory and clinic...
  10. pmc A nonhuman primate model of human radiation-induced venocclusive liver disease and hepatocyte injury
    Govardhana Rao Yannam
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska
    Int J Radiat Oncol Biol Phys 88:404-11. 2014
    ....
  11. ncbi request reprint Mild donor liver steatosis has no impact on hepatitis C virus fibrosis progression following liver transplantation
    Jean F Botha
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198 3285, USA
    Liver Int 27:758-63. 2007
    ..This study examines the impact of donor liver macrovesicular steatosis on recurrence of hepatitis C virus (HCV) disease after liver transplantation...
  12. pmc Heart xenograft survival with chimeric pig donors and modest immune suppression
    William E Beschorner
    Department of Surgery, Transplantation Section, University Nebraska Medical Center, Omaha, NE 68198 3285, USA
    Ann Surg 237:265-72. 2003
    ..The clinical use of pig organ xenografts is currently precluded by severe acute rejection, which resists standard immune suppression...
  13. ncbi request reprint Long-term transgene expression and survival of transgene-expressing grafts following lentivirus transduction of bone marrow side population cells
    Jai lin Zhang
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
    Transplantation 79:882-8. 2005
    ..Successful transduction of hematopoietic stem cells is essential if gene therapy is to be used clinically to induce immunologic tolerance...
  14. ncbi request reprint Isolated hepatocyte transplantation in an infant with a severe urea cycle disorder
    Simon P Horslen
    Section of Pediatric Gastroenterology, University of Nebraska Medical Center, Omaha, Nebraska 68198 3285, USA
    Pediatrics 111:1262-7. 2003
    ....
  15. ncbi request reprint Induction of chimerism in mice using human MHC class I-mismatched Hoechst 33342 side population donor stem cells
    John D Jackson
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Cell Transplant 11:779-85. 2002
    ..Therefore, SP cells may be useful for establishing mixed chimerism, which may induce immunologic nonresponsiveness to donor antigens in solid organ transplantation...
  16. ncbi request reprint Treatment of liver failure in rats with end-stage cirrhosis by transplantation of immortalized hepatocytes
    Jin Cai
    Department of Surgery, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Hepatology 36:386-94. 2002
    ..Further investigation is warranted regarding the mechanisms of loss of mass or function of the transplanted hepatocytes over time and how the relatively few engrafted hepatocytes can ameliorate liver decompensation in cirrhosis...
  17. ncbi request reprint Radiolabeled constructs for evaluation of the asialoglycoprotein receptor status and hepatic functional reserves
    Michio Abe
    University of Nebraska Medical Center, Departments of Radiation Oncology and Surgery, J Bruce Henriksen Laboratories for Cancer Research, Omaha, Nebraska 68198, USA
    Bioconjug Chem 14:997-1006. 2003
    ..These differences in rates of liver uptake and clearance of catabolized radiolabeled AF can be used to determine functional activity of liver and transplanted hepatocytes...
  18. ncbi request reprint Hepatocyte transplantation
    Simon P Horslen
    1 Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE 68198 3285, USA
    Transplantation 77:1481-6. 2004
    ..The potential of isolated hepatocyte transplantation remains largely untapped and awaits alternate sources of cells for transplantation other than those from discarded human cadaveric livers...
  19. pmc A whole-organ regenerative medicine approach for liver replacement
    Alejandro Soto-Gutierrez
    Transplantation Section, Department of Surgery, Children s Hospital of Pittsburgh, Center for Innovative Regenerative Therapies, University of Pittsburgh, Pennsylvania, USA
    Tissue Eng Part C Methods 17:677-86. 2011
    ..The present study investigates a new, minimally disruptive method for whole-organ liver decellularization and three different cell reseeding strategies to engineer functional liver tissue...
  20. pmc Isolated liver transplantation in infants with end-stage liver disease associated with short bowel syndrome
    Simon P Horslen
    Department of Pediatrics, University of Nebraska, Omaha, Nebraska 68198 3285, USA
    Ann Surg 235:435-9. 2002
    ..To evaluate experience with isolated orthotopic liver transplantation in children with liver failure associated with short bowel syndrome (SBS)...
  21. pmc Differentiation and transplantation of human embryonic stem cell-derived hepatocytes
    Hesham Basma
    Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Gastroenterology 136:990-9. 2009
    ..Embryonic stem cells are pluripotent, potentially can differentiate into any cell type, and therefore could be developed as a source of human hepatocytes...
  22. ncbi request reprint Omeprozole therapy in pediatric patients after liver and intestinal transplantation
    Stuart S Kaufman
    Joint Section of Pediatric Gastroenterology and Nutrition, Departments of Pediatrics, University of Nebraska Medical Center and Creighton University, Omaha, Nebraska, USA
    J Pediatr Gastroenterol Nutr 34:194-8. 2002
    ..In this investigation, the acid-suppressive potency of omeprazole was assessed in one at-risk group, pediatric patients undergoing liver or intestinal transplantation, or both...
  23. ncbi request reprint Intrasplenic hepatocyte transplantation prolonged the survival in Nagase analbuminemic rats with liver failure induced by common bile duct ligation
    Masahiro Ito
    Department of Surgery, Fujita Health University, Toyoake, Aichi, Japan
    Cell Transplant 16:547-53. 2007
    ..This study indicates that hepatocytes can be transplanted to temporarily provide life-supporting liver-specific metabolic function and prolong the survival in recipient rats with liver failure induced by CBDL...
  24. doi request reprint To be or not to be: generation of hepatocytes from cells outside the liver
    Ira J Fox
    Gastroenterology 134:878-81. 2008
  25. ncbi request reprint Hepatic repopulation with stably transduced conditionally immortalized hepatocytes in the Gunn rat
    Yujo Kawashita
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York, NY 10461, USA
    J Hepatol 49:99-106. 2008
    ....
  26. ncbi request reprint Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytes
    Alejandro Soto-Gutierrez
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nat Biotechnol 24:1412-9. 2006
    ..After functioning in the BAL, ES cell-derived hepatocytes developed characteristics nearly identical to those of primary hepatocytes...
  27. ncbi request reprint Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines
    Alejandro Soto-Gutierrez
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Nat Protoc 2:347-56. 2007
    ..The sorted cells produce albumin in culture and metabolize ammonia, lidocaine and diazepam at approximately two-thirds the rate of primary mouse hepatocytes...
  28. ncbi request reprint Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice
    Jorge D Rivas-Carrillo
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Shikata cho, Okayama, Japan
    Diabetes 56:1259-67. 2007
    ..Following isolation and transplantation, islets are susceptible to apoptosis, which limits their function and probably long-term islet graft survival...
  29. ncbi request reprint Instant hepatic differentiation of human embryonic stem cells using activin A and a deleted variant of HGF
    Yong Chen
    Department of Surgery, Okayama University Graduate School of Medicine and Dentistry, Okayama 700 8558, Japan
    Cell Transplant 15:865-71. 2006
    ..We developed an efficient method to differentiate KhES-1 cells into hepatocyte-like cells in vitro using 50 ng/ml of activin A and 500 ng/ml of dHGF...
  30. ncbi request reprint Immortalized hepatocytes using human artificial chromosome
    Masahiro Ito
    Department of Surgery, Fujita Health University, Toyaoke City, Aichi, Japan
    Cell Transplant 17:165-71. 2008
    ..In further experiments, this cell line will be used for transplantable cells or artificial organ using HAC. These results represent an important step toward the development of immortalized hepatocytes...
  31. ncbi request reprint Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells
    Elena V Mashalova
    Department of Microbiology and Immunology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 45:755-66. 2007
    ..CONCLUSION: AdE3 gene products prevent hepatocyte allograft rejection mainly by protecting the cells from the effector limb of the host immune response and could be used as a tool to facilitate allogeneic hepatocyte transplantation...