Donald Fox

Summary

Affiliation: University of Houston
Country: USA

Publications

  1. pmc Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses
    Jerry E Johnson
    Department of Natural Sciences, University of Houston Downtown, Houston, TX, USA
    Mol Vis 13:887-919. 2007
  2. pmc Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice
    J Leigh Leasure
    Department of Psychology, University of Houston, Houston, Texas 77204 2020, USA
    Environ Health Perspect 116:355-61. 2008
  3. pmc Low-level gestational lead exposure increases retinal progenitor cell proliferation and rod photoreceptor and bipolar cell neurogenesis in mice
    Anand Giddabasappa
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 2020, USA
    Environ Health Perspect 119:71-7. 2011
  4. pmc Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption
    Guy A Perkins
    National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, USA
    Mol Vis 18:3029-48. 2012
  5. pmc Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies
    Donald A Fox
    University of Houston, College of Optometry, Houston, TX, USA
    Neurotoxicology 33:810-6. 2012
  6. pmc Low-level human equivalent gestational lead exposure produces supernormal scotopic electroretinograms, increased retinal neurogenesis, and decreased retinal dopamine utilization in rats
    Donald A Fox
    College of Optometry, University of Houston, 4901 Calhoun Rd, Houston, TX 77204 2020, USA
    Environ Health Perspect 116:618-25. 2008
  7. ncbi request reprint Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection
    D A Fox
    College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
    Eur J Ophthalmol 13:S44-56. 2003
  8. pmc Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice
    Donald A Fox
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Toxicol Appl Pharmacol 256:258-67. 2011
  9. ncbi request reprint Molecular mechanism of the lead-induced inhibition of rod cGMP phosphodiesterase
    D A Fox
    College of Optometry, University of Houston, TX 77204 6052, USA
    Toxicol Lett 82:263-70. 1995
  10. ncbi request reprint Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis
    D A Fox
    College of Optometry, University of Houston, TX 77204, USA
    Toxicol Lett 102:359-61. 1998

Collaborators

Detail Information

Publications16

  1. pmc Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses
    Jerry E Johnson
    Department of Natural Sciences, University of Houston Downtown, Houston, TX, USA
    Mol Vis 13:887-919. 2007
    ..The goal of our structural and functional studies was to determine the spatiotemporal regulation of ATP and Ca2+ dynamics in rod spherules and cone pedicles...
  2. pmc Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice
    J Leigh Leasure
    Department of Psychology, University of Houston, Houston, Texas 77204 2020, USA
    Environ Health Perspect 116:355-61. 2008
    ..Low-level developmental lead exposure is linked to cognitive and neurological disorders in children. However, the long-term effects of gestational lead exposure (GLE) have received little attention...
  3. pmc Low-level gestational lead exposure increases retinal progenitor cell proliferation and rod photoreceptor and bipolar cell neurogenesis in mice
    Anand Giddabasappa
    Department of Biology and Biochemistry, University of Houston, Houston, Texas 77204 2020, USA
    Environ Health Perspect 119:71-7. 2011
    ..Gestational lead exposure (GLE) produces novel and persistent rod-mediated electroretinographic (ERG) supernormality in children and adult animals...
  4. pmc Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption
    Guy A Perkins
    National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, USA
    Mol Vis 18:3029-48. 2012
    ..Thus, our experiments investigated the structural and functional effects of environmentally relevant postnatal lead exposure on rod spherule and cone pedicle mitochondria and whether Bcl-xL overexpression provided neuroprotection...
  5. pmc Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies
    Donald A Fox
    University of Houston, College of Optometry, Houston, TX, USA
    Neurotoxicology 33:810-6. 2012
    ..The results indicate that developmental neurotoxicity results in permanent changes, thus emphasizing the need to prevent such toxicity...
  6. pmc Low-level human equivalent gestational lead exposure produces supernormal scotopic electroretinograms, increased retinal neurogenesis, and decreased retinal dopamine utilization in rats
    Donald A Fox
    College of Optometry, University of Houston, 4901 Calhoun Rd, Houston, TX 77204 2020, USA
    Environ Health Perspect 116:618-25. 2008
    ..In contrast, low-level gestational Pb exposure (GLE) increases the amplitude of scotopic ERGs in children (supernormality)...
  7. ncbi request reprint Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection
    D A Fox
    College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
    Eur J Ophthalmol 13:S44-56. 2003
    ....
  8. pmc Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice
    Donald A Fox
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Toxicol Appl Pharmacol 256:258-67. 2011
    ....
  9. ncbi request reprint Molecular mechanism of the lead-induced inhibition of rod cGMP phosphodiesterase
    D A Fox
    College of Optometry, University of Houston, TX 77204 6052, USA
    Toxicol Lett 82:263-70. 1995
    ..These results may have implications for other enzymes using Mg2+ as a co-factor and suggest that Mg2+ may be useful for reversing the PDE inhibition by Pb2+...
  10. ncbi request reprint Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis
    D A Fox
    College of Optometry, University of Houston, TX 77204, USA
    Toxicol Lett 102:359-61. 1998
    ..These results suggest that lead-induced rod and bipolar cell apoptosis is triggered by Ca2+ and Pb2+ overload due to altered cGMP phosphodiesterase activity and that mitochondrial alterations play a central role in this process...
  11. pmc Gene-chemical interactions in the developing mammalian nervous system: Effects on proliferation, neurogenesis and differentiation
    Donald A Fox
    University of Houston, College of Optometry, Department of Biology and Biochemistry, 4901 Calhoun Road, Houston, TX 77024 2020, USA
    Neurotoxicology 31:589-97. 2010
    ..Bernard Weiss illustrated how environmental endocrine disruptors produced age- and sex-dependent alterations in synaptogenesis and cognitive behavior...
  12. ncbi request reprint Oxygen consumption in the rat outer and inner retina: light- and pharmacologically-induced inhibition
    C J Medrano
    College of Optometry, University of Houston, Texas 77204 6052, USA
    Exp Eye Res 61:273-84. 1995
    ..abstract truncated at 400 words)..
  13. ncbi request reprint Increased ERG a- and b-wave amplitudes in 7- to 10-year-old children resulting from prenatal lead exposure
    Stephen J Rothenberg
    National Institute of Public Health, Cuernavaca, Mexico
    Invest Ophthalmol Vis Sci 43:2036-44. 2002
    ..To determine the dose-response relationship between blood lead concentration ([PbB]) and scotopic ERG amplitude in 7- to 10-year-old children with lifetime lead exposure...
  14. ncbi request reprint Gene expression profiling in embryonic mouse lenses
    Weimin Xiao
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Mol Vis 12:1692-8. 2006
    ..In this study, we used laser capture microdissection (LCM) and microarray hybridization technology to compare the gene expression profiles of mouse embryonic days 10 and 12 lenses (E10 and E12)...
  15. ncbi request reprint Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications
    Guy A Perkins
    Department of Neurosciences and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, USA
    Mol Vis 9:60-73. 2003
    ..Therefore, we investigated the oxidative metabolism and three-dimensional membrane architecture of mouse rod and cone inner segment mitochondria...
  16. pmc Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
    Lihua He
    College of Optometry, Department of Biology, University of Houston, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 100:1022-7. 2003
    ..These results have relevance for therapies in a wide variety of progressive retinal and neuronal degenerations where Ca(2+) overload, lead exposure, andor mitochondrial dysfunction occur...