Donald Fox

Summary

Affiliation: University of Houston
Country: USA

Publications

  1. ncbi Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies
    Donald A Fox
    University of Houston, College of Optometry, Houston, TX, USA
    Neurotoxicology 33:810-6. 2012
  2. ncbi Molecular mechanism of the lead-induced inhibition of rod cGMP phosphodiesterase
    D A Fox
    College of Optometry, University of Houston, TX 77204 6052, USA
    Toxicol Lett 82:263-70. 1995
  3. ncbi Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis
    D A Fox
    College of Optometry, University of Houston, TX 77204, USA
    Toxicol Lett 102:359-61. 1998
  4. ncbi Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice
    Donald A Fox
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Toxicol Appl Pharmacol 256:258-67. 2011
  5. ncbi Gene-chemical interactions in the developing mammalian nervous system: Effects on proliferation, neurogenesis and differentiation
    Donald A Fox
    University of Houston, College of Optometry, Department of Biology and Biochemistry, 4901 Calhoun Road, Houston, TX 77024 2020, USA
    Neurotoxicology 31:589-97. 2010
  6. ncbi Low-level human equivalent gestational lead exposure produces supernormal scotopic electroretinograms, increased retinal neurogenesis, and decreased retinal dopamine utilization in rats
    Donald A Fox
    College of Optometry, University of Houston, 4901 Calhoun Rd, Houston, TX 77204 2020, USA
    Environ Health Perspect 116:618-25. 2008
  7. ncbi Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection
    D A Fox
    College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
    Eur J Ophthalmol 13:S44-56. 2003
  8. ncbi Oxygen consumption in the rat outer and inner retina: light- and pharmacologically-induced inhibition
    C J Medrano
    College of Optometry, University of Houston, Texas 77204 6052, USA
    Exp Eye Res 61:273-84. 1995
  9. ncbi Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses
    Jerry E Johnson
    Department of Natural Sciences, University of Houston Downtown, Houston, TX, USA
    Mol Vis 13:887-919. 2007
  10. ncbi Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice
    J Leigh Leasure
    Department of Psychology, University of Houston, Houston, Texas 77204 2020, USA
    Environ Health Perspect 116:355-61. 2008

Research Grants

  1. Low-Level Prenatal Lead Exposure and Retinal Toxicity
    Donald Fox; Fiscal Year: 2009

Collaborators

  • D Srivastava
  • Philippe Grandjean
  • Weimin Xiao
  • E Casanueva
  • A M Geller
  • Guy A Perkins
  • Jerry E Johnson
  • Mark H Ellisman
  • J Leigh Leasure
  • Shawntay Chaney
  • Anand Giddabasappa
  • Lihua He
  • Stephen J Rothenberg
  • Konstantinos Pothakos
  • Yuen Sum Lau
  • Jenna Waggoner
  • Joshua M Brown
  • Andrew D White
  • Jeffrey B Harris
  • Michael Hung
  • Ann T Poblenz
  • Manuel Salgado-Valladares
  • Lourdes Schnaas
  • H Kenneth Hudnell
  • C J Medrano

Detail Information

Publications14

  1. ncbi Developmental origins of adult diseases and neurotoxicity: epidemiological and experimental studies
    Donald A Fox
    University of Houston, College of Optometry, Houston, TX, USA
    Neurotoxicology 33:810-6. 2012
    ..The results indicate that developmental neurotoxicity results in permanent changes, thus emphasizing the need to prevent such toxicity...
  2. ncbi Molecular mechanism of the lead-induced inhibition of rod cGMP phosphodiesterase
    D A Fox
    College of Optometry, University of Houston, TX 77204 6052, USA
    Toxicol Lett 82:263-70. 1995
    ..These results may have implications for other enzymes using Mg2+ as a co-factor and suggest that Mg2+ may be useful for reversing the PDE inhibition by Pb2+...
  3. ncbi Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis
    D A Fox
    College of Optometry, University of Houston, TX 77204, USA
    Toxicol Lett 102:359-61. 1998
    ..These results suggest that lead-induced rod and bipolar cell apoptosis is triggered by Ca2+ and Pb2+ overload due to altered cGMP phosphodiesterase activity and that mitochondrial alterations play a central role in this process...
  4. ncbi Gestational lead exposure selectively decreases retinal dopamine amacrine cells and dopamine content in adult mice
    Donald A Fox
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Toxicol Appl Pharmacol 256:258-67. 2011
    ....
  5. ncbi Gene-chemical interactions in the developing mammalian nervous system: Effects on proliferation, neurogenesis and differentiation
    Donald A Fox
    University of Houston, College of Optometry, Department of Biology and Biochemistry, 4901 Calhoun Road, Houston, TX 77024 2020, USA
    Neurotoxicology 31:589-97. 2010
    ..Bernard Weiss illustrated how environmental endocrine disruptors produced age- and sex-dependent alterations in synaptogenesis and cognitive behavior...
  6. ncbi Low-level human equivalent gestational lead exposure produces supernormal scotopic electroretinograms, increased retinal neurogenesis, and decreased retinal dopamine utilization in rats
    Donald A Fox
    College of Optometry, University of Houston, 4901 Calhoun Rd, Houston, TX 77204 2020, USA
    Environ Health Perspect 116:618-25. 2008
    ..In contrast, low-level gestational Pb exposure (GLE) increases the amplitude of scotopic ERGs in children (supernormality)...
  7. ncbi Pharmacological strategies to block rod photoreceptor apoptosis caused by calcium overload: a mechanistic target-site approach to neuroprotection
    D A Fox
    College of Optometry, University of Houston, Houston, Texas 77204 2020, USA
    Eur J Ophthalmol 13:S44-56. 2003
    ....
  8. ncbi Oxygen consumption in the rat outer and inner retina: light- and pharmacologically-induced inhibition
    C J Medrano
    College of Optometry, University of Houston, Texas 77204 6052, USA
    Exp Eye Res 61:273-84. 1995
    ..abstract truncated at 400 words)..
  9. ncbi Spatiotemporal regulation of ATP and Ca2+ dynamics in vertebrate rod and cone ribbon synapses
    Jerry E Johnson
    Department of Natural Sciences, University of Houston Downtown, Houston, TX, USA
    Mol Vis 13:887-919. 2007
    ..The goal of our structural and functional studies was to determine the spatiotemporal regulation of ATP and Ca2+ dynamics in rod spherules and cone pedicles...
  10. ncbi Low-level human equivalent gestational lead exposure produces sex-specific motor and coordination abnormalities and late-onset obesity in year-old mice
    J Leigh Leasure
    Department of Psychology, University of Houston, Houston, Texas 77204 2020, USA
    Environ Health Perspect 116:355-61. 2008
    ..Low-level developmental lead exposure is linked to cognitive and neurological disorders in children. However, the long-term effects of gestational lead exposure (GLE) have received little attention...
  11. ncbi Three-dimensional analysis of mouse rod and cone mitochondrial cristae architecture: bioenergetic and functional implications
    Guy A Perkins
    Department of Neurosciences and National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA, USA
    Mol Vis 9:60-73. 2003
    ..The greater ATP generation by cones may also provide increased protection against metabolic insults and apoptosis compared to rods...
  12. ncbi Bcl-xL overexpression blocks bax-mediated mitochondrial contact site formation and apoptosis in rod photoreceptors of lead-exposed mice
    Lihua He
    College of Optometry, Department of Biology, University of Houston, Houston, TX 77204, USA
    Proc Natl Acad Sci U S A 100:1022-7. 2003
    ..These results have relevance for therapies in a wide variety of progressive retinal and neuronal degenerations where Ca(2+) overload, lead exposure, andor mitochondrial dysfunction occur...
  13. ncbi Increased ERG a- and b-wave amplitudes in 7- to 10-year-old children resulting from prenatal lead exposure
    Stephen J Rothenberg
    National Institute of Public Health, Cuernavaca, Mexico
    Invest Ophthalmol Vis Sci 43:2036-44. 2002
    ..These novel findings reveal that the developing retina is a sensitive target for lead and suggest that lead-exposed children be examined for possible future visual system deficits...
  14. ncbi Gene expression profiling in embryonic mouse lenses
    Weimin Xiao
    College of Optometry, University of Houston, Houston, TX 77204 2020, USA
    Mol Vis 12:1692-8. 2006
    ..In this study, we used laser capture microdissection (LCM) and microarray hybridization technology to compare the gene expression profiles of mouse embryonic days 10 and 12 lenses (E10 and E12)...

Research Grants7

  1. Low-Level Prenatal Lead Exposure and Retinal Toxicity
    Donald Fox; Fiscal Year: 2009
    ....