Catherine A Fox

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. pmc Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin
    Madeleine A Palacios DeBeer
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Genes Dev 17:1817-22. 2003
  2. pmc Palmitoylation in the nucleus: a little fat around the edges
    Catherine A Fox
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Nucleus 3:251-5. 2012
  3. pmc Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1
    Zhonggang Hou
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine andPublic Health, Madison, Wisconsin 53706 1532, USA
    Mol Cell Biol 29:687-702. 2009
  4. ncbi request reprint Toward biochemical understanding of a transcriptionally silenced chromosomal domain in Saccharomyces cerevisiae
    Catherine A Fox
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 280:8629-32. 2005
  5. pmc Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa
    Kristopher H McConnell
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, 587 MSC, 1300 University Ave, Madison, WI 53706 1532
    Mol Cell Biol 26:1955-66. 2006
  6. pmc The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain
    Melissa E Bose
    Department of Biomolecular Chemistry, 587 MSC, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 43706 1532, USA
    Mol Cell Biol 24:774-86. 2004
  7. pmc The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin
    Philipp Müller
    Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Genes Dev 24:1418-33. 2010
  8. pmc Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing
    Zhonggang Hou
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Medical Sciences Center, 1300 University Avenue, Madison, WI 53706 1532, USA
    Proc Natl Acad Sci U S A 102:8489-94. 2005
  9. pmc The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae
    Erin E Patterson
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 1532, USA
    Genetics 180:771-83. 2008
  10. pmc Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1
    Sookhee Park
    Department of Biomolecular Chemistry and Laboratory of Genetics, School of Medicine and Public Health and College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 108:14572-7. 2011

Collaborators

  • Michael Weinreich
  • ASEEM ANSARI
  • James R Broach
  • Barry Williams
  • Zhonggang Hou
  • Ulrika Muller
  • Erin E Patterson
  • Sookhee Park
  • Kristopher H McConnell
  • Erika Shor
  • Philipp Müller
  • Melissa E Bose
  • James L Keck
  • Christopher L Warren
  • Laurieann Casey
  • John R Danzer
  • Carrie Gabrielse
  • Madeleine A Palacios DeBeer
  • Judith A Sharp
  • Jenel Cobb
  • Marc R Gartenberg
  • Anjon Audhya
  • Dana J Huebert
  • David M MacAlpine
  • Matthew L Eaton
  • Ilaria Alborelli
  • Conrad A Nieduszynski
  • Liza Mendoza
  • Adrian I Yemm
  • Joshua Tietjen
  • Lev Borisov
  • Florence H Gohard
  • Aaron DeWard
  • Charles T Miller
  • Douglas A Bernstein
  • Kelly A Gardner-Aukema
  • Paul D Kaufman
  • Denise C Krawitz
  • Kelly A Gardner

Detail Information

Publications17

  1. pmc Differential DNA affinity specifies roles for the origin recognition complex in budding yeast heterochromatin
    Madeleine A Palacios DeBeer
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    Genes Dev 17:1817-22. 2003
    ..Therefore, the ORC's interaction with its target site could modulate ORC activity within a heterochromatin domain in vivo...
  2. pmc Palmitoylation in the nucleus: a little fat around the edges
    Catherine A Fox
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Nucleus 3:251-5. 2012
    ..A well-recognized paradigm is farnesylation of the Ras GTPase that helps target this critical signaling protein to the plasma membrane...
  3. pmc Phylogenetic conservation and homology modeling help reveal a novel domain within the budding yeast heterochromatin protein Sir1
    Zhonggang Hou
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine andPublic Health, Madison, Wisconsin 53706 1532, USA
    Mol Cell Biol 29:687-702. 2009
    ..Thus, the Sir1 N terminus exhibited both positive and negative roles in the formation of a Sir1-ORC silencing complex. This functional duality might contribute to Sir1's selectivity for silencer-bound ORCs in vivo...
  4. ncbi request reprint Toward biochemical understanding of a transcriptionally silenced chromosomal domain in Saccharomyces cerevisiae
    Catherine A Fox
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Madison, Wisconsin 53706, USA
    J Biol Chem 280:8629-32. 2005
  5. pmc Tolerance of Sir1p/origin recognition complex-dependent silencing for enhanced origin firing at HMRa
    Kristopher H McConnell
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, 587 MSC, 1300 University Ave, Madison, WI 53706 1532
    Mol Cell Biol 26:1955-66. 2006
    ..However, although the robust origin/silencer fusions silenced HMRa quite well, they were measurably less effective than a comparable silencer containing HMR-E's native ORC binding site...
  6. pmc The origin recognition complex and Sir4 protein recruit Sir1p to yeast silent chromatin through independent interactions requiring a common Sir1p domain
    Melissa E Bose
    Department of Biomolecular Chemistry, 587 MSC, University of Wisconsin Medical School, 1300 University Avenue, Madison, WI 43706 1532, USA
    Mol Cell Biol 24:774-86. 2004
    ....
  7. pmc The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin
    Philipp Müller
    Department of Biomolecular Chemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Genes Dev 24:1418-33. 2010
    ....
  8. pmc Structural basis of the Sir1-origin recognition complex interaction in transcriptional silencing
    Zhonggang Hou
    Department of Biomolecular Chemistry, University of Wisconsin Medical School, Medical Sciences Center, 1300 University Avenue, Madison, WI 53706 1532, USA
    Proc Natl Acad Sci U S A 102:8489-94. 2005
    ..These data provide important structural insights into a protein-protein interaction critical for the formation of a specialized chromatin domain within eukaryotic chromosomes...
  9. pmc The Ku complex in silencing the cryptic mating-type loci of Saccharomyces cerevisiae
    Erin E Patterson
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 1532, USA
    Genetics 180:771-83. 2008
    ..Additional ChIP experiments provided evidence that Ku functioned directly at the HM loci. Thus Ku and Sir1 had overlapping roles in silencing the HM loci...
  10. pmc Palmitoylation controls the dynamics of budding-yeast heterochromatin via the telomere-binding protein Rif1
    Sookhee Park
    Department of Biomolecular Chemistry and Laboratory of Genetics, School of Medicine and Public Health and College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 108:14572-7. 2011
    ..These data supported a model in which Pfa4-dependent palmitoylation of Rif1 anchored it to the inner nuclear membrane, influencing its role in heterochromatin dynamics...
  11. pmc The origin recognition complex interacts with a subset of metabolic genes tightly linked to origins of replication
    Erika Shor
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, United States of America
    PLoS Genet 5:e1000755. 2009
    ..Taken together, these results suggest a surprising connection among ORC, replication origins, and cellular metabolism...
  12. pmc Conversion of a replication origin to a silencer through a pathway shared by a Forkhead transcription factor and an S phase cyclin
    Laurieann Casey
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, WI 53706, USA
    Mol Biol Cell 19:608-22. 2008
    ..These and other data supported a model in which FKH1 and CLB5 modulated Sir2-4 chromatin and late-origin firing through opposing regulation of a common pathway...
  13. pmc Structure of the Sir3 protein bromo adjacent homology (BAH) domain from S. cerevisiae at 1.95 A resolution
    Zhonggang Hou
    Department of Biomolecular Chemistry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53706 1532, USA
    Protein Sci 15:1182-6. 2006
    ..These findings imply that the Sir3p-BAH domain structure has evolved for functions distinct from those of the Orc1p-BAH domain...
  14. ncbi request reprint Beyond heterochromatin: SIR2 inhibits the initiation of DNA replication
    Catherine A Fox
    Department of Biomolecular Chemistry, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin, USA
    Cell Cycle 7:3330-4. 2008
    ..Here, we highlight key conclusions from this study, place them in perspective with earlier work, and outline important future questions...
  15. pmc A Dbf4p BRCA1 C-terminal-like domain required for the response to replication fork arrest in budding yeast
    Carrie Gabrielse
    Laboratory of Chromosome Replication, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Genetics 173:541-55. 2006
    ..Rad53p likely directly phosphorylated Dbf4p in response to RF arrest and Dbf4p was required for Rad53p abundance. Rad53p and Dbf4p therefore cooperated to coordinate a robust cellular response to RF arrest...
  16. ncbi request reprint The activities of eukaryotic replication origins in chromatin
    Michael Weinreich
    Laboratory of Chromosome Replication, Van Andel Research Institute, 333 Bostwick Ave NE, Grand Rapids, MI 49503, USA
    Biochim Biophys Acta 1677:142-57. 2004
    ..These roles are not linked obligatorily to replication origin activity per se, but instead exploit multi-subunit replication proteins with the potential to form context-dependent protein-protein interactions...
  17. pmc The budding yeast silencing protein Sir1 is a functional component of centromeric chromatin
    Judith A Sharp
    Lawrence Berkeley National Laboratory and Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California 94720, USA
    Genes Dev 17:2356-61. 2003
    ....