Jack F Fowler
Affiliation: University of Wisconsin
- Loss of biological effect in prolonged fraction deliveryJack F Fowler
Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI 53792, USA
Int J Radiat Oncol Biol Phys 59:242-9. 2004..In this article, we model repair rates for a range of doses per fraction and draw conclusions...
- Sensitivity analysis of parameters in linear-quadratic radiobiologic modelingJack F Fowler
Department of Human Oncology, School of Medicine, University of Wisconsin, Madison, WI, USA
Int J Radiat Oncol Biol Phys 73:1532-7. 2009..The present article shows how much the linear-quadratic (LQ) (calculated biologically equivalent dose [BED] varies when individual parameters of the LQ formula are varied by +/-20% and by 1%...
- A challenge to traditional radiation oncologyJack F Fowler
Department of Human Oncology, Medical School of the University of Wisconsin, Madison, WI, USA
Int J Radiat Oncol Biol Phys 60:1241-56. 2004....
- Development of radiobiology for oncology-a personal viewJack F Fowler
Human Oncology and Medical Physics, University of Wisconsin Medical School, Madison, WI 53792, USA
Phys Med Biol 51:R263-86. 2006..This is the very personal story of what I saw happening in the subject, decade by decade. I was happy to experience all this together with scientists in many other countries, and our own, along the way...
- On the inclusion of proliferation in tumour control probability calculations for inhomogeneously irradiated tumoursWolfgang A Tome
Department of Human Oncology, University of Wisconsin Medical School, K4 344 CSC 600 Highland Avenue, Madison, WI 53792, USA
Phys Med Biol 48:N261-8. 2003....
- The radiobiology of prostate cancer including new aspects of fractionated radiotherapyJack F Fowler
Emeritus of Medical School of Wisconsin University, Department of Human Oncology, University of Wisconsin Madison, USA
Acta Oncol 44:265-76. 2005..Monotherapy by brachytherapy for low-risk cancer prostate using two to four fractions in a few days can give even higher biological effects on the tumors...
- Correction to Kasibhatla et al. How much radiation is the chemotherapy worth in advanced head and neck cancer? (Int j radiat oncol biol phys 2007;68:1491-1495)Jack F Fowler
Department of Human Oncology and Medical Physics, University of Wisconsin, Madison, WI, USA
Int J Radiat Oncol Biol Phys 71:326-9. 2008....
- Acute radiation reactions in oral and pharyngeal mucosa: tolerable levels in altered fractionation schedulesJack F Fowler
Department of Human Oncology K4 316, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
Radiother Oncol 69:161-8. 2003..To investigate whether a predictive estimate can be obtained for a 'tolerance level' of acute oral and pharyngeal mucosal reactions in patients receiving head and neck radiotherapy, using an objective set of dose and time data...
- What hypofractionated protocols should be tested for prostate cancer?Jack F Fowler
Department of Human Oncology, University of Wisconsin Madison, Madison, WI 53792, USA
Int J Radiat Oncol Biol Phys 56:1093-104. 2003..We analyze here possible high-gain/low-risk hypofractionated protocols for prostate cancer to test this suggestion...
- Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancer, in comparison to conventional field arrangementsRufus A Scrimger
Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
Am J Clin Oncol 26:70-8. 2003..This has important implications for dose escalation strategies in the future...
- On cold spots in tumor subvolumesWolfgang A Tome
Department of Human Oncology, University of Wisconsin Medical School, CSc, Madison 53792, USA
Med Phys 29:1590-8. 2002..The effect of cold regions on TCP can be minimized if the EUD associated with the target DVH is constrained to be equal to or larger than the prescription dose...
- Repair between dose fractions: a simpler method of analyzing and reporting apparently biexponential repairJack F Fowler
Department of Human Oncology, University of Wisconsin Medical School, K4 316, 600 Highland Avenue, Madison, Wisconsin 53792, USA
Radiat Res 158:141-51. 2002..A much larger proportion of damage would therefore remain unrepaired at several half-times than is estimated by current mono- or biexponential models. The practical implications for clinical radiotherapy are important...
- High-dose-rate brachytherapy-. High-dose, high-tech, and high resultsDaniel G Petereit
Int J Radiat Oncol Biol Phys 55:1159-61. 2003
- Isn't it reasonable to ask for fraction numbers?Jack F Fowler
Int J Radiat Oncol Biol Phys 72:313-4. 2008
- The optimal fraction size in high-dose-rate brachytherapy: dependency on tissue repair kinetics and low-dose ratePeter Sminia
Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands p sminia vumc nl
Int J Radiat Oncol Biol Phys 52:844-9. 2002....
- Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: first clinical trial resultsBerit L Madsen
Section of Radiation Oncology, Virginia Mason Medical Center, Seattle, WA 98101, USA
Int J Radiat Oncol Biol Phys 67:1099-105. 2007..To evaluate the feasibility and toxicity of stereotactic hypofractionated accurate radiotherapy (SHARP) for localized prostate cancer...
- Comments on "Comparison of in vitro and in vivo alpha/beta ratios for prostate cancer"Alexandru Daşu
Phys Med Biol 50:L1-4; author reply L5-8. 2005
- The prospects for new treatments for prostate cancerJack F Fowler
Int J Radiat Oncol Biol Phys 52:3-5. 2002
- The effect of fraction time in intensity modulated radiotherapy: theoretical and experimental evaluation of an optimization problem (the real conclusions): in regard to Mu et al. Radiotherapy on Oncology 2003; 68: 181-87Wofgang A Tomé
Radiother Oncol 72:113-4; author reply 114-5. 2004
- Yes, the alpha/beta ratio for prostate cancer is low or "methinks the lady doth protest too much...about a low alpha/beta that is"Christopher R King
Int J Radiat Oncol Biol Phys 54:626-7; author reply 627-8. 2002
- Should single or distributed parameters be used to explain the steepness of tumour control probability curves?Alexandru Daşu
Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
Phys Med Biol 48:387-97. 2003..This contradiction suggests that single values for the parameters are not likely to explain reasonably the clinical observations and that some distributions of input parameters should be taken into consideration...
- How low is the alpha/beta ratio for prostate cancer? In regard to Wang et al., IJROBP 2003;55:194-203Jack F Fowler
Int J Radiat Oncol Biol Phys 57:593-5; author reply 595-6. 2003
- Dose rate in external beam radiotherapy for prostate cancer: an overlooked confounding variable?James S Welsh
Urology 62:204-6. 2003
- Walking forward: the South Dakota Native American projectDaniel G Petereit
John T Vucurevich Cancer Institute, Rapid City, SD 57701, USA
J Cancer Educ 20:65-70. 2005..It is hypothesized that a conventional course of cancer treatment lasting 6 to 8 weeks may be a barrier...
- Theoretical simulation of oxygen tension measurement in the tissue using a microelectrode: II. Simulated measurements in tissuesIuliana Toma-Daşu
Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
Radiother Oncol 64:109-18. 2002....
- Influence of overall treatment time and radiobiological parameters on biologically effective doses in cervical cancer patients treated with radiation therapy aloneAnna Gasinska
Laboratory of Radiation Biology, Department of Radiation Therapy, Centre of Oncology, Krakow, Poland
Acta Oncol 43:657-66. 2004..037), BrdUrdLI </= 8.8% (p=0.003), tumour aneuploidy (p=0.043), and BED10 </= 103 Gy (p=0.017). The examined tumour biological parameters should be taken into account for RT and provide a basis for adjuvant RT...