J F Fowler

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Biological factors influencing optimum fractionation in radiation therapy
    J F Fowler
    Department of Human Oncology, University of Wisconsin Hospital, Madison 53792, USA
    Acta Oncol 40:712-7. 2001
  2. ncbi request reprint What hypofractionated protocols should be tested for prostate cancer?
    Jack F Fowler
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 56:1093-104. 2003
  3. ncbi request reprint What can we expect from dose escalation using proton beams?
    J F Fowler
    Department of Human Oncology, Medical School of the University of Wisconsin, Madison, Wisconsin 53792, USA
    Clin Oncol (R Coll Radiol) 15:S10-5. 2003
  4. ncbi request reprint Repair between dose fractions: a simpler method of analyzing and reporting apparently biexponential repair
    Jack F Fowler
    Department of Human Oncology, University of Wisconsin Medical School, K4 316, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Radiat Res 158:141-51. 2002
  5. pmc 21 years of biologically effective dose
    J F Fowler
    University of Wisconsin Medical School, Madison, WI 53792, USA
    Br J Radiol 83:554-68. 2010
  6. ncbi request reprint Is there an optimum overall time for head and neck radiotherapy? A review, with new modelling
    J F Fowler
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Clin Oncol (R Coll Radiol) 19:8-22. 2007
  7. ncbi request reprint Phase II trial of hyperfractionated accelerated radiation therapy for nonresectable non-small-cell lung cancer: results of Eastern Cooperative Oncology Group 4593
    M P Mehta
    Department of Human Oncology, University of Wisconsin Medical School, Madison 53792 0600, USA
    J Clin Oncol 16:3518-23. 1998
  8. ncbi request reprint Selective boosting of tumor subvolumes
    W A Tome
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 48:593-9. 2000
  9. ncbi request reprint Optimum overall times II: Extended modelling for head and neck radiotherapy
    J F Fowler
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Clin Oncol (R Coll Radiol) 20:113-26. 2008
  10. ncbi request reprint The Denekamp diadems--a review of Julie's achievements
    J F Fowler
    Department of Human Oncology, University of Wisconsin, Madison, USA
    Acta Oncol 40:903-12. 2001

Detail Information

Publications34

  1. ncbi request reprint Biological factors influencing optimum fractionation in radiation therapy
    J F Fowler
    Department of Human Oncology, University of Wisconsin Hospital, Madison 53792, USA
    Acta Oncol 40:712-7. 2001
    ..New evidence is presented showing that their alpha/beta ratio may indeed be lower than 3 Gy. For an entirely different reason from that above, hypofractionation should be tested...
  2. ncbi request reprint What hypofractionated protocols should be tested for prostate cancer?
    Jack F Fowler
    Department of Human Oncology, University of Wisconsin Madison, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 56:1093-104. 2003
    ..We analyze here possible high-gain/low-risk hypofractionated protocols for prostate cancer to test this suggestion...
  3. ncbi request reprint What can we expect from dose escalation using proton beams?
    J F Fowler
    Department of Human Oncology, Medical School of the University of Wisconsin, Madison, Wisconsin 53792, USA
    Clin Oncol (R Coll Radiol) 15:S10-5. 2003
    ..There is a considerable way to go yet to achieve really high non-recurrence rates, especially in the lung tumours. Proton beams would make this progress much safer and more effective than any variants with photons...
  4. ncbi request reprint Repair between dose fractions: a simpler method of analyzing and reporting apparently biexponential repair
    Jack F Fowler
    Department of Human Oncology, University of Wisconsin Medical School, K4 316, 600 Highland Avenue, Madison, Wisconsin 53792, USA
    Radiat Res 158:141-51. 2002
    ..A much larger proportion of damage would therefore remain unrepaired at several half-times than is estimated by current mono- or biexponential models. The practical implications for clinical radiotherapy are important...
  5. pmc 21 years of biologically effective dose
    J F Fowler
    University of Wisconsin Medical School, Madison, WI 53792, USA
    Br J Radiol 83:554-68. 2010
    ..BED is now used for dose escalation studies, radiochemotherapy, brachytherapy, high-LET particle beams, radionuclide-targeted therapy, and for quantifying any treatments using ionising radiation...
  6. ncbi request reprint Is there an optimum overall time for head and neck radiotherapy? A review, with new modelling
    J F Fowler
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Clin Oncol (R Coll Radiol) 19:8-22. 2007
    ..To test by modelling whether a non-standard fractionated schedule giving optimum log cell kill could be expected, between short (accelerated) and longer multiple fraction/day schedules...
  7. ncbi request reprint Phase II trial of hyperfractionated accelerated radiation therapy for nonresectable non-small-cell lung cancer: results of Eastern Cooperative Oncology Group 4593
    M P Mehta
    Department of Human Oncology, University of Wisconsin Medical School, Madison 53792 0600, USA
    J Clin Oncol 16:3518-23. 1998
    ..To assess the feasibility, toxicity, and efficacy of hyperfractionated accelerated radiation therapy (HART) for non-small-cell lung cancer (NSCLC)...
  8. ncbi request reprint Selective boosting of tumor subvolumes
    W A Tome
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 48:593-9. 2000
    ..New methods of tumor imaging might show regions of specific activity or hypoxia which could be selectively targeted. This paper investigates by modeling the effect of boosting, by dose ratios up to 2, for a range of tumor subvolumes...
  9. ncbi request reprint Optimum overall times II: Extended modelling for head and neck radiotherapy
    J F Fowler
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI 53792, USA
    Clin Oncol (R Coll Radiol) 20:113-26. 2008
    ..Some numerical errors in the Tables in part I are also corrected in the present appendix. These made no difference to the main conclusions just described...
  10. ncbi request reprint The Denekamp diadems--a review of Julie's achievements
    J F Fowler
    Department of Human Oncology, University of Wisconsin, Madison, USA
    Acta Oncol 40:903-12. 2001
    ....
  11. doi request reprint Summary of meeting on "Radiobiological modelling in treatment planning" at the BIR on 12 December 2006
    J F Fowler
    University of Wisconsin Medical School, Madison, Wisconsin, USA
    Br J Radiol 81:89-90. 2008
  12. ncbi request reprint A challenge to traditional radiation oncology
    Jack F Fowler
    Department of Human Oncology, Medical School of the University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 60:1241-56. 2004
    ....
  13. ncbi request reprint The radiobiology of prostate cancer including new aspects of fractionated radiotherapy
    Jack F Fowler
    Emeritus of Medical School of Wisconsin University, Department of Human Oncology, University of Wisconsin Madison, USA
    Acta Oncol 44:265-76. 2005
    ..Monotherapy by brachytherapy for low-risk cancer prostate using two to four fractions in a few days can give even higher biological effects on the tumors...
  14. ncbi request reprint Development of radiobiology for oncology-a personal view
    Jack F Fowler
    Human Oncology and Medical Physics, University of Wisconsin Medical School, Madison, WI 53792, USA
    Phys Med Biol 51:R263-86. 2006
    ..This is the very personal story of what I saw happening in the subject, decade by decade. I was happy to experience all this together with scientists in many other countries, and our own, along the way...
  15. ncbi request reprint Comments on "Comparison of in vitro and in vivo alpha/beta ratios for prostate cancer"
    Alexandru Daşu
    Phys Med Biol 50:L1-4; author reply L5-8. 2005
  16. ncbi request reprint On cold spots in tumor subvolumes
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, CSc, Madison 53792, USA
    Med Phys 29:1590-8. 2002
    ..The effect of cold regions on TCP can be minimized if the EUD associated with the target DVH is constrained to be equal to or larger than the prescription dose...
  17. ncbi request reprint Stereotactic hypofractionated accurate radiotherapy of the prostate (SHARP), 33.5 Gy in five fractions for localized disease: first clinical trial results
    Berit L Madsen
    Section of Radiation Oncology, Virginia Mason Medical Center, Seattle, WA 98101, USA
    Int J Radiat Oncol Biol Phys 67:1099-105. 2007
    ..To evaluate the feasibility and toxicity of stereotactic hypofractionated accurate radiotherapy (SHARP) for localized prostate cancer...
  18. doi request reprint Correction to Kasibhatla et al. How much radiation is the chemotherapy worth in advanced head and neck cancer? (Int j radiat oncol biol phys 2007;68:1491-1495)
    Jack F Fowler
    Department of Human Oncology and Medical Physics, University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 71:326-9. 2008
    ....
  19. ncbi request reprint Isn't it reasonable to ask for fraction numbers?
    Jack F Fowler
    Int J Radiat Oncol Biol Phys 72:313-4. 2008
  20. ncbi request reprint The effect of fraction time in intensity modulated radiotherapy: theoretical and experimental evaluation of an optimization problem (the real conclusions): in regard to Mu et al. Radiotherapy on Oncology 2003; 68: 181-87
    Wofgang A Tomé
    Radiother Oncol 72:113-4; author reply 114-5. 2004
  21. ncbi request reprint Loss of biological effect in prolonged fraction delivery
    Jack F Fowler
    Department of Human Oncology, Medical School, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 59:242-9. 2004
    ..In this article, we model repair rates for a range of doses per fraction and draw conclusions...
  22. ncbi request reprint Yes, the alpha/beta ratio for prostate cancer is low or "methinks the lady doth protest too much...about a low alpha/beta that is"
    Christopher R King
    Int J Radiat Oncol Biol Phys 54:626-7; author reply 627-8. 2002
  23. ncbi request reprint Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancer, in comparison to conventional field arrangements
    Rufus A Scrimger
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Am J Clin Oncol 26:70-8. 2003
    ..This has important implications for dose escalation strategies in the future...
  24. ncbi request reprint The optimal fraction size in high-dose-rate brachytherapy: dependency on tissue repair kinetics and low-dose rate
    Peter Sminia
    Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands p sminia vumc nl
    Int J Radiat Oncol Biol Phys 52:844-9. 2002
    ....
  25. ncbi request reprint Should single or distributed parameters be used to explain the steepness of tumour control probability curves?
    Alexandru Daşu
    Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
    Phys Med Biol 48:387-97. 2003
    ..This contradiction suggests that single values for the parameters are not likely to explain reasonably the clinical observations and that some distributions of input parameters should be taken into consideration...
  26. ncbi request reprint High-dose-rate brachytherapy-. High-dose, high-tech, and high results
    Daniel G Petereit
    Int J Radiat Oncol Biol Phys 55:1159-61. 2003
  27. ncbi request reprint Dose rate in external beam radiotherapy for prostate cancer: an overlooked confounding variable?
    James S Welsh
    Urology 62:204-6. 2003
  28. ncbi request reprint How low is the alpha/beta ratio for prostate cancer? In regard to Wang et al., IJROBP 2003;55:194-203
    Jack F Fowler
    Int J Radiat Oncol Biol Phys 57:593-5; author reply 595-6. 2003
  29. ncbi request reprint The prospects for new treatments for prostate cancer
    Jack F Fowler
    Int J Radiat Oncol Biol Phys 52:3-5. 2002
  30. ncbi request reprint Acute radiation reactions in oral and pharyngeal mucosa: tolerable levels in altered fractionation schedules
    Jack F Fowler
    Department of Human Oncology K4 316, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
    Radiother Oncol 69:161-8. 2003
    ..To investigate whether a predictive estimate can be obtained for a 'tolerance level' of acute oral and pharyngeal mucosal reactions in patients receiving head and neck radiotherapy, using an objective set of dose and time data...
  31. ncbi request reprint On the inclusion of proliferation in tumour control probability calculations for inhomogeneously irradiated tumours
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin Medical School, K4 344 CSC 600 Highland Avenue, Madison, WI 53792, USA
    Phys Med Biol 48:N261-8. 2003
    ....
  32. ncbi request reprint Walking forward: the South Dakota Native American project
    Daniel G Petereit
    John T Vucurevich Cancer Institute, Rapid City, SD 57701, USA
    J Cancer Educ 20:65-70. 2005
    ..It is hypothesized that a conventional course of cancer treatment lasting 6 to 8 weeks may be a barrier...
  33. ncbi request reprint Influence of overall treatment time and radiobiological parameters on biologically effective doses in cervical cancer patients treated with radiation therapy alone
    Anna Gasinska
    Laboratory of Radiation Biology, Department of Radiation Therapy, Centre of Oncology, Krakow, Poland
    Acta Oncol 43:657-66. 2004
    ..037), BrdUrdLI </= 8.8% (p=0.003), tumour aneuploidy (p=0.043), and BED10 </= 103 Gy (p=0.017). The examined tumour biological parameters should be taken into account for RT and provide a basis for adjuvant RT...
  34. ncbi request reprint Theoretical simulation of oxygen tension measurement in the tissue using a microelectrode: II. Simulated measurements in tissues
    Iuliana Toma-Daşu
    Department of Radiation Sciences, Umea University, S 901 85 Umea, Sweden
    Radiother Oncol 64:109-18. 2002
    ....