Research Topics
Species | Gary N FoulksSummaryAffiliation: University of Louisville Country: USA Publications
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Publications
Treatment of dry eye disease by the non-ophthalmologistGary N Foulks
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, 301 East Muhammad Ali Boulevard, Louisville, KY 40202, USA
Rheum Dis Clin North Am 34:987-1000, x. 2008..The array of potential treatments both topical and systemic has evolved to provide a much more targeted and effective arsenal from which the clinician may choose...- Clinical evaluation of the efficacy of PEG/PG lubricant eye drops with gelling agent (HP-Guar) for the relief of the signs and symptoms of dry eye disease: a reviewGary N Foulks
Professor of Ophthalmology, University of Kentucky, Louisville, Kentucky, USA
Drugs Today (Barc) 43:887-96. 2007.... 
Topical azithromycin therapy for meibomian gland dysfunction: clinical response and lipid alterationsGary N Foulks
Department of Ophthalmology and Vision Science, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
Cornea 29:781-8. 2010....- Meibomian gland dysfunction: the past, present, and futureGary N Foulks
Department of Ophthalmology and Visual Sciences, University of Louisville School of Medicine, Louisville, KY 40202, USA
Eye Contact Lens 36:249-53. 2010..To recount the historic evaluation of meibomian gland dysfunction (MGD) and describe new techniques to monitor disease and therapy... 
Prolonging contact lens wear and making contact lens wear saferGary N Foulks
University of Louisville, School of Medicine, Louisville, Kentucky 40202, USA
Am J Ophthalmol 141:369-373. 2006..To summarize the present status of safety and efficacy of contact lens wear...- Wax-tear and meibum protein, wax-β-carotene interactions in vitro using infrared spectroscopySamad Faheem
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
Exp Eye Res 100:32-9. 2012..Among the tear fluid proteins studied, mucin is the most likely to influence the conformation and carbonyl environment of meibum at the tear film surface... - Expression in human ocular surface tissues of the GalNAc-transferases that initiate mucin-type O-glycosylationYoannis Imbert
Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, University of Louisville, Louisville, KY 40292, USA
Cornea 25:1193-9. 2006..However, there is no evidence to date to suggest that differences of ppGaNTase expression levels might contribute to susceptibility to dry eye disease... - Human meibum lipid conformation and thermodynamic changes with meibomian-gland dysfunctionDouglas Borchman
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
Invest Ophthalmol Vis Sci 52:3805-17. 2011..In this study the conformation of Md was quantified to test this finding... - Differences in human meibum lipid composition with meibomian gland dysfunction using NMR and principal component analysisDouglas Borchman
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
Invest Ophthalmol Vis Sci 53:337-47. 2012..This tool was used to measure changes in human meibum composition with meibomian gland dysfunction (MGD)... - Physical changes in human meibum with age as measured by infrared spectroscopyDouglas Borchman
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY, USA
Ophthalmic Res 44:34-42. 2010..This study also serves as a foundation to examine meibum conformational differences in meibum from people with meibomian gland dysfunction... - Factors affecting evaporation rates of tear film components measured in vitroDouglas Borchman
Department of Ophthalmology, University of Louisville, Louisville, KY, USA
Eye Contact Lens 35:32-7. 2009..The impact of temperature, air flow, and humidity on the evaporation rate of tears was measured in vitro... - Topical azithromycin and oral doxycycline therapy of meibomian gland dysfunction: a comparative clinical and spectroscopic pilot studyGary N Foulks
Department of Surgery, Robley Rex Veterans Affairs Medical Center, Louisville, KY, USA
Cornea 32:44-53. 2013.... - Changes in human meibum lipid composition with age using nuclear magnetic resonance spectroscopyDouglas Borchman
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
Invest Ophthalmol Vis Sci 53:475-82. 2012..Human tear film stability decreases with increasing age. In this study, the changes in meibum composition were measured in search of markers of tear film instability... - Glycoprotein 340 in normal human ocular surface tissues and tear filmMarcia M Jumblatt
Department of Ophthalmology and Visual Science, University of Louisville School of Medicine, Louisville, KY 40292, USA
Infect Immun 74:4058-63. 2006..These results suggest that gp340 is a normal component of the tear film and that the glycoprotein may function as a bacterial agglutinin... - Changes in human meibum lipid with meibomian gland dysfunction using principal component analysisDouglas Borchman
Department of Ophthalmology and Visual Sciences, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
Exp Eye Res 91:246-56. 2010..This study also demonstrates the power of the combination of infrared spectroscopy and PCA as a diagnostic tool that discriminates between Mn and Md... - Confirmation of changes in human meibum lipid infrared spectra with age using principal component analysisDouglas Borchman
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
Curr Eye Res 35:778-86. 2010..In this study, the remaining 99% of the spectral frequencies were analyzed to gain insight into changes that occur in meibum with age... - Analysis of the composition of lipid in human meibum from normal infants, children, adolescents, adults, and adults with meibomian gland dysfunction using ¹H-NMR spectroscopyRashmi K Shrestha
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
Invest Ophthalmol Vis Sci 52:7350-8. 2011..The results highlight the applicability of (1)H-NMR spectroscopy for the quantitative analysis of waxes, cholesteryl esters, and glycerides in meibum lipid (ML)... - Contact lenses and the rate of evaporation measured in vitro; the influence of wear, squalene and waxSravya Vishnubhatla
Department of Ophthalmology and Visual Sciences, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
Cont Lens Anterior Eye 35:277-81. 2012..If the ERTCL could be minimized in vivo, contact lenses could potentially be used to relieve dry eye symptoms in patients with evaporative dry eye... - Improving awareness, identification, and management of meibomian gland dysfunctionGary N Foulks
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Kentucky, USA
Ophthalmology 119:S1-12. 2012.... - Temperature-induced conformational changes in human tearlipids hydrocarbon chainsDouglas Borchman
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, KY 40202, USA
Biopolymers 87:124-33. 2007.... - Quantification of human sebum on skin and human meibum on the eye lid margin using Sebutape®, spectroscopy and chemical analysisZara Ashraf
Department of Ophthalmology and Visual Sciences, University of Louisville, Louisville, Kentucky, USA
Curr Eye Res 36:553-62. 2011.... - MUC1 and estrogen receptor alpha gene polymorphisms in dry eye patientsYoannis Imbert
Department of Biochemistry and Molecular Biology, School of Medicine, University of Louisville, Louisville, KY 40292, USA
Exp Eye Res 88:334-8. 2009..Therefore, mechanisms influencing protection of the ocular surface against inflammation and damage in different types of dry eye disease warrant further investigation particularly in relation to MUC1 genotype... - Pharmacological management of dry eye in the elderly patientGary N Foulks
Arthur and Virginia Keeney Professor of Ophthalmology, Department of Ophthalmology and Vision Science, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
Drugs Aging 25:105-18. 2008..In the elderly patient it is important to recognize the physical and cognitive limitations that will influence the selection of appropriate topical medication... - Spectroscopic evaluation of human tear lipidsDouglas Borchman
Department of Ophthalmology and Visual Science, University of Louisville, 301 E Muhammad Ali Blvd, Louisville, KY 40202, USA
Chem Phys Lipids 147:87-102. 2007..The results provide a foundation for future studies to assess possible differences with age and sex in tears from normal and dry eye subjects... - Topical cyclosporine for treatment of ocular surface diseaseGary N Foulks
Kentucky Lion's Eye Center, Louisville, KY 40207, USA
Int Ophthalmol Clin 46:105-22. 2006 - Ocular surface effects of thyroid diseaseJason A Sokol
Department of Ophthalmology and Visual Sciences, Kentucky Lions Eye Center, University of Louisville, Louisville, KY 40202, USA
Ocul Surf 8:29-39. 2010.... - The correlation between the tear film lipid layer and dry eye diseaseGary N Foulks
Department of Ophthalmology and Vision Science, University of Louisville, Louisville, KY, USA
Surv Ophthalmol 52:369-74. 2007..Thus, therapies targeted at replenishing or stabilizing the lipid layer are key to the treatment of dry eye, either as monotherapy or in conjunction with therapies designed to enhance aqueous production... - Acanthamoeba keratitis and contact lens wear: static or increasing problem?Gary N Foulks
University of Louisville School of Medicine, Louisville, KY, USA
Eye Contact Lens 33:412-4; discussion 424-5. 2007..Strategies for prevention, including patient education, improved decontaminating agents, maintenance of water treatment standards, and possible immunization of subjects at risk, are needed... - MUC1 splice variants in human ocular surface tissues: possible differences between dry eye patients and normal controlsYoannis Imbert
Department of Molecular, Cellular and Craniofacial Biology, School of Dentistry, University of Louisville, 501 S. Preston St, Louisville, KY 40292, USA
Exp Eye Res 83:493-501. 2006.... - The definition and classification of dry eye disease: Report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007)Michael A Lemp
Ocul Surf 5:75-92. 2007..These guidelines are not intended to override the clinical assessment and judgment of an expert clinician in individual cases, but they should prove helpful in the conduct of clinical practice and research... - What is dry eye and what does it mean to the contact lens wearer?Gary N Foulks
Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Eye Contact Lens 29:S96-100; discussion S115-8, S192-4. 2003..To relate tear function to contact lens wear and review the problems dry eye causes with contact lens tolerance and performance... - Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 yearsLaurie D Barber
Department of Ophthalmology, University of Arkansas, Little Rock, Arkansas 72205, USA
Ophthalmology 112:1790-4. 2005..1% ophthalmic emulsion for 1 to 3 years was safe, well tolerated, and not associated with systemic side effects. The results supplement the safety record of the commercially available cyclosporine 0.05% ophthalmic emulsion... - Therapeutic contact lenses: the role of high-Dk lensesGary N Foulks
Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Pittsburgh, PA 15213, USA
Ophthalmol Clin North Am 16:455-61. 2003..Not all of the available lenses are FDA approved for therapeutic use, and such wear is an off-label use. The patient should be informed of the goal of therapy as well as the benefits and risks of therapeutic contact lenses... - Changing trends in the definition and diagnosis of dry eyesMurat Dogru
Am J Ophthalmol 140:507-8. 2005 - Removal of INTACS for myopiaThomas E Clinch
University Ophthalmic Consultants of Washington, DC 20016, USA
Ophthalmology 109:1441-6. 2002..INTACS removal was associated with a reversal to preoperative values in most cases... - Development and validation of a short global dry eye symptom indexDebra A Schaumberg
Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts 02215, USA
Ocul Surf 5:50-7. 2007..The results are encouraging and suggest that further refinement and testing of the SANDE questionnaire in larger populations may result in a reliable questionnaire to detect change in irritative symptoms over time... - Ocular surface morphogenesis and pathogenesis in health and diseaseGary N Foulks
Ocul Surf 6:1. 2008 - Different ways of looking at thingsGary N Foulks
Ocul Surf 6:60. 2008 - Pathways, new visions, and old challengesGary N Foulks
Ocul Surf 6:103. 2008 - The changing times in dry eye researchKelly K Nichols
Optom Vis Sci 85:613-4. 2008 - The evolving treatment of dry eyeGary N Foulks
Eye and Ear Institute, Department of Ophthalmology, University of Pittsburgh School of Medicine, 203 Lothrop Street, Pittsburgh, PA 15213, USA
Ophthalmol Clin North Am 16:29-35. 2003..It has taken 20 years of investigation to reach this threshold. The next 3 years should see promising treatments approved for dry eye disease...