THOMAS HARRISON FOSTER

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Fluorescence anisotropy imaging reveals localization of meso-tetrahydroxyphenyl chlorin in the nuclear envelope
    Thomas H Foster
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Photochem Photobiol 81:1544-7. 2005
  2. ncbi request reprint Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model
    Jarod C Finlay
    Department of Physics and Radiology, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, New York 14642 0001, USA
    Appl Opt 44:1917-33. 2005
  3. ncbi request reprint Index-of-refraction-dependent subcellular light scattering observed with organelle-specific dyes
    Jeremy D Wilson
    University of Rochester, Department of Physics and Astronomy, Rochester, New York 14627, USA
    J Biomed Opt 12:014010. 2007
  4. ncbi request reprint Confocal fluorescence polarization microscopy in turbid media: effects of scattering-induced depolarization
    Chad E Bigelow
    Institute of Optics, University of Rochester, Rochester, New York 14627, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2932-43. 2006
  5. ncbi request reprint Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation
    Jarod C Finlay
    Department of Radiology and of Physics and Astronomy, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Med Phys 31:1949-59. 2004
  6. pmc Photodynamic dose does not correlate with long-term tumor response to mTHPC-PDT performed at several drug-light intervals
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Med Phys 35:3518-26. 2008
  7. ncbi request reprint Characterization of lysosomal contribution to whole-cell light scattering by organelle ablation
    Jeremy D Wilson
    University of Rochester, Department of Physics, Rochester, New York 14642, USA
    J Biomed Opt 12:030503. 2007
  8. pmc Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions
    Karl A Kasischke
    Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cereb Blood Flow Metab 31:68-81. 2011
  9. ncbi request reprint Mie theory interpretations of light scattering from intact cells
    Jeremy D Wilson
    Department of Radiology, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Opt Lett 30:2442-4. 2005
  10. pmc In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Neoplasia 10:429-38. 2008

Research Grants

  1. Optical Dosimetry for Clinical Trials of Pc 4 Photodynamic Therapy
    Thomas Foster; Fiscal Year: 2007
  2. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2007
  3. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2009
  4. Optical Dosimetry for Clinical Trials of Pc 4 Photodynamic Therapy
    Thomas Foster; Fiscal Year: 2009
  5. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    THOMAS HARRISON FOSTER; Fiscal Year: 2010
  6. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2006
  7. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2002
  8. Optical Dosimetry for Clinical Trials of Pc 4 Photodynamic Therapy
    THOMAS HARRISON FOSTER; Fiscal Year: 2010

Collaborators

  • Jeremy D Wilson
  • Jarod C Finlay
  • Allan R Oseroff
  • Soumya Mitra
  • Chad E Bigelow
  • Harris Gelbard
  • Michael S Patterson
  • Robert S Knox
  • David Bellnier
  • Barbara Henderson
  • Ken Kang Hsin Wang
  • Yeissa Chabrier-Roselló
  • Ryan J Cummings
  • Edith M Lord
  • Constantine G Haidaris
  • William J Cottrell
  • Karl A Kasischke
  • Mukund Seshadri
  • Tammy K Lee
  • Kathlyn Santos
  • John G Frelinger
  • Scott A Gerber
  • Joseph M Bliss
  • Kanji Nakai
  • John M Larkin
  • Stéphanie Coutier
  • Robert W Burgess
  • Ben Panepento
  • Maiken Nedergaard
  • Elton M Lambert
  • Anita Sun
  • Francisco J De Jesús-Andino
  • Benjamin R Giesselman
  • Anne D Paquette
  • Kenneth R Keymel
  • Joseph A Spernyak
  • Elma D Baron
  • Lurine A Vaughan
  • Richard Mazurchuk
  • Erin Conway
  • Malcolm E Kenney
  • Howard J Federoff
  • Amit Lugade
  • Stephen Dewhurst
  • David A L Simon
  • William J Bowers
  • Amit A Lugade
  • Viktoriya Y Rybalko
  • Nelissa Pérez-Nazario
  • Katsuji Shima
  • Robert Michel Parache
  • William R Donaldson
  • Yuji Numaguchi
  • Lina N Bezdetnaya
  • Francois Guillemin
  • Makoto Kikuchi

Detail Information

Publications39

  1. ncbi request reprint Fluorescence anisotropy imaging reveals localization of meso-tetrahydroxyphenyl chlorin in the nuclear envelope
    Thomas H Foster
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Photochem Photobiol 81:1544-7. 2005
    ..12. The change from a positive intrinsic anisotropy in homogeneous solution to a negative value in cells suggests an environmentally induced change in the relative orientations of the absorption and emission dipole moments...
  2. ncbi request reprint Recovery of hemoglobin oxygen saturation and intrinsic fluorescence with a forward-adjoint model
    Jarod C Finlay
    Department of Physics and Radiology, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, New York 14642 0001, USA
    Appl Opt 44:1917-33. 2005
    ..Both methods are validated with Monte Carlo simulations and experimentally in scattering phantoms containing nicotinamide adenine dinucleotide and human erythrocytes. Preliminary measurements from murine tumors in vivo are presented...
  3. ncbi request reprint Index-of-refraction-dependent subcellular light scattering observed with organelle-specific dyes
    Jeremy D Wilson
    University of Rochester, Department of Physics and Astronomy, Rochester, New York 14627, USA
    J Biomed Opt 12:014010. 2007
    ..4. The reduction in scattering cross section induced by NPe6 constrains the refractive index of lysosomes to be significantly higher. We estimate the refractive index of lysosomes in EMT6 cells to be approximately 1.6...
  4. ncbi request reprint Confocal fluorescence polarization microscopy in turbid media: effects of scattering-induced depolarization
    Chad E Bigelow
    Institute of Optics, University of Rochester, Rochester, New York 14627, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2932-43. 2006
    ..From this detailed analysis and comparison of experiment with simulation, we determine that fluorescence polarization is maintained to depths at which meaningful intensity images can be acquired...
  5. ncbi request reprint Hemoglobin oxygen saturations in phantoms and in vivo from measurements of steady-state diffuse reflectance at a single, short source-detector separation
    Jarod C Finlay
    Department of Radiology and of Physics and Astronomy, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Med Phys 31:1949-59. 2004
    ..The successful implementation of single, short detector separations enables the measurement of intratumor heterogeneities in hemoglobin oxygen saturation and responses to carbogen using a simple fiber-based probe design...
  6. pmc Photodynamic dose does not correlate with long-term tumor response to mTHPC-PDT performed at several drug-light intervals
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Med Phys 35:3518-26. 2008
    ..In situations like this one, other reporters of biological response to therapy would be necessary...
  7. ncbi request reprint Characterization of lysosomal contribution to whole-cell light scattering by organelle ablation
    Jeremy D Wilson
    University of Rochester, Department of Physics, Rochester, New York 14642, USA
    J Biomed Opt 12:030503. 2007
    ..From these measurements, we conclude that lysosomes scatter approximately 14% of the light from EMT6 cells at 633 nm and that their size distribution has a mean and standard deviation of 0.8 and 0.4 microm, respectively...
  8. pmc Two-photon NADH imaging exposes boundaries of oxygen diffusion in cortical vascular supply regions
    Karl A Kasischke
    Department of Neurology, Center for Neural Development and Disease, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cereb Blood Flow Metab 31:68-81. 2011
    ..Thus, two-photon NADH imaging can be applied to expose vascular supply regions and to localize functionally relevant microregional cortical hypoxia with micrometer spatial resolution...
  9. ncbi request reprint Mie theory interpretations of light scattering from intact cells
    Jeremy D Wilson
    Department of Radiology, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Opt Lett 30:2442-4. 2005
    ....
  10. pmc In vivo confocal fluorescence imaging of the intratumor distribution of the photosensitizer mono-L-aspartylchlorin-e6
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Neoplasia 10:429-38. 2008
    ..Our findings are of immediate clinical relevance and demonstrate the importance of an in vivo imaging approach to examine the dynamic process of intratumor drug distribution...
  11. ncbi request reprint Photodynamic therapy mediates the oxygen-independent activation of hypoxia-inducible factor 1alpha
    Soumya Mitra
    Department of Imaging Sciences, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Mol Cancer Ther 5:3268-74. 2006
    ....
  12. ncbi request reprint Confocal fluorescence spectroscopy and anisotropy imaging system
    Chad E Bigelow
    University of Rochester, Department of Radiology and the Institute of Optics, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Opt Lett 28:695-7. 2003
    ..The quality of the axial sectioning that is achieved in the confocal fluorescence spectroscopy mode is demonstrated experimentally, and examples of polarization-sensitive fluorescence imaging are demonstrated in tumor cell monolayers...
  13. ncbi request reprint Activation of heat shock protein 70 promoter with meso-tetrahydroxyphenyl chlorin photodynamic therapy reported by green fluorescent protein in vitro and in vivo
    Soumya Mitra
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA
    Photochem Photobiol 78:615-22. 2003
    ....
  14. ncbi request reprint Carbogen breathing significantly enhances the penetration of red light in murine tumours in vivo
    Soumya Mitra
    Department of Biochemistry and Biophysics, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Phys Med Biol 49:1891-904. 2004
    ....
  15. ncbi request reprint Photobleaching kinetics of Photofrin in vivo and in multicell tumour spheroids indicate two simultaneous bleaching mechanisms
    Jarod C Finlay
    Department of Physics and Astronomy, University of Rochester, Rochester, NY 14642, USA
    Phys Med Biol 49:4837-60. 2004
    ..At all concentrations, photoproduct accumulation was greater under conditions of abundant oxygen...
  16. ncbi request reprint A comprehensive mathematical model of microscopic dose deposition in photodynamic therapy
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14642, USA
    Med Phys 34:282-93. 2007
    ..We anticipate that this model will make useful dosimetry predictions that should inform optimal treatment conditions and improve current clinical protocols...
  17. ncbi request reprint Effect of pigment packaging on diffuse reflectance spectroscopy of samples containing red blood cells
    Jarod C Finlay
    Departments of Radiology and of Physics and Astronomy, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Opt Lett 29:965-7. 2004
    ..Biophys. Acta 19, 1 (1956)] and that the adoption of basis spectra that take this effect into account improves the accuracy of fitting diffuse reflectance spectra...
  18. pmc Susceptibility of Candida species to photodynamic effects of photofrin
    Joseph M Bliss
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 48:2000-6. 2004
    ..The results indicate that photodynamic therapy may be a useful adjunct or alternative to current anti-Candida therapeutic modalities, particularly for superficial infections on surfaces amenable to illumination...
  19. ncbi request reprint In vivo mTHPC photobleaching in normal rat skin exhibits unique irradiance-dependent features
    Jarod C Finlay
    Department of Physics and Astronomy, University of Rochester, NY 14642, USA
    Photochem Photobiol 75:282-8. 2002
    ..The fluorescence from the in vivo bleaching experiments thus reports a phenomenon that is not reported by measurements of the photochemical oxygen consumption in the spheroids...
  20. ncbi request reprint Temporally and spatially heterogeneous distribution of mTHPC in a murine tumor observed by two-color confocal fluorescence imaging and spectroscopy in a whole-mount model
    Soumya Mitra
    Department of Radiology, University of Rochester, Rochester, NY, USA
    Photochem Photobiol 81:1123-30. 2005
    ..This imaging technique can be applied to screen the dynamic intratumor distribution of other fluorescent photosensitizers and anticancer drugs...
  21. pmc Migration of skin dendritic cells in response to ionizing radiation exposure
    Ryan J Cummings
    Department of Microbiology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Radiat Res 171:687-97. 2009
    ....
  22. doi request reprint Respiratory deficiency enhances the sensitivity of the pathogenic fungus Candida to photodynamic treatment
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA
    Photochem Photobiol 84:1141-8. 2008
    ....
  23. ncbi request reprint Irradiation-induced enhancement of Pc 4 fluorescence and changes in light scattering are potential dosimeters for Pc 4-PDT
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, NY, USA
    Photochem Photobiol 83:1056-62. 2007
    ..Taken together, these data suggest that Pc 4 is initially aggregated at high local concentration in mitochondria and that irradiation relaxes the quenching of Pc 4 fluorescence through a mechanism that may involve mitochondrial swelling...
  24. ncbi request reprint Lysosome-damage-induced scattering changes coincide with release of cytochrome c
    Jeremy D Wilson
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Opt Lett 32:2517-9. 2007
    ....
  25. pmc Simulations of measured photobleaching kinetics in human basal cell carcinomas suggest blood flow reductions during ALA-PDT
    Ken Kang Hsin Wang
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14627, USA
    Lasers Surg Med 41:686-96. 2009
    ..We have performed a detailed analysis of this hypothesis...
  26. pmc Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling
    Jeremy D Wilson
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14642, USA
    Biophys J 88:2929-38. 2005
    ..Thus, in this system, angularly resolved light scattering reports oxidative-stress-induced changes in mitochondrial morphology...
  27. ncbi request reprint Photophysical parameters, photosensitizer retention and tissue optical properties completely account for the higher photodynamic efficacy of meso-tetra-hydroxyphenyl-chlorin vs Photofrin
    Soumya Mitra
    Department of Radiology, University of Rochester, 601 Elmwood Avenue, Box 648, Rochester, NY 14642, USA
    Photochem Photobiol 81:849-59. 2005
    ....
  28. pmc Inhibition of electron transport chain assembly and function promotes photodynamic killing of Candida
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, University of Rochester Medical Center, Box 672, 601 Elmwood Ave, Rochester, NY 14642, USA
    J Photochem Photobiol B 99:117-25. 2010
    ..The data demonstrate that selective inhibition of ETC Complexes III and IV significantly increases the sensitivity of C. albicans, C. glabrata and S. cerevisiae to PDT sensitized with TMP-1363...
  29. ncbi request reprint Spatial and temporal expression of herpes simplex virus type 1 amplicon-encoded genes: implications for their use as immunization vectors
    Kathlyn Santos
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Hum Gene Ther 18:93-105. 2007
    ..From this and previous work, we conclude that amplicons may engender a potent immune response by directly transducing dendritic cells as well as by cross-priming of antigen produced by other transduced host cells...
  30. ncbi request reprint Imaging enzyme activity with polarization-sensitive confocal fluorescence microscopy
    Chad E Bigelow
    The Institute of Optics, University of Rochester, NY 14642, USA
    J Microsc 215:24-33. 2004
    ..These results suggest wide applicability of the technique in biological systems when used in conjunction with appropriately designed constructs...
  31. pmc Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 169:1739-52. 2006
    ..These sites provide metastatic cells with a microenvironment highly conducive to survival and subsequent growth...
  32. pmc Antibody-labeled fluorescence imaging of dendritic cell populations in vivo
    Ryan J Cummings
    University of Rochester Medical Center, Department of Microbiology and Immunology, Rochester, New York 14642, USA
    J Biomed Opt 13:044041. 2008
    ..The method achieves micron-scale spatial resolution to depths greater than 100 mum. We illustrate the capabilities of this approach by imaging two dendritic cell populations in the skin and normal and tumor vasculature in vivo...
  33. pmc Monitoring Pc 4 photodynamic therapy in clinical trials of cutaneous T-cell lymphoma using noninvasive spectroscopy
    Tammy K Lee
    University of Rochester, Institute of Optics and Department of Imaging Sciences, Rochester, New York 14642, USA
    J Biomed Opt 13:030507. 2008
    ..Preliminary patient data show a significant effect of Pc 4 on the tissue absorption, modest Pc 4 photobleaching, and heterogeneity of Pc 4 within and between the lesions...
  34. pmc Irradiance-dependent photobleaching and pain in delta-aminolevulinic acid-photodynamic therapy of superficial basal cell carcinomas
    William J Cottrell
    Department of Imaging Sciences, University of Rochester, Rochester, New York, USA
    Clin Cancer Res 14:4475-83. 2008
    ..High irradiance and/or photosensitizer levels cause inefficient treatment from oxygen depletion in preclinical models...
  35. ncbi request reprint Endovascular treatment using low-power ultraviolet laser for delayed vasospasm in the rabbit carotid artery model
    Kanji Nakai
    Department of Radiology, University of Rochester Medical Center, Rochester, NY, USA
    AJNR Am J Neuroradiol 23:1725-31. 2002
    ..The purpose of this study was to investigate the preventive effect of endovascular UV light on vasospasm after blood immersion by using the same animal model...
  36. ncbi request reprint Reverse intersystem crossing in rose bengal. II. Fluence dependence of fluorescence following 532 nm laser excitation
    John M Larkin
    Laboratory for Laser Energetics, University of Rochester, NY 68409, USA
    Photochem Photobiol 75:221-8. 2002
    ..In this work this hypothesis is analyzed quantitatively, using numerical models of the population dynamics. These models suggest that reverse intersystem crossing alone cannot adequately explain the differences in biological response...
  37. ncbi request reprint Effect of irradiation fluence rate on the efficacy of photodynamic therapy and tumor oxygenation in meta-tetra (hydroxyphenyl) chlorin (mTHPC)-sensitized HT29 xenografts in nude mice
    Stéphanie Coutier
    Unite de Recherche en Therapie Photodynamique, Centre Alexis Vautrin, Vandoeuvre les Nancy, France
    Radiat Res 158:339-45. 2002
    ..Improved tumor destruction could be expected by reducing the rate and the extent of oxygen depletion during meta-tetra(hydroxyphenyl)chlorin photodynamic therapy using low fluence rates...
  38. pmc Light delivery over extended time periods enhances the effectiveness of photodynamic therapy
    Mukund Seshadri
    Department of Cell Stress Biology and Photodynamic Therapy Center, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Clin Cancer Res 14:2796-805. 2008
    ..The objective of this study was to investigate the relationship between irradiance, photosensitizer dose, and PDT dose with regard to treatment outcome and tumor oxygenation in a rat tumor model...
  39. pmc Sensitivity of Candida albicans germ tubes and biofilms to photofrin-mediated phototoxicity
    Yeissa Chabrier-Roselló
    Department of Microbiology and Immunology, Center for Oral Biology, University of Rochester Medical Center, New York 14642, USA
    Antimicrob Agents Chemother 49:4288-95. 2005
    ..albicans. These observations provide support and rationale for the continued investigation of PDT as an adjunctive, or possibly alternative, mode of therapy against cutaneous and mucocutaneous candidiasis...

Research Grants21

  1. Optical Dosimetry for Clinical Trials of Pc 4 Photodynamic Therapy
    Thomas Foster; Fiscal Year: 2007
    ..Research proposed here will develop means for measuring the quantities that determine the outcome of this therapy. Results will contribute to the ongoing clinical trials. ..
  2. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2007
    ..Studies proposed in this grant address both of these objectives. ..
  3. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2009
    ..Studies proposed in this grant address both of these objectives. ..
  4. Optical Dosimetry for Clinical Trials of Pc 4 Photodynamic Therapy
    Thomas Foster; Fiscal Year: 2009
    ..Research proposed here will develop means for measuring the quantities that determine the outcome of this therapy. Results will contribute to the ongoing clinical trials. ..
  5. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    THOMAS HARRISON FOSTER; Fiscal Year: 2010
    ..Studies proposed in this grant address both of these objectives. ..
  6. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2006
    ....
  7. PHOTOPHYSICS OF PHOTODYNAMIC THERAPY
    Thomas Foster; Fiscal Year: 2002
    ....
  8. Optical Dosimetry for Clinical Trials of Pc 4 Photodynamic Therapy
    THOMAS HARRISON FOSTER; Fiscal Year: 2010
    ..Research proposed here will develop means for measuring the quantities that determine the outcome of this therapy. Results will contribute to the ongoing clinical trials. ..