Thomas C Foster

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging
    T C Jackson
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Cell Death Differ 16:439-48. 2009
  2. pmc Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity
    Thomas C Foster
    Department of Neuroscience, Evelyn F and William L McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, USA
    Prog Neurobiol 96:283-303. 2012
  3. pmc Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Hippocampus 22:656-69. 2012
  4. pmc Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Mol Ther 16:1587-93. 2008
  5. ncbi request reprint Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Front Neuroendocrinol 26:51-64. 2005
  6. ncbi request reprint Calcium homeostasis and modulation of synaptic plasticity in the aged brain
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Aging Cell 6:319-25. 2007
  7. pmc Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Learn Mem 87:522-35. 2007
  8. ncbi request reprint Biological markers of age-related memory deficits: treatment of senescent physiology
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    CNS Drugs 20:153-66. 2006
  9. pmc Environmental enrichment restores neurogenesis and rapid acquisition in aged rats
    Rachel B Speisman
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Neurobiol Aging 34:263-74. 2013
  10. pmc Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Neurobiol Aging 33:828.e1-17. 2012

Research Grants

Collaborators

Detail Information

Publications45

  1. pmc Regional hippocampal differences in AKT survival signaling across the lifespan: implications for CA1 vulnerability with aging
    T C Jackson
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Cell Death Differ 16:439-48. 2009
    ....
  2. pmc Dissecting the age-related decline on spatial learning and memory tasks in rodent models: N-methyl-D-aspartate receptors and voltage-dependent Ca2+ channels in senescent synaptic plasticity
    Thomas C Foster
    Department of Neuroscience, Evelyn F and William L McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, USA
    Prog Neurobiol 96:283-303. 2012
    ..Thus, VDCC-dependent synaptic plasticity and extrahippocampal systems may contribute to incremental learning deficits observed with advanced aging...
  3. pmc Role of estrogen receptor alpha and beta expression and signaling on cognitive function during aging
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Hippocampus 22:656-69. 2012
    ..Finally, the role of ERα/ERβ on rapid E2 signaling and synaptogenesis as it relates to hippocampal aging is discussed...
  4. pmc Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Mol Ther 16:1587-93. 2008
    ..We propose that constitutive estrogen receptor activity is important for maintaining hippocampus-dependent memory function in adults...
  5. ncbi request reprint Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Front Neuroendocrinol 26:51-64. 2005
    ....
  6. ncbi request reprint Calcium homeostasis and modulation of synaptic plasticity in the aged brain
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Aging Cell 6:319-25. 2007
    ..Physiological and biological models are outlined, which relate a shift in Ca2+ regulation with changes in cell excitability and synaptic plasticity, resulting in a functional lesion of the hippocampus...
  7. pmc Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Learn Mem 87:522-35. 2007
    ..The results indicate that the increased susceptibility to LTD induction is associated with impaired memory and results from a shift in the induction process. The possible relationship between LTD and memory function is discussed...
  8. ncbi request reprint Biological markers of age-related memory deficits: treatment of senescent physiology
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    CNS Drugs 20:153-66. 2006
    ..Accordingly, the effectiveness of treatment needs to be verified for both cognitive changes and biological markers that are specific for age-related memory deficits...
  9. pmc Environmental enrichment restores neurogenesis and rapid acquisition in aged rats
    Rachel B Speisman
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611, USA
    Neurobiol Aging 34:263-74. 2013
    ....
  10. pmc Influence of late-life exposure to environmental enrichment or exercise on hippocampal function and CA1 senescent physiology
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Neurobiol Aging 33:828.e1-17. 2012
    ....
  11. pmc Role of estrogen receptor α and β in preserving hippocampal function during aging
    Xiaoxia Han
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    J Neurosci 33:2671-83. 2013
    ..Thus, our results indicate that ERα and ERβ interact with hormone levels to regulate transcription involved in maintaining hippocampal function during aging...
  12. pmc AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation
    Ji Jing Pang
    Departments of Ophthalmology, University of Florida, Gainesville, Florida 32610, USA
    Invest Ophthalmol Vis Sci 49:4278-83. 2008
    ..To test AAV-mediated gene therapy in the rd10 mouse, a natural model of recessive RP caused by mutation of the beta-subunit of rod photoreceptor cGMP phosphodiesterase...
  13. pmc Linking redox regulation of NMDAR synaptic function to cognitive decline during aging
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610
    J Neurosci 33:15710-5. 2013
    ..These results provide evidence for a link between the redox-mediated decline in NMDAR function and emergence of an age-related cognitive phenotype, impairment in the rapid acquisition and retention of novel spatial information. ..
  14. pmc Enhanced expression of Pctk1, Tcf12 and Ccnd1 in hippocampus of rats: Impact on cognitive function, synaptic plasticity and pathology
    Ke Wu
    Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Learn Mem 97:69-80. 2012
    ..In contrast, the learning and memory deficits in Tcf12 animals are likely due to neuropathology associated with Tcf12 gene expression...
  15. ncbi request reprint Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, USA
    Brain Res 1031:125-8. 2005
    ..The idea that ICS may play prominent role in regulating synaptic modifiability through regulation of cell excitability and the timing of pre and postsynaptic activity is discussed...
  16. ncbi request reprint Shift in induction mechanisms underlies an age-dependent increase in DHPG-induced synaptic depression at CA3 CA1 synapses
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, USA
    J Neurophysiol 98:2729-36. 2007
    ..The results provide evidence that DHPG-LTD is one of the few forms of synaptic plasticity that increases with advanced age and suggest that DHPG-LTD may contribute to age-related changes in hippocampal function...
  17. pmc PHLPP1 splice variants differentially regulate AKT and PKCα signaling in hippocampal neurons: characterization of PHLPP proteins in the adult hippocampus
    Travis C Jackson
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    J Neurochem 115:941-55. 2010
    ..The results provide unique evidence for a divergence in the function of PHLPP1α and PHLPP1β/SCOP, and suggest that PHLPP1α plays a major role in regulating AKT signaling in neurons...
  18. pmc Daily exercise improves memory, stimulates hippocampal neurogenesis and modulates immune and neuroimmune cytokines in aging rats
    Rachel B Speisman
    J Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL 32611 6131, USA
    Brain Behav Immun 28:25-43. 2013
    ..Our correlational data begin to provide a framework for systematically manipulating these immune and neuroimmune signaling molecules to test their effects on cognition and neurogenesis across lifespan in future experiments...
  19. pmc Estrogen effects on cognition and hippocampal transcription in middle-aged mice
    Kristina K Aenlle
    Department of Neuroscience, McKnight Brain Institute, University of Florida, P O Box 100244, Gainesville, FL 32610 0244, USA
    Neurobiol Aging 30:932-45. 2009
    ..Our results indicate that estrogen treatment in middle-aged animals may promote hippocampal health during the aging process...
  20. pmc Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction
    Zane Zeier
    Department of Neuroscience, McKnight Brain Institute, University of Florida, P O Box 100244, Gainesville, FL 32610 0244, USA
    Mech Ageing Dev 132:8-19. 2011
    ..It is concluded that regional disparity in response to aging and CR relates to differences in vulnerability to stressors, the availability of neurotrophic, and cell survival mechanisms, and differences in cell function...
  21. pmc Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging
    Wei Hua Lee
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Antioxid Redox Signal 16:339-50. 2012
    ....
  22. doi request reprint Altered behavior in experimental cortical dysplasia
    Fu Wen Zhou
    Department of Neurosurgery, University of Florida, Gainesville, Florida 32610, USA
    Epilepsia 52:2293-303. 2011
    ..We studied cognition and behavior in an animal model of diffuse cortical dysplasia (CD), in utero irradiation, using a battery of behavioral tests for neuromuscular and cognitive function...
  23. pmc Intracellular redox state alters NMDA receptor response during aging through Ca2+/calmodulin-dependent protein kinase II
    Karthik Bodhinathan
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 30:1914-24. 2010
    ..These findings indicate a link between oxidation of CaMKII during aging, a decline in NMDAR responses, and altered synaptic plasticity...
  24. ncbi request reprint Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area CA1
    Ashok Kumar
    Dept of Neuroscience, The Evelyn F and William L McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    J Neurophysiol 98:594-601. 2007
    ..Thus impairment of the basic synaptic mechanisms responsible for expression of these forms of plasticity is not likely to account for decline in memory function within this age range...
  25. pmc AAV-mediated gene therapy in the guanylate cyclase (RetGC1/RetGC2) double knockout mouse model of Leber congenital amaurosis
    Sanford L Boye
    Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Hum Gene Ther 24:189-202. 2013
    ....
  26. pmc Usefulness of preclinical models for assessing the efficacy of late-life interventions for sarcopenia
    Christy S Carter
    Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA
    J Gerontol A Biol Sci Med Sci 67:17-27. 2012
    ..We finish by providing our perspective regarding the implications of this body of work and future areas of research that may also contribute to the ultimate goal of extending healthspan...
  27. pmc Comparison of lifelong and late life exercise on oxidative stress in the cerebellum
    Li Cui
    Department of Neuroscience, Evelyn F and William L McKnight Brain Institute, University of Florida College of Medicine, PO Box 100244, Gainesville, FL 32610 0244, USA
    Neurobiol Aging 30:903-9. 2009
    ..In addition, modest exercise initiated late in life can have a beneficial effect on lipid oxidation and motor function...
  28. pmc Redox sensitive calcium stores underlie enhanced after hyperpolarization of aged neurons: role for ryanodine receptor mediated calcium signaling
    Karthik Bodhinathan
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    J Neurophysiol 104:2586-93. 2010
    ..The results add support to the idea that a shift in the intracellular redox state contributes to Ca(2+) dysregulation during aging...
  29. pmc Aging alters the expression of genes for neuroprotection and synaptic function following acute estradiol treatment
    Kristina K Aenlle
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
    Hippocampus 20:1047-60. 2010
    ..The age differences in gene expression for rapid signaling pathways may relate to disparity in basal pathway activity and estradiol mediated activation of rapid signaling cascades...
  30. ncbi request reprint Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats
    Ying Xu
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA
    Brain Res 1162:9-18. 2007
    ..Moreover, curcumin treatment, via up-regulation of 5-HT(1A) receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin...
  31. ncbi request reprint Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    J Neurophysiol 91:2437-44. 2004
    ....
  32. pmc Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity
    Christy S Carter
    Department of Aging and Geriatric Research, College of Medicine, University of Florida, 210 East Mowry Road, Gainesville, FL 32610, USA
    J Gerontol A Biol Sci Med Sci 64:850-9. 2009
    ..Finally, CR resulted in an overall increase in physical activity, one of several behavioral confounders to consider in the interpretation of cognitive outcomes in both tasks...
  33. ncbi request reprint Gene therapy restores vision-dependent behavior as well as retinal structure and function in a mouse model of RPE65 Leber congenital amaurosis
    Ji Jing Pang
    Department of Ophthalmology, University of Florida, Gainesville, FL 32610, USA
    Mol Ther 13:565-72. 2006
    ....
  34. pmc Differential effects of enalapril and losartan on body composition and indices of muscle quality in aged male Fischer 344 × Brown Norway rats
    Christy S Carter
    Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL 32610, USA
    Age (Dordr) 33:167-83. 2011
    ..These data suggest that attenuation of the severity of skeletal muscle apoptosis promoted by enalapril may represent a distinct mechanism through which this compound improves muscle strength/quality...
  35. pmc Muscleblind-like 2-mediated alternative splicing in the developing brain and dysregulation in myotonic dystrophy
    Konstantinos Charizanis
    Department of Molecular Genetics and Microbiology and the Center for NeuroGenetics, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    Neuron 75:437-50. 2012
    ..Importantly, the majority of the Mbnl2-regulated exons examined were similarly misregulated in DM. We propose that major pathological features of the DM brain result from disruption of the MBNL2-mediated developmental splicing program...
  36. pmc Susceptibility to Calcium Dysregulation during Brain Aging
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida Gainesville, FL, USA
    Front Aging Neurosci 1:2. 2009
    ..Incorporating the knowledge of the complexity of age-related alterations in Ca(2+) homeostasis will positively shape the development of highly effective therapeutics to treat brain disorders...
  37. doi request reprint Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida
    Hippocampus 24:466-75. 2014
    ..For DHPG-LTD, AIDA blocked DHPG-LTD and individually applied NMDAR or VDCC attenuated but did not block DHPG-LTD, indicating that the magnitude of DHPG-LTD depends on all three mechanisms...
  38. ncbi request reprint Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance
    Xuan V Nguyen
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, 800 Rose Street, 310 Whitney Henrickson Facility, Lexington, Kentucky 40536, USA
    Behav Brain Res 161:254-62. 2005
    ..Although the underlying mechanisms have yet to be elucidated, the results suggest that chronic increases in endogenous dynorphin expression with age, especially in frontal cortex, may adversely affect learning and memory...
  39. ncbi request reprint Calcineurin as a potential contributor in estradiol regulation of hippocampal synaptic function
    Keith M Sharrow
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Neuroscience 113:89-97. 2002
    ..From these results we suggest that EB can act to rapidly influence Ca(2+) signaling pathways including the activity of Ca(2+)-regulated phosphatases involved in synaptic plasticity...
  40. ncbi request reprint Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurosci 23:3807-19. 2003
    ....
  41. ncbi request reprint Regulation of synaptic plasticity in memory and memory decline with aging
    Thomas C Foster
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Prog Brain Res 138:283-303. 2002
  42. ncbi request reprint Calcium dysregulation in the aging brain
    Thomas C Foster
    University of Kentucky, College of Medicine, Department of Molecular and Biomedical Pharmacology, Lexington, KY 40536, USA
    Neuroscientist 8:297-301. 2002
    ....
  43. ncbi request reprint 17beta-estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons
    Ashok Kumar
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington 40536, USA
    J Neurophysiol 88:621-6. 2002
    ..The results support a role for EB in modifying hippocampal Ca(2+)-dependent processes in a manner diametrically opposite that observed during aging, possibly through L-channel inhibition...
  44. ncbi request reprint Interaction of age and chronic estradiol replacement on memory and markers of brain aging
    Thomas C Foster
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Neurobiol Aging 24:839-52. 2003
    ..Results indicate that the level of chronic hormone replacement interacts with age to influence hippocampal function...
  45. ncbi request reprint The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546, USA
    Alcohol Clin Exp Res 27:1724-35. 2003
    ..The following studies use organotypic hippocampal slice cultures at a mature age to investigate the potential for this interplay in the neurotoxicity associated with withdrawal from long-term ethanol exposure...

Research Grants21

  1. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2002
    ..abstract_text> ..
  2. Mechanism for Altered Synaptic Function During Aging
    Thomas Foster; Fiscal Year: 2007
    ..Specifc aim 3 will addresses the issue of how oxidative stress contributes to calcium dysregulation during aging in the hippocampus by examining the influence of redox state on Ca2+ dependent processes. ..
  3. Mechanism for Altered Synaptic Function During Aging
    Thomas Foster; Fiscal Year: 2009
    ..Specifc aim 3 will addresses the issue of how oxidative stress contributes to calcium dysregulation during aging in the hippocampus by examining the influence of redox state on Ca2+ dependent processes. ..
  4. Mechanism for Altered Synaptic Function During Aging
    Thomas Foster; Fiscal Year: 2004
    ....
  5. Mechanism for Altered Synaptic Function During Aging
    Thomas Foster; Fiscal Year: 2001
    ....
  6. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2007
    ..abstract_text> ..
  7. Mechanism for Altered Synaptic Function During Aging
    Thomas Foster; Fiscal Year: 2002
    ....
  8. MECHANISMS FOR ALTERED SYNAPTIC FUNCTION DURING AGING
    Thomas Foster; Fiscal Year: 2000
    ..The results of these experiments will add significantly to our knowledge of mechanisms for regulation of synaptic function across the life span and provide a basis for understanding the role of synaptic plasticity in cognitive function. ..
  9. Mechanism for Altered Synaptic Function During Aging
    Thomas C Foster; Fiscal Year: 2010
    ..Specifc aim 3 will addresses the issue of how oxidative stress contributes to calcium dysregulation during aging in the hippocampus by examining the influence of redox state on Ca2+ dependent processes. ..
  10. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2006
    ..abstract_text> ..
  11. Mechanism for Altered Synaptic Function During Aging
    Thomas Foster; Fiscal Year: 2005
    ....
  12. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2004
    ..abstract_text> ..
  13. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2005
    ..abstract_text> ..
  14. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2003
    ..abstract_text> ..
  15. MECHANISMS FOR ALTERED SYNAPTIC FUNCTION DURING AGING
    Thomas Foster; Fiscal Year: 1999
    ..The results of these experiments will add significantly to our knowledge of mechanisms for regulation of synaptic function across the life span and provide a basis for understanding the role of synaptic plasticity in cognitive function. ..
  16. Signaling cascades and memory deficits during aging
    Thomas C Foster; Fiscal Year: 2010
    ..The long range goal is to provide interventions to delay, prevent, or treat cognitive decline associated with unsuccessful aging in order to improve the health and well- being of older Americans ..
  17. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2001
    ..abstract_text> ..
  18. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2009
    ..abstract_text> ..
  19. ESTROGEN AND COGNITION OVER THE LIFESPAN
    Thomas Foster; Fiscal Year: 2000
    ..abstract_text> ..