T C Foster

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Regulation of synaptic plasticity in memory and memory decline with aging
    Thomas C Foster
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Prog Brain Res 138:283-303. 2002
  2. ncbi request reprint Calcium dysregulation in the aging brain
    Thomas C Foster
    University of Kentucky, College of Medicine, Department of Molecular and Biomedical Pharmacology, Lexington, KY 40536, USA
    Neuroscientist 8:297-301. 2002
  3. pmc Calcineurin links Ca2+ dysregulation with brain aging
    T C Foster
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, Kentucky 40536, USA
    J Neurosci 21:4066-73. 2001
  4. ncbi request reprint Mechanism for increased hippocampal synaptic strength following differential experience
    T C Foster
    Department of Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 6209, USA
    J Neurophysiol 85:1377-83. 2001
  5. ncbi request reprint Receptor blockade reveals a correspondence between hippocampal-dependent behavior and experience-dependent synaptic enhancement
    T C Foster
    University of Kentucky, College of Medicine, Department of Pharmacology, 40536, Lexington, KY, USA
    Brain Res 871:39-43. 2000
  6. ncbi request reprint Involvement of hippocampal synaptic plasticity in age-related memory decline
    T C Foster
    Department of Pharmacology, College of Medicine, University of Kentucky, MS 305 UKMC, Lexington, KY, USA
    Brain Res Brain Res Rev 30:236-49. 1999
  7. ncbi request reprint Sex differences in the activational effect of ERalpha on spatial learning
    H N Fugger
    Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, 22903, USA
    Horm Behav 34:163-70. 1998
  8. ncbi request reprint Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice
    H N Fugger
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 309:207-9. 2001
  9. ncbi request reprint Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function
    H N Fugger
    Neuroscience Program, University of Virginia, Charlottesville, VA 22904, USA
    Brain Res 883:258-64. 2000
  10. ncbi request reprint Calcineurin as a potential contributor in estradiol regulation of hippocampal synaptic function
    Keith M Sharrow
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Neuroscience 113:89-97. 2002

Collaborators

Detail Information

Publications28

  1. ncbi request reprint Regulation of synaptic plasticity in memory and memory decline with aging
    Thomas C Foster
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Prog Brain Res 138:283-303. 2002
  2. ncbi request reprint Calcium dysregulation in the aging brain
    Thomas C Foster
    University of Kentucky, College of Medicine, Department of Molecular and Biomedical Pharmacology, Lexington, KY 40536, USA
    Neuroscientist 8:297-301. 2002
    ....
  3. pmc Calcineurin links Ca2+ dysregulation with brain aging
    T C Foster
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, Kentucky 40536, USA
    J Neurosci 21:4066-73. 2001
    ..The results suggest that altered regulation of CaN is one of the processes that could link Ca(2+) dyshomeostasis to age-related changes in neural function and cognition...
  4. ncbi request reprint Mechanism for increased hippocampal synaptic strength following differential experience
    T C Foster
    Department of Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 6209, USA
    J Neurophysiol 85:1377-83. 2001
    ....
  5. ncbi request reprint Receptor blockade reveals a correspondence between hippocampal-dependent behavior and experience-dependent synaptic enhancement
    T C Foster
    University of Kentucky, College of Medicine, Department of Pharmacology, 40536, Lexington, KY, USA
    Brain Res 871:39-43. 2000
    ..The results suggest a relationship between hippocampal-dependent behavior and experience-dependent modification of perforant path synaptic function through NMDAR activation...
  6. ncbi request reprint Involvement of hippocampal synaptic plasticity in age-related memory decline
    T C Foster
    Department of Pharmacology, College of Medicine, University of Kentucky, MS 305 UKMC, Lexington, KY, USA
    Brain Res Brain Res Rev 30:236-49. 1999
    ....
  7. ncbi request reprint Sex differences in the activational effect of ERalpha on spatial learning
    H N Fugger
    Neuroscience Graduate Program, University of Virginia, Charlottesville, Virginia, 22903, USA
    Horm Behav 34:163-70. 1998
    ..Because ligand-bound ERalpha appears to operate differently in male and female mice we hypothesize that the ability of ERalpha to affect learning is organized during development...
  8. ncbi request reprint Examination of estradiol effects on the rapid estradiol mediated increase in hippocampal synaptic transmission in estrogen receptor alpha knockout mice
    H N Fugger
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Neurosci Lett 309:207-9. 2001
    ..The results suggest that the rapid effect of E(2) on synaptic transmission is not mediated by ER alpha, however, ER alpha appears to modulate non-genomic influences on synaptic transmission...
  9. ncbi request reprint Novel effects of estradiol and estrogen receptor alpha and beta on cognitive function
    H N Fugger
    Neuroscience Program, University of Virginia, Charlottesville, VA 22904, USA
    Brain Res 883:258-64. 2000
    ..The results indicate an important role for ERalpha, relative to ERbeta, in the establishment of cognitive function and suggest that E(2) modulates memory function via a novel estrogenic mechanism...
  10. ncbi request reprint Calcineurin as a potential contributor in estradiol regulation of hippocampal synaptic function
    Keith M Sharrow
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington, KY 40536, USA
    Neuroscience 113:89-97. 2002
    ..From these results we suggest that EB can act to rapidly influence Ca(2+) signaling pathways including the activity of Ca(2+)-regulated phosphatases involved in synaptic plasticity...
  11. ncbi request reprint Age-associated changes in Ca(2+)-dependent processes: relation to hippocampal synaptic plasticity
    T C Foster
    Department of Psychology, University of Virginia, Charlottesville 22903, USA
    Hippocampus 7:602-12. 1997
    ..The authors suggest that changes in Ca2+ regulation could adjust the thresholds for synaptic modification, favoring processes for depression of synaptic strength during aging...
  12. ncbi request reprint 17beta-estradiol benzoate decreases the AHP amplitude in CA1 pyramidal neurons
    Ashok Kumar
    Department of Molecular and Biomedical Pharmacology, University of Kentucky, College of Medicine, Lexington 40536, USA
    J Neurophysiol 88:621-6. 2002
    ..The results support a role for EB in modifying hippocampal Ca(2+)-dependent processes in a manner diametrically opposite that observed during aging, possibly through L-channel inhibition...
  13. ncbi request reprint Interaction of age and chronic estradiol replacement on memory and markers of brain aging
    Thomas C Foster
    Department of Molecular and Biomedical Pharmacology, College of Medicine, University of Kentucky, Lexington, KY 40536, USA
    Neurobiol Aging 24:839-52. 2003
    ..Results indicate that the level of chronic hormone replacement interacts with age to influence hippocampal function...
  14. ncbi request reprint Gene microarrays in hippocampal aging: statistical profiling identifies novel processes correlated with cognitive impairment
    Eric M Blalock
    Department of Molecular and Biomedical Pharmacology, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0298, USA
    J Neurosci 23:3807-19. 2003
    ....
  15. ncbi request reprint Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area CA1
    Ashok Kumar
    Dept of Neuroscience, The Evelyn F and William L McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, FL 32610, USA
    J Neurophysiol 98:594-601. 2007
    ..Thus impairment of the basic synaptic mechanisms responsible for expression of these forms of plasticity is not likely to account for decline in memory function within this age range...
  16. ncbi request reprint Prodynorphin knockout mice demonstrate diminished age-associated impairment in spatial water maze performance
    Xuan V Nguyen
    Department of Anatomy and Neurobiology, University of Kentucky Medical Center, 800 Rose Street, 310 Whitney Henrickson Facility, Lexington, Kentucky 40536, USA
    Behav Brain Res 161:254-62. 2005
    ..Although the underlying mechanisms have yet to be elucidated, the results suggest that chronic increases in endogenous dynorphin expression with age, especially in frontal cortex, may adversely affect learning and memory...
  17. ncbi request reprint Sex with knockout models: behavioral studies of estrogen receptor alpha
    E F Rissman
    Department of Biology, Neuroscience Graduate Program, Gilmer Hall, University of Virginia, Charlottesville, VA 22903, USA
    Brain Res 835:80-90. 1999
    ..Based on these data we hypothesize that ERalpha mediates many of the effects of estrogen on sexual behavior, learning, and memory...
  18. pmc Influence of calorie restriction on measures of age-related cognitive decline: role of increased physical activity
    Christy S Carter
    Department of Aging and Geriatric Research, College of Medicine, University of Florida, 210 East Mowry Road, Gainesville, FL 32610, USA
    J Gerontol A Biol Sci Med Sci 64:850-9. 2009
    ..Finally, CR resulted in an overall increase in physical activity, one of several behavioral confounders to consider in the interpretation of cognitive outcomes in both tasks...
  19. ncbi request reprint The neurotoxicity induced by ethanol withdrawal in mature organotypic hippocampal slices might involve cross-talk between metabotropic glutamate type 5 receptors and N-methyl-D-aspartate receptors
    Barton R Harris
    Department of Molecular and Biomedical Pharmacology, University of Kentucky Chandler Medical Center, Lexington 40546, USA
    Alcohol Clin Exp Res 27:1724-35. 2003
    ..The following studies use organotypic hippocampal slice cultures at a mature age to investigate the potential for this interplay in the neurotoxicity associated with withdrawal from long-term ethanol exposure...
  20. pmc Viral vector-mediated delivery of estrogen receptor-alpha to the hippocampus improves spatial learning in estrogen receptor-alpha knockout mice
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    Mol Ther 16:1587-93. 2008
    ..We propose that constitutive estrogen receptor activity is important for maintaining hippocampus-dependent memory function in adults...
  21. ncbi request reprint Shift in induction mechanisms underlies an age-dependent increase in DHPG-induced synaptic depression at CA3 CA1 synapses
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, USA
    J Neurophysiol 98:2729-36. 2007
    ..The results provide evidence that DHPG-LTD is one of the few forms of synaptic plasticity that increases with advanced age and suggest that DHPG-LTD may contribute to age-related changes in hippocampal function...
  22. ncbi request reprint Intracellular calcium stores contribute to increased susceptibility to LTD induction during aging
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, PO Box 100244, Gainesville, FL 32610 0244, USA
    Brain Res 1031:125-8. 2005
    ..The idea that ICS may play prominent role in regulating synaptic modifiability through regulation of cell excitability and the timing of pre and postsynaptic activity is discussed...
  23. ncbi request reprint Calcium homeostasis and modulation of synaptic plasticity in the aged brain
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Aging Cell 6:319-25. 2007
    ..Physiological and biological models are outlined, which relate a shift in Ca2+ regulation with changes in cell excitability and synaptic plasticity, resulting in a functional lesion of the hippocampus...
  24. ncbi request reprint Enhanced long-term potentiation during aging is masked by processes involving intracellular calcium stores
    Ashok Kumar
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    J Neurophysiol 91:2437-44. 2004
    ....
  25. ncbi request reprint Biological markers of age-related memory deficits: treatment of senescent physiology
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0244, USA
    CNS Drugs 20:153-66. 2006
    ..Accordingly, the effectiveness of treatment needs to be verified for both cognitive changes and biological markers that are specific for age-related memory deficits...
  26. ncbi request reprint Interaction of rapid signal transduction cascades and gene expression in mediating estrogen effects on memory over the life span
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0244, USA
    Front Neuroendocrinol 26:51-64. 2005
    ....
  27. pmc Susceptibility to induction of long-term depression is associated with impaired memory in aged Fischer 344 rats
    Thomas C Foster
    Department of Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
    Neurobiol Learn Mem 87:522-35. 2007
    ..The results indicate that the increased susceptibility to LTD induction is associated with impaired memory and results from a shift in the induction process. The possible relationship between LTD and memory function is discussed...
  28. ncbi request reprint Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats
    Ying Xu
    Department of Biomedical Engineering, University of Florida, Gainesville, FL, 32611, USA
    Brain Res 1162:9-18. 2007
    ..Moreover, curcumin treatment, via up-regulation of 5-HT(1A) receptors and BDNF, may reverse or protect hippocampal neurons from further damage in response to chronic stress, which may underlie the therapeutic actions of curcumin...