John L Foster

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis
    Richard L Watkins
    Division of Infectious Diseases, Center for AIDS Research, 2042 Genetic Medicine, University of North Carolina, Campus Box 7042, Chapel Hill, NC 27599 7042, USA
    Retrovirology 10:125. 2013
  2. pmc HIV restriction by APOBEC3 in humanized mice
    John F Krisko
    Division of Infectious Diseases, Department of Internal Medicine, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 9:e1003242. 2013
  3. pmc Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
    Lillian S Kuo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y9 206, Dallas, TX 75390, USA
    Retrovirology 9:47. 2012
  4. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
  5. pmc HIV-1 Nef: at the crossroads
    John L Foster
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Retrovirology 5:84. 2008
  6. pmc Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes
    Wei Zou
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599 7042, USA
    Retrovirology 9:44. 2012
  7. pmc Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef
    Eduardo O'Neill
    Department of Internal Medicine, Division of Infectious Diseases Y9 206, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9113, USA
    J Virol 80:1311-20. 2006
  8. pmc Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation
    Bangdong L Wei
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Virol 79:14976-80. 2005
  9. ncbi request reprint Role of Nef in HIV-1 replication and pathogenesis
    John L Foster
    Department of Internal Medicine, University of Texas Southwestern, Medical Center, Dallas, TX 75390, USA
    Adv Pharmacol 55:389-409. 2007
  10. pmc Mechanisms of HIV-1 Nef function and intracellular signaling
    John L Foster
    Division of Infectious Diseases, Center for AIDS Research, Chapel Hill, NC 27599 7042, USA
    J Neuroimmune Pharmacol 6:230-46. 2011

Collaborators

Detail Information

Publications13

  1. ncbi request reprint In vivo analysis of highly conserved Nef activities in HIV-1 replication and pathogenesis
    Richard L Watkins
    Division of Infectious Diseases, Center for AIDS Research, 2042 Genetic Medicine, University of North Carolina, Campus Box 7042, Chapel Hill, NC 27599 7042, USA
    Retrovirology 10:125. 2013
    ..Here, we use the BLT humanized mouse model of HIV-1 infection to assess their impact on viral replication and pathogenesis and the selection pressure to restore these activities using enforced in vivo evolution...
  2. pmc HIV restriction by APOBEC3 in humanized mice
    John F Krisko
    Division of Infectious Diseases, Department of Internal Medicine, Center for AIDS Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Pathog 9:e1003242. 2013
    ..Our results provide novel insight into a highly specific subset of cells that potentially circumvent the action of APOBEC3; however our results also demonstrate the massive inactivation of CCR5-tropic HIV in the absence of Vif...
  3. pmc Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix
    Lillian S Kuo
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Y9 206, Dallas, TX 75390, USA
    Retrovirology 9:47. 2012
    ..Further, mutation of the non-motif "X" residues, (Q73, V74, and L75) would give altered patterns of inhibition for different Nef/SH3 domain protein interactions...
  4. pmc Functional characterization of the human immunodeficiency virus type 1 Nef acidic domain
    Laura L Baugh
    Y9 206, Department of Internal Medicine, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    J Virol 82:9657-67. 2008
    ..Our results are consistent with an alternative model in which (62)EEEE(65) plays a stabilizing role in the formation of a ternary complex between Nef, the MHC-I cytoplasmic domain, and AP-1...
  5. pmc HIV-1 Nef: at the crossroads
    John L Foster
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Retrovirology 5:84. 2008
    ..Finally, we conclude that inhibiting the CD4 downregulation function is the most promising Nef-targeted approach for developing a new anti-viral as a contribution to combating AIDS...
  6. pmc Nef functions in BLT mice to enhance HIV-1 replication and deplete CD4+CD8+ thymocytes
    Wei Zou
    Division of Infectious Diseases, University of North Carolina, Chapel Hill, NC 27599 7042, USA
    Retrovirology 9:44. 2012
    ..The major problem in determining the role of Nef in HIV/AIDS has been the lack of tractable in vivo models where Nef's complex pathogenic phenotype can be recapitulated...
  7. pmc Dynamic evolution of the human immunodeficiency virus type 1 pathogenic factor, Nef
    Eduardo O'Neill
    Department of Internal Medicine, Division of Infectious Diseases Y9 206, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9113, USA
    J Virol 80:1311-20. 2006
    ..Thus, L85/H89/F191 and F85/F89/R191 are dominant in subtype B and subtype E or C, respectively. Our results provide support for developing subtype-specific interventions in HIV-1 disease...
  8. pmc Activation of p21-activated kinase 2 by human immunodeficiency virus type 1 Nef induces merlin phosphorylation
    Bangdong L Wei
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    J Virol 79:14976-80. 2005
    ..The finding that Nef induces phosphorylation of the key signaling molecule merlin suggests several possible roles for PAK2 activation in HIV pathogenesis...
  9. ncbi request reprint Role of Nef in HIV-1 replication and pathogenesis
    John L Foster
    Department of Internal Medicine, University of Texas Southwestern, Medical Center, Dallas, TX 75390, USA
    Adv Pharmacol 55:389-409. 2007
  10. pmc Mechanisms of HIV-1 Nef function and intracellular signaling
    John L Foster
    Division of Infectious Diseases, Center for AIDS Research, Chapel Hill, NC 27599 7042, USA
    J Neuroimmune Pharmacol 6:230-46. 2011
    ..We report the results of a PPI-Pred analysis for protein-protein interfaces. There are three predicted patches produced by the analysis which describe regions consistent with the currently known mutational analyses of Nef function...
  11. pmc Reconstitution and molecular analysis of an active human immunodeficiency virus type 1 Nef/p21-activated kinase 2 complex
    Alexa Raney
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, 75390 9113, USA
    J Virol 79:12732-41. 2005
    ..As demonstrated herein, the cell-free system is a new and important tool in the investigation of the mechanism of PAK-2 activation by Nef...
  12. ncbi request reprint HIV pathogenesis: Nef loses control
    John L Foster
    Division of Infectious Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75390, USA
    Cell 125:1034-5. 2006
    ..This loss of function in the Nef of HIV-1 may partly explain the pathogenicity of this virus...
  13. pmc Inhibition of lysosome and proteasome function enhances human immunodeficiency virus type 1 infection
    Bangdong L Wei
    Department of Internal Medicine, Division of Infectious Diseases, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    J Virol 79:5705-12. 2005
    ....