Research Topics
| John FosterSummaryAffiliation: University of South Alabama Country: USA Publications
Research Grants
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Detail Information
Publications
Escherichia coli acid resistance: tales of an amateur acidophileJohn W Foster
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
Nat Rev Microbiol 2:898-907. 2004..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...- When protons attack: microbial strategies of acid adaptationJ W Foster
Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
Curr Opin Microbiol 2:170-4. 1999..In addition, there is significant evidence linking pH responses with virulence... 
Control of acid resistance in Escherichia coliM P Castanie-Cornet
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
J Bacteriol 181:3525-35. 1999....- Escherichia coli acid resistance: cAMP receptor protein and a 20 bp cis-acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genesM P Castanie-Cornet
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
Microbiology 147:709-15. 2001..Deletions of the regulatory region upstream of gadA provided evidence that a 20 bp conserved region located 50 bp from the transcriptional start of both operons is required for expression... - Effects of DksA and ClpP protease on sigma S production and virulence in Salmonella typhimuriumC Webb
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL, USA
Mol Microbiol 34:112-23. 1999..As a result of their effects on gene expression, mutations in clpP and dksA decreased the virulence of S. typhimurium in mice, consistent with a role for sigmaS in pathogenesis... - Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteriaJ P Audia
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
Int J Med Microbiol 291:97-106. 2001..In addition, we will review three dedicated acid resistance systems of E. coli, not present in Salmonella, that allow this organism to survive extreme (pH 2) acid challenge... - A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stressB L Bearson
Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile 36688, USA
J Bacteriol 180:2409-17. 1998..The involvement of four regulators, two of which are implicated in virulence, underscores the complexity of the acid tolerance stress response and further suggests that features of acid tolerance and virulence are interwoven... - Low pH adaptation and the acid tolerance response of Salmonella typhimuriumJ W Foster
Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile 36688, USA
Crit Rev Microbiol 21:215-37. 1995..typhimurium exhibit reduced virulence. This review summarizes these aspects of acid adaptation and includes a discussion of acid-regulated gene expression... - The rpoS-dependent starvation-stress response locus stiA encodes a nitrate reductase (narZYWV) required for carbon-starvation-inducible thermotolerance and acid tolerance in Salmonella typhimuriumM P Spector
Department of Biomedical Sciences, University of South Alabama, Mobile 36688, USA
Microbiology 145:3035-45. 1999.... - Regulation of sigma S degradation in Salmonella enterica var typhimurium: in vivo interactions between sigma S, the response regulator MviA(RssB) and ClpXM Moreno
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
J Mol Microbiol Biotechnol 2:245-54. 2000.... - Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri, and Escherichia coliJ Lin
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
J Bacteriol 177:4097-104. 1995..The arginine AR system was only observed in E. coli and required stationary-phase induction in acidified complex medium. The product of the adi locus, arginine decarboxylase, was responsible for arginine-based acid survival... - Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operonJ W Foster
Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile 36688
J Bacteriol 172:4187-96. 1990..As NAD levels increase within the cell, the affinity of NadR for the operator regions of nadA, nadB, and pncB increases, repressing the transcription of these target genes... - The Escherichia coli AraC-family regulators GadX and GadW activate gadE, the central activator of glutamate-dependent acid resistanceAtef K Sayed
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
Microbiology 153:2584-92. 2007..These regulatory regions and proteins appear to integrate a variety of physiological signals that forecast a need for GadE-dependent gene expression and acid resistance... - Loss of topoisomerase I function affects the RpoS-dependent and GAD systems of acid resistance in Escherichia coliNatalee Stewart
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, 10595, USA
Microbiology 151:2783-91. 2005..The effect of the topA mutation could be suppressed by an hns mutation, so topoisomerase I might be required to counteract the effect of H-NS protein on gene expression, in addition to its influence on RpoS-dependent transcription... - The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coliShimei Gong
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
Mol Microbiol 54:948-61. 2004..The significance of this network extends beyond acid resistance as the target of this control, GadE, regulates numerous genes in addition to gadA/BC... - Characterization of EvgAS-YdeO-GadE branched regulatory circuit governing glutamate-dependent acid resistance in Escherichia coliZhuo Ma
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
J Bacteriol 186:7378-89. 2004..Since GadE controls the expression of numerous genes besides gadA and gadBC, the relevance of these regulatory circuits extends beyond acid resistance... - Escherichia coli glutamate- and arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potentialHope Richard
Department of Microbiology and Immunology, University of South Alabama College of Medicine, 307 University Blvd, Mobile, AL 36688, USA
J Bacteriol 186:6032-41. 2004..Thus, reversing DeltaPsi may be a more important acid resistance strategy than maintaining a specific pHi value... - pH-Dependent modulation of cyclic AMP levels and GadW-dependent repression of RpoS affect synthesis of the GadX regulator and Escherichia coli acid resistanceZhuo Ma
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
J Bacteriol 185:6852-9. 2003..The presence of multiple pH control pathways governing expression of this acid resistance system is thought to reflect different environmental routes to a low pH... - Sodium regulates Escherichia coli acid resistance, and influences GadX- and GadW-dependent activation of gadEHope Richard
Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
Microbiology 153:3154-61. 2007..Since Na(+) levels did not regulate gadX or gadW transcription, it is proposed that GadX and GadW sense intracellular Na(+) concentration or some consequence of altered Na(+) levels... - GadE (YhiE) activates glutamate decarboxylase-dependent acid resistance in Escherichia coli K-12Zhuo Ma
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
Mol Microbiol 49:1309-20. 2003..The number of regulatory proteins (five), sigma factors (two) and regulatory feedback loops focused on gadA/BC expression make this one of the most intensively regulated systems in E. coli... - YjdE (AdiC) is the arginine:agmatine antiporter essential for arginine-dependent acid resistance in Escherichia coliShimei Gong
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
J Bacteriol 185:4402-9. 2003..The data also illustrate that the AdiA decarboxylase:AdiC antiporter system is designed to function only at acid levels sufficient to harm the cell... - Genes of the GadX-GadW regulon in Escherichia coliDon L Tucker
Advanced Center for Genome Technology, The University of Oklahoma, Norman, Oklahoma 73019, USA
J Bacteriol 185:3190-201. 2003..Thus, E. coli colonization of the mouse does not appear to require glutamate-dependent acid resistance... - Collaborative regulation of Escherichia coli glutamate-dependent acid resistance by two AraC-like regulators, GadX and GadW (YhiW)Zhuo Ma
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
J Bacteriol 184:7001-12. 2002..These complex control circuits impose tight rein over expression of the gadA and gadBC system yet provide flexibility for inducing acid resistance under many conditions that presage acid stress... - Autoinduction of the ompR response regulator by acid shock and control of the Salmonella enterica acid tolerance responseIel Soo Bang
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
Mol Microbiol 44:1235-50. 2002.... - Products of the Escherichia coli acid fitness island attenuate metabolite stress at extremely low pH and mediate a cell density-dependent acid resistanceAaron K Mates
Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
J Bacteriol 189:2759-68. 2007..Density-dependent acid resistance does not require any demonstrable secreted factor and may involve cell contact-dependent activation. These findings further define the complex physiology of E. coli acid resistance... - CuiD is a crucial gene for survival at high copper environment in Salmonella enterica serovar TyphimuriumSung Young Lim
Department of Microbiology, Han Nam University, Daejeon, Korea
Mol Cells 14:177-84. 2002..The H2O2 sensitive phenotype of the cuiD mutant indicates that cuiD may be involved in oxidative stress response... - Acid shock accumulation of sigma S in Salmonella enterica involves increased translation, not regulated degradationJonathon P Audia
Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
J Mol Microbiol Biotechnol 5:17-28. 2003..Therefore, constitutive degradation may enable the cell to reset the level of sigma(S) once acid stress is alleviated... - Acid resistance systems required for survival of Escherichia coli O157:H7 in the bovine gastrointestinal tract and in apple cider are differentStuart B Price
Department of Pathobiology, College of Veterinary Medicine, 264 Greene Hall, Auburn University, Auburn, AL 36849, USA
Appl Environ Microbiol 70:4792-9. 2004..AR system 3-deficient cells survived well in both apple cider and calves. Taken together, these results indicate that E. coli O157:H7 utilizes different acid resistance systems based on the type of acidic environment encountered... - DksA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTPBrian J Paul
Department of Bacteriology, University of Wisconsin, 420 Henry Mall, Madison 53706, USA
Cell 118:311-22. 2004.... - Acid resistance in Escherichia coliHope T Richard
Department of Microbiology and Immunology, College of Medicine, University of South Alabama Mobile, Alabama 36688, USA
Adv Appl Microbiol 52:167-86. 2003..5. They also protect against acid stress involved in food processing and facilitate the low infectious dose characteristic of E. coli, significantly contributing to the pathogenesis of this organism...
Research Grants
- MECHANISMS AND CONTROL OF ACID RESISTANCE IN E COLIJohn Foster; Fiscal Year: 2004..In a broader sense, knowledge gained from this study will also provide insights into fundamental questions concerning proton circulations, protein structure-function relationships and gene expression as each relates to acid stress ..