John Foster

Summary

Affiliation: University of South Alabama
Country: USA

Publications

  1. ncbi request reprint Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
  2. ncbi request reprint When protons attack: microbial strategies of acid adaptation
    J W Foster
    Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Curr Opin Microbiol 2:170-4. 1999
  3. pmc Control of acid resistance in Escherichia coli
    M P Castanie-Cornet
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Bacteriol 181:3525-35. 1999
  4. ncbi request reprint Escherichia coli acid resistance: cAMP receptor protein and a 20 bp cis-acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genes
    M P Castanie-Cornet
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Microbiology 147:709-15. 2001
  5. ncbi request reprint Effects of DksA and ClpP protease on sigma S production and virulence in Salmonella typhimurium
    C Webb
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL, USA
    Mol Microbiol 34:112-23. 1999
  6. ncbi request reprint Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteria
    J P Audia
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    Int J Med Microbiol 291:97-106. 2001
  7. pmc A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress
    B L Bearson
    Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile 36688, USA
    J Bacteriol 180:2409-17. 1998
  8. ncbi request reprint Low pH adaptation and the acid tolerance response of Salmonella typhimurium
    J W Foster
    Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile 36688, USA
    Crit Rev Microbiol 21:215-37. 1995
  9. ncbi request reprint The rpoS-dependent starvation-stress response locus stiA encodes a nitrate reductase (narZYWV) required for carbon-starvation-inducible thermotolerance and acid tolerance in Salmonella typhimurium
    M P Spector
    Department of Biomedical Sciences, University of South Alabama, Mobile 36688, USA
    Microbiology 145:3035-45. 1999
  10. ncbi request reprint Regulation of sigma S degradation in Salmonella enterica var typhimurium: in vivo interactions between sigma S, the response regulator MviA(RssB) and ClpX
    M Moreno
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    J Mol Microbiol Biotechnol 2:245-54. 2000

Research Grants

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Escherichia coli acid resistance: tales of an amateur acidophile
    John W Foster
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36695, USA
    Nat Rev Microbiol 2:898-907. 2004
    ..Surprisingly, certain microorganisms that grow at neutral pH have elegantly regulated systems that enable survival during excursions into acidic environments. The best-characterized acid-resistance system is found in E. coli...
  2. ncbi request reprint When protons attack: microbial strategies of acid adaptation
    J W Foster
    Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Curr Opin Microbiol 2:170-4. 1999
    ..In addition, there is significant evidence linking pH responses with virulence...
  3. pmc Control of acid resistance in Escherichia coli
    M P Castanie-Cornet
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Bacteriol 181:3525-35. 1999
    ....
  4. ncbi request reprint Escherichia coli acid resistance: cAMP receptor protein and a 20 bp cis-acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genes
    M P Castanie-Cornet
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Microbiology 147:709-15. 2001
    ..Deletions of the regulatory region upstream of gadA provided evidence that a 20 bp conserved region located 50 bp from the transcriptional start of both operons is required for expression...
  5. ncbi request reprint Effects of DksA and ClpP protease on sigma S production and virulence in Salmonella typhimurium
    C Webb
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL, USA
    Mol Microbiol 34:112-23. 1999
    ..As a result of their effects on gene expression, mutations in clpP and dksA decreased the virulence of S. typhimurium in mice, consistent with a role for sigmaS in pathogenesis...
  6. ncbi request reprint Breaking through the acid barrier: an orchestrated response to proton stress by enteric bacteria
    J P Audia
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    Int J Med Microbiol 291:97-106. 2001
    ..In addition, we will review three dedicated acid resistance systems of E. coli, not present in Salmonella, that allow this organism to survive extreme (pH 2) acid challenge...
  7. pmc A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress
    B L Bearson
    Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile 36688, USA
    J Bacteriol 180:2409-17. 1998
    ..The involvement of four regulators, two of which are implicated in virulence, underscores the complexity of the acid tolerance stress response and further suggests that features of acid tolerance and virulence are interwoven...
  8. ncbi request reprint Low pH adaptation and the acid tolerance response of Salmonella typhimurium
    J W Foster
    Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile 36688, USA
    Crit Rev Microbiol 21:215-37. 1995
    ..typhimurium exhibit reduced virulence. This review summarizes these aspects of acid adaptation and includes a discussion of acid-regulated gene expression...
  9. ncbi request reprint The rpoS-dependent starvation-stress response locus stiA encodes a nitrate reductase (narZYWV) required for carbon-starvation-inducible thermotolerance and acid tolerance in Salmonella typhimurium
    M P Spector
    Department of Biomedical Sciences, University of South Alabama, Mobile 36688, USA
    Microbiology 145:3035-45. 1999
    ....
  10. ncbi request reprint Regulation of sigma S degradation in Salmonella enterica var typhimurium: in vivo interactions between sigma S, the response regulator MviA(RssB) and ClpX
    M Moreno
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    J Mol Microbiol Biotechnol 2:245-54. 2000
    ....
  11. pmc Comparative analysis of extreme acid survival in Salmonella typhimurium, Shigella flexneri, and Escherichia coli
    J Lin
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    J Bacteriol 177:4097-104. 1995
    ..The arginine AR system was only observed in E. coli and required stationary-phase induction in acidified complex medium. The product of the adi locus, arginine decarboxylase, was responsible for arginine-based acid survival...
  12. pmc Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon
    J W Foster
    Department of Microbiology and Immunology, College of Medicine, University of South Alabama, Mobile 36688
    J Bacteriol 172:4187-96. 1990
    ..As NAD levels increase within the cell, the affinity of NadR for the operator regions of nadA, nadB, and pncB increases, repressing the transcription of these target genes...
  13. ncbi request reprint The Escherichia coli AraC-family regulators GadX and GadW activate gadE, the central activator of glutamate-dependent acid resistance
    Atef K Sayed
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Microbiology 153:2584-92. 2007
    ..These regulatory regions and proteins appear to integrate a variety of physiological signals that forecast a need for GadE-dependent gene expression and acid resistance...
  14. pmc Loss of topoisomerase I function affects the RpoS-dependent and GAD systems of acid resistance in Escherichia coli
    Natalee Stewart
    Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, 10595, USA
    Microbiology 151:2783-91. 2005
    ..The effect of the topA mutation could be suppressed by an hns mutation, so topoisomerase I might be required to counteract the effect of H-NS protein on gene expression, in addition to its influence on RpoS-dependent transcription...
  15. ncbi request reprint The Era-like GTPase TrmE conditionally activates gadE and glutamate-dependent acid resistance in Escherichia coli
    Shimei Gong
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Mol Microbiol 54:948-61. 2004
    ..The significance of this network extends beyond acid resistance as the target of this control, GadE, regulates numerous genes in addition to gadA/BC...
  16. pmc Characterization of EvgAS-YdeO-GadE branched regulatory circuit governing glutamate-dependent acid resistance in Escherichia coli
    Zhuo Ma
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    J Bacteriol 186:7378-89. 2004
    ..Since GadE controls the expression of numerous genes besides gadA and gadBC, the relevance of these regulatory circuits extends beyond acid resistance...
  17. pmc Escherichia coli glutamate- and arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potential
    Hope Richard
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, 307 University Blvd, Mobile, AL 36688, USA
    J Bacteriol 186:6032-41. 2004
    ..Thus, reversing DeltaPsi may be a more important acid resistance strategy than maintaining a specific pHi value...
  18. pmc pH-Dependent modulation of cyclic AMP levels and GadW-dependent repression of RpoS affect synthesis of the GadX regulator and Escherichia coli acid resistance
    Zhuo Ma
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Bacteriol 185:6852-9. 2003
    ..The presence of multiple pH control pathways governing expression of this acid resistance system is thought to reflect different environmental routes to a low pH...
  19. ncbi request reprint Sodium regulates Escherichia coli acid resistance, and influences GadX- and GadW-dependent activation of gadE
    Hope Richard
    Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, AL 36688, USA
    Microbiology 153:3154-61. 2007
    ..Since Na(+) levels did not regulate gadX or gadW transcription, it is proposed that GadX and GadW sense intracellular Na(+) concentration or some consequence of altered Na(+) levels...
  20. ncbi request reprint GadE (YhiE) activates glutamate decarboxylase-dependent acid resistance in Escherichia coli K-12
    Zhuo Ma
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Mol Microbiol 49:1309-20. 2003
    ..The number of regulatory proteins (five), sigma factors (two) and regulatory feedback loops focused on gadA/BC expression make this one of the most intensively regulated systems in E. coli...
  21. pmc YjdE (AdiC) is the arginine:agmatine antiporter essential for arginine-dependent acid resistance in Escherichia coli
    Shimei Gong
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, Alabama 36688, USA
    J Bacteriol 185:4402-9. 2003
    ..The data also illustrate that the AdiA decarboxylase:AdiC antiporter system is designed to function only at acid levels sufficient to harm the cell...
  22. pmc Genes of the GadX-GadW regulon in Escherichia coli
    Don L Tucker
    Advanced Center for Genome Technology, The University of Oklahoma, Norman, Oklahoma 73019, USA
    J Bacteriol 185:3190-201. 2003
    ..Thus, E. coli colonization of the mouse does not appear to require glutamate-dependent acid resistance...
  23. pmc Collaborative regulation of Escherichia coli glutamate-dependent acid resistance by two AraC-like regulators, GadX and GadW (YhiW)
    Zhuo Ma
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile 36688, USA
    J Bacteriol 184:7001-12. 2002
    ..These complex control circuits impose tight rein over expression of the gadA and gadBC system yet provide flexibility for inducing acid resistance under many conditions that presage acid stress...
  24. ncbi request reprint Autoinduction of the ompR response regulator by acid shock and control of the Salmonella enterica acid tolerance response
    Iel Soo Bang
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    Mol Microbiol 44:1235-50. 2002
    ....
  25. pmc Products of the Escherichia coli acid fitness island attenuate metabolite stress at extremely low pH and mediate a cell density-dependent acid resistance
    Aaron K Mates
    Department of Microbiology and Immunology, University of South Alabama College of Medicine, Mobile, AL 36688, USA
    J Bacteriol 189:2759-68. 2007
    ..Density-dependent acid resistance does not require any demonstrable secreted factor and may involve cell contact-dependent activation. These findings further define the complex physiology of E. coli acid resistance...
  26. ncbi request reprint CuiD is a crucial gene for survival at high copper environment in Salmonella enterica serovar Typhimurium
    Sung Young Lim
    Department of Microbiology, Han Nam University, Daejeon, Korea
    Mol Cells 14:177-84. 2002
    ..The H2O2 sensitive phenotype of the cuiD mutant indicates that cuiD may be involved in oxidative stress response...
  27. ncbi request reprint Acid shock accumulation of sigma S in Salmonella enterica involves increased translation, not regulated degradation
    Jonathon P Audia
    Department of Microbiology and Immunology, University of South Alabama, College of Medicine, Mobile, Alabama 36688, USA
    J Mol Microbiol Biotechnol 5:17-28. 2003
    ..Therefore, constitutive degradation may enable the cell to reset the level of sigma(S) once acid stress is alleviated...
  28. pmc Acid resistance systems required for survival of Escherichia coli O157:H7 in the bovine gastrointestinal tract and in apple cider are different
    Stuart B Price
    Department of Pathobiology, College of Veterinary Medicine, 264 Greene Hall, Auburn University, Auburn, AL 36849, USA
    Appl Environ Microbiol 70:4792-9. 2004
    ..AR system 3-deficient cells survived well in both apple cider and calves. Taken together, these results indicate that E. coli O157:H7 utilizes different acid resistance systems based on the type of acidic environment encountered...
  29. ncbi request reprint DksA: a critical component of the transcription initiation machinery that potentiates the regulation of rRNA promoters by ppGpp and the initiating NTP
    Brian J Paul
    Department of Bacteriology, University of Wisconsin, 420 Henry Mall, Madison 53706, USA
    Cell 118:311-22. 2004
    ....
  30. ncbi request reprint Acid resistance in Escherichia coli
    Hope T Richard
    Department of Microbiology and Immunology, College of Medicine, University of South Alabama Mobile, Alabama 36688, USA
    Adv Appl Microbiol 52:167-86. 2003
    ..5. They also protect against acid stress involved in food processing and facilitate the low infectious dose characteristic of E. coli, significantly contributing to the pathogenesis of this organism...

Research Grants4

  1. MECHANISMS AND CONTROL OF ACID RESISTANCE IN E COLI
    John Foster; Fiscal Year: 2004
    ..In a broader sense, knowledge gained from this study will also provide insights into fundamental questions concerning proton circulations, protein structure-function relationships and gene expression as each relates to acid stress ..