Research Topics
Species | J FoskettSummaryAffiliation: University of Pennsylvania Country: USA Publications
Research Grants
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Detail Information
Publications
Single-channel properties in endoplasmic reticulum membrane of recombinant type 3 inositol trisphosphate receptorD O Mak
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Gen Physiol 115:241-56. 2000....- ATP-dependent adenophostin activation of inositol 1,4,5-trisphosphate receptor channel gating: kinetic implications for the durations of calcium puffs in cellsD O Mak
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Gen Physiol 117:299-314. 2001..Comparisons of single-channel gating kinetics of the InsP(3)R activated by InsP(3), AdA, and its analogues also identify molecular elements in InsP(3)R ligands that contribute to binding and activation of channel gating... - ATP regulation of recombinant type 3 inositol 1,4,5-trisphosphate receptor gatingD O Mak
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Gen Physiol 117:447-56. 2001..Complex regulation by ATP of the types 1 and 3 InsP3R channel activities may enable cells to generate sophisticated patterns of Ca2+ signals with cytoplasmic ATP as one of the second messengers... - Regulation by Ca2+ and inositol 1,4,5-trisphosphate (InsP3) of single recombinant type 3 InsP3 receptor channels. Ca2+ activation uniquely distinguishes types 1 and 3 insp3 receptorsD O Mak
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Gen Physiol 117:435-46. 2001..Thus, distinct Ca2+ signals may be conferred by complementary Ca2+ activation properties of different InsP3R isoforms... 
ClC and CFTR chloride channel gatingJ K Foskett
Department of Physiology, University of Pennsylvania, Philadelphia 19104 6100, USA
Annu Rev Physiol 60:689-717. 1998..The focus of this review is on recent studies that have provided new insights into the mechanisms governing the opening and closing, i.e. gating, of the ClC and CFTR chloride channels...- Spontaneous channel activity of the inositol 1,4,5-trisphosphate (InsP3) receptor (InsP3R). Application of allosteric modeling to calcium and InsP3 regulation of InsP3R single-channel gatingDon On Daniel Mak
Department of Physiology, B39 Anatomy Chemistry, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
J Gen Physiol 122:583-603. 2003..The validity of this model was established by its successful quantitative prediction of channel behavior after it had been exposed to ultra-low bath [Ca2+]... - Inositol trisphosphate receptor Ca2+ release channels in neurological diseasesJ Kevin Foskett
Department of Physiology, University of Pennsylvania School of Medicine, B39 Anatomy Chemistry Bldg, 414 Guardian Dr, Philadelphia, PA 19104, USA
Pflugers Arch 460:481-94. 2010.... - Inositol trisphosphate receptor Ca2+ release channelsJ Kevin Foskett
Department of Physiology, University of Pennsylvania, Philadelphia 19104 6085, USA
Physiol Rev 87:593-658. 2007..Here, we focus on these developments and review and synthesize the literature regarding the structure and single-channel properties of the InsP3R... - Novel model of calcium and inositol 1,4,5-trisphosphate regulation of InsP3 receptor channel gating in native endoplasmic reticulumJ Kevin Foskett
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
Biol Res 37:513-9. 2004..Ca2+ inhibition of InsP3-liganded channels is mediated by an InsP3-independent second inhibitory site... - Graded recruitment and inactivation of single InsP3 receptor Ca2+-release channels: implications for quantal [corrected] Ca2+releaseLucian Ionescu
Department of Physiology, B39 Anatomy Chemistry Building, 414 Guardian Drive, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
J Physiol 573:645-62. 2006.... - Novel regulation of calcium inhibition of the inositol 1,4,5-trisphosphate receptor calcium-release channelDon On Daniel Mak
Department of Physiology, B39 Anatomy Chemistry Bldg 6085, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
J Gen Physiol 122:569-81. 2003..Furthermore, these observations support an allosteric model in which Ca2+ inhibition of the InsP3R is mediated by two Ca2+ binding sites, only one of which is sensitive to InsP3... - Mode switching is the major mechanism of ligand regulation of InsP3 receptor calcium release channelsLucian Ionescu
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
J Gen Physiol 130:631-45. 2007..This novel observation therefore reveals modal switching as the major mechanism of physiological regulation of InsP(3)R channel activity, with implications for the kinetics of Ca(2+) release events in cells... - A new mode of Ca2+ signaling by G protein-coupled receptors: gating of IP3 receptor Ca2+ release channels by GbetagammaWeizhong Zeng
Department of Physiology, University of Texas Southwestern Medical Center, Dallas 75390, USA
Curr Biol 13:872-6. 2003..We propose that gating of IP(3)R by Gbetagamma is a new mode of Ca(2+) signaling with particular significance for Gi-coupled receptors... - Identification of a family of calcium sensors as protein ligands of inositol trisphosphate receptor Ca(2+) release channelsJun Yang
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
Proc Natl Acad Sci U S A 99:7711-6. 2002.... - Redox-regulated heterogeneous thresholds for ligand recruitment among InsP3R Ca2+-release channelsHoria Vais
Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Biophys J 99:407-16. 2010..No intrinsic termination of channel activity with a timescale comparable to that for quantal Ca2+ release was observed under any steady ligand conditions, indicating that this process is unlikely to contribute... - CIB1, a ubiquitously expressed Ca2+-binding protein ligand of the InsP3 receptor Ca2+ release channelCarl White
Department of Physiology, University of Pennsylvania, Philadelphia, 19104, USA
J Biol Chem 281:20825-33. 2006..These results establish CIB1 as a ubiquitously expressed activating and inhibiting protein ligand of the InsP(3)R... - Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gatingKing Ho Cheung
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Neuron 58:871-83. 2008..These observations provide molecular insights into the "Ca2+ dysregulation" hypothesis of AD pathogenesis and suggest novel targets for therapeutic intervention... - Rapid ligand-regulated gating kinetics of single inositol 1,4,5-trisphosphate receptor Ca2+ release channelsDon On Daniel Mak
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
EMBO Rep 8:1044-51. 2007..These results provide new insights into the channel regulatory mechanisms that contribute to complex spatial and temporal features of intracellular Ca(2+) signals... - Identification of the erythrocyte Rh blood group glycoprotein as a mammalian ammonium transporterConnie M Westhoff
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 510 Stellar Chance, Philadelphia, PA 19104, USA
J Biol Chem 277:12499-502. 2002..14 mm) consistent with the hypothesis that the uptake of MA and ammonium involves a similar H(+)-coupled counter-transport mechanism... - Mechanism of genetic complementation of ammonium transport in yeast by human erythrocyte Rh-associated glycoproteinConnie M Westhoff
Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennyslvania 19104, USA
J Biol Chem 279:17443-8. 2004..This report clarifies and expands previous observations of RhAG-mediated transport in yeast and supports the hypothesis that ammonium transport is coupled to the H(+) gradient and that RhAG functions as a NH(4)(+)/H(+) exchanger... - Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCGDon On Daniel Mak
American Red Cross, 700 Spring Garden St, Philadelphia, PA 19123, USA
Am J Physiol Renal Physiol 290:F297-305. 2006.... - Translational mobility of the type 3 inositol 1,4,5-trisphosphate receptor Ca2+ release channel in endoplasmic reticulum membraneMichelle Ferreri-Jacobia
Department of Physiology, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104, USA
J Biol Chem 280:3824-31. 2005..The observed InsP3R3 mobility may be higher than its intrinsic diffusional mobility because of additional ATP- and microtubule-facilitated motility of the channel... - Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neuronsKing Ho Cheung
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Sci Signal 3:ra22. 2010..These results indicate that exaggerated Ca(2+) signaling through IP(3)R-PS interaction is a disease-specific and robust proximal mechanism in FAD... - Assembly and trafficking of a multiprotein ROMK (Kir 1.1) channel complex by PDZ interactionsDana Yoo
Department of Physiology, University of Maryland School of Medicine, Baltimore 21201, USA
J Biol Chem 279:6863-73. 2004..Thus NHERF facilitates assembly of a ternary complex containing ROMK and CFTR. These observations raise the possibility that PDZ-based interactions may underscore physiological regulation and membrane targeting of ROMK in the kidney... - The endoplasmic reticulum gateway to apoptosis by Bcl-X(L) modulation of the InsP3RCarl White
Department of Physiology, Abramson Family Cancer Research Institute, Philadelphia, PA 19104, USA
Nat Cell Biol 7:1021-8. 2005..As a consequence, cells are protected against apoptosis by a more sensitive and dynamic coupling of ER to mitochondria through Ca(2+)-dependent signal transduction that enhances cellular bioenergetics and preserves survival... - The proapoptotic factors Bax and Bak regulate T Cell proliferation through control of endoplasmic reticulum Ca(2+) homeostasisRussell G Jones
Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA 19104, USA
Immunity 27:268-80. 2007..Together, the data establish that Bax and Bak play an essential role in the control of T cell proliferation by modulating ER Ca(2+) release... - Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondriaCesar Cardenas
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
Cell 142:270-83. 2010..Thus, constitutive InsP(3)R Ca(2+) release to mitochondria is an essential cellular process that is required for efficient mitochondrial respiration and maintenance of normal cell bioenergetics... - Visualization of inositol 1,4,5-trisphosphate receptors on the nuclear envelope outer membrane by freeze-drying and rotary shadowing for electron microscopyCesar Cardenas
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
J Struct Biol 171:372-81. 2010..The combination of nuclear isolation with freeze-drying and rotary shadow techniques allows direct visualization of InsP(3)Rs in native nuclear envelopes and can be used to determine their spatial distribution and density... - G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherenceBrian J Hawkins
Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6068, USA
Mol Cell Biol 27:7582-93. 2007..These results demonstrate that mROS is the downstream effector molecule that translates receptor-mediated Ca(2+) signals into proinflammatory signaling and leukocyte/EC firm adhesion... - Optical imaging of Ca2+-evoked fluid secretion by murine nasal submucosal gland serous acinar cellsRobert J Lee
Department of Physiology, Division of Medical Genetics, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
J Physiol 582:1099-124. 2007.... 
Mechanisms of Ca2+-stimulated fluid secretion by porcine bronchial submucosal gland serous acinar cellsRobert J Lee
Departments of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Am J Physiol Lung Cell Mol Physiol 298:L210-31. 2010....- HCO3(-) secretion by murine nasal submucosal gland serous acinar cells during Ca2+-stimulated fluid secretionRobert J Lee
Department of Physiology, Division of Medical Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
J Gen Physiol 132:161-83. 2008..In addition, other Na(+)-dependent pH(i) regulatory mechanisms exist, as evidenced by stronger inhibition of alkalinization in Na(+)-free media... - cAMP-activated Ca2+ signaling is required for CFTR-mediated serous cell fluid secretion in porcine and human airwaysRobert J Lee
Department of Physiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6085, USA
J Clin Invest 120:3137-48. 2010..These results identify important molecular mechanisms of cAMP-dependent secretion, including a requirement for Ca2+ signaling, and suggest new therapeutic approaches to correct defective submucosal gland secretion in CF... - A kinase-regulated mechanism controls CFTR channel gating by disrupting bivalent PDZ domain interactionsViswanathan Raghuram
Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
Proc Natl Acad Sci U S A 100:9620-5. 2003..Our results identify a role for PKC and suggest that phosphorylation of NHERF PDZ2 domain may be an important mechanism for regulating CFTR channel activity... - Inhibition of TRPC5 channels by Ca2+-binding protein 1 in Xenopus oocytesMariko Kinoshita-Kawada
Department of Neuroscience and Center for Molecular Neurobiology, The Ohio State University, 168 Rightmire Hall, 1060 Carmack Road, Columbus, OH 43210, USA
Pflugers Arch 450:345-54. 2005..The CaBP1-binding sites at the C terminus of TRPC5 are closely localized, but not identical, to CaM-binding sites. We conclude that TRPC5 is a Ca2+-regulated channel, and its activity is negatively controlled by CaBP1... - DANGER, a novel regulatory protein of inositol 1,4,5-trisphosphate-receptor activityDamian B van Rossum
Department of Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 281:37111-6. 2006..DANGER appears to allosterically modulate the sensitivity of IP(3) RtoCa(2+) inhibition, which likely alters IP(3)R-mediated Ca(2+) dynamics in cells where DANGER and IP(3)R are co-expressed... - Apoptosis regulation by Bcl-x(L) modulation of mammalian inositol 1,4,5-trisphosphate receptor channel isoform gatingChi Li
Molecular Targets Group, J G Brown Cancer Center, Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40202, USA
Proc Natl Acad Sci U S A 104:12565-70. 2007..Rather, apoptosis protection is conferred by enhanced spontaneous [Ca(2+)](i) signaling by Bcl-x(L) interaction with all isoforms of the InsP(3)R... - A kinetic model of single and clustered IP3 receptors in the absence of Ca2+ feedbackJianwei Shuai
Department of Neurobiology and Behavior, University of California, Irvine, California 92697 4550, USA
Biophys J 93:1151-62. 2007.... - The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosisChuanxi Cai
Department of Physiology and Biophysics, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, NJ 08854, USA
J Biol Chem 281:16649-55. 2006..Therefore, targeting the function of PS2-LP could provide a useful therapeutic tool for the treatment of cancer and degenerative diseases... - Regulation of channel gating by AMP-activated protein kinase modulates cystic fibrosis transmembrane conductance regulator activity in lung submucosal cellsKenneth R Hallows
Renal Electrolyte Division, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15261, USA
J Biol Chem 278:998-1004. 2003..As a metabolic sensor in cells, AMPK may be important in tuning CFTR activity to cellular energy charge, thereby linking transepithelial transport and the maintenance of cellular ion gradients to cellular metabolism... - Expression of cystic fibrosis transmembrane conductance regulator during early human embryo developmentAvraham Ben-Chetrit
Division of Reproductive Sciences, Department of Obstetrics and Gynaecology, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Ontario, Canada
Mol Hum Reprod 8:758-64. 2002..These data suggest that CFTR may contribute to blastocoele formation in the early human embryo... - A polymorphism in CALHM1 influences Ca2+ homeostasis, Abeta levels, and Alzheimer's disease riskUte Dreses-Werringloer
Litwin Zucker Research Center for the Study of Alzheimer s Disease, The Feinstein Institute for Medical Research, North Shore LIJ, Manhasset, NY 11030, USA
Cell 133:1149-61. 2008..We propose that CALHM1 encodes an essential component of a previously uncharacterized cerebral Ca(2+) channel that controls Abeta levels and susceptibility to late-onset AD...
Research Grants
- Molecular physiology of mammalian INSP3 receptorJ Kevin Foskett; Fiscal Year: 2009..The results of these studies should provide new insights into the molecular physiology of this ubiquitous family of Ca2+ release channels. ..
- ELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTORJ Kevin Foskett; Fiscal Year: 2010..The results of these studies should provide important insights into the molecular mechanisms that regulate apoptosis, and into the development of novel targets for therapeutic interventions in human diseases. ..
- ELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTORJ Kevin Foskett; Fiscal Year: 2009..The results of these studies should provide important insights into the molecular mechanisms that regulate apoptosis, and into the development of novel targets for therapeutic interventions in human diseases. ..
- ELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTORJ Kevin Foskett; Fiscal Year: 2006..The results of these studies should provide new insights into a novel concept in the regulation of Ca 2 release. ..
- ELECTROPHYSIOLOGY OF NUCLEAR MEMBRANE INSP3 RECEPTORJ Foskett; Fiscal Year: 2002..Finally, we will explore whether InsP3Rs cluster, by analyzing their ultrastructural localization, and determine the functional consequences of clustering for single channel gating and regulation. ..
- MOLECULAR PHYSIOLOGY OF MAMMALIAN INSP3 RECEPTORSJ Kevin Foskett; Fiscal Year: 2004....
- MOLECULAR PHYSIOLOGY OF MAMMALIAN INSP3 RECEPTORSJ Kevin Foskett; Fiscal Year: 2010....