M E Fortini

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Notch and presenilin: a proteolytic mechanism emerges
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories, Room 709C, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Cell Biol 13:627-34. 2001
  2. pmc A survey of human disease gene counterparts in the Drosophila genome
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 150:F23-30. 2000
  3. ncbi Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Genet 16:161-7. 2000
  4. pmc Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 146:1351-64. 1999
  5. pmc Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
    G Periz
    Department of Genetics, Stellar Chance Laboratories 709C, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    EMBO J 18:5983-93. 1999
  6. ncbi Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 398:525-9. 1999
  7. ncbi Characterization of Drosophila Presenilin and its colocalization with Notch during development
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories 709C, Philadelphia 19104, USA
    Mech Dev 79:199-211. 1998
  8. pmc Genetic characterization of cytological region 77A-D harboring the presenilin gene of Drosophila melanogaster
    N I Lukinova
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6069, USA
    Genetics 153:1789-97. 1999
  9. ncbi Identification and characterization of the Drosophila tau homolog
    G Heidary
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories 709C, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Mech Dev 108:171-8. 2001
  10. ncbi Surviving Drosophila eye development: integrating cell death with differentiation during formation of a neural structure
    N M Bonini
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Bioessays 21:991-1003. 1999

Collaborators

Detail Information

Publications23

  1. ncbi Notch and presenilin: a proteolytic mechanism emerges
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories, Room 709C, 422 Curie Boulevard, Philadelphia, Pennsylvania 19104, USA
    Curr Opin Cell Biol 13:627-34. 2001
    ..In this pathway, the Presenilins perform a regulated cleavage event that follows additional processing steps during receptor maturation and ligand-induced ectodomain removal...
  2. pmc A survey of human disease gene counterparts in the Drosophila genome
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 150:F23-30. 2000
  3. ncbi Modeling human neurodegenerative diseases in Drosophila: on a wing and a prayer
    M E Fortini
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Trends Genet 16:161-7. 2000
    ..With the advent of complete genomic sequencing on the horizon, Drosophila will continue to be an outstanding model system in which to unravel the complexities, causes and treatments for human neural degeneration...
  4. pmc Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Cell Biol 146:1351-64. 1999
    ....
  5. pmc Ca(2+)-ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila
    G Periz
    Department of Genetics, Stellar Chance Laboratories 709C, University of Pennsylvania School of Medicine, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    EMBO J 18:5983-93. 1999
    ..Notch and several other transmembrane proteins are mislocalized in tissue clones homozygous for Ca-P60A mutations, demonstrating a general effect on membrane protein trafficking caused by a deficiency in Ca(2+)-ATPase...
  6. ncbi Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Nature 398:525-9. 1999
    ..They also link the role of presenilin in Notch signalling to its effect on amyloid production in Alzheimer's disease...
  7. ncbi Characterization of Drosophila Presenilin and its colocalization with Notch during development
    Y Ye
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories 709C, Philadelphia 19104, USA
    Mech Dev 79:199-211. 1998
    ....
  8. pmc Genetic characterization of cytological region 77A-D harboring the presenilin gene of Drosophila melanogaster
    N I Lukinova
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6069, USA
    Genetics 153:1789-97. 1999
    ..In addition, some viable mutations were recovered in the screen, including new alleles of the clipped and inturned loci...
  9. ncbi Identification and characterization of the Drosophila tau homolog
    G Heidary
    Department of Genetics, University of Pennsylvania School of Medicine, Stellar Chance Laboratories 709C, 422 Curie Boulevard, Philadelphia, PA 19104, USA
    Mech Dev 108:171-8. 2001
    ....
  10. ncbi Surviving Drosophila eye development: integrating cell death with differentiation during formation of a neural structure
    N M Bonini
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Bioessays 21:991-1003. 1999
    ..Finally, we address how the Drosophila eye may allow identification of additional mechanisms that contribute to the normal integration of cell survival with appropriate events of cellular differentiation...
  11. ncbi Fringe benefits to carbohydrates
    M E Fortini
    Nature 406:357-8. 2000
  12. ncbi An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye
    M E Fortini
    Department of Cell Biology, Yale University, New Haven, Connecticut 06536
    Nature 365:555-7. 1993
    ..Moreover, an activated Notch protein lacking the transmembrane domain is translocated to the nucleus, raising the possibility that Notch may participate directly in nuclear events...
  13. ncbi Analysis of cis-acting requirements of the Rh3 and Rh4 genes reveals a bipartite organization to rhodopsin promoters in Drosophila melanogaster
    M E Fortini
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Genes Dev 4:444-63. 1990
    ....
  14. ncbi Notch signaling
    S Artavanis-Tsakonas
    Howard Hughes Medical Institute, Boyer Center for Molecular Medicine, Yale University, New Haven, CT 06536, USA
    Science 268:225-32. 1995
    ..Several vertebrate Notch receptors have also been discovered recently and play important roles in normal development and tumorigenesis...
  15. ncbi The suppressor of hairless protein participates in notch receptor signaling
    M E Fortini
    Howard Hughes Medical Institute, Department of Biology, Yale University, New Haven, Connecticut 06536
    Cell 79:273-82. 1994
    ..These results indicate that Notch activity may regulate nuclear events by controlling the activity of a DNA-binding protein...
  16. ncbi Notch: neurogenesis is only part of the picture
    M E Fortini
    Howard Hughes Medical Institute, Department of Biology, Yale University, New Haven, Connecticut 06536
    Cell 75:1245-7. 1993
  17. pmc Analysis of dominant enhancers and suppressors of activated Notch in Drosophila
    E M Verheyen
    Howard Hughes Medical Institute, Yale University, New Haven, Connecticut 06536, USA
    Genetics 144:1127-41. 1996
    ..We discuss the data with respect to known features of Notch receptor signaling and Drosophila eye development...
  18. ncbi Genetic analysis of the role of the drosophila fat facets gene in the ubiquitin pathway
    Z Wu
    Department of Molecular Cell and Developmental Biology and Institute for Cellular and Molecular Biology, University of Texas at Austin, 78712, USA
    Dev Genet 25:312-20. 1999
    ..The results of these experiments support the hypothesis that FAT FACETS activity antagonizes that of the proteolytic machinery. The implications of these results for the specificity of FAF and yeast UBPs are discussed as well...
  19. ncbi The optic lobe projection pattern of polarization-sensitive photoreceptor cells in Drosophila melanogaster
    M E Fortini
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cell Tissue Res 265:185-91. 1991
    ....
  20. ncbi The embryonic expression patterns of zfh-1 and zfh-2, two Drosophila genes encoding novel zinc-finger homeodomain proteins
    Z C Lai
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Mech Dev 34:123-34. 1991
    ..The expression patterns of zfh-1 and zfh-2 suggest that both genes may be involved in Drosophila neurogenesis and that zfh-1 may have additional functions in mesoderm development...
  21. ncbi The Drosophila zfh-1 and zfh-2 genes encode novel proteins containing both zinc-finger and homeodomain motifs
    M E Fortini
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Mech Dev 34:113-22. 1991
    ..The novel arrangement of interspersed homeodomain and zinc-finger motifs in the primary sequences of the zfh-1 and zfh-2 gene products may signify an unusual mechanism of transcriptional regulation by these proteins...
  22. ncbi Signal transduction pathway initiated by activation of the sevenless tyrosine kinase receptor
    M A Simon
    Howard Hughes Medical Institute, Department of Molecular and Cell Biology, University of California, Berkeley 94720
    Cold Spring Harb Symp Quant Biol 57:375-80. 1992
  23. ncbi Signalling by the sevenless protein tyrosine kinase is mimicked by Ras1 activation
    M E Fortini
    Howard Hughes Medical Institute, University of California, Berkeley 94720
    Nature 355:559-61. 1992
    ..Similar activation of the Drosophila Ras2 protein does not produce these effects, demonstrating Ras protein specificity...