Donald Forthal

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells
    Sandeep Gupta
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, California, United States of America
    PLoS Pathog 9:e1003776. 2013
  2. ncbi request reprint Antibody-dependent enhancement and the risk of HIV infection
    Andrea Gorlani
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, 3044 Hewitt Hall, UC Irvine, Irvine, CA 92697, USA
    Curr HIV Res 11:421-6. 2013
  3. pmc Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Retrovirology 9:57. 2012
  4. pmc Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92967, USA
    J Acquir Immune Defic Syndr 63:31-3. 2013
  5. pmc Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
    Blood 120:2836-42. 2012
  6. pmc In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds
    Donald N Forthal
    Department of Medicine Infectious Diseases, University of California, Irvine School of Medicine, 3044 Hewitt Hall, Irvine, CA 92697, USA
    Int J Antimicrob Agents 40:354-60. 2012
  7. pmc Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses
    Dawnnica Eastman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Virol J 5:90. 2008
  8. pmc Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, California, USA
    Virol J 3:22. 2006
  9. ncbi request reprint Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine, CA 92697, USA
    J Immunol 178:6596-603. 2007
  10. ncbi request reprint Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
    J Immunol 185:6876-82. 2010

Research Grants

Collaborators

Detail Information

Publications29

  1. pmc The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells
    Sandeep Gupta
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, California, United States of America
    PLoS Pathog 9:e1003776. 2013
    ..Acidity and Env-specific IgG enhance transcytosis of virus across epithelial cells via FcRn and could facilitate translocation of virus to susceptible target cells following sexual exposure. ..
  2. ncbi request reprint Antibody-dependent enhancement and the risk of HIV infection
    Andrea Gorlani
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, 3044 Hewitt Hall, UC Irvine, Irvine, CA 92697, USA
    Curr HIV Res 11:421-6. 2013
    ....
  3. pmc Prolonged tenofovir treatment of macaques infected with K65R reverse transcriptase mutants of SIV results in the development of antiviral immune responses that control virus replication after drug withdrawal
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, CA 95616, USA
    Retrovirology 9:57. 2012
    ..We report here follow-up data on 5 such animals that received tenofovir for 8 to 14 years...
  4. pmc Antibody-dependent cell-mediated virus inhibition antibody activity does not correlate with risk of HIV-1 superinfection
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92967, USA
    J Acquir Immune Defic Syndr 63:31-3. 2013
    ..We found no association between plasma ADCVI activity and superinfection status. ADCVI antibody activity against heterologous virus elicited by the original infection may not contribute to preventing a superinfecting HIV-1...
  5. pmc Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccination
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
    Blood 120:2836-42. 2012
    ..Our results generate the hypothesis that recombinant gp120 vaccine may have increased the likelihood of acquiring HIV infection in individuals with the VV genotype (present in ~ 10% of the population) at low behavioral risk of infection...
  6. pmc In vitro anti-HIV-1 activity of salicylidene acylhydrazide compounds
    Donald N Forthal
    Department of Medicine Infectious Diseases, University of California, Irvine School of Medicine, 3044 Hewitt Hall, Irvine, CA 92697, USA
    Int J Antimicrob Agents 40:354-60. 2012
    ..The activity of these compounds against other sexually transmitted pathogens makes them potential candidates to formulate for use as a broad-spectrum topical genital microbicide...
  7. pmc Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responses
    Dawnnica Eastman
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
    Virol J 5:90. 2008
    ..To begin to address this, we analyzed the envelope sequence variation of viruses that evolved in animals infected with variants of SIVMne that had been cloned from an index animal at different stages of infection...
  8. pmc Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11
    Koen K A Van Rompay
    California National Primate Research Center, University of California, Davis, California, USA
    Virol J 3:22. 2006
    ..Thus, CD8+ cell-mediated immune responses play an important role in controlling SIVmac1A11 replication during acute viremia...
  9. ncbi request reprint Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rate
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine, CA 92697, USA
    J Immunol 178:6596-603. 2007
    ..However, such activity requires the presence of FcR-bearing effector cells. Our results provide further evidence that ADCVI may play a role in preventing HIV infection...
  10. ncbi request reprint Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
    J Immunol 185:6876-82. 2010
    ..Such alterations may result in better immunotherapeutic reagents. Moreover, biasing vaccine-induced immune responses toward optimal Fc glycosylation patterns could result in improved vaccine efficacy...
  11. doi request reprint IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylation
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, USA
    AIDS 25:2099-104. 2011
    ..To determine the effect of IgG2 opsonization on internalization of HIV-1 virus-like particles (VLPs) by monocytes and to determine the effect of gp120 glycosylation on IgG subclass binding...
  12. ncbi request reprint FcgammaRIIa genotype predicts progression of HIV infection
    Donald N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
    J Immunol 179:7916-23. 2007
    ..These results demonstrate the importance of FcgammaRs in AIDS pathogenesis and point toward a critical role for interactions between FcgammaRs and immune complexes in disease progression...
  13. pmc Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cells
    Donald N Forthal
    Department of Medicine, Division of Infectious Diseases, School of Medicine, University of California Irvine, Irvine, CA 92697 4028, USA
    J Virol 80:9217-25. 2006
    ..Finally, our data underscore the potential importance of Fc-Fc receptor interactions in mediating biological activities of antibody...
  14. ncbi request reprint In vitro reduction of virus infectivity by antibody-dependent cell-mediated immunity
    D N Forthal
    Department of Medicine, University of California, Irvine College of Medicine, USA
    J Immunol Methods 220:129-38. 1998
    ..Finally, arming cytokine-activated effector cells with measles-seropositive serum also reduced virus infectivity. This novel assay provides an important tool for evaluating the anti-viral effects mediated by antibody and effector cells...
  15. pmc Interactions between natural killer cells and antibody Fc result in enhanced antibody neutralization of human immunodeficiency virus type 1
    Donald N Forthal
    Department of Medicine, Division of Infectious Diseases, University of California, Irvine, School of Medicine, Route 81, 101 City Dr, Orange, CA 92868, USA
    J Virol 79:2042-9. 2005
    ..Since FcgammaR-bearing cells are always present in vivo, FcgammaR-mediated antibody function may play a role in the ability of antibody to control lentivirus infection...
  16. ncbi request reprint Antibody inhibition of cytomegalovirus: the role of natural killer and macrophage effector cells
    D N Forthal
    Division of Infectious Diseases, University of California, Irvine College of Medicine, Orange 92868, USA
    Transpl Infect Dis 3:31-4. 2001
    ..Antibody-dependent, effector cell-mediated functions may underlie the ability of CytoGam to prevent or modulate CMV infection in vivo...
  17. pmc Antibody from patients with acute human immunodeficiency virus (HIV) infection inhibits primary strains of HIV type 1 in the presence of natural-killer effector cells
    D N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine College of Medicine, Irvine, California, USA
    J Virol 75:6953-61. 2001
    ..HIV-1-specific antibody may be an important contributor to the early control of HIV viremia...
  18. ncbi request reprint Relationship between antibody-dependent cellular cytotoxicity, plasma HIV type 1 RNA, and CD4+ lymphocyte count
    D N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine College of Medicine, Orange, California 92868, USA
    AIDS Res Hum Retroviruses 17:553-61. 2001
    ..In a novel assay, ADCC reduced virus yield from CD4+ lymphocytes infected with a primary HIV isolate. ADCC may contribute to control of viremia, and CD4+ lymphocytes likely play a role in ADCC effector and antibody functions...
  19. ncbi request reprint Antibody-dependent cellular cytotoxicity independently predicts survival in severely immunocompromised human immunodeficiency virus-infected patients
    D N Forthal
    Division of Infectious Diseases, Department of Medicine, University of California, Irvine, Orange, CA 92868, USA
    J Infect Dis 180:1338-41. 1999
    ..18; 95% confidence interval, 0.05-0.75). ADCC may be an important determinant of disease progression independently of anti-retroviral therapy, CD4 cell count, and HIV RNA...
  20. pmc Fc receptor-mediated antiviral antibodies
    Donald N Forthal
    Department of Medicine, Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California, USA
    Curr Opin HIV AIDS 4:388-93. 2009
    ..These activities include Fcgamma receptor-mediated inhibition and neutralization of HIV on antigen-presenting cells, antibody-dependent cellular cytotoxicity, and antibody-dependent cell-mediated virus inhibition (ADCVI)...
  21. pmc Antiviral antibodies are necessary for control of simian immunodeficiency virus replication
    Christopher J Miller
    Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
    J Virol 81:5024-35. 2007
    ..0001). These observations indicate that antiviral antibody responses are critical in maintaining effective control of SIV replication at early time points postinfection...
  22. ncbi request reprint The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysis
    Richard H Haubrich
    University of California at San Diego, San Diego, California, USA
    AIDS 16:F33-40. 2002
    ..To evaluate the clinical significance of hypersusceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI)...
  23. ncbi request reprint A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575
    Richard H Haubrich
    University of California, San Diego, California, USA
    AIDS 19:295-302. 2005
    ..To assess phenotype susceptibility testing (PHENO) with standard of care (SOC) to improve antiretroviral therapy...
  24. pmc Chemically Modified Peptides Based on the Membrane-Proximal External Region of the HIV-1 Envelope Induce High-Titer, Epitope-Specific Nonneutralizing Antibodies in Rabbits
    Vincent J Venditto
    Departments of Bioengineering and Therapeutic Sciences, School of Pharmacy, University of California, San Francisco, San Francisco, California, USA
    Clin Vaccine Immunol 21:1086-93. 2014
    ....
  25. ncbi request reprint CD8+ T-cell mediated tumor protection by Pseudomonas exotoxin fused to ovalbumin in C57BL/6 mice
    Juan C Becerra
    Department of Surgery, Medical Center, University of California Irvine, 101 The City Drive, Orange, CA 92868, USA
    Surgery 133:404-10. 2003
    ..We investigated whether PE could be used in vivo to deliver CD8+ T-cell epitopes to the MHC-class I antigen presentation pathway to trigger a specific cytotoxic T-lymphocyte (CTL) response...
  26. ncbi request reprint Fc receptor but not complement binding is important in antibody protection against HIV
    Ann J Hessell
    Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Nature 449:101-4. 2007
    ..Overall, the data suggest the potential importance of activity against both infected cells and free virus for effective protection against HIV...
  27. ncbi request reprint Evaluation of passively transferred, nonneutralizing antibody-dependent cellular cytotoxicity-mediating IgG in protection of neonatal rhesus macaques against oral SIVmac251 challenge
    Ruth H Florese
    Vaccine Branch, National Cancer Institute, Bethesda, MD 20892 5065, USA
    J Immunol 177:4028-36. 2006
    ..Future studies should explore additional challenge routes in juvenile macaques using higher amounts of potent IgG preparations...
  28. ncbi request reprint Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infection
    Neil M Flynn
    University of California at Davis Medical Center, USA
    J Infect Dis 191:654-65. 2005
    ..A vaccine is needed to prevent human immunodeficiency virus type 1 (HIV-1) infection...
  29. ncbi request reprint The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patients
    Julie M Yasuda
    San Diego State University, San Diego, Calif, USA
    Antivir Ther 9:753-61. 2004
    ..The objective of this analysis was to assess the independent predictive value of protease inhibitor (PI) concentrations as a supplement to self-report as markers of medication adherence...

Research Grants9

  1. Novel Biological Activities of Anti-Viral Antibody
    Donald Forthal; Fiscal Year: 2002
    ..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
  2. Novel Biological Activities of Anti-Viral Antibody
    Donald Forthal; Fiscal Year: 2003
    ..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
  3. Novel Biological Activities of Anti-Viral Antibody
    Donald Forthal; Fiscal Year: 2004
    ..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
  4. Novel Biological Activities of Anti-Viral Antibody
    Donald Forthal; Fiscal Year: 2005
    ..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
  5. Novel Biological Activities of Anti-Viral Antibody
    Donald Forthal; Fiscal Year: 2006
    ..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
  6. Fcy Receptor Polymorphisms and Risk of HIV Infection
    Donald Forthal; Fiscal Year: 2007
    ..Information gained from this research will be crucial to understanding early events in HIV infection and provide direction for the development of effective HIV vaccines. ..
  7. Broadly Reactive Antibodies Against Chimeric Virus-Host Antigens
    Donald N Forthal; Fiscal Year: 2010
    ..We propose an exceptionally novel approach to discover such immunogens. If successful, this research may lead directly to a vaccine that prevents HIV infection. ..