Research Topics
Genomes and Genes | Donald ForthalSummaryAffiliation: University of California Country: USA Publications
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Publications
Association of Fcγ receptor IIIa genotype with the rate of HIV infection after gp120 vaccinationDonald N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
Blood 120:2836-42. 2012..Our results generate the hypothesis that recombinant gp120 vaccine may have increased the likelihood of acquiring HIV infection in individuals with the VV genotype (present in ~ 10% of the population) at low behavioral risk of infection...- In vitro anti-HIV-1 activity of salicylidene acylhydrazide compoundsDonald N Forthal
Department of Medicine Infectious Diseases, University of California, Irvine School of Medicine, 3044 Hewitt Hall, Irvine, CA 92697, USA
Int J Antimicrob Agents 40:354-60. 2012..The activity of these compounds against other sexually transmitted pathogens makes them potential candidates to formulate for use as a broad-spectrum topical genital microbicide... - Heavily glycosylated, highly fit SIVMne variants continue to diversify and undergo selection after transmission to a new host and they elicit early antibody dependent cellular responses but delayed neutralizing antibody responsesDawnnica Eastman
Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, USA
Virol J 5:90. 2008..To begin to address this, we analyzed the envelope sequence variation of viruses that evolved in animals infected with variants of SIVMne that had been cloned from an index animal at different stages of infection... - Role of CD8+ cells in controlling replication of nonpathogenic Simian Immunodeficiency Virus SIVmac1A11Koen K A Van Rompay
California National Primate Research Center, University of California, Davis, California, USA
Virol J 3:22. 2006..Thus, CD8+ cell-mediated immune responses play an important role in controlling SIVmac1A11 replication during acute viremia... 
Fc-glycosylation influences Fcγ receptor binding and cell-mediated anti-HIV activity of monoclonal antibody 2G12Donald N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
J Immunol 185:6876-82. 2010..Such alterations may result in better immunotherapeutic reagents. Moreover, biasing vaccine-induced immune responses toward optimal Fc glycosylation patterns could result in improved vaccine efficacy...- Fc receptor-mediated antiviral antibodiesDonald N Forthal
Department of Medicine, Division of Infectious Diseases, University of California, Irvine School of Medicine, Irvine, California, USA
Curr Opin HIV AIDS 4:388-93. 2009..These activities include Fcgamma receptor-mediated inhibition and neutralization of HIV on antigen-presenting cells, antibody-dependent cellular cytotoxicity, and antibody-dependent cell-mediated virus inhibition (ADCVI)... - IgG2 inhibits HIV-1 internalization by monocytes, and IgG subclass binding is affected by gp120 glycosylationDonald N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, USA
AIDS 25:2099-104. 2011..To determine the effect of IgG2 opsonization on internalization of HIV-1 virus-like particles (VLPs) by monocytes and to determine the effect of gp120 glycosylation on IgG subclass binding... 
FcgammaRIIa genotype predicts progression of HIV infectionDonald N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine School of Medicine, Irvine, CA 92697, USA
J Immunol 179:7916-23. 2007..These results demonstrate the importance of FcgammaRs in AIDS pathogenesis and point toward a critical role for interactions between FcgammaRs and immune complexes in disease progression...- Recombinant gp120 vaccine-induced antibodies inhibit clinical strains of HIV-1 in the presence of Fc receptor-bearing effector cells and correlate inversely with HIV infection rateDonald N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine, CA 92697, USA
J Immunol 178:6596-603. 2007..However, such activity requires the presence of FcR-bearing effector cells. Our results provide further evidence that ADCVI may play a role in preventing HIV infection... - Rhesus macaque polyclonal and monoclonal antibodies inhibit simian immunodeficiency virus in the presence of human or autologous rhesus effector cellsDonald N Forthal
Department of Medicine, Division of Infectious Diseases, School of Medicine, University of California Irvine, Irvine, CA 92697 4028, USA
J Virol 80:9217-25. 2006..Finally, our data underscore the potential importance of Fc-Fc receptor interactions in mediating biological activities of antibody... - In vitro reduction of virus infectivity by antibody-dependent cell-mediated immunityD N Forthal
Department of Medicine, University of California, Irvine College of Medicine, USA
J Immunol Methods 220:129-38. 1998..Finally, arming cytokine-activated effector cells with measles-seropositive serum also reduced virus infectivity. This novel assay provides an important tool for evaluating the anti-viral effects mediated by antibody and effector cells... - Antibody-dependent cellular cytotoxicity independently predicts survival in severely immunocompromised human immunodeficiency virus-infected patientsD N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine, Orange, CA 92868, USA
J Infect Dis 180:1338-41. 1999..18; 95% confidence interval, 0.05-0.75). ADCC may be an important determinant of disease progression independently of anti-retroviral therapy, CD4 cell count, and HIV RNA... - Interactions between natural killer cells and antibody Fc result in enhanced antibody neutralization of human immunodeficiency virus type 1Donald N Forthal
Department of Medicine, Division of Infectious Diseases, University of California, Irvine, School of Medicine, Route 81, 101 City Dr, Orange, CA 92868, USA
J Virol 79:2042-9. 2005..Since FcgammaR-bearing cells are always present in vivo, FcgammaR-mediated antibody function may play a role in the ability of antibody to control lentivirus infection... - Relationship between antibody-dependent cellular cytotoxicity, plasma HIV type 1 RNA, and CD4+ lymphocyte countD N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine College of Medicine, Orange, California 92868, USA
AIDS Res Hum Retroviruses 17:553-61. 2001..In a novel assay, ADCC reduced virus yield from CD4+ lymphocytes infected with a primary HIV isolate. ADCC may contribute to control of viremia, and CD4+ lymphocytes likely play a role in ADCC effector and antibody functions... - Antibody from patients with acute human immunodeficiency virus (HIV) infection inhibits primary strains of HIV type 1 in the presence of natural-killer effector cellsD N Forthal
Division of Infectious Diseases, Department of Medicine, University of California, Irvine College of Medicine, Irvine, California, USA
J Virol 75:6953-61. 2001..HIV-1-specific antibody may be an important contributor to the early control of HIV viremia... - Antibody inhibition of cytomegalovirus: the role of natural killer and macrophage effector cellsD N Forthal
Division of Infectious Diseases, University of California, Irvine College of Medicine, Orange 92868, USA
Transpl Infect Dis 3:31-4. 2001..Antibody-dependent, effector cell-mediated functions may underlie the ability of CytoGam to prevent or modulate CMV infection in vivo... - Antiviral antibodies are necessary for control of simian immunodeficiency virus replicationChristopher J Miller
Center for Comparative Medicine, California National Primate Research Center, University of California, Davis, Davis, California 95616, USA
J Virol 81:5024-35. 2007..0001). These observations indicate that antiviral antibody responses are critical in maintaining effective control of SIV replication at early time points postinfection... - The clinical relevance of non-nucleoside reverse transcriptase inhibitor hypersusceptibility: a prospective cohort analysisRichard H Haubrich
University of California at San Diego, San Diego, California, USA
AIDS 16:F33-40. 2002..1). CONCLUSION: NNRTI hypersusceptibility occurred in more than 20% of nucleoside-experienced patients and was associated with greater reduction of HIV RNA and increase in CD4 cells... - A randomized, prospective study of phenotype susceptibility testing versus standard of care to manage antiretroviral therapy: CCTG 575Richard H Haubrich
University of California, San Diego, California, USA
AIDS 19:295-302. 2005..To assess phenotype susceptibility testing (PHENO) with standard of care (SOC) to improve antiretroviral therapy... - CD8+ T-cell mediated tumor protection by Pseudomonas exotoxin fused to ovalbumin in C57BL/6 miceJuan C Becerra
Department of Surgery, Medical Center, University of California-Irvine, 101 The City Drive, Orange, CA 92868, USA
Surgery 133:404-10. 2003..CONCLUSIONS: Our results indicate that PE(D) may be used as a vehicle to stimulate a protective CTL response to heterologous antigen in vivo... - Fc receptor but not complement binding is important in antibody protection against HIVAnn J Hessell
Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
Nature 449:101-4. 2007..Overall, the data suggest the potential importance of activity against both infected cells and free virus for effective protection against HIV... - The correlation between plasma concentrations of protease inhibitors, medication adherence and virological outcome in HIV-infected patientsJulie M Yasuda
San Diego State University, San Diego, Calif, USA
Antivir Ther 9:753-61. 2004..CONCLUSIONS: Repeated, random PI concentration values are independently predictive of virological response and may add to self-report of adherence in understanding the response to ART... - Evaluation of passively transferred, nonneutralizing antibody-dependent cellular cytotoxicity-mediating IgG in protection of neonatal rhesus macaques against oral SIVmac251 challengeRuth H Florese
Vaccine Branch, National Cancer Institute, Bethesda, MD 20892-5065, USA
J Immunol 177:4028-36. 2006..Future studies should explore additional challenge routes in juvenile macaques using higher amounts of potent IgG preparations... - Placebo-controlled phase 3 trial of a recombinant glycoprotein 120 vaccine to prevent HIV-1 infectionNeil M Flynn
University of California at Davis Medical Center, USA
J Infect Dis 191:654-65. 2005..10, adjusted for multiple subgroup comparisons). CONCLUSIONS: There was no overall protective effect. The efficacy trends in subgroups may provide clues for the development of effective immunization approaches...
Research Grants
- Novel Biological Activities of Anti-Viral AntibodyDonald Forthal; Fiscal Year: 2006..This project may provide crucial insights for guiding the development of vaccines, immunoprophylaxis and immunotherapy. ..
- Fcy Receptor Polymorphisms and Risk of HIV InfectionDonald Forthal; Fiscal Year: 2007..Information gained from this research will be crucial to understanding early events in HIV infection and provide direction for the development of effective HIV vaccines. ..
- Broadly Reactive Antibodies Against Chimeric Virus-Host AntigensDonald N Forthal; Fiscal Year: 2010..We propose an exceptionally novel approach to discover such immunogens. If successful, this research may lead directly to a vaccine that prevents HIV infection. ..