M S Forman

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi Genotype-phenotype correlations in FTDP-17: does form follow function?
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 187:229-34. 2004
  2. ncbi 'Unfolding' pathways in neurodegenerative disease
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3600 Spruce Street, Maloney Building, 3rd Floor, Philadelphia, PA 19104, USA
    Trends Neurosci 26:407-10. 2003
  3. ncbi Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis
    M S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd, 605B Stellar Chance Building, Philadelphia, PA 19104, USA
    Neurology 68:757-63. 2007
  4. ncbi Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations
    Mark S Forman
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropathol Exp Neurol 65:571-81. 2006
  5. ncbi Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 25:3539-50. 2005
  6. ncbi Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
    Bin Zhang
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurosci 24:4657-67. 2004
  7. ncbi Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model
    J M Abrahams
    Department of Neurosurgery, Institute for Medicine and Engineering, The Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    AJNR Am J Neuroradiol 22:1410-7. 2001
  8. ncbi Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies
    Makoto Higuchi
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 25:9434-43. 2005
  9. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
  10. ncbi Initiation and synergistic fibrillization of tau and alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine
    Science 300:636-40. 2003

Research Grants

  1. Mechanisms of Tau-Based Neurodegeneration
    Mark Forman; Fiscal Year: 2005

Collaborators

Detail Information

Publications47

  1. ncbi Genotype-phenotype correlations in FTDP-17: does form follow function?
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 187:229-34. 2004
  2. ncbi 'Unfolding' pathways in neurodegenerative disease
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3600 Spruce Street, Maloney Building, 3rd Floor, Philadelphia, PA 19104, USA
    Trends Neurosci 26:407-10. 2003
    ....
  3. ncbi Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis
    M S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd, 605B Stellar Chance Building, Philadelphia, PA 19104, USA
    Neurology 68:757-63. 2007
    ..Mild cognitive impairment, hypothesized to be prodromal Alzheimer disease (AD), shows abundant senile plaques and neurofibrillary tangles, but its biochemical correlates remain undefined...
  4. ncbi Novel ubiquitin neuropathology in frontotemporal dementia with valosin-containing protein gene mutations
    Mark S Forman
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, 19104, USA
    J Neuropathol Exp Neurol 65:571-81. 2006
    ..Our findings are consistent with the hypothesis that the pathology associated with VCP gene mutations is the result of impairment of ubiquitin-based degradation pathways...
  5. ncbi Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 25:3539-50. 2005
    ..Thus, these Tg mice recapitulate key features of astrocytic pathology observed in human tauopathies and demonstrate functional consequences of this pathology including neuron degeneration in the absence of neuronal tau inclusions...
  6. ncbi Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
    Bin Zhang
    The Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, and Institute on Aging, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    J Neurosci 24:4657-67. 2004
    ....
  7. ncbi Delivery of human vascular endothelial growth factor with platinum coils enhances wall thickening and coil impregnation in a rat aneurysm model
    J M Abrahams
    Department of Neurosurgery, Institute for Medicine and Engineering, The Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    AJNR Am J Neuroradiol 22:1410-7. 2001
    ..This is the first study to hypothesize that rhVEGF may be useful as a surface modification to GDCs for enhancing their therapeutic effects in the treatment of cerebral aneurysms...
  8. ncbi Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies
    Makoto Higuchi
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, Philadelphia, Pennsylvania 19104
    J Neurosci 25:9434-43. 2005
    ..We suggest that similar defects may also occur in sporadic and hereditary human tauopathies with OLG tau pathologies...
  9. pmc Frontotemporal dementia: clinicopathological correlations
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Ann Neurol 59:952-62. 2006
    ..This study assessed whether specific clinical features predict the underlying pathology...
  10. ncbi Initiation and synergistic fibrillization of tau and alpha-synuclein
    Benoit I Giasson
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine
    Science 300:636-40. 2003
    ..This suggests that interactions between alpha-syn and tau can promote their fibrillization and drive the formation of pathological inclusions in human neurodegenerative diseases...
  11. ncbi Cognitive and motor assessment in autopsy-proven corticobasal degeneration
    R Murray
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Neurology 68:1274-83. 2007
    ..To investigate the clinical features of autopsy-proven corticobasal degeneration (CBD)...
  12. pmc Longitudinal decline in autopsy-defined frontotemporal lobar degeneration
    M Grossman
    Department of Neurology, University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Neurology 70:2036-45. 2008
    ..The natural history of patients with pathologically proven frontotemporal lobar degeneration (FTLD) is important from clinical and biologic perspectives, but is not well documented quantitatively...
  13. ncbi Impaired glutamate transport in a mouse model of tau pathology in astrocytes
    Deepa V Dabir
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Children s Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 26:644-54. 2006
    ..Thus, these Tg mice recapitulate features of astrocytic pathology observed in tauopathies and implicate a role for altered astrocyte function in the pathogenesis of these disorders...
  14. ncbi Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy
    Jake B Guinto
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, 422 Curie Blvd, 605B Stellar Chance Building, Philadelphia, PA, 19104 6140, USA
    Acta Neuropathol 114:55-61. 2007
    ..In this report, we review current literature on IBMPFD, focusing on the pathology of the disease and the biology of VCP with respect to IBMPFD...
  15. ncbi Hemangiopericytoma of the third ventricle. Case report
    J M Abrahams
    Department of Neurosurgery, The Hospital of the University of Pennsylvania, Philadelphia 19104, USA
    J Neurosurg 90:359-62. 1999
    ..These lesions have a propensity to recur and metastasize in the central nervous system and periphery, thus making the goal of treatment a complete surgical resection followed by postoperative radiation therapy in most cases...
  16. ncbi TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions
    Murray Grossman
    Department of Neurology, University of Pennsylvania School of Medicine, 2 Gibson, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1449-54. 2007
    ..TDP-43 is a major ubiquitinated disease protein in the pathologic condition of frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U)...
  17. pmc TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97
    Gillian P Ritson
    Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 30:7729-39. 2010
    ..We suggest that these findings are likely relevant to the pathogenic mechanism of a broad array of TDP-43 proteinopathies, including frontotemporal lobar degeneration and amyotrophic lateral sclerosis...
  18. ncbi Fatal subacute cytomegalovirus encephalitis associated with hypogammaglobulinemia and thymoma
    Brett L Cucchiara
    Department of Neurology, University of Pennsylvania Medical Center, Philadelphia 19104, USA
    Mayo Clin Proc 78:223-7. 2003
    ..The possibility of a cytomegalovirus infection should be considered early in the evaluation of patients with Good syndrome if appropriate clinical symptoms are present...
  19. ncbi Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia
    Murray Grossman
    Department of Neurology, 2 Gibson, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1601-9. 2007
    ..Clinical-pathologic studies are crucial to understanding brain-behavior relations and improving diagnostic accuracy in neurodegenerative diseases...
  20. ncbi Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual
    Vivianna M Van Deerlin
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research and Institute on Aging, University of Pennsylvania, 3600 Spruce St, 3 Maloney Bldg, Philadelphia, PA, 19104, USA
    Acta Neuropathol 113:471-9. 2007
    ..This is also the first reported case of any MAPT mutation in an individual of African American ethnicity...
  21. pmc Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology
    Deepa V Dabir
    Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 4283, USA
    Am J Pathol 164:155-66. 2004
    ....
  22. ncbi Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons
    B I Giasson
    Center for Neurodegenerative Disease Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Exp Neurol 172:354-62. 2001
    ....
  23. pmc Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam
    Mark S Forman
    Center for Neurodegenerative Disease Research and Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 160:1725-31. 2002
    ..Furthermore, in PDC, tau and alpha-synuclein pathology occurs independent of beta-amyloid deposition in amygdala thereby implicating the aggregation of these molecules in the severe neurodegeneration frequently observed in this location...
  24. pmc Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies
    Kunihiro Uryu
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Neuropathol Exp Neurol 67:555-64. 2008
    ..These findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis...
  25. ncbi Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam
    John Q Trojanowski
    The Center for Neurodegenerative Disease Research, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Exp Neurol 176:1-11. 2002
    ..Thus, tau Tg mice recapitulate key phenotypic features of ALS/PDC neuropathology in an ethnic minority on Guam, and these animal models provide new opportunities to discover novel therapies for this and related tauopathies...
  26. pmc Signature tau neuropathology in gray and white matter of corticobasal degeneration
    Mark S Forman
    Center for Neurodegenerative Disease Research and the Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Pathol 160:2045-53. 2002
    ..Thus, although clinically heterogeneous, CBD is a distinct lobar and basal ganglionic tauopathy with selective aggregation of 4R-tau...
  27. pmc Multiple pathologies in a patient with a progressive neurodegenerative syndrome
    T W Liang
    Neurology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    J Neurol Neurosurg Psychiatry 76:252-5. 2005
    ..This case raises the possibility that three distinct neuropathological diagnoses share a common aetiology...
  28. ncbi Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
    Mark S Forman
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, 36th and Spruce Streets, Maloney Building, 3rd Floor, Philadelphia, Pennsylvania 19104 4283, USA
    Nat Med 10:1055-63. 2004
    ....
  29. ncbi Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations
    Vivianna M Van Deerlin
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 4283, USA
    Arch Neurol 64:1148-53. 2007
    ..Patients with frontotemporal dementia due to mutation of progranulin may have a distinct phenotype...
  30. pmc TDP-43: a novel neurodegenerative proteinopathy
    Mark S Forman
    Department of Pathology and Laboratory Medicine and Institute on Aging, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Curr Opin Neurobiol 17:548-55. 2007
    ..Thus, TDP-43 is the newest member of the growing list of neurodegenerative proteinopathies, but unique in that it lacks features of brain amyloidosis...
  31. ncbi Genotypically defined lissencephalies show distinct pathologies
    Mark S Forman
    Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA, and Department of Neurology, Radcliffe Infirmary, Oxford, UK
    J Neuropathol Exp Neurol 64:847-57. 2005
    ..Based on these data, a new classification for lissencephaly is proposed that incorporates both pathologic and genetic findings...
  32. ncbi July 2000: A 70 year old with rigidity, decreased ocular movements, and dementia
    K M Fung
    Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, USA
    Brain Pathol 11:119-20, 125. 2001
    ..He died 18 months later and autopsy showed the classic neuropathological findings of typical Progressive supranuclear palsy, including tau-positive glial inclusions...
  33. ncbi Biodegradable polyglycolide endovascular coils promote wall thickening and drug delivery in a rat aneurysm model
    J M Abrahams
    Department of Neurosurgery, Silverstein 5, The Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    Neurosurgery 49:1187-93; discussion 1193-5. 2001
    ..BPCs were also tested for use in local drug delivery...
  34. ncbi Symptomatic lateral ventricular ependymal cysts: criteria for distinguishing these rare cysts from other symptomatic cysts of the ventricles: case report
    J A Boockvar
    Department of Neurosurgery, Hospital of the University of Pennsylvania, Philadelphia Veterans Administration, University of Pennsylvania School of Medicine, 19104, USA
    Neurosurgery 46:1229-32; discussion 1232-3. 2000
    ..Two previous cases of this lesion have been reported in the literature. We report a third case and provide radiological and histopathological criteria for differentiating this entity from common intracranial cysts...
  35. ncbi Co-occurrence of Parkinson's disease with progressive supranuclear palsy
    Alexander R Judkins
    Division of Neuropathology, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Acta Neuropathol 103:526-30. 2002
    ..This case provides strategies for the reliable molecular validation of concomitant PD and PSP, and demonstrates the utility of these techniques in patients with atypical clinical presentations...
  36. ncbi Subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive multiple system atrophy. Case report
    Kelvin L Chou
    Parkinson s Disease and Movement Disorders Center and Department of Neurosurgery, Penn Neurological Institute at Pennsylvania Hospital, Philadelphia, Pennsylvania 19107, USA
    J Neurosurg 100:553-6. 2004
    ....
  37. ncbi Bilateral subthalamic nucleus deep brain stimulation for advanced PD: correlation of intraoperative MER and postoperative MRI with neuropathological findings
    George J Counelis
    Department of Neurosurgery, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Mov Disord 18:1062-5. 2003
    ....
  38. ncbi Nosology of Parkinson's disease: looking for the way out of a quagmire
    Mark S Forman
    Department of Pathology and Laboratory Medicine, Institute on Aging, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuron 47:479-82. 2005
    ....
  39. pmc Role for Akt3/protein kinase Bgamma in attainment of normal brain size
    Rachael M Easton
    Department of Medicine, University of Pennsylvania School of Medicine, Clinical Research Building 322, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 25:1869-78. 2005
    ..Finally, mammalian target of rapamycin signaling is attenuated in the brains of Akt3-/- but not Akt1-/- mice, suggesting that differential regulation of this pathway contributes to an isoform-specific regulation of cell growth...
  40. pmc Clinical studies in familial VCP myopathy associated with Paget disease of bone and frontotemporal dementia
    Virginia E Kimonis
    Division of Genetics and Metabolism, Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Am J Med Genet A 146:745-57. 2008
    ..The presence of PDB in 28 (57%) individuals suggests that measuring serum alkaline phosphatase (ALP) activity may be a useful screen for IBMPFD in patients with myopathy...
  41. pmc TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions
    Nigel J Cairns
    MRCPath, Department of Pathology and Immunology, Washington University School of Medicine, Campus Box 8118, St Louis, MO 63110, USA
    Am J Pathol 171:227-40. 2007
    ....
  42. ncbi Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
    Ian R A Mackenzie
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 61:427-34. 2007
    ..We recently identified TDP-43 as the major pathological protein in sporadic ALS. In this study, we investigated TDP-43 in a larger series of ALS cases (n = 111), including familial cases with and without SOD1 mutations...
  43. ncbi 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions
    Kirk C Wilhelmsen
    Ernest Gallo Clinic and Research Center, Emeryville, CA, USA
    Arch Neurol 61:398-406. 2004
    ..The most common familial form of this condition is caused by mutations in the microtubule-associated protein tau gene (MAP tau) and is associated with neuronal or glial tau inclusions...
  44. ncbi Frontotemporal lobar degeneration with motor neuron disease: a clinical and pathological spectrum
    Christopher M Clark
    Arch Neurol 63:489-90. 2006
  45. ncbi Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid
    Olaf Goldbaum
    University of Oldenburg, Department of Biology, Molecular Neurobiology, D 26111 Oldenburg, Germany
    J Neurosci 23:8872-80. 2003
    ....
  46. ncbi The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts
    Amanda J Myers
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, 35 Convent Drive, Bethesda, MD 20892 3707, USA
    Neurobiol Dis 25:561-70. 2007
    ..We discuss these findings both in terms of the problems facing the dissection of the etiologies of complex traits and the pathogenesis of the tauopathies...
  47. ncbi TDP-43 in the ubiquitin pathology of frontotemporal dementia with VCP gene mutations
    Manuela Neumann
    Center for Neuropathology and Prion Research, Ludwig Maximilians University, Munich, Germany
    J Neuropathol Exp Neurol 66:152-7. 2007
    ..TDP-43 is a common pathologic substrate linking a variety of distinct patterns of FTLD-U pathology caused by different genetic alterations...

Research Grants1

  1. Mechanisms of Tau-Based Neurodegeneration
    Mark Forman; Fiscal Year: 2005
    ..This proposal will also facilitate my transition from a trainee to a fully independent experimental neuropathologist. ..