Nicholas K Foreman

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint A study of sequential high dose cyclophosphamide and high dose carboplatin with peripheral stem-cell rescue in resistant or recurrent pediatric brain tumors
    N K Foreman
    The Children s Hospital, Denver, and The University of Colorado, Health Sciences Center, Denver, Colorado 80218, USA
    J Neurooncol 71:181-7. 2005
  2. ncbi request reprint Gefitinib is effective against juvenile pilocytic astrocytoma in vitro
    Nicholas K Foreman
    University of Colorado at Denver and Health Sciences Center UCDHSC and The Children s Hospital, Denver, Colorado
    Pediatr Blood Cancer 47:293-8. 2006
  3. ncbi request reprint Molecular array analyses of 51 pediatric tumors shows overlap between malignant intracranial ectomesenchymoma and MPNST but not medulloblastoma or atypical teratoid rhabdoid tumor
    B K Kleinschmidt-Demasters
    University of Colorado at Denver and Health Science Center, 4200 East Ninth Avenue, B 216, Denver, CO 80262, USA
    Acta Neuropathol 113:695-703. 2007
  4. doi request reprint Radiation-induced glioblastoma multiforme in children treated for medulloblastoma with characteristics of both medulloblastoma and glioblastoma multiforme
    Jennifer R Madden
    Department of Neuro Oncology, The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Hematol Oncol 32:e272-8. 2010
  5. doi request reprint Claudin 6 is a positive marker for atypical teratoid/rhabdoid tumors
    Diane K Birks
    Department of Neurosurgery, Anschutz Medical Campus, University of Colorado at Denver, Aurora, Colorado, USA
    Brain Pathol 20:140-50. 2010
  6. pmc Clinical and molecular characteristics of congenital glioblastoma
    Margaret E Macy
    Department of Pediatrics, University of Colorado, Denver, CO, USA
    Neuro Oncol 14:931-41. 2012
  7. ncbi request reprint Predicting which children are at risk for ependymoma relapse
    Kristina Sowar
    University of Colorado at Denver and Health Sciences Center UCDHSC and Denver Children s Hospital, Denver, Colorado 80045, USA
    J Neurooncol 78:41-6. 2006
  8. doi request reprint PARP1 expression in pediatric central nervous system tumors
    Valerie N Barton
    Department of Pediatrics, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA
    Pediatr Blood Cancer 53:1227-30. 2009
  9. ncbi request reprint MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
    Andrew M Donson
    University of Colorado at Denver and Health Sciences Center and Denver Children s Hospital, Denver, Colorado, USA
    Pediatr Blood Cancer 48:403-7. 2007
  10. doi request reprint Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
    Diane K Birks
    Department of Neurosurgery, Anschutz Medical Campus, University of Colorado at Denver, Aurora, Colorado 80010, USA
    Pediatr Blood Cancer 60:1095-102. 2013

Collaborators

Detail Information

Publications27

  1. ncbi request reprint A study of sequential high dose cyclophosphamide and high dose carboplatin with peripheral stem-cell rescue in resistant or recurrent pediatric brain tumors
    N K Foreman
    The Children s Hospital, Denver, and The University of Colorado, Health Sciences Center, Denver, Colorado 80218, USA
    J Neurooncol 71:181-7. 2005
    ..To determine the maximum tolerated dose (MTD) of carboplatin with autologous hematopoietic stem-cell rescue, in children with poor-prognosis brain tumors...
  2. ncbi request reprint Gefitinib is effective against juvenile pilocytic astrocytoma in vitro
    Nicholas K Foreman
    University of Colorado at Denver and Health Sciences Center UCDHSC and The Children s Hospital, Denver, Colorado
    Pediatr Blood Cancer 47:293-8. 2006
    ..To explore the possibility for a novel therapeutic approach we measured the effect of the epidermal growth factor receptor (EGFR) small molecule tyrosine kinase inhibitor gefitinib on five JPA primary cell-cultures...
  3. ncbi request reprint Molecular array analyses of 51 pediatric tumors shows overlap between malignant intracranial ectomesenchymoma and MPNST but not medulloblastoma or atypical teratoid rhabdoid tumor
    B K Kleinschmidt-Demasters
    University of Colorado at Denver and Health Science Center, 4200 East Ninth Avenue, B 216, Denver, CO 80262, USA
    Acta Neuropathol 113:695-703. 2007
    ..This suggests a common stem cell origin or embryonic gene recapitulation for these tumors and provides novel insights into their underlying biology...
  4. doi request reprint Radiation-induced glioblastoma multiforme in children treated for medulloblastoma with characteristics of both medulloblastoma and glioblastoma multiforme
    Jennifer R Madden
    Department of Neuro Oncology, The Children s Hospital, Aurora, CO 80045, USA
    J Pediatr Hematol Oncol 32:e272-8. 2010
    ..We recommend biopsy for tissue confirmation and genetic expression profile to shed light on the etiology of radiation-induced neoplasms...
  5. doi request reprint Claudin 6 is a positive marker for atypical teratoid/rhabdoid tumors
    Diane K Birks
    Department of Neurosurgery, Anschutz Medical Campus, University of Colorado at Denver, Aurora, Colorado, USA
    Brain Pathol 20:140-50. 2010
    ..IHC staining results closely matched the level of mRNA expression detected by microarray. CLDN6 may be a useful positive marker to help further identify AT/RTs for diagnostic and treatment purposes...
  6. pmc Clinical and molecular characteristics of congenital glioblastoma
    Margaret E Macy
    Department of Pediatrics, University of Colorado, Denver, CO, USA
    Neuro Oncol 14:931-41. 2012
    ..Further study may determine whether identified gene expression differences contribute to the improved survival seen in these tumors...
  7. ncbi request reprint Predicting which children are at risk for ependymoma relapse
    Kristina Sowar
    University of Colorado at Denver and Health Sciences Center UCDHSC and Denver Children s Hospital, Denver, Colorado 80045, USA
    J Neurooncol 78:41-6. 2006
    ..In summary, gene expression profiling may be valuable, perhaps in combination with clinical findings identified in some studies, for identifying children at high risk for ependymoma relapse...
  8. doi request reprint PARP1 expression in pediatric central nervous system tumors
    Valerie N Barton
    Department of Pediatrics, Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA
    Pediatr Blood Cancer 53:1227-30. 2009
    ..Poly(ADP-ribose) polymerase-1 (PARP1) is a DNA repair protein that has been studied in a variety of malignancies and may interfere with therapy-induced DNA damage, however expression in pediatric CNS tumors is unknown...
  9. ncbi request reprint MGMT promoter methylation correlates with survival benefit and sensitivity to temozolomide in pediatric glioblastoma
    Andrew M Donson
    University of Colorado at Denver and Health Sciences Center and Denver Children s Hospital, Denver, Colorado, USA
    Pediatr Blood Cancer 48:403-7. 2007
    ..We explored MGMT promoter methylation in pediatric GBM and its relationship to survival and temozolomide sensitivity...
  10. doi request reprint Pediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
    Diane K Birks
    Department of Neurosurgery, Anschutz Medical Campus, University of Colorado at Denver, Aurora, Colorado 80010, USA
    Pediatr Blood Cancer 60:1095-102. 2013
    ..The aim of this study was to determine genes and biological process dysregulated in common to both AT/RTs and KRTs...
  11. pmc MicroRNA 218 acts as a tumor suppressor by targeting multiple cancer phenotype-associated genes in medulloblastoma
    Sujatha Venkataraman
    Department of Pediatrics, Children s Hospital Colorado, University of Colorado, Denver, Colorado 80045, USA
    J Biol Chem 288:1918-28. 2013
    ..Additional work further confirmed CDK6, RICTOR, and CTSB (cathepsin B) as targets of miR-218 and examined the functional role of one of these targets, CDK6, in medulloblastoma...
  12. ncbi request reprint Radiographic response at end of therapy with carboplatin and vincristine as a prognostic indicator in children with low-grade astrocytoma
    Kira Wendorf
    Department of Radiology, University of Colorado Health Sciences Center, Denver and The Children s Hospital, Denver, Colorado 80218, USA
    Med Pediatr Oncol 41:566-7. 2003
  13. doi request reprint Interpretation of magnetic resonance images in diffuse intrinsic pontine glioma: a survey of pediatric neurosurgeons
    Todd C Hankinson
    Division of Pediatric Neurosurgery, The Children s Hospital of Colorado, University of Colorado, Denver, Colorado 80045, USA
    J Neurosurg Pediatr 8:97-102. 2011
    ..This study sought to examine the consistency of North American pediatric neurosurgeons in assessing MR images in this patient population, and in their surgical plans based on the interpretation of those images...
  14. doi request reprint Vascular abnormalities in pediatric craniopharyngioma patients treated with radiation therapy
    Arthur K Liu
    Department of Radiation Oncology, University of Colorado Denver, Aurora, Colorado, USA
    Pediatr Blood Cancer 52:227-30. 2009
    ..We report on the incidence of vascular abnormalities seen in the children with craniopharyngioma who received radiation therapy at our institution...
  15. doi request reprint Creative arts therapy improves quality of life for pediatric brain tumor patients receiving outpatient chemotherapy
    Jennifer R Madden
    University of Colorado Denver, Aurora, CO 80045, USA
    J Pediatr Oncol Nurs 27:133-45. 2010
    ..With heightened interest in complementary therapy for children with cancer, future research with a larger sample size is needed to document the impact of incorporating creative arts into the healing process...
  16. ncbi request reprint Brain stem glioma in a child: false diagnosis of radiation necrosis with FDG PET
    Laura Z Fenton
    The Children s Hospital, Department of Radiology, Denver, Colorado 80218, USA
    Med Pediatr Oncol 40:260-2. 2003
  17. ncbi request reprint Measurement of tamoxifen-induced apoptosis in glioblastoma by cytometric bead analysis of active caspase-3
    Joy K Zartman
    University of Colorado Health Sciences Center, The Children s Hospital, Denver, CO 80262, USA
    J Neurooncol 67:3-7. 2004
    ..Cytometric bead array provides a rapid technique for measuring apoptosis and the kinetics of caspase-3 activity in glioblastoma...
  18. doi request reprint Memory deficits in patients with pediatric CNS germ cell tumors
    Greta N Wilkening
    The Children s Hospital, Denver, Aurora, CO, USA
    Pediatr Blood Cancer 57:486-91. 2011
    ..Although case studies suggest that memory deficits may be associated with GCT, this is the first study to investigate memory function across a series of pediatric intracranial GCT patients...
  19. doi request reprint Cytotoxicity of glioblastoma cells mediated ex vivo by varicella-zoster virus-specific T cells
    Jennifer Canniff
    Department of Pediatrics, University Colorado Denver School of Medicine, Denver, CO, USA
    J Neurovirol 17:448-54. 2011
    ..The protective effect of prior VZV infection against the incidence of glioma may be mediated by CTL that recognizes epitopes shared by VZV and glioma cells...
  20. doi request reprint Experience with electrolyte levels after craniotomy for pediatric brain tumors
    Jennifer R Madden
    Department of Oncology, The Children s Hospital, University of Colorado Medical School, Denver, CO 80218, USA
    J Pediatr Oncol Nurs 27:21-3. 2010
    ..The nurse is in the ideal role to monitor closely the pediatric brain tumor patient at high risk for abnormal sodium levels...
  21. ncbi request reprint Pilomyxoid astrocytoma: neuroimaging with clinicopathologic correlates in 4 cases followed over time
    Sirisha T Komakula
    Department of Radiology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Pediatr Hematol Oncol 29:465-70. 2007
    ..Radiologists should consider this diagnosis particularly in young children with hypothalamic tumors that lack the typical cystic appearance seen in PA...
  22. doi request reprint Germ cell tumors of the brainstem: report on two cases with pulmonary complications and a review of the literature
    Jenny Madden
    Department of Neuro Oncology, The Children s Hospital, Aurora, CO, USA
    J Neurooncol 93:405-8. 2009
    ..The two patients did well, in terms of disease control, but have significant morbidity related to respiratory issues. One patient remains ventilator dependent and the second died from respiratory arrest...
  23. ncbi request reprint Cytogenetics in pediatric low-grade astrocytomas
    Lesley C Orr
    University of Colorado Health Sciences Center, Denver, Colorado, USA
    Med Pediatr Oncol 38:173-7. 2002
    ..The literature on adults with LGA suggest better survival for those whose tumors have normal cytogenetics compared to those with abnormal. We hypothesized this would also be true of children with low-grade astrocytomas...
  24. ncbi request reprint Midpoint CD34 measurement as a predictor of PBPC product yield in pediatric patients undergoing high-dose chemotherapy
    Rameshwar S Sidhu
    Department of Pathology and Department of Pediatrics Hematology and Oncology Division, University of Colorado Health Sciences Center, The Children s Hospital, Denver, Colorado 80262, USA
    J Clin Apher 21:165-8. 2006
    ..5 of 5 TBV initially set to predict the maximum goal of CD34 cells /kg needed on the same day of PBPC collection; and (3) PBPC collection in pediatric patients <10 kg body weight (as low as 5.8 kg body weight)...
  25. ncbi request reprint Atypical teratoid/rhabdoid tumor of the central nervous system in children: an atypical series and review
    Laura Z Fenton
    Department of Radiology, The Children s Hospital, 1056 East 19th Avenue B125, Denver, CO 80218, USA
    Pediatr Radiol 33:554-8. 2003
    ..We present four consecutive cases of AT/RhT, three in locations other than the cerebellum, seen at our institution in a 14-month period, indicating that this tumor may be more common than previously thought...
  26. ncbi request reprint Paired overexpression of ErbB3 and Sox10 in pilocytic astrocytoma
    Steven O Addo-Yobo
    Department of Pediatrics and Pathology, University of Colorado at Denver and Health Sciences Center UCDHSC, 80045, USA
    J Neuropathol Exp Neurol 65:769-75. 2006
    ....
  27. ncbi request reprint Unique molecular characteristics of radiation-induced glioblastoma
    Andrew M Donson
    Department of Pediatrics, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045, USA
    J Neuropathol Exp Neurol 66:740-9. 2007
    ..Western blot analyses confirmed that ErbB3, Sox10, and platelet-derived growth factor receptor-alpha proteins were consistently expressed in RIGs but rarely in pediatric GBMs...

Research Grants1

  1. Molecular and Cellular Characterization of Prognostic Immune Response in Childhoo
    Nicholas K Foreman; Fiscal Year: 2010
    ..We have found an immune response in a type of childhood brain tumor called an ependymoma. We wish to explore whether this immune response can be used to cure ependymomas and potentially other brain tumors. ..