Research Topics
Genomes and GenesSpecies | Jason D FontenotSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Molecular aspects of regulatory T cell developmentJason D Fontenot
Howard Hughes Medical Institute, Box 357370, Health Science Bldg I604I, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
Semin Immunol 16:73-80. 2004..This review highlights the major molecular pathways that have been implicated to date in the development of this T cell lineage...- Regulatory T cell lineage specification by the forkhead transcription factor foxp3Jason D Fontenot
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Immunity 22:329-41. 2005..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions... - A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3Jason D Fontenot
Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA
Nat Immunol 6:331-7. 2005.... - Foxp3-dependent programme of regulatory T-cell differentiationMarc A Gavin
Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nature 445:771-5. 2007..This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis... - A function for interleukin 2 in Foxp3-expressing regulatory T cellsJason D Fontenot
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 6:1142-51. 2005..Thus, IL-2 signaling seems to be critically required for maintaining the homeostasis and competitive fitness of T(reg) cells in vivo... - Developmental regulation of Foxp3 expression during ontogenyJason D Fontenot
Department of Immunology, University of Washington, Seattle, WA 98195, USA
J Exp Med 202:901-6. 2005..Based on our data, we speculate that induction of Foxp3 in developing thymocytes and, thus, commitment to the T reg cell lineage is facilitated by a signal largely associated with the thymic medulla... - An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoiresChyi Song Hsieh
Department of Medicine and Division of Rheumatology, University of Washington, Seattle, Washington 98195, USA
Nat Immunol 7:401-10. 2006..Our analyses suggest that T(reg) cells and potentially pathogenic autoimmune T cells use overlapping pools of self-reactive TCRs... - Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory diseaseBlythe D Sather
Benaroya Research Institute, Seattle, WA 98101, USA
J Exp Med 204:1335-47. 2007..Thus, selectively altering T reg cell distribution in vivo leads to the development of tissue-specific inflammatory disease... - Foxp3 programs the development and function of CD4+CD25+ regulatory T cellsJason D Fontenot
Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
Nat Immunol 4:330-6. 2003..Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function... - Expansion and function of Foxp3-expressing T regulatory cells during tuberculosisJames P Scott-Browne
Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
J Exp Med 204:2159-69. 2007..Thus, after aerosol infection, T reg cells proliferate and accumulate at sites of infection, and have the capacity to suppress immune responses that contribute to the control of Mtb... - Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitisHolm H Uhlig
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
J Immunol 177:5852-60. 2006....