Jason D Fontenot

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Molecular aspects of regulatory T cell development
    Jason D Fontenot
    Howard Hughes Medical Institute, Box 357370, Health Science Bldg I604I, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Semin Immunol 16:73-80. 2004
  2. ncbi request reprint Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
  3. ncbi request reprint A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nat Immunol 6:331-7. 2005
  4. ncbi request reprint Foxp3-dependent programme of regulatory T-cell differentiation
    Marc A Gavin
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:771-5. 2007
  5. ncbi request reprint A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
  6. pmc Developmental regulation of Foxp3 expression during ontogeny
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 202:901-6. 2005
  7. ncbi request reprint An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    Chyi Song Hsieh
    Department of Medicine and Division of Rheumatology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 7:401-10. 2006
  8. pmc Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
    Blythe D Sather
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:1335-47. 2007
  9. ncbi request reprint Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003
  10. pmc Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
    James P Scott-Browne
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:2159-69. 2007

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Molecular aspects of regulatory T cell development
    Jason D Fontenot
    Howard Hughes Medical Institute, Box 357370, Health Science Bldg I604I, University of Washington School of Medicine, 1959 NE Pacific Street, Seattle, WA 98195, USA
    Semin Immunol 16:73-80. 2004
    ..This review highlights the major molecular pathways that have been implicated to date in the development of this T cell lineage...
  2. ncbi request reprint Regulatory T cell lineage specification by the forkhead transcription factor foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Immunity 22:329-41. 2005
    ..Analysis of Foxp3 expression during thymic development suggests that this mechanism is not hard-wired but is dependent on TCR/MHC ligand interactions...
  3. ncbi request reprint A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3
    Jason D Fontenot
    Department of Immunology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    Nat Immunol 6:331-7. 2005
    ....
  4. ncbi request reprint Foxp3-dependent programme of regulatory T-cell differentiation
    Marc A Gavin
    Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nature 445:771-5. 2007
    ..This adaptation includes Foxp3-dependent repression of cyclic nucleotide phosphodiesterase 3B, affecting genes responsible for Tr cell homeostasis...
  5. ncbi request reprint A function for interleukin 2 in Foxp3-expressing regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 6:1142-51. 2005
    ..Thus, IL-2 signaling seems to be critically required for maintaining the homeostasis and competitive fitness of T(reg) cells in vivo...
  6. pmc Developmental regulation of Foxp3 expression during ontogeny
    Jason D Fontenot
    Department of Immunology, University of Washington, Seattle, WA 98195, USA
    J Exp Med 202:901-6. 2005
    ..Based on our data, we speculate that induction of Foxp3 in developing thymocytes and, thus, commitment to the T reg cell lineage is facilitated by a signal largely associated with the thymic medulla...
  7. ncbi request reprint An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires
    Chyi Song Hsieh
    Department of Medicine and Division of Rheumatology, University of Washington, Seattle, Washington 98195, USA
    Nat Immunol 7:401-10. 2006
    ..Our analyses suggest that T(reg) cells and potentially pathogenic autoimmune T cells use overlapping pools of self-reactive TCRs...
  8. pmc Altering the distribution of Foxp3(+) regulatory T cells results in tissue-specific inflammatory disease
    Blythe D Sather
    Benaroya Research Institute, Seattle, WA 98101, USA
    J Exp Med 204:1335-47. 2007
    ..Thus, selectively altering T reg cell distribution in vivo leads to the development of tissue-specific inflammatory disease...
  9. ncbi request reprint Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    Jason D Fontenot
    Howard Hughes Medical Institute, Department of Immunology, University of Washington, Box 357370, Seattle, WA 98195, USA
    Nat Immunol 4:330-6. 2003
    ..Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4+CD25- T cells. Thus, Foxp3 is a critical regulator of CD4+CD25+ regulatory T cell development and function...
  10. pmc Expansion and function of Foxp3-expressing T regulatory cells during tuberculosis
    James P Scott-Browne
    Department of Pediatrics, University of Washington, Seattle, WA 98195, USA
    J Exp Med 204:2159-69. 2007
    ..Thus, after aerosol infection, T reg cells proliferate and accumulate at sites of infection, and have the capacity to suppress immune responses that contribute to the control of Mtb...
  11. ncbi request reprint Characterization of Foxp3+CD4+CD25+ and IL-10-secreting CD4+CD25+ T cells during cure of colitis
    Holm H Uhlig
    Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom
    J Immunol 177:5852-60. 2006
    ....