Genomes and Genes
Affiliation: University of California
- HOX genes: not just myeloid oncogenes any moreH J Lawrence
Department of Medicine, Division of Hematology and Medical Oncology, University of California School of Medicine, VA Medical Center, San Francisco, CA 94121, USA
Leukemia 19:1328-30. 2005
- Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cellsH Jeffrey Lawrence
Division of Hematology and Medical Oncology, Department of Medicine, University of California School of Medicine, Hematology Research 151H, Veterans Affairs VA Medical Center, 4150 Clement St, San Francisco, CA 94121, USA
Blood 106:3988-94. 2005..Hoxa-9 appears to be specifically required for normal hematopoietic stem cell function both in vitro and in vivo...
- Evidence that the Pim1 kinase gene is a direct target of HOXA9Yu Long Hu
Hematology Research, Medical Service, UCSF Veterans Affairs Medical Center, University of California San Francisco, 4150 Clement Street, San Francisco, CA 94121, USA
Blood 109:4732-8. 2007..Since HOXA9 is frequently up-regulated in acute myeloid leukemia, Pim1 may be a therapeutic target in human disease...
- HOXA9 regulates miR-155 in hematopoietic cellsYu Long Hu
Department of Medicine, Department of Veterans Affairs Medical Center and University of California, San Francisco, CA 94143, USA
Nucleic Acids Res 38:5472-8. 2010..Pu.1, an important regulator of myelopoiesis, was identified as a putative down stream target for miR-155. Although miR-155 was shown to down-regulate the Pu.1 protein, HOXA9 did not appear to modulate Pu.1 expression in murine BM cells...
- HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivoNeal A Fischbach
Department of Medicine, Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Blood 105:1456-66. 2005..These biologic effects of HOXB6 were largely dependent on DNA binding but independent of direct interaction with PBX1...
- HOXA9 GENE AS A THERAPEUTIC TARGET IN LEUKEMIAHUGH LAWRENCE; Fiscal Year: 2002..We anticipate that therapies targeting the expression and/or function of HOX proteins could have a major role in the clinical treatment of leukemia. ..
- THE ROLE OF HOX HOMEOBOX GENES IN NORMAL HEMATOPOIESISHUGH LAWRENCE; Fiscal Year: 2003..This will involve a) analysis of Hox gene activation in hematopoietic precursors by retinoic acid and b) assessing responses of specific Hox deficient blood cells to retinoids. ..