LOREN FONG

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice
    Loren G Fong
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:18111-6. 2004
  2. pmc Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides
    Loren G Fong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2462-71. 2009
  3. pmc Prelamin A and lamin A appear to be dispensable in the nuclear lamina
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    J Clin Invest 116:743-52. 2006
  4. ncbi request reprint A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:1621-3. 2006
  5. pmc Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
    Shao H Yang
    Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA
    J Clin Invest 118:3291-300. 2008
  6. doi request reprint Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele
    Shao H Yang
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:7094-9. 2008
  7. pmc The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
  8. pmc Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
    Shao H Yang
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:10291-6. 2005
  9. pmc Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:34511-8. 2008
  10. pmc Laminopathies and the long strange trip from basic cell biology to therapy
    Howard J Worman
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Invest 119:1825-36. 2009

Research Grants

Collaborators

Detail Information

Publications53

  1. pmc Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice
    Loren G Fong
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:18111-6. 2004
    ..These data suggest that prelamin A is toxic and that reducing its levels by as little as 50% provides striking protection from disease...
  2. pmc Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides
    Loren G Fong
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 18:2462-71. 2009
    ..Thus, different ASOs can be used to increase or decrease 'HGPS splicing'. ASOs represent a new and powerful tool for recreating HGPS pathophysiology in wild-type cells...
  3. pmc Prelamin A and lamin A appear to be dispensable in the nuclear lamina
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA
    J Clin Invest 116:743-52. 2006
    ..These studies suggest a new therapeutic strategy for treating progeria and other lamin A diseases...
  4. ncbi request reprint A protein farnesyltransferase inhibitor ameliorates disease in a mouse model of progeria
    Loren G Fong
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Science 311:1621-3. 2006
    ..The FTI-treated mice exhibited improved body weight, grip strength, bone integrity, and percent survival at 20 weeks of age. These results suggest that FTIs may have beneficial effects in humans with progeria...
  5. pmc Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated
    Shao H Yang
    Department of Medicine, UCLA David Geffen School of Medicine, Los Angeles, California, USA
    J Clin Invest 118:3291-300. 2008
    ....
  6. doi request reprint Eliminating the synthesis of mature lamin A reduces disease phenotypes in mice carrying a Hutchinson-Gilford progeria syndrome allele
    Shao H Yang
    Department of Medicine, David Geffen School of Medicine, UCLA, Los Angeles, California 90095, USA
    J Biol Chem 283:7094-9. 2008
    ..These studies suggest that compositional changes in the nuclear lamina can influence both the steady-state levels of progerin and the severity of progeria-like disease phenotypes...
  7. pmc The acidic domain of GPIHBP1 is important for the binding of lipoprotein lipase and chylomicrons
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:29554-62. 2008
    ..These studies indicate that the acidic domain of GPIHBP1 is important and that electrostatic interactions play a key role in ligand binding...
  8. pmc Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation
    Shao H Yang
    Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:10291-6. 2005
    ..0001 by chi2 statistic). These studies suggest a possible treatment strategy for HGPS...
  9. pmc Abnormal patterns of lipoprotein lipase release into the plasma in GPIHBP1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 283:34511-8. 2008
    ..The differences in LPL release after intravenous heparin and Intralipid strongly suggest that GPIHBP1 represents an important binding site for LPL in vivo...
  10. pmc Laminopathies and the long strange trip from basic cell biology to therapy
    Howard J Worman
    Department of Medicine, Columbia University College of Physicians and Surgeons, 630 West 168th Street, New York, NY 10032, USA
    J Clin Invest 119:1825-36. 2009
    ..Here, we review the laminopathies and the long strange trip from basic cell biology to therapeutic approaches for these diseases...
  11. doi request reprint Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:126-34. 2009
    ..The steady-state levels of progerin, relative to lamin C, were lower in Lmna(ggHG/+) mice than in Lmna(HG/+) mice, providing a potential explanation for the milder disease in Lmna(ggHG/+) mice...
  12. pmc Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria
    Shao H Yang
    Department of Medicine, University of California, Los Angeles, Los Angeles, CA
    J Lipid Res 51:400-5. 2010
    ..The failure of the FTI to ameliorate disease in Lmna(nHG/+) mice supports the idea that the beneficial effects of an FTI in Lmna(HG/+) mice are due to the effect of drug on the farnesylation of progerin...
  13. pmc Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes
    Julia I Toth
    Department of Medicine and Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 102:12873-8. 2005
    ..0003 and P < 0.0001). These findings establish a paradigm for ameliorating the most obvious cellular pathology in lamin-related progeroid syndromes and suggest a potential strategy for treating these diseases...
  14. ncbi request reprint Lamins A and C but not lamin B1 regulate nuclear mechanics
    Jan Lammerding
    Cardiovascular Division, Department of Medicine, and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02139, USA
    J Biol Chem 281:25768-80. 2006
    ..Our study indicates that lamins A and C are important contributors to the mechanical stiffness of nuclei, whereas lamin B1 contributes to nuclear integrity but not stiffness...
  15. pmc Normal binding of lipoprotein lipase, chylomicrons, and apo-AV to GPIHBP1 containing a G56R amino acid substitution
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1771:1464-8. 2007
    ....
  16. pmc Treatment with a farnesyltransferase inhibitor improves survival in mice with a Hutchinson-Gilford progeria syndrome mutation
    Shao H Yang
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Biochim Biophys Acta 1781:36-9. 2008
    ..Treatment with the FTI also improved body weight curves and reduced the number of spontaneous rib fractures. This study provides further evidence for a beneficial effect of an FTI in HGPS...
  17. ncbi request reprint Protein farnesyltransferase inhibitors and progeria
    Margarita Meta
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Trends Mol Med 12:480-7. 2006
    ..In addition, recent data showing that FTIs ameliorate disease phenotypes in a pair of mouse models of progeria are discussed...
  18. pmc GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Metab 12:42-52. 2010
    ..Our experiments define the function of GPIHBP1 in triglyceride metabolism and provide a mechanism for the transport of LPL into capillaries...
  19. pmc The expression of GPIHBP1, an endothelial cell binding site for lipoprotein lipase and chylomicrons, is induced by peroxisome proliferator-activated receptor-gamma
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 22:2496-504. 2008
    ..We conclude that GPIHBP1 is regulated by dietary factors and by PPARgamma...
  20. pmc GPIHBP1, a GPI-anchored protein required for the lipolytic processing of triglyceride-rich lipoproteins
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 50:S57-62. 2009
    ..Here, we review recent progress in understanding GPIHBP1 and discuss its role in lipolysis...
  21. pmc Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists
    Elena Scotti
    Howard Hughes Medical Institute, UCLA School of Medicine, Box 951662, Los Angeles, CA 90095 1662, USA
    Mol Cell Biol 31:1885-93. 2011
    ..These results demonstrate that the LXR-Idol pathway is an important contributor to feedback inhibition of the LDLR by sterols and a biological determinant of cellular LDL uptake...
  22. pmc Chylomicronemia with a mutant GPIHBP1 (Q115P) that cannot bind lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 29:956-62. 2009
    ..Because GPIHBP1 deficiency causes chylomicronemia in mice, we sought to determine whether some cases of chylomicronemia in humans could be attributable to defective GPIHBP1 proteins...
  23. pmc GPIHBP1 and lipolysis: an update
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Lipidol 20:211-6. 2009
    ..This review will provide an update on the structure of GPIHBP1, a 28-kDa glycosylphosphatidylinositol-anchored glycoprotein, and its role in the lipolytic processing of triglyceride-rich lipoproteins...
  24. pmc An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria
    Brandon S J Davies
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:2682-94. 2010
    ..The latter finding is potentially relevant to the long-term use of protein farnesyltransferase inhibitors, which lead to an accumulation of non-farnesylated prelamin A...
  25. pmc Binding preferences for GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells
    Peter Gin
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Arterioscler Thromb Vasc Biol 31:176-82. 2011
    ..To define the ability of GPIHBP1 to bind other lipase family members and other apolipoproteins (apos) and lipoproteins...
  26. pmc The posttranslational processing of prelamin A and disease
    Brandon S J Davies
    Department of Medicine, University of California, Los Angeles, California 90095, USA
    Annu Rev Genomics Hum Genet 10:153-74. 2009
    ..In this review, we discuss the posttranslational modifications of prelamin A and their relevance to the pathogenesis and treatment of progeroid syndromes...
  27. pmc Highly conserved cysteines within the Ly6 domain of GPIHBP1 are crucial for the binding of lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 284:30240-7. 2009
    ..In this assay, wild-type soluble GPIHBP1 bound LPL avidly, but the cysteine mutants did not. Thus, our studies suggest that a structurally intact Ly6 domain (in addition to the acidic domain) is essential for LPL binding...
  28. pmc Direct synthesis of lamin A, bypassing prelamin a processing, causes misshapen nuclei in fibroblasts but no detectable pathology in mice
    Catherine Coffinier
    Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Biol Chem 285:20818-26. 2010
    ..We conclude that prelamin A processing is dispensable in mice and that direct synthesis of mature lamin A has little if any effect on the targeting of lamin A to the nuclear rim in mouse tissues...
  29. pmc Abnormal development of the cerebral cortex and cerebellum in the setting of lamin B2 deficiency
    Catherine Coffinier
    Departments of Medicine and Human Genetics, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 107:5076-81. 2010
    ..These studies establish an essential function for lamin B2 in neuronal migration and brain development...
  30. pmc Chylomicronemia elicits atherosclerosis in mice--brief report
    Michael M Weinstein
    Departments of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:20-3. 2010
    ..In this study, we examined susceptibility to atherosclerosis in Gpihbp1-deficient mice (Gpihbp1(-/-)), which manifest severe chylomicronemia as a result of defective lipolysis...
  31. ncbi request reprint Prelamin A, Zmpste24, misshapen cell nuclei, and progeria--new evidence suggesting that protein farnesylation could be important for disease pathogenesis
    Stephen G Young
    Division of Cardiology, Department of Internal Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 46:2531-58. 2005
    ....
  32. ncbi request reprint Prelamin A farnesylation and progeroid syndromes
    Stephen G Young
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    J Biol Chem 281:39741-5. 2006
    ..Also, administering an FTI to mouse models of HGPS and RD ameliorates the phenotypes of progeria. These studies have prompted interest in testing the efficacy of FTIs in children with HGPS...
  33. pmc GPIHBP1: an endothelial cell molecule important for the lipolytic processing of chylomicrons
    Stephen G Young
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Curr Opin Lipidol 18:389-96. 2007
    ..To summarize recent data indicating that glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) plays a key role in the lipolytic processing of chylomicrons...
  34. pmc HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells
    Catherine Coffinier
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:13432-7. 2007
    ..6 microM; tipranavir, 1.2 +/- 0.4 microM). We conclude that the HIV-PIs inhibit ZMPSTE24, leading to an accumulation of farnesyl-prelamin A. The inhibition of ZMPSTE24 by HIV-PIs could play a role in the side effects of these drugs...
  35. pmc A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells
    Catherine Coffinier
    Department of Medicine and Human Genetics, David Geffen School of Medicine, University of California Los Angeles, 695 Charles E Young Drive South, Los Angeles, CA 90095, USA
    J Biol Chem 283:9797-804. 2008
    ..Ritonavir, like lopinavir, inhibits ZMPSTE24 and leads to an accumulation of prelamin A...
  36. pmc Glycosylation of Asn-76 in mouse GPIHBP1 is critical for its appearance on the cell surface and the binding of chylomicrons and lipoprotein lipase
    Anne P Beigneux
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Lipid Res 49:1312-21. 2008
    ..These studies demonstrate that N-glycosylation of GPIHBP1 is important for the trafficking of GPIHBP1 to the cell surface...
  37. pmc Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons
    Anne P Beigneux
    Department of Medicine Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, and Children s Hospital Oakland Research Institute 94609, USA
    Cell Metab 5:279-91. 2007
    ..Expression of GPIHBP1 in cultured cells confers the ability to bind both LpL and chylomicrons. These studies strongly suggest that GPIHBP1 is an important platform for the LpL-mediated processing of chylomicrons in capillaries...
  38. pmc Cholesterol intake modulates plasma triglyceride levels in glycosylphosphatidylinositol HDL-binding protein 1-deficient mice
    Michael M Weinstein
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, USA
    Arterioscler Thromb Vasc Biol 30:2106-13. 2010
    ..To determine whether plasma triglyceride levels in adult Glycosylphosphatidylinositol HDL-binding protein 1 (GPIHBP1)-deficient (Gpihbp1(-/-)) mice would be sensitive to cholesterol intake...
  39. pmc Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
    Seung Soon Im
    Department of Molecular Biology and Biochemistry, University of California, Irvine, California 92697 3900, USA
    Mol Cell Biol 29:4864-72. 2009
    ..Our chromatin immunoprecipitation results support this hypothesis...
  40. pmc A farnesyltransferase inhibitor improves disease phenotypes in mice with a Hutchinson-Gilford progeria syndrome mutation
    Shao H Yang
    Department of Medicine, Division of Cardiology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095, USA, and Department of Medicine, Wallenberg Laboratory, Sahlgrenska University Hospital, Goteborg, Sweden
    J Clin Invest 116:2115-21. 2006
    ..These studies suggest that FTIs could be useful for treating humans with HGPS...
  41. pmc Genetic studies on the functional relevance of the protein prenyltransferases in skin keratinocytes
    Roger Lee
    Department of Medicine, David Geffen School of Medicine, University of California, LA, Los Angeles, CA 90095, USA
    Hum Mol Genet 19:1603-17. 2010
    ..Like Fntb-deficient keratinocytes, Pggt1b-deficient keratinocytes did not proliferate in culture. Thus, both FTase and GGTase-I are required for the homeostasis of skin keratinocytes...
  42. pmc A novel approach to tag and identify geranylgeranylated proteins
    Lai N Chan
    Departments of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, CA 90095 1489, USA
    Electrophoresis 30:3598-606. 2009
    ..The "GG-azide"-labeling approach provides a new tool for the detection and proteomic analysis of geranylgeranylated proteins, and it can readily be extended to other post-translational modifications...
  43. pmc Caution! Analyze transcripts from conditional knockout alleles
    Shao H Yang
    Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Transgenic Res 18:483-9. 2009
    ..With thousands of new conditional knockout alleles under construction within mouse mutagenesis consortiums, the protein farnesyltransferase allele holds an important lesson-to characterize knockout alleles at both the DNA and RNA levels...
  44. pmc Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells
    Alex S Nord
    Department of Medicine, MacDonald Medical Research Laboratories, University of California at Los Angeles, California, USA
    PLoS ONE 2:e617. 2007
    ..However, the rules governing its efficiency are not fully understood, and the effects of vector design on the likelihood of gene-trapping events have not been tested on a genome-wide scale...
  45. pmc HIV-protease inhibitors block the enzymatic activity of purified Ste24p
    Sarah E Hudon
    Department of Chemistry and the Purdue Cancer Center, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 2084, USA
    Biochem Biophys Res Commun 374:365-8. 2008
    ....
  46. pmc Mouse models of the laminopathies
    Colin L Stewart
    Laboratory of Cancer and Developmental Biology, National Cancer Institute, Frederick, Maryland 21702, USA
    Exp Cell Res 313:2144-56. 2007
    ..These mouse lines are providing insights into the functions of the lamina and how changes to the lamina affect the mechanical integrity of the nucleus as well as signaling pathways that, when disrupted, may contribute to the disease...
  47. pmc Genetic analyses of the role of RCE1 in RAS membrane association and transformation
    Martin O Bergo
    Wallenberg Laboratory, Department of Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
    Methods Enzymol 438:367-89. 2008
    ..Here, we will review methods that have been used to define the physiologic importance of the endoproteolytic processing step of CAAX protein processing...
  48. ncbi request reprint Increased progerin expression associated with unusual LMNA mutations causes severe progeroid syndromes
    Casey L Moulson
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Hum Mutat 28:882-9. 2007
    ..Thus, farnesyltransferase inhibitors may prove to be useful even when progerin expression levels are higher than those in typical HGPS patients...
  49. ncbi request reprint Cell nuclei spin in the absence of lamin b1
    Julie Y Ji
    Cardiovascular Division, Brigham and Women s Hospital, Cambridge, Massachusetts 02139, USA
    J Biol Chem 282:20015-26. 2007
    ..These findings demonstrate that lamin B1 serves a fundamental role within the nuclear envelope: anchoring the nucleus to the cytoskeleton...
  50. pmc LDL and cAMP cooperate to regulate the functional expression of the LRP in rat ovarian granulosa cells
    Salman Azhar
    Geriatric Research, Education, and Clinical Center, Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA
    J Lipid Res 47:2538-50. 2006
    ..In summary, our studies demonstrate a role for LRP in lipoprotein-supported ovarian granulosa cell steroidogenesis...
  51. ncbi request reprint A mouse monoclonal antibody specific for mouse apoB48 and apoB100 produced by immunizing "apoB39-only" mice with mouse apoB48
    Anh T Nguyen
    Lipoprotein and Atherosclerosis Research Group, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, Canada K1Y 4W7
    Biochim Biophys Acta 1761:182-5. 2006
    ..The antibody will be an important reagent for studying mouse models of atherosclerosis. The study also underscores the utility of genetically modified mice for generating mouse mAbs against mouse proteins...
  52. pmc Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models
    Murielle M Veniant
    Amgen Inc, One Amgen Center Drive, Thousand Oaks, CA 91320 1799, USA
    Curr Drug Targets 9:174-89. 2008
    ..Defining the extent of atherosclerosis in these mice should provide new insights into the atherogenicity of large, triglyceride-rich lipoproteins...
  53. ncbi request reprint PCSK9 function and physiology
    Andrew S Peterson
    Department of Molecular Biology, Genentech, South San Francisco, CA, USA
    J Lipid Res 49:1595-9. 2008
    ..Dr. Jay Horton's group at UT Southwestern describe the kinetics and metabolism of PCSK9 and the impact of PCSK9 on LDL receptors in the liver and adrenal gland...

Research Grants7

  1. New Therapeutic Approaches for Hutchinson-Gilford Progeria Syndrome
    LOREN FONG; Fiscal Year: 2007
    ..Preliminary studies also suggest that this strategy is feasible. These studies stand a significant chance of identifying treatments for HGPS, which would be a welcome development for those affected by this disease. ..
  2. Protein Prenylation and Progeria
    LOREN FONG; Fiscal Year: 2009
    ..New mouse models will be created to study the development of disease and to test a new therapeutic approach. ..
  3. New Therapeutic Approaches for Hutchinson-Gilford Progeria Syndrome
    LOREN GI FONG; Fiscal Year: 2010
    ..Preliminary studies also suggest that this strategy is feasible. These studies stand a significant chance of identifying treatments for HGPS, which would be a welcome development for those affected by this disease. ..
  4. Protein Prenylation and Progeria
    LOREN GI FONG; Fiscal Year: 2010
    ..New mouse models will be created to study the development of disease and to test a new therapeutic approach. ..