Research Topics
Genomes and Genes | Dmitri E FomenkoSummaryAffiliation: University of Nebraska Country: USA Publications
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Publications
The microbial selenoproteome of the Sargasso SeaYan Zhang
Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
Genome Biol 6:R37. 2005..Herein, we characterized the selenoproteome of the largest microbial sequence dataset, the Sargasso Sea environmental genome project...
Evolutionary dynamics of eukaryotic selenoproteomes: large selenoproteomes may associate with aquatic life and small with terrestrial lifeAlexey V Lobanov
Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA
Genome Biol 8:R198. 2007..Selenoproteins occur in both eukaryotes and prokaryotes, but the selenoprotein content of organisms (selenoproteome) is highly variable and some organisms do not utilize Sec at all...
Comparative genomics of thiol oxidoreductases reveals widespread and essential functions of thiol-based redox control of cellular processesDmitri E Fomenko
Department of Biochemistry and Redox Biology Center, University of Nebraska Lincoln, USA
Antioxid Redox Signal 16:193-201. 2012..We wanted to identify thiol oxidoreductases on a genome-wide scale and use this information to obtain insights into the general principles of thiol-based redox control...
Functional analysis of free methionine-R-sulfoxide reductase from Saccharomyces cerevisiaeDung Tien Le
Department of Biochemistry and Redox Biology Center, University of Nebraska Lincoln, Lincoln, Nebraska 68588, USA
J Biol Chem 284:4354-64. 2009..The data show that fRMsr is the main enzyme responsible for the reduction of free Met-R-SO in S. cerevisiae...
Analysis of methionine/selenomethionine oxidation and methionine sulfoxide reductase function using methionine-rich proteins and antibodies against their oxidized formsDung Tien Le
Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, USA
Biochemistry 47:6685-94. 2008..These findings, reagents, assays, and approaches should facilitate research and applications in the area of Met sulfoxide reduction, oxidative stress, and aging...
Characterization of surface-exposed reactive cysteine residues in Saccharomyces cerevisiaeStefano M Marino
Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, USA
Biochemistry 49:7709-21. 2010....
Compartmentalization and regulation of mitochondrial function by methionine sulfoxide reductases in yeastAlaattin Kaya
Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, USA
Biochemistry 49:8618-25. 2010..These results show that oxidative stress contributes to mitochondrial dysfunction through oxidation of methionine residues in proteins located in different cellular compartments...
Diversity of protein and mRNA forms of mammalian methionine sulfoxide reductase B1 due to intronization and protein processingXinwen Liang
Department of Biochemistry and Redox Biology Center, University of Nebraska Lincoln, Lincoln, Nebraska, United States of America
PLoS ONE 5:e11497. 2010..MsrB1 is a selenocysteine-containing cytosolic/nuclear Msr with high expression in liver and kidney...
MsrB1 (methionine-R-sulfoxide reductase 1) knock-out mice: roles of MsrB1 in redox regulation and identification of a novel selenoprotein formDmitri E Fomenko
Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, Nebraska 68588, USA
J Biol Chem 284:5986-93. 2009..Overall, this study established an important contribution of MsrB1 to the redox control in mouse liver and kidney and identified a novel form of this protein...
Functional diversity of cysteine residues in proteins and unique features of catalytic redox-active cysteines in thiol oxidoreductasesDmitri E Fomenko
Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588 0664, USA
Mol Cells 26:228-35. 2008....
Genetic code supports targeted insertion of two amino acids by one codonAnton A Turanov
Department of Biochemistry and Redox Biology Center, University of Nebraska, Lincoln, NE 68588, USA
Science 323:259-61. 2009..Thus, the genetic code supports the use of one codon to code for multiple amino acids...
CxxS: fold-independent redox motif revealed by genome-wide searches for thiol/disulfide oxidoreductase functionDmitri E Fomenko
Department of Biochemistry, University of Nebraska Lincoln, 68588 0664, USA
Protein Sci 11:2285-96. 2002..The data also indicate a general approach of genome-wide identification of redox proteins by searching for simple conserved motifs within secondary structure patterns...
