Daniel R Foltz

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. pmc Propagation of centromeric chromatin requires exit from mitosis
    Lars E T Jansen
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 176:795-805. 2007
  2. pmc HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
    Meghan C Barnhart
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Cell Biol 194:229-43. 2011
  3. pmc Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP
    Daniel R Foltz
    Ludwig Institute for Cancer Research, La Jolla, CA 92093 0670, USA
    Cell 137:472-84. 2009
  4. ncbi request reprint The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
  5. ncbi request reprint Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain
    Ben E Black
    Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 25:309-22. 2007
  6. ncbi request reprint Structural determinants for generating centromeric chromatin
    Ben E Black
    Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California 92093, USA
    Nature 430:578-82. 2004
  7. doi request reprint Putting CENP-A in its place
    Madison E Stellfox
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, PO Box 800733, Charlottesville, VA 22908, USA
    Cell Mol Life Sci 70:387-406. 2013
  8. pmc Posttranslational modification of CENP-A influences the conformation of centromeric chromatin
    Aaron O Bailey
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 110:11827-32. 2013
  9. pmc Kinetochores: orchestrating the chromosomal minuet
    P Todd Stukenberg
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Curr Biol 20:R522-5. 2010
  10. pmc A new histone at the centromere?
    Daniel R Foltz
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Cell 148:394-6. 2012

Collaborators

Detail Information

Publications11

  1. pmc Propagation of centromeric chromatin requires exit from mitosis
    Lars E T Jansen
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    J Cell Biol 176:795-805. 2007
    ....
  2. pmc HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochore
    Meghan C Barnhart
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, Charlottesville, VA 22908, USA
    J Cell Biol 194:229-43. 2011
    ....
  3. pmc Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP
    Daniel R Foltz
    Ludwig Institute for Cancer Research, La Jolla, CA 92093 0670, USA
    Cell 137:472-84. 2009
    ..We propose HJURP to be a cell-cycle-regulated CENP-A-specific histone chaperone required for centromeric chromatin assembly...
  4. ncbi request reprint The human CENP-A centromeric nucleosome-associated complex
    Daniel R Foltz
    Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Nat Cell Biol 8:458-69. 2006
    ..The CENP-A NAC is essential, as disruption of the complex causes errors of chromosome alignment and segregation that preclude cell survival despite continued centromere-derived mitotic checkpoint signalling...
  5. ncbi request reprint Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domain
    Ben E Black
    Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Cell 25:309-22. 2007
    ..These data offer direct support for centromere identity maintained by a unique nucleosome that serves to distinguish the centromere from the rest of the chromosome...
  6. ncbi request reprint Structural determinants for generating centromeric chromatin
    Ben E Black
    Ludwig Institute for Cancer Research, University of California, San Diego, La Jolla, California 92093, USA
    Nature 430:578-82. 2004
    ..Thus, the centromere-targeting domain of CENP-A confers a unique structural rigidity to the nucleosomes into which it assembles, and is likely to have a role in maintaining centromere identity...
  7. doi request reprint Putting CENP-A in its place
    Madison E Stellfox
    Department of Biochemistry and Molecular Genetics, University of Virginia Medical School, PO Box 800733, Charlottesville, VA 22908, USA
    Cell Mol Life Sci 70:387-406. 2013
    ..We will also highlight a few recent discoveries that begin to elucidate the factors that temporally and spatially control CENP-A deposition...
  8. pmc Posttranslational modification of CENP-A influences the conformation of centromeric chromatin
    Aaron O Bailey
    Department of Cell Biology, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 110:11827-32. 2013
    ..Our studies have revealed that the major modifications on the N-terminal tail of CENP-A alter the physical properties of the chromatin fiber at the centromere. ..
  9. pmc Kinetochores: orchestrating the chromosomal minuet
    P Todd Stukenberg
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Curr Biol 20:R522-5. 2010
    ..When it comes to microtubules, kinetochores leave nothing to chance. Recent studies have provided insight into an amazingly choreographed dance between the proteins in the kinetochore and their substrate and power source--the microtubule...
  10. pmc A new histone at the centromere?
    Daniel R Foltz
    Department of Biochemistry and Molecular Genetics, University of Virginia, School of Medicine, Charlottesville, VA 22908, USA
    Cell 148:394-6. 2012
    ..Now Nishino et al. reveal a new level of complexity for centromeric chromatin, by showing that the kinetochore complex CENP-T-W-S-X shares structural and functional properties with canonical histones...
  11. pmc Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint
    Geert J P L Kops
    Ludwig Institute for Cancer Research and Department of Cellular and Molecular Medicine, University of California at San Diego, La Jolla, CA 92093 0670, USA
    Proc Natl Acad Sci U S A 101:8699-704. 2004
    ..Thus, suppression of mitotic checkpoint signaling is invariably lethal as the consequence of massive chromosome loss, findings that have implications for inhibiting proliferation of tumor cells...