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Genomes and Genes | Aaron FolsomSummaryAffiliation: University of Minnesota Country: USA Publications
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Troponin T, N-terminal pro-B-type natriuretic peptide, and incidence of stroke: the atherosclerosis risk in communities studyAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Stroke 44:961-7. 2013..In a prospective epidemiological study, we tested the hypothesis that high-sensitivity troponin T (TnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are associated positively with incidence of stroke...
Effect of 9p21 genetic variation on coronary heart disease is not modified by other risk markers. The Atherosclerosis Risk in Communities (ARIC) StudyAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA
Atherosclerosis 224:435-9. 2012..To determine whether the 9p21 SNP association with coronary heart disease is modified by other classical or novel risk markers...
Risk of intraparenchymal hemorrhage with magnetic resonance imaging-defined leukoaraiosis and brain infarctsAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA
Ann Neurol 71:552-9. 2012....
Kidney function and multiple hemostatic markers: cross sectional associations in the multi-ethnic study of atherosclerosisRuth Dubin
Department of Medicine, Division Nephrology, University of California San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143 0532, USA
BMC Nephrol 12:3. 2011..73 m2, chronic kidney disease (CKD) is strongly and independently associated with cardiovascular and overall mortality. We hypothesized that reduced kidney function would be characterized by abnormalities of hemostasis...
Carotid intima-media thickness, electrocardiographic left ventricular hypertrophy, and incidence of intracerebral hemorrhageAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454, USA
Stroke 42:3075-9. 2011..We hypothesized that greater carotid intima-media thickness and the presence of electrocardiographic left ventricular hypertrophy would be independently associated with increased ICH incidence...
Variation in ANGPTL4 and risk of coronary heart disease: the Atherosclerosis Risk in Communities StudyAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Metabolism 57:1591-6. 2008..In conclusion, in this prospective study, the 40K variant of ANGPTL4 appeared to confer reduced genetic risk for CHD...
Risk factor correlates of platelet and leukocyte markers assessed by flow cytometry in a population-based sampleAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Atherosclerosis 205:272-8. 2009..Platelet and leukocyte products are involved in atherothrombosis. However, the determinants of platelet and leukocyte markers assessed by flow cytometry have not been documented in a population-based sample...
Coronary artery calcification compared with carotid intima-media thickness in the prediction of cardiovascular disease incidence: the Multi-Ethnic Study of Atherosclerosis (MESA)Aaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second St, Ste 300, Minneapolis, MN 55454 1015, USA
Arch Intern Med 168:1333-9. 2008..Our objective was to assess whether maximum carotid IMT or CAC (Agatston score) is the better predictor of incident CVD...
Low protein C and incidence of ischemic stroke and coronary heart disease: the Atherosclerosis Risk in Communities (ARIC) StudyA R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
J Thromb Haemost 7:1774-8. 2009..Protein C is an important plasma natural anticoagulant. Although protein C deficiency increases risk of venous thrombosis, it remains uncertain whether low protein C increases risk of atherothrombosis...
C-reactive protein and venous thromboembolism. A prospective investigation in the ARIC cohortAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454 USA
Thromb Haemost 102:615-9. 2009..76 (95% CI 1.23, 2.52) for CRP above versus below the 90(th) percentile. In conclusion, this prospective, population-based study suggests elevated CRP is independently associated with increased risk of VTE...
Chronic kidney disease and venous thromboembolism: a prospective studyAaron R Folsom
1Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Nephrol Dial Transplant 25:3296-301. 2010..The incidence of venous thromboembolism (VTE) is increased with severe kidney disease, but whether less-severe chronic kidney disease (CKD) increases the risk of VTE is less certain...
Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidenceAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA
J Am Coll Cardiol 57:1690-6. 2011..The purpose of this study is to estimate the prevalence of ideal cardiovascular health and its relationship with incident cardiovascular disease (CVD)...
Absolute and attributable risks of heart failure incidence in relation to optimal risk factorsAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minn 55454, USA
Circ Heart Fail 2:11-7. 2009..The degree to which this applies to heart failure incidence is not well documented...
Serum albumin and risk of venous thromboembolismAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Minneapolis, MN 55454, USA
Thromb Haemost 104:100-4. 2010..The observed association likely does not reflect cause and effect, but rather that low serum albumin reflects a hyperinflammatory or hypercoagulable state. Whether this association has clinical relevance warrants further study...
Carotid artery wall thickness and risk of stroke subtypes: the atherosclerosis risk in communities studyTetsuya Ohira
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Stroke 42:397-403. 2011..Understanding associations of carotid atherosclerosis with stroke subtypes may contribute to more effective prevention of stroke...
Risk factors for ischemic stroke subtypes: the Atherosclerosis Risk in Communities studyTetsuya Ohira
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd St, Minneapolis, MN 55454-1015, USA
Stroke 37:2493-8. 2006..CONCLUSIONS: The impact of traditional and nontraditional risk factors other than hypertension on the incidence of ischemic stroke varied according to its subtype...
Risk factors for cardiovascular event recurrence in the Atherosclerosis Risk in Communities (ARIC) studyKeattiyoat Wattanakit
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minn 55454-1015, USA
Am Heart J 149:606-12. 2005..CONCLUSION: Established risk factors, but only a few of novel risk factors and markers, were independent predictors of recurrent CVD events...
Risk factors for breast cancer in elderly womenCarol Sweeney
University of Minnesota, Minneapolis, MN, USA
Am J Epidemiol 160:868-75. 2004..67, 95% CI: 0.51, 0.88 for five or more births compared with one or two). Obesity, a modifiable risk factor, remained positively associated with breast cancer for all age groups of postmenopausal women...
Association between nonsteroidal anti-inflammatory drug use and the incidence of lung cancer in the Iowa women's health studyJennifer H Hayes
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454-1015, USA
Cancer Epidemiol Biomarkers Prev 15:2226-31. 2006..Information on dosage and duration of use were not available for this analysis. CONCLUSION: These findings do not suggest that aspirin or other NSAIDs reduce risk of lung cancer in this cohort of postmenopausal women...
Coagulation factors, inflammation markers, and venous thromboembolism: the longitudinal investigation of thromboembolism etiology (LITE)Albert W Tsai
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
Am J Med 113:636-42. 2002..Venous thromboembolism, unlike arterial disease, was not related to inflammatory markers...
Association of aspirin and nonsteroidal anti-inflammatory drug use with breast cancerTrista W Johnson
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA
Cancer Epidemiol Biomarkers Prev 11:1586-91. 2002..The adjusted RR of using other NSAIDs six or more times per week compared with no use was 1.01 (95% CI 0.83-1.25). CONCLUSION: This prospective study corroborates other reports that use of aspirin might reduce risk of breast cancer...
The metabolic syndrome and risk of incident colorectal cancerRehana L Ahmed
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA
Cancer 107:28-36. 2006..Evidence is growing that the metabolic syndrome may be a marker for a physiologic milieu of growth that encourages tumor initiation, promotion, and/or progression...
Heart rate-corrected QT interval prolongation predicts risk of coronary heart disease in black and white middle-aged men and women: the ARIC studyJacqueline M Dekker
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
J Am Coll Cardiol 43:565-71. 2004....
Incidence of colorectal cancer in relation to glycemic index and load in a cohort of womenMary McCarl
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454-1015, USA
Cancer Epidemiol Biomarkers Prev 15:892-6. 2006..CONCLUSION: Our findings suggest that high GI or GL are not major CRC risk factors among older women in general, but may increase CRC risk among women who are obese...
Risk factors for peripheral arterial disease incidence in persons with diabetes: the Atherosclerosis Risk in Communities (ARIC) StudyKeattiyoat Wattanakit
Division of Epidemiology, School of Public Health, University of Minnesota, Suite 300, 1300 South 2nd Street, Minneapolis, MN 55454-1015, USA
Atherosclerosis 180:389-97. 2005..CONCLUSION: These markers might be useful to identify individuals with diabetes at particular risk for PAD...
Absolute and attributable risks of cardiovascular disease incidence in relation to optimal and borderline risk factors: comparison of African American with white subjects--Atherosclerosis Risk in Communities StudyAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Arch Intern Med 167:573-9. 2007..Among white Americans, a large proportion of cardiovascular disease (CVD) events is explained by borderline or any elevated CVD risk factor levels. The degree to which this is true among African American subjects is unclear...
Hemostatic and inflammatory risk factors for intracerebral hemorrhage in a pooled cohortJared D Sturgeon
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second St, Minneapolis, MN 55454 1015, USA
Stroke 39:2268-73. 2008..The purpose of this study was to identify novel risk factors for intracerebral hemorrhagic stroke (ICH)...
Dietary risk factors for upper aerodigestive tract cancersChristine M Kasum
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
Int J Cancer 99:267-72. 2002..These findings confirm previous observations that high intake of fruits and vegetables and that intake of whole grains and the fiber derived from them may reduce risk of upper aerodigestive tract cancers...
Antioxidant intake from fruits, vegetables and other sources and risk of non-Hodgkin's lymphoma: the Iowa Women's Health StudyCarrie A Thompson
Department of Medicine, College of Medicine Mayo Clinic, Rochester, MN, USA
Int J Cancer 126:992-1003. 2010..In conclusion, these results support a role for vegetables, and perhaps fruits and associated antioxidants from food sources, as protective factors against the development of NHL and follicular lymphoma in particular...
Diabetes mellitus and subsite-specific colorectal cancer risks in the Iowa Women's Health StudyPaul J Limburg
Division of Epidemiology, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454, USA
Cancer Epidemiol Biomarkers Prev 14:133-7. 2005....
Serum uric acid and risk of ischemic stroke: the ARIC StudyAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454-1015, USA
Atherosclerosis 187:401-7. 2006..08). CONCLUSION: Our findings suggest that UA is an independent predictor of ischemic stroke among subjects not using diuretics, but that elevated UA itself may not cause ischemic stroke...
Serum homocysteine, thermolabile variant of methylene tetrahydrofolate reductase (MTHFR), and venous thromboembolism: Longitudinal Investigation of Thromboembolism Etiology (LITE)Albert W Tsai
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Am J Hematol 72:192-200. 2003..74, 95% CI = 0.56-0.98). Our prospective data showed, at most, a weak relationship between homocysteine and VTE risk, with associations larger among younger participants. MTHFR C677T was not a risk factor for VTE...
Incidence of atrial fibrillation in whites and African-Americans: the Atherosclerosis Risk in Communities (ARIC) studyAlvaro Alonso
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd Street, Minneapolis, MN 55454 USA
Am Heart J 158:111-7. 2009..To define the incidence and cumulative risk of atrial fibrillation (AF) in a population-based cohort of whites and African Americans...
Nonsteroidal anti-inflammatory drugs and subsite-specific colorectal cancer incidence in the Iowa women's health studyAmit Mahipal
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Minneapolis, MN 55454, USA
Cancer Epidemiol Biomarkers Prev 15:1785-90. 2006..DISCUSSION: Our study is consistent with a limited number of prior reports that have observed stronger associations between NSAID use and proximal versus distal colorectal cancer...
A hypothesis: interaction between supplemental iron intake and fermentation affecting the risk of colon cancer. The Iowa Women's Health StudyDuk-Hee Lee
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Nutr Cancer 48:1-5. 2004..01). This hypothesis needs confirmation in other cohort studies because, despite the significant trend, only nine cases were included in the top category of > or = 50 mg supplemental iron, and this finding could have arisen by chance...
Electrocardiographic findings and incident coronary heart disease among participants in the Atherosclerosis Risk in Communities (ARIC) studyDaniella B Machado
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, Minnesota, USA
Am J Cardiol 97:1176-1181. 2006..In conclusion, several 12-lead ECG findings were independently associated with incident CHD in middle-aged adults. With only a few exceptions, the associations were similar for blacks and whites...
Periodontitis and coronary artery calcification: the Atherosclerosis Risk in Communities (ARIC) studySarah A Nakib
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA
J Periodontol 75:505-10. 2004..This study offers some reference for the magnitude of the association between CAC and periodontitis and information regarding the minimal power necessary for future studies...
Ankle-brachial index and hemostatic markers in the Atherosclerosis Risk in Communities (ARIC) study cohortLaura M Reich
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Vasc Med 12:267-73. 2007..56-4.65), for beta-TG was 1.80 (95% CI 1.12-2.88), and for CRP was 1.57 (95% CI 0.84-2.95). Plasma levels of hemostatic and inflammatory markers are elevated in PAD, suggesting these processes are involved in the pathophysiology of PAD...
The association of hip circumference with incident hip fracture in a cohort of postmenopausal women: the Iowa Women's Health StudyEmily D Parker
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
Ann Epidemiol 18:836-41. 2008..As the mean age of the U.S. population increases, the public health burden of osteoporotic fractures is expected to increase. This study prospectively examined the independent association of hip circumference with hip fracture...
Anthropometric characteristics and risk of multiple myelomaCindy K Blair
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
Epidemiology 16:691-4. 2005..5 (0.92-2.6); for weight, 1.9 (1.1-3.4); for waist circumference, 2.0 (1.1-3.5); and for hip circumference, 1.8 (1.0-3.0). CONCLUSION: Greater adiposity may increase the risk of multiple myeloma...
Risk factors for intracerebral hemorrhage in a pooled prospective studyJared D Sturgeon
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
Stroke 38:2718-25. 2007..We studied risk factors for ICH in a pooled cohort of the Atherosclerosis Risk in Communities Study (ARIC) and the Cardiovascular Health Study (CHS)...
Associations between HDL-cholesterol and polymorphisms in hepatic lipase and lipoprotein lipase genes are modified by dietary fat intake in African American and White adultsJennifer A Nettleton
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Atherosclerosis 194:e131-40. 2007..In conclusion, these data show that plasma HDL-C differs according to LIPC, LPL, and CETP genotypes. In the case of LIPC and LPL, data suggest dietary fat modifies these relations...
Associations of obesity measures with subtypes of ischemic stroke in the ARIC StudyHiroshi Yatsuya
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
J Epidemiol 20:347-54. 2010..Associations between obesity and lacunar, nonlacunar thrombotic, and cardioembolic stroke are not firmly established...
Dietary phosphorus, blood pressure, and incidence of hypertension in the atherosclerosis risk in communities study and the multi-ethnic study of atherosclerosisAlvaro Alonso
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S 2nd St, Suite 300, Minneapolis, MN 55454, USA
Hypertension 55:776-84. 2010..04 (0.93 to 1.17; P for trend=0.48) for phosphorus from other foods. These findings could indicate an effect of phosphorus in conjunction with other dairy constituents or of dairy itself without involvement of phosphorus...
Trends in hospitalization rate, hospital case fatality, and mortality rate of stroke by subtype in Minneapolis-St. Paul, 1980-2002Jared D Sturgeon
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454 1015, USA
Neuroepidemiology 28:39-45. 2007..Little information exists on trends in stroke subtypes. We examined trends in mortality, hospitalization rate, and hospital case fatality of stroke by subtype in the Minneapolis-St. Paul area from 1980 to 2002...
Hyperinsulinemia, dyslipidemia, and obesity as risk factors for hospitalized gallbladder disease. A prospective studyLori L Boland
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454-1015, USA
Ann Epidemiol 12:131-40. 2002....
The association of physical activity with lung cancer incidence in a cohort of older women: the Iowa Women's Health StudyPenny Sinner
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South 2nd Street, Suite 300, Minneapolis, MN 55454-1015, USA
Cancer Epidemiol Biomarkers Prev 15:2359-63. 2006..63 (95% CI, 0.43-0.92) in former smokers, but was not significant in never smokers. CONCLUSION: These results suggest that physical activity might reduce the risk of lung cancer in women who are current or former smokers...
A genetic variant on chromosome 9p21 and incident heart failure in the ARIC studyKazumasa Yamagishi
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 S Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
Eur Heart J 30:1222-8. 2009..We tested the association of chromosome 9p21 polymorphisms with non-coronary atherosclerotic diseases...
Lack of association of physical activity and obesity with incident pancreatic cancer in elderly womenPenny J Sinner
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, Minnesota 55454-1015, USA
Cancer Epidemiol Biomarkers Prev 14:1571-3. 2005
Iron, zinc, and alcohol consumption and mortality from cardiovascular diseases: the Iowa Women's Health StudyDuk-Hee Lee
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Am J Clin Nutr 81:787-91. 2005....
Occurrence of unrecognized myocardial infarction in subjects aged 45 to 65 years (the ARIC study)Lori L Boland
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA
Am J Cardiol 90:927-31. 2002..The percentage of unrecognized MIs in men and women was similar. The percentage of unrecognized MIs in the ARIC sample between 1987 and 1998 was slightly lower than previous estimates from other populations...
CYP1B1 and CYP19 gene polymorphisms and breast cancer incidence: no association in the ARIC studyBharat Thyagarajan
School of Public Health, Division of Epidemiology, University of Minnesota, Minneapolis, MN 55454, USA
Cancer Lett 207:183-9. 2004..Our data shows no association between breast cancer and the Leu432Val polymorphism of the CYP1B1 gene or the tetranucleotide repeats of the CYP19 gene...
The association of alpha-fibrinogen Thr312Ala polymorphism and venous thromboembolism in the LITE studyLaura J Rasmussen-Torvik
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, 1300 S Second St Suite 300, Minneapolis, MN 55454, USA
Thromb Res 121:1-7. 2007..However, the effect of this common variant on risk of venous thromboembolism (VTE) is unclear. This paper reports the association between the Thr312Ala variant and VTE in the LITE study...
Kidney function and risk of peripheral arterial disease: results from the Atherosclerosis Risk in Communities (ARIC) StudyKeattiyoat Wattanakit
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 South Second Street, Minneapolis, MN 55454 1015, USA
J Am Soc Nephrol 18:629-36. 2007..56 (95% CI 1.13 to 2.14). Patients with CKD are at increased risk for incident PAD. Development of strategies for screening and prevention of PAD in this high-risk population seems warranted...
Anthropometric variables, physical activity, and incidence of ovarian cancer: The Iowa Women's Health StudyJeffrey P Anderson
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454-1015, USA
Cancer 100:1515-21. 2004....
Reproductive risk factors for incident bladder cancer: Iowa Women's Health StudyAnna E Prizment
Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454 1015, USA
Int J Cancer 120:1093-8. 2007..This study provides evidence that increased risk of bladder cancer is associated with earlier age at menopause in postmenopausal women...
Cardiovascular risk factors and venous thromboembolism incidence: the longitudinal investigation of thromboembolism etiologyAlbert W Tsai
Division of Epidemiology, School of Public Health, University of Minnesota, 1300 S Second St, Suite 300, Minneapolis, MN 55454, USA
Arch Intern Med 162:1182-9. 2002..In addition, the findings suggest a hypothesis that avoidance of obesity and diabetes or vigilance in prophylaxis in patients with those conditions may prevent some venous thromboses...
Lung function and ischemic stroke incidence: the Atherosclerosis Risk in Communities studyAtsushi Hozawa
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454-1015, USA
Chest 130:1642-9. 2006..CONCLUSIONS: Among white subjects, participants with impaired lung function have a modestly higher risk of ischemic stroke even if they have never smoked nor had respiratory symptoms...
Does supplemental vitamin C increase cardiovascular disease risk in women with diabetes?Duk Hee Lee
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454, USA
Am J Clin Nutr 80:1194-200. 2004..These observations led us to hypothesize that a high intake of vitamin C in diabetic persons might promote atherosclerosis...
Lipoprotein(a) and incident ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) studyTetsuya Ohira
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN, USA
Stroke 37:1407-12. 2006..CONCLUSIONS: A high Lp(a) concentration is associated with a higher incidence of ischemic stroke in blacks and white women, but not in white men...
Associations of factor VIIIc, D-dimer, and plasmin-antiplasmin with incident cardiovascular disease and all-cause mortalityAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
Am J Hematol 84:349-53. 2009..Instead, elevated levels of these three hemostatic factors were associated independently with increased risk of death. Elevated D-dimer and factor VIII(c) were associated with increased cancer death...
Associations of acculturation and socioeconomic status with subclinical cardiovascular disease in the multi-ethnic study of atherosclerosisPamela L Lutsey
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55455, USA
Am J Public Health 98:1963-70. 2008....
Risk factors for urinary bladder carcinoma in postmenopausal women. The Iowa Women's Health StudyApeksha Tripathi
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota 55454, USA
Cancer 95:2316-23. 2002..We also identified diabetes as a potential risk factor, which may invite more research on its role in the development of urinary bladder carcinoma...
Lack of association of soluble endothelial protein C receptor and PROCR 6936A/G polymorphism with the risk of venous thromboembolism in a prospective studyKazumasa Yamagishi
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA
Br J Haematol 145:221-6. 2009..51[1.01-2.26]). The 6963A/G polymorphism was not associated with VTE risk (OR = 0.93[0.70-1.25]). In conclusion, sEPCR levels and the PROCR 6963A/G polymorphism were not associated overall with increased risk of VTE...
Estrogen replacement therapy and ovarian cancerAaron R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota55454 1015, USA
Epidemiology 15:100-4. 2004..However, several subsequent studies have suggested that long-term ERT could increase ovarian cancer risk...
Prospective study of fibrinolytic markers and venous thromboembolismAaron R Folsom
Division of Epidemiology, School of Public Health, University of Minnesota, 1300 South Second Street, Suite 300, Minneapolis, MN 55454 1015, USA
J Clin Epidemiol 56:598-603. 2003..There was weak evidence for an interaction of PAP with elevated factor VIIIc and elevated D-dimer in augmenting VTE risk. We conclude that, for the most part, these fibrinolytic markers do not identify healthy subjects at risk for VTE...
Chronic kidney disease increases risk for venous thromboembolismKeattiyoat Wattanakit
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Suite 300, 1300 S 2nd Street, Minneapolis, MN 55454 1015, USA
J Am Soc Nephrol 19:135-40. 2008..In conclusion, middle-aged and elderly patients with CKD (stages 3 through 4) are at increased risk for incident VTE, suggesting that VTE prophylaxis may be particularly important in this population...
Correlates and consequences of venous thromboembolism: The Iowa Women's Health StudyPamela L Lutsey
University of Minnesota, Minneapolis, USA
Am J Public Health 100:1506-13. 2010..We sought to document incidence, case-fatality, and recurrence rates of venous thromboembolism (VTE) in women and to explore the relationship of demographic, lifestyle, and anthropometric factors to VTE incidence...
Magnesium intake and reduced risk of colon cancer in a prospective study of womenAaron R Folsom
Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA
Am J Epidemiol 163:232-5. 2006..If replicated by other observational studies, a clinical trial would be needed to determine whether it is magnesium, specifically, and not other aspects of the contributing foods, that may offer benefit...
Coronary artery calcification and myocardial perfusion in asymptomatic adults: the MESA (Multi-Ethnic Study of Atherosclerosis)Lu Wang
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
J Am Coll Cardiol 48:1018-26. 2006..Myocardial perfusion could be impaired by or manifest the progression to subclinical coronary atherosclerosis in the absence of clinical CHD...
Risk factor associations with the presence of a lipid core in carotid plaque of asymptomatic individuals using high-resolution MRI: the multi-ethnic study of atherosclerosis (MESA)Bruce A Wasserman
The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
Stroke 39:329-35. 2008..Atheroma vulnerability to rupture is increased in the presence of a large lipid core. Factors associated with a lipid core in the general population have not been studied...
Physical activity and stroke risk: a meta-analysisChong Do Lee
Department of Sports and Exercise Sciences, West Texas A and M University, Canyon, TX 79016, USA
Stroke 34:2475-81. 2003..Whether physical activity reduces stroke risk remains controversial. We used a meta-analysis to examine the overall association between physical activity or cardiorespiratory fitness and stroke incidence or mortality...
ADD1 460W allele associated with cardiovascular disease in hypertensive individualsAlanna C Morrison
Human Genetics Center, University of Texas Houston Health Science Center, Houston, Tex 77030, USA
Hypertension 39:1053-7. 2002..An interaction with hypertension in the association between the ADD1 G460W polymorphism and cardiovascular disease merits further testing in additional populations...
Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States)Ilja C W Arts
National Institute of Public Health and the Environment RIVM, Department of Chronic Diseases Epidemiology, Bilthoven, The Netherlands
Cancer Causes Control 13:373-82. 2002..We investigated whether a high intake of catechins are associated with cancer incidence among postmenopausal women...
The association of atherosclerosis, vascular risk factors, and retinopathy in adults with diabetes : the atherosclerosis risk in communities studyRonald Klein
Department of Ophthalmology and Visual Sciences, University of Wisconsin-Madison, 610 North Walnut Street, Madison, WI 53705-2397, USA
Ophthalmology 109:1225-34. 2002....
Serum insulin and glucose levels and breast cancer incidence: the atherosclerosis risk in communities studyPamela J Mink
Division of Cancer Prevention and Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852, USA
Am J Epidemiol 156:349-52. 2002..39, 95% confidence interval: 0.86, 2.23). Circulating insulin levels were not predictive of future breast cancer incidence, but there may be a weak association with type 2 diabetes, perhaps modulated via increased adiposity...
Risk factor groupings related to insulin resistance and their synergistic effects on subclinical atherosclerosis: the atherosclerosis risk in communities studySherita Hill Golden
Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Diabetes 51:3069-76. 2002..Interventions aimed at ameliorating the IRS may produce reductions in atherosclerotic risk beyond that predicted by treatment of individual IRS-related risk factors...
Nut consumption and risk of type 2 diabetesEmily D Parker
JAMA 290:38-9; author reply 39-40. 2003
Interaction of dietary folate intake, alcohol, and risk of hormone receptor-defined breast cancer in a prospective study of postmenopausal womenThomas A Sellers
Department of Health Sciences Research, Mayo Clinic and Mayo Clinic Cancer Center, Rochester, Minnesota 55905, USA
Cancer Epidemiol Biomarkers Prev 11:1104-7. 2002....
Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities studyBruce B Duncan
Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grande do Sul, Porto Alegre, Brazil
Diabetes 52:1799-805. 2003..7 (P for linear trend = 0.008). In conclusion, a low-grade inflammation predicts incident type 2 diabetes. The association is absent in smokers and African-Americans...
Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart StudyLuc Djousse
Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University School of Medicine, MA 02118, USA
Am J Clin Nutr 77:819-25. 2003..Dietary intake of linolenic acid is associated with a lower risk of cardiovascular disease mortality. However, it is unknown whether linolenic acid is associated with a lower risk of carotid atherosclerosis...
Risk factors for coronary heart disease in African Americans: the atherosclerosis risk in communities study, 1987-1997Daniel W Jones
Division of Hypertension, Department of Medicine, The University of Mississippi Medical Center, 2500 N State St, Jackson, MS 39216 4505, USA
Arch Intern Med 162:2565-71. 2002....
Fibrin fragment D-dimer and the risk of future venous thrombosisMary Cushman
Laboratory for Clinical Biochemistry Research and Department of Medicine, University of Vermont, Colchester, VT 05446, USA
Blood 101:1243-8. 2003..D-dimer is strongly and positively related to the occurrence of future venous thrombosis...
Coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC) studyLloyd E Chambless
Department of Biostatistics, University of North Carolina, CB 8300, 137 East Franklin Street, Suite 400, Bank of America Center, Chapel Hill, NC 27514 4145, USA
J Clin Epidemiol 56:880-90. 2003..These factors substantially improved prediction of future CHD for men, less for women, and also increased attributable risks...
Serum total cholesterol concentrations and awareness, treatment, and control of hypercholesterolemia among US adultsAaron R Folsom
Circulation 108:e152; author reply e152. 2003
Dairy foods, calcium, and colorectal cancer: a pooled analysis of 10 cohort studiesEunyoung Cho
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
J Natl Cancer Inst 96:1015-22. 2004..Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive...
Coffee and sweetened beverage consumption and the risk of type 2 diabetes mellitus: the atherosclerosis risk in communities studyNina P Paynter
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
Am J Epidemiol 164:1075-84. 2006..In summary, increased coffee consumption was significantly associated with a decreased risk of diagnosed type 2 diabetes mellitus in community-based US adults...
Adherence to the AICR cancer prevention recommendations and subsequent morbidity and mortality in the Iowa Women's Health Study cohortJames R Cerhan
Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
Cancer Epidemiol Biomarkers Prev 13:1114-20. 2004....
Association between alcoholic beverage consumption and incidence of coronary heart disease in whites and blacks: the Atherosclerosis Risk in Communities StudyFlavio D Fuchs
Division of Cardiology, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Ramiro Barcelos 2350, Porto Alegre 90035903, Rio Grande do Sul, Brazil
Am J Epidemiol 160:466-74. 2004..61, 95% CI: 1.11, 6.17). The contrasting findings in Whites and Black men in this cohort raise the question of whether the cardioprotective effect of alcohol is real or may be confounded by lifestyle characteristics of drinkers...
Functional limitations in elderly female cancer survivorsCarol Sweeney
Health Research Center, Department of Family and Preventive Medicine, University of Utah School of Medicine, Salt Lake City, UT, USA
J Natl Cancer Inst 98:521-9. 2006..The elderly population, including many who are long-term cancer survivors, is increasing. Aspects of quality of life in elderly cancer survivors are not well understood...
CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the population science discussion groupStephen P Fortmann
Circulation 110:e554-9. 2004..Although considerable work has been published since this review was completed, the perspectives and issues presented are still useful in evaluating the use of inflammation markers for risk stratisfication and prevention...
Traditional and nontraditional risk factors predict coronary heart disease in chronic kidney disease: results from the atherosclerosis risk in communities studyPaul Muntner
Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Avenue, SL 18, New Orleans, LA 70112, USA
J Am Soc Nephrol 16:529-38. 2005..CHD risk factors in the general population remain predictive among patients with CKD. Given the high risk for CHD among patients with CKD, control of these risk factors may have a substantial impact on their excess burden of CHD...
The association of spatial T wave axis deviation with incident coronary events. The ARIC cohortGeorgeta D Vaidean
Department of Epidemiology, University of North Carolina at Chapel Hill, USA
BMC Cardiovasc Disord 5:2. 2005....
NOS3 polymorphisms, cigarette smoking, and cardiovascular disease risk: the Atherosclerosis Risk in Communities studyCraig R Lee
Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27709, USA
Pharmacogenet Genomics 16:891-9. 2006..We sought to determine whether cigarette smoking modified the association between NOS3 polymorphisms and risk of coronary heart disease or stroke...
Deep vein thrombosis and pulmonary embolism in two cohorts: the longitudinal investigation of thromboembolism etiologyMary Cushman
Department of Medicine, University of Vermont, Burlington, USA
Am J Med 117:19-25. 2004..To determine the incidence of deep vein thrombosis and pulmonary embolism in two cohorts representing regions of the United States...
Relation between intake of vitamins C and E and risk of diabetic retinopathy in the Atherosclerosis Risk in Communities StudyAmy E Millen
Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, 610 North Walnut Street, 405 WARF Building, Madison, WI 53705-2197, USA
Am J Clin Nutr 79:865-73. 2004..The observed association between risk of retinopathy and supplement use may reflect nondietary factors or a possible benefit of supplementation...
Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: the Atherosclerosis Risk in Communities (ARIC) studyJingzhong Ding
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe St, Room 6009, Baltimore, MD 21205, USA
Stroke 35:16-21. 2004..We examined the associations of alcohol intake with MRI-defined cerebral abnormalities in a middle-aged, population-based cohort...
Smoking and diabetes differ in their associations with subclinical atherosclerosis and coronary heart disease-the ARIC StudyA Richey Sharrett
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, 615 N Wolfe Street, Room E6518, Baltimore, MD, USA
Atherosclerosis 172:143-9. 2004....
Lipoprotein-associated phospholipase A2, high-sensitivity C-reactive protein, and risk for incident coronary heart disease in middle-aged men and women in the Atherosclerosis Risk in Communities (ARIC) studyChristie M Ballantyne
Section of Atherosclerosis and Lipoprotein Research, Department of Medicine, Baylor College of Medicine, and Methodist DeBakey Heart Center, Houston, Tex 77030, USA
Circulation 109:837-42. 2004..Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a proinflammatory enzyme associated primarily with LDL...
Cardiovascular events in diabetic and nondiabetic adults with or without history of myocardial infarctionChong Do Lee
Department of Sports and Exercise Sciences, West Texas A and M University, Canyon, Tex, USA
Circulation 109:855-60. 2004..77). CONCLUSIONS: Diabetic patients without MI had lower risk of CHD events and mortality from CVD compared with nondiabetic patients with MI, but stroke risk was similar between these 2 groups...
Heme iron, zinc, alcohol consumption, and colon cancer: Iowa Women's Health StudyDuk-Hee Lee
Department of Preventive Medicine, College of Medicine, Kyungpook National University, Daegu, Korea
J Natl Cancer Inst 96:403-7. 2004....
Research Grants
- EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISMAaron Folsom; Fiscal Year: 2003..Continuation of this comprehensive prospective study will provide additional important epidemiologic insights into the etiology of VTE. This could lead to new strategies for prevention or treatment of VTE. ..
- EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENAaron Folsom; Fiscal Year: 2004..S. Specific Populations) and on survival (PA-98-027 Cancer Survival Studies in Established Epidemiologic Cohorts). The information that the IWHS will provide could be valuable in the control of this major public health problem. ..
- EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISMAaron Folsom; Fiscal Year: 2006..Continuation of this comprehensive prospective study will provide additional important epidemiologic insights into the etiology of VTE. This could lead to new strategies for prevention or treatment of VTE. ..
- EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENAaron Folsom; Fiscal Year: 2007..With this progressive approach, continued funding of the IWHS should prove to be of value in the control of this major public health problem. ..
- EPIDEMIOLOGY OF CANCER IN A COHORT OF OLDER WOMENAaron Folsom; Fiscal Year: 2009..With this progressive approach, continued funding of the IWHS should prove to be of value in the control of this major public health problem. ..
- EPIDEMIOLOGY OF VENOUS THROMBOSIS AND PULMONARY EMBOLISMAaron Folsom; Fiscal Year: 2000....
- DISTRIBUTION OF BODY FAT AND CANCER RISK IN WOMENAaron Folsom; Fiscal Year: 1993..The proposed project will provide new information on the risk of cancer in older women. This information could be valuable in the primary prevention of disease...
- DISTRIBUTION OF BODY FAT AND CANCER RISK IN WOMENAaron Folsom; Fiscal Year: 1999..The proposed project will provide new information on the risk of cancer in older women. This information could be valuable in the primary prevention of this major public health problem. ..
- Epidemiology of Venous Thrombosis & Pulmonary EmbolismAaron Folsom; Fiscal Year: 2009..This study is designed to provide new information on genetic risk for VTE, with potential implications for prevention and treatment of VTE. ..
