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..Low-dose PIO (15 mg/day) improves glycaemic control, beta cell function and inflammatory state in obese patients with type 2 diabetes. Clinical.Trial.gov NCT01223196. This study was funded by TAKEDA. ..
Andreozzi F, Raciti G, Nigro C, Mannino G, Procopio T, Davalli A, et al
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..Finally, EXE also induces glucose transporter Glut-4 translocation to the plasma membrane. In L6 myotubes, EXE and liraglutide increase glucose uptake in an insulin-independent manner by activating AMPK. ..
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..Activation of insulin signaling, FoxO1 and proteins in ?-cell-cycle progression are attractive therapeutic targets to enhance ?-cell regeneration in the treatment of T2DM. ..
Daniele G, Winnier D, Mari A, Bruder J, Fourcaudot M, Pengou Z, et al
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..The correlation between sclerostin and insulin clearance at fasting state and during OGTT is novel; thus, studies are needed to explore the potential causal relationship. ..
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..Further, we suggest a future research agenda. ..