Thomas F Floyd

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint Clinically silent cerebral ischemic events after cardiac surgery: their incidence, regional vascular occurrence, and procedural dependence
    Thomas F Floyd
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvani, USA
    Ann Thorac Surg 81:2160-6. 2006
  2. ncbi request reprint Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Appl Physiol (1985) 95:2453-61. 2003
  3. ncbi request reprint Integrity of the cerebral blood-flow response to hyperoxia after cardiopulmonary bypass
    Thomas F Floyd
    Department of Anesthesiology, Penn Presbyterian Hospital, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Cardiothorac Vasc Anesth 21:212-7. 2007
  4. ncbi request reprint Recurrence of stroke after cardiac surgery: insight into pathogenesis via diffusion-weighted and continuous arterial spin labeling perfusion magnetic resonance imaging
    Thomas F Floyd
    Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cardiothorac Vasc Anesth 21:106-9. 2007
  5. ncbi request reprint Perioperative changes in cerebral blood flow after cardiac surgery: influence of anemia and aging
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 76:2037-42. 2003
  6. ncbi request reprint Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territories
    Thomas F Floyd
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 18:649-55. 2003
  7. pmc Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg
    Erin K Englund
    Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:70. 2013
  8. pmc Vessel-wall imaging and quantification of flow-mediated dilation using water-selective 3D SSFP-echo
    Michael C Langham
    Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, USA
    J Cardiovasc Magn Reson 15:100. 2013
  9. pmc Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRI
    Wen Chau Wu
    Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 28:445-52. 2008
  10. pmc Quantitative CMR markers of impaired vascular reactivity associated with age and peripheral artery disease
    Michael C Langham
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:17. 2013

Research Grants

  1. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2003
  2. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2004
  3. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2005
  4. Senescense and cerebral oxygenation with acute anemia
    Thomas Floyd; Fiscal Year: 2005
  5. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2006
  6. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2007
  7. Stroke & cognition in surgical aortic stenosis
    Thomas Floyd; Fiscal Year: 2007
  8. Stroke & cognition in surgical aortic stenosis
    Thomas Floyd; Fiscal Year: 2009

Detail Information

Publications24

  1. ncbi request reprint Clinically silent cerebral ischemic events after cardiac surgery: their incidence, regional vascular occurrence, and procedural dependence
    Thomas F Floyd
    Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvani, USA
    Ann Thorac Surg 81:2160-6. 2006
    ..We also document the association of preexisting white matter lesions with new postoperative ischemic lesions...
  2. ncbi request reprint Independent cerebral vasoconstrictive effects of hyperoxia and accompanying arterial hypocapnia at 1 ATA
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Appl Physiol (1985) 95:2453-61. 2003
    ..Regression analysis confirmed the independent cerebral vasoconstrictive effect of increased arterial Po2. The present results also demonstrate that the magnitude of this effect at 1.0 ATA is greater than previously measured...
  3. ncbi request reprint Integrity of the cerebral blood-flow response to hyperoxia after cardiopulmonary bypass
    Thomas F Floyd
    Department of Anesthesiology, Penn Presbyterian Hospital, University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Cardiothorac Vasc Anesth 21:212-7. 2007
    ..In this study, the hypothesis that cardiopulmonary bypass (CPB) alters the cerebral blood flow (CBF) vasoconstrictive response to hyperoxia was tested...
  4. ncbi request reprint Recurrence of stroke after cardiac surgery: insight into pathogenesis via diffusion-weighted and continuous arterial spin labeling perfusion magnetic resonance imaging
    Thomas F Floyd
    Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cardiothorac Vasc Anesth 21:106-9. 2007
  5. ncbi request reprint Perioperative changes in cerebral blood flow after cardiac surgery: influence of anemia and aging
    Thomas F Floyd
    Department of Anesthesia, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 76:2037-42. 2003
    ..To better understand changes in perioperative CBF physiology we have measured changes in CBF and the influence of anemia and aging on these changes...
  6. ncbi request reprint Precision of the CASL-perfusion MRI technique for the measurement of cerebral blood flow in whole brain and vascular territories
    Thomas F Floyd
    University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Magn Reson Imaging 18:649-55. 2003
    ..To analyze the precision of cerebral blood flow (CBF) measurements made with continuous arterial spin labeling(CASL) perfusion magnetic resonance imaging (MRI) over experimentally relevant intervals...
  7. pmc Combined measurement of perfusion, venous oxygen saturation, and skeletal muscle T2* during reactive hyperemia in the leg
    Erin K Englund
    Department of Radiology, Laboratory of Structural NMR Imaging, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:70. 2013
    ..The purpose of this work is to develop and evaluate a magnetic resonance (MR) technique for simultaneous measurement of perfusion, SvO2, and skeletal muscle T2*...
  8. pmc Vessel-wall imaging and quantification of flow-mediated dilation using water-selective 3D SSFP-echo
    Michael C Langham
    Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, USA
    J Cardiovasc Magn Reson 15:100. 2013
    ..To introduce a new, efficient method for vessel-wall imaging of carotid and peripheral arteries by means of a flow-sensitive 3D water-selective SSFP-echo pulse sequence...
  9. pmc Transit delay and flow quantification in muscle with continuous arterial spin labeling perfusion-MRI
    Wen Chau Wu
    Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Magn Reson Imaging 28:445-52. 2008
    ..To test the hypothesis that flow measurements using continuous arterial spin labeling (CASL) magnetic resonance imaging (MRI) in muscle depend upon transit delay, and examine the repeatability of CASL measurements...
  10. pmc Quantitative CMR markers of impaired vascular reactivity associated with age and peripheral artery disease
    Michael C Langham
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    J Cardiovasc Magn Reson 15:17. 2013
    ....
  11. pmc Skeletal muscle microvascular flow in progressive peripheral artery disease: assessment with continuous arterial spin-labeling perfusion magnetic resonance imaging
    Wen Chau Wu
    Department of Radiology, Hospital of University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Am Coll Cardiol 53:2372-7. 2009
    ..We present the novel application of continuous arterial spin-labeling (CASL) magnetic resonance imaging (MRI) for the measurement of calf muscle perfusion in subjects with progressive peripheral arterial disease (PAD)...
  12. pmc Sex, aging, and preexisting cerebral ischemic disease in patients with aortic stenosis
    Ping Wang
    Department of Radiology, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Ann Thorac Surg 90:1230-5. 2010
    ..We tested the hypotheses that increasing age, female sex, coronary artery disease, and the severity of AS are predictive of the severity of preexisting cerebral ischemic lesions...
  13. pmc Acute anemia elicits cognitive dysfunction and evidence of cerebral cellular hypoxia in older rats with systemic hypertension
    Min Li
    Department of Anesthesiology and Critical Care, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Anesthesiology 113:845-58. 2010
    ..Cerebrovascular changes related to chronic hypertension may expose cells to increased hypoxia with anemia...
  14. pmc Rapid magnetic resonance measurement of global cerebral metabolic rate of oxygen consumption in humans during rest and hypercapnia
    Varsha Jain
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Cereb Blood Flow Metab 31:1504-12. 2011
    ..44, P=0.052). A CVR value of 6.1%±1.6%/mm Hg was determined using a linear-fit model. Additionally, an average undershoot of 6.7%±4% and 17.1%±7% was observed in S(v)O(2) and tCBF upon recovery from hypercapnia in six subjects...
  15. pmc Hyperemic flow heterogeneity within the calf, foot, and forearm measured with continuous arterial spin labeling MRI
    Wen Chau Wu
    Department of Radiology, The Hospital of University of Pennsylvania, 3400 Spruce St, Philadelphia, PA 19104, USA
    Am J Physiol Heart Circ Physiol 294:H2129-36. 2008
    ..These results demonstrate that CASL is sensitive to flow heterogeneity between diverse muscle groups and that nonuniform hyperemic flow patterns following an ischemic paradigm correlate with relative fiber-type predominance...
  16. pmc Evaluation of cuff-induced ischemia in the lower extremity by magnetic resonance oximetry
    Michael C Langham
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 55:598-606. 2010
    ....
  17. pmc Accuracy and precision of MR blood oximetry based on the long paramagnetic cylinder approximation of large vessels
    Michael C Langham
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Magn Reson Med 62:333-40. 2009
    ..In conclusion, the data suggest that %HbO(2) can be measured reproducibly in vivo in large vessels of the peripheral circulation on the basis of the paramagnetic cylinder approximation of the incremental field...
  18. ncbi request reprint Aging: impact upon local cerebral oxygenation and blood flow with acute isovolemic hemodilution
    Min Li
    Department of Anesthesiology and Critical Care, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
    J Neurosurg Anesthesiol 18:125-31. 2006
    ..Aged animals were also fully capable of mounting a robust local cerebral hyperemic response to the anemic challenge that was not separable from the response of younger animals...
  19. ncbi request reprint Rapid and rational echocardiographic-assisted management of cardiogenic shock after coronary artery bypass surgery
    John G Augoustides
    Department of Anesthesia, Hospital of the University of Pennsylvania, Philadelphia, PA 19104 4283, USA
    J Cardiothorac Vasc Anesth 19:772-4. 2005
  20. pmc Stroke after aortic valve surgery: results from a prospective cohort
    Steven R Messe
    From the Departments of Neurology S R M, S E K, Surgery M A A, M F, W Y S, J E B, W C H, and Radiology M B, and Section of Vascular Medicine, Cardiovascular Division, Department of Medicine E R M, Hospital of the University of Pennsylvania, Philadelphia, PA Department of Psychology, Temple University, Philadelphia, PA T G Department of Biostatistics and Epidemiology, University of Pennsylvania, Philadelphia, PA S J R Department of Anesthesia and Critical Care, State University of New York, Stony Brook, NY T F F
    Circulation 129:2253-61. 2014
    ..The incidence and impact of clinical stroke and silent radiographic cerebral infarction complicating open surgical aortic valve replacement (AVR) are poorly characterized...
  21. doi request reprint An organized, comprehensive, and security-enabled strategic response to the Haiti earthquake: a description of pre-deployment readiness preparation and preliminary experience from an academic anesthesiology department with no preexisting international dis
    Maureen McCunn
    Department of Anesthesiology and Critical Care, University of Pennsylvania School of Medicine, 3400 Spruce St, Philadelphia, PA 19104, USA
    Anesth Analg 111:1438-44. 2010
    ..The focus of this article is the pre-deployment readiness process, and is not a post-deployment report describing the medical care provided in Haiti...
  22. pmc Detection of lactate with a hadamard slice selected, selective multiple quantum coherence, chemical shift imaging sequence (HDMD-SelMQC-CSI) on a clinical MRI scanner: Application to tumors and muscle ischemia
    Eric A Mellon
    Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Magn Reson Med 62:1404-13. 2009
    ..In conclusion, the Hadamard encoded-selective homonuclear multiple quantum coherence transfer-chemical shift imaging sequence is demonstrated on a phantom and in two lipid-rich, clinically relevant, in vivo conditions...
  23. ncbi request reprint Major clinical outcomes in adults undergoing thoracic aortic surgery requiring deep hypothermic circulatory arrest: quantification of organ-based perioperative outcome and detection of opportunities for perioperative intervention
    John G Augoustides
    Department of Anesthesia, Cardiothoracic Section, Hospital of the University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104 4283, USA
    J Cardiothorac Vasc Anesth 19:446-52. 2005
    ....
  24. ncbi request reprint Echocardiography in suspected acute type a aortic dissection: detection and definitive management of a false-positive presentation
    John G T Augoustides
    J Cardiothorac Vasc Anesth 20:912-4. 2006

Research Grants9

  1. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2003
    ..Finally, we will apply them prospectively to predict graft patency and wound healing after amputation. ..
  2. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2004
    ..Finally, we will apply them prospectively to predict graft patency and wound healing after amputation. ..
  3. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2005
    ..Finally, we will apply them prospectively to predict graft patency and wound healing after amputation. ..
  4. Senescense and cerebral oxygenation with acute anemia
    Thomas Floyd; Fiscal Year: 2005
    ..We propose to study the effect of AIA on cerebral oxygenation and cognition in young and aged spontaneously hypertensive rats. ..
  5. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2006
    ..Finally, we will apply them prospectively to predict graft patency and wound healing after amputation. ..
  6. MRI Correlates of Limb Ischemia in PVD
    Thomas Floyd; Fiscal Year: 2007
    ..Finally, we will apply them prospectively to predict graft patency and wound healing after amputation. ..
  7. Stroke & cognition in surgical aortic stenosis
    Thomas Floyd; Fiscal Year: 2007
    ..Finally, the study database will allow us to closely examine the long-term risks for cognitive impairment & dementia from embolic processes during heart surgery.. ..
  8. Stroke & cognition in surgical aortic stenosis
    Thomas Floyd; Fiscal Year: 2009
    ..Finally, the study database will allow us to closely examine the long-term risks for cognitive impairment & dementia from embolic processes during heart surgery.. ..