ROBERT FLOYD

Summary

Affiliation: University of Oklahoma Health Sciences Center
Country: USA

Publications

  1. pmc Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines
    Robert A Floyd
    Experimental Therapeutics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 62:145-56. 2013
  2. ncbi request reprint Oxidative biochemical markers; clues to understanding aging in long-lived species
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Exp Gerontol 36:619-40. 2001
  3. ncbi request reprint Nitrone inhibition of age-associated oxidative damage
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
    Ann N Y Acad Sci 899:222-37. 2000
  4. ncbi request reprint Nitrones as neuroprotectants and antiaging drugs
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Ann N Y Acad Sci 959:321-9. 2002
  5. ncbi request reprint Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Mol Cell Biochem 234:195-203. 2002
  6. ncbi request reprint Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 23:795-807. 2002
  7. ncbi request reprint Antioxidants, oxidative stress, and degenerative neurological disorders
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Proc Soc Exp Biol Med 222:236-45. 1999
  8. ncbi request reprint Methylene blue photoinactivation of RNA viruses
    Robert A Floyd
    Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
    Antiviral Res 61:141-51. 2004
  9. ncbi request reprint Direct administration of interleukin-1 and interferon-gamma to rat pancreas leads to the in vivo production of nitric oxide and expression of inducible nitric oxide synthase and inducible cyclooxygenase
    T Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Pancreas 23:316-22. 2001
  10. ncbi request reprint Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus
    T Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    FEBS Lett 407:148-52. 1997

Research Grants

  1. OMRF MRI SYSTEM
    ROBERT FLOYD; Fiscal Year: 2004
  2. FREE RADICALS AND CHOLINE DEFICIENT LIVER CARCINOGENESIS
    ROBERT FLOYD; Fiscal Year: 2005

Collaborators

Detail Information

Publications53

  1. pmc Nitrone-based therapeutics for neurodegenerative diseases: their use alone or in combination with lanthionines
    Robert A Floyd
    Experimental Therapeutics, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 62:145-56. 2013
    ..There is much more research and development activity ongoing for various indications with the nitrones, alone or in combination with other active compounds, as briefly noted in this review. ..
  2. ncbi request reprint Oxidative biochemical markers; clues to understanding aging in long-lived species
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Exp Gerontol 36:619-40. 2001
    ....
  3. ncbi request reprint Nitrone inhibition of age-associated oxidative damage
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, USA
    Ann N Y Acad Sci 899:222-37. 2000
    ....
  4. ncbi request reprint Nitrones as neuroprotectants and antiaging drugs
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Ann N Y Acad Sci 959:321-9. 2002
    ..On the basis of novel ideas about the action of secretory products formed by senescent cells on bystander cells, it is postulated that nitrones will mitigate these processes and that this may be the mechanism of their antiaging activity...
  5. ncbi request reprint Reactive oxygen species in choline deficiency induced carcinogenesis and nitrone inhibition
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Mol Cell Biochem 234:195-203. 2002
    ..This is considered to be the primary reason the size of the preneoplastic lesions are significantly decreased and why the nitrones are potent anti-carcinogenic agents in this model...
  6. ncbi request reprint Oxidative stress in brain aging. Implications for therapeutics of neurodegenerative diseases
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Neurobiol Aging 23:795-807. 2002
    ..Novel therapeutics based on blocking neuron damaging neuroinflammatory processes show great promise for abating dementia progression although they have yet to make it to clinical practice...
  7. ncbi request reprint Antioxidants, oxidative stress, and degenerative neurological disorders
    R A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Proc Soc Exp Biol Med 222:236-45. 1999
    ..Outcomes of clinical trials on antioxidants will become less confusing as more knowledge is amassed on the basic processes involved...
  8. ncbi request reprint Methylene blue photoinactivation of RNA viruses
    Robert A Floyd
    Oklahoma Medical Research Foundation, Auburn University, Auburn, AL 36849, USA
    Antiviral Res 61:141-51. 2004
    ..MB photoinactivation of viruses show significant promise because the technology not only offers significant potency but the history of safe MB use in human therapy makes it attractive also...
  9. ncbi request reprint Direct administration of interleukin-1 and interferon-gamma to rat pancreas leads to the in vivo production of nitric oxide and expression of inducible nitric oxide synthase and inducible cyclooxygenase
    T Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Pancreas 23:316-22. 2001
    ..The compound phenyl N-tert-butylnitrone, which protects mice against streptozotocin-induced IDDM, inhibits NO formation and downregulates both iNOS and COX-2 mRNA levels...
  10. ncbi request reprint Spin trapping agent phenyl N-tert-butylnitrone protects against the onset of drug-induced insulin-dependent diabetes mellitus
    T Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    FEBS Lett 407:148-52. 1997
    ..EPR spin trapping experiments in the pancreas indicated the in vivo formation of NO in STZ-treated animals and its attenuation by PBN treatment...
  11. ncbi request reprint COX-2 inhibition prevents insulin-dependent diabetes in low-dose streptozotocin-treated mice
    T Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, Oklahoma 73104, USA
    Biochem Biophys Res Commun 273:699-704. 2000
    ..These results demonstrate the critical importance of COX-2 activity in autoimmune destruction of beta cells, and point to the fact that COX-2 inhibition can potentially develop into a preventive therapy against IDDM...
  12. pmc Specific repression of beta-globin promoter activity by nuclear ferritin
    R H Broyles
    Departments of Biochemistry and Molecular Biology, and Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Proc Natl Acad Sci U S A 98:9145-50. 2001
    ..Such a repressor could be helpful in treating sickle cell and other genetic diseases...
  13. ncbi request reprint Induction of Akt phosphorylation in rat primary astrocytes by H2O2 occurs upstream of phosphatidylinositol 3-kinase: no evidence for oxidative inhibition of PTEN
    S Salsman
    Department of Biochemistry and Molecular Biology, Oklahoma University Health Sciences Center, Oklahoma City 73104, USA
    Arch Biochem Biophys 386:275-80. 2001
    ..The data indicate that major oxidative effects do not occur at the level of the PI 3-K-antagonizing phosphatase PTEN...
  14. ncbi request reprint Reactive oxygen species, cell signaling, and cell injury
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 28:1456-62. 2000
    ..Introduction of antioxidant therapies into mainstream medicine is possible and promising, but will require significant advances in basic cell biology, pharmacology, and clinical bioanalysis...
  15. ncbi request reprint Q beta bacteriophage photoinactivated by methylene blue plus light involves inactivation of its genomic RNA
    J E Schneider
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA
    Photochem Photobiol 70:902-9. 1999
    ....
  16. ncbi request reprint Measurement of 3-nitrotyrosine and 5-nitro-gamma-tocopherol by high-performance liquid chromatography with electrochemical detection
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    Free Radic Biol Med 28:520-8. 2000
    ..Techniques are described for the determination of 3-nitro-tyrosine and 5-nitro-gamma-tocopherol in biological samples using high-performance liquid chromatography with electrochemical detection...
  17. ncbi request reprint Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development
    R A Floyd
    Oklahoma Medical Research Foundation, and the Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA
    Free Radic Biol Med 26:1346-55. 1999
    ..This hypothesis can be experimentally examined by development of definitive methods to quantitate unique products that are formed by processes predicted to occur under neurodegenerative conditions...
  18. ncbi request reprint Potential mechanisms of photodynamic inactivation of virus by methylene blue. I. RNA-protein crosslinks and other oxidative lesions in Q beta bacteriophage
    J E Schneider
    Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City 73104, USA
    Photochem Photobiol 67:350-7. 1998
    ..Due to its close correlation with Q beta inactivation and its expected lethality, RNA-protein crosslink formation may be important as an inactivating lesion in bacteriophage Q beta following MB + L exposure...
  19. ncbi request reprint Dietary choline restriction causes complex I dysfunction and increased H(2)O(2) generation in liver mitochondria
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73014, USA
    Carcinogenesis 21:983-9. 2000
    ....
  20. ncbi request reprint Inhibition of the cytokine-mediated inducible nitric oxide synthase expression in rat insulinoma cells by phenyl N-tert-butylnitrone
    T Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, 73104, USA
    Nitric Oxide 4:157-67. 2000
    ..These results indicate that PBN protects against IDDM at least in part by prevention of cytokine-induced NO generation by pancreatic beta-cells...
  21. ncbi request reprint Quantitation of protein-bound 3-nitrotyrosine and 3,4-dihydroxyphenylalanine by high-performance liquid chromatography with electrochemical array detection
    K Hensley
    Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, Oklahoma, 73104, USA
    Anal Biochem 251:187-95. 1997
    ..A method of sample preparation wherein tyrosine analogs are enzymatically hydrolyzed from protein without the need for sample extraction, concentration, or derivatization is reported...
  22. ncbi request reprint CPI-1189 inhibits interleukin 1beta-induced p38-mitogen-activated protein kinase phosphorylation: an explanation for its neuroprotective properties?
    K Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma 73104, USA
    Neurosci Lett 281:179-82. 2000
    ....
  23. ncbi request reprint Region-selective effects of neuroinflammation and antioxidant treatment on peripheral benzodiazepine receptors and NMDA receptors in the rat brain
    A Biegon
    Lawrence Berkeley National Laboratory, Berkeley, California, USA Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    J Neurochem 82:924-34. 2002
    ..Loss of NMDA receptor function in cortical and hippocampal regions may contribute to the cognitive deficits observed in diseases with a neuroinflammatory component, such as meningitis or Alzheimer's disease...
  24. ncbi request reprint Reactive oxygen species-mediated inactivation of pyruvate dehydrogenase
    T Tabatabaie
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, Oklahoma, 73104, USA
    Arch Biochem Biophys 336:290-6. 1996
    ..A similar mechanism may be responsible for the PDH inactivation during ischemia/reperfusion...
  25. doi request reprint Antioxidant treatment reduces blast-induced cochlear damage and hearing loss
    DONALD L EWERT
    Hough Ear Institute, 3400 N W 56th Street, Oklahoma City, OK 73112, USA
    Hear Res 285:29-39. 2012
    ....
  26. pmc In vivo MRS assessment of altered fatty acyl unsaturation in liver tumor formation of a TGF alpha/c-myc transgenic mouse model
    J Griffitts
    Advanced Magnetic Resonance Center, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    J Lipid Res 50:611-22. 2009
    ....
  27. ncbi request reprint Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats
    Yoshiko Inoue
    Free Radical Biology and Aging Research Program, Oklahoma City, OK 73104, USA
    Free Radic Res 41:972-80. 2007
    ..The CD diet model is also considered as a model for non-alcoholic steatohepatitis (NASH) in humans and early expression of Fas could also be a good index of the progression of NASH...
  28. ncbi request reprint Nitrone-related therapeutics: potential of NXY-059 for the treatment of acute ischaemic stroke
    Kirk R Maples
    Anacor Pharmaceuticals Inc, Palo Alto, California, USA
    CNS Drugs 18:1071-84. 2004
    ..Further experiments are required to fully elucidate the mechanism of action of these very effective neuroprotective agents...
  29. ncbi request reprint Oxidative modification of proteins in cell signaling
    Kenneth Hensley
    Antioxid Redox Signal 7:523-5. 2005
  30. ncbi request reprint Mitochondrial dysfunction in choline deficiency-induced apoptosis in cultured rat hepatocytes
    Wei Xing Guo
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, MB21, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 39:641-50. 2005
    ..These data indicate that the disruption of MMP is an upstream event in CD-induced apoptosis, and mitochondrial dysfunction plays a key role in mediating CD-induced apoptosis in CWSV-1 cells...
  31. ncbi request reprint Methylene blue photoinactivation abolishes West Nile virus infectivity in vivo
    James F Papin
    Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, USA
    Antiviral Res 68:84-7. 2005
    ..Since MB is already approved for human use at a dose of 100mg/kg/day, we conjecture that MB+light treatment of blood products for high-risk patients will be efficacious and suitable for use in resource-limited settings...
  32. ncbi request reprint Nitrones as therapeutics in age-related diseases
    Robert A Floyd
    Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Aging Cell 5:51-7. 2006
    ....
  33. ncbi request reprint The arachidonic acid 5-lipoxygenase inhibitor nordihydroguaiaretic acid inhibits tumor necrosis factor alpha activation of microglia and extends survival of G93A-SOD1 transgenic mice
    Melinda West
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 91:133-43. 2004
    ..Thus, TNFalpha antagonists and especially 5LOX inhibitors might offer new opportunities for treatment of ALS...
  34. ncbi request reprint Reactive oxygen species in choline deficiency-induced apoptosis in rat hepatocytes
    Wei Xing Guo
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 37:1081-9. 2004
    ..Our data also demonstrated that ROS generation occurred before CD-induced apoptosis, suggesting ROS may play a key role in signaling CD-induced apoptosis in CWSV-1 cells...
  35. ncbi request reprint Nitrones, their value as therapeutics and probes to understand aging
    Robert A Floyd
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 N E 13th Street, Oklahoma City, OK 73104 5046, USA
    Mech Ageing Dev 123:1021-31. 2002
    ..Stabilization of phosphorylation networks associated with checkpoint proteins could slow cell cycle processes and this could be the basis of the nitrones anti-senescent activity...
  36. ncbi request reprint Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    J Neurochem 82:365-74. 2002
    ....
  37. ncbi request reprint Effects of phenyl N-tert-butyl nitrone and its derivatives on the early phase of hepatocarcinogenesis in rats fed a choline-deficient, L-amino acid-defined diet
    Dai Nakae
    Department of Pathology, Sasaki Institute, Sasaki Foundation, 2 2 Kanda Surugadai, Chiyoda, Tokyo 101 0062
    Cancer Sci 94:26-31. 2003
    ..Further, the metabolic conversion to 4-hydroxyphenyl N-tert-butyl nitrone may also be important for the inhibitory effects of phenyl N-tert-butyl nitrone on hepatocarcinogenesis...
  38. ncbi request reprint Reactive oxygen species and protein oxidation in aging: a look back, a look ahead
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Arch Biochem Biophys 397:377-83. 2002
    ..Emerging technologies, particularly proteomic technologies, are discussed that will facilitate further evolution in the field of reactive oxygen biochemistry...
  39. ncbi request reprint Message and protein-level elevation of tumor necrosis factor alpha (TNF alpha) and TNF alpha-modulating cytokines in spinal cords of the G93A-SOD1 mouse model for amyotrophic lateral sclerosis
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Neurobiol Dis 14:74-80. 2003
    ..Our data support a model wherein TNFalpha acts as a principal driver for neuroinflammation, while several co-stimulating cytokines and chemokines act to potentiate the TNFalpha effects...
  40. ncbi request reprint New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine
    Kenneth Hensley
    Free Radical Biology and Aging Research Program, Oklahoma Medical Reserach Foundation, Oklahoma City, OK 73104, USA
    Free Radic Biol Med 36:1-15. 2004
    ..The data argue for thorough experimental and epidemiological reappraisal of desmethyl tocopherols, especially within the contexts of cardiovascular disease and cancer biology...
  41. ncbi request reprint Inhibition of the development of hepatocellular carcinomas by phenyl N-tert-butyl nitrone in rats fed with a choline-deficient, L-amino acid-defined diet
    Dai Nakae
    Department of Pathology, Sasaki Institute, Sasaki Foundation, 2 2 Kanda Surugadai, Chiyoda, Tokyo 101 0062, Japan
    Cancer Lett 206:1-13. 2004
    ..If such findings can be generalized, PBN may be able to serve as a good tool to investigate molecular mechanisms underlying carcinogenic processes...
  42. ncbi request reprint Oxidative stress and neuroinflammation in Alzheimer's disease and amyotrophic lateral sclerosis: common links and potential therapeutic targets
    Molina Mhatre
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA
    J Alzheimers Dis 6:147-57. 2004
    ..A discussion is made regarding the relevance of neuroinflammation to potential therapeutic implications for both ALS and AD...
  43. ncbi request reprint Nitric oxide production by primary liver cells isolated from amino acid diet-fed rats
    Yashige Kotake
    Oklahoma Medical Research Foundation, Free Radical Biology and Aging Research Program, Oklahoma City, OK 73104, USA
    Methods Enzymol 396:535-41. 2005
    ..L-arginine or L-glutamine (material for L-arginine biosynthesis) enriched diet showed the same NO augmentation as in AA diet. It is speculated that a high content of free L-arginine in AA diet may have caused enhanced NO production...
  44. ncbi request reprint The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain
    Kelly S Williamson
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA
    Nitric Oxide 6:221-7. 2002
    ..The findings are discussed in reference to the neuroinflammatory hypothesis of AD and the possible role of gamma-tocopherol as a major lipid-phase scavenger of reactive nitrogen species...
  45. ncbi request reprint Anti-inflammatory effects of tocopherol metabolites
    Paula Grammas
    Oklahoma Center for Neuroscience, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Biochem Biophys Res Commun 319:1047-52. 2004
    ..These results show that the anti-inflammatory effects of tocopherols are highly cell type-, stimulus-, and endpoint-dependent...
  46. pmc Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
    Randy Strong
    Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
    Aging Cell 7:641-50. 2008
    ..Further studies are warranted to find whether NDGA or aspirin, over a range of doses,might prove to postpone death and various age-related outcomes reproducibly in mice...
  47. doi request reprint Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla
    Chul Hee Choi
    Hough Ear Institute, Oklahoma City, OK 73112, USA
    Free Radic Biol Med 44:1772-84. 2008
    ..These results demonstrate that 4-OHPBN and combinations of antioxidants can effectively treat acute acoustic trauma and drug combinations may increase the effectiveness of treatment and decrease the required individual medication dose...
  48. ncbi request reprint Phenyl-tert-butylnitrone induces tumor regression and decreases angiogenesis in a C6 rat glioma model
    Sabrina Doblas
    Oklahoma University Bioengineering Center, Norman, OK, USA
    Free Radic Biol Med 44:63-72. 2008
    ..The MR methods that we used also proved to be particularly suitable in following the angiogenic behavior and treatment response of a potential anti-glioma agent in a rat C6 glioma model...
  49. ncbi request reprint An Aging Interventions Testing Program: study design and interim report
    Richard A Miller
    Department of Pathology and Geriatrics Center, University of Michigan, Ann Arbor VA Medical Center, Ann Arbor, MI 48109 2200, USA
    Aging Cell 6:565-75. 2007
    ..More data will be needed to determine if any of these compounds can extend maximal lifespan, but the current data show that NDGA reduces early life mortality risks in genetically heterogeneous mice at multiple test sites...
  50. ncbi request reprint Sensitivity of protein tyrosine phosphatase activity to the redox environment, cytochrome C, and microperoxidase
    Scott J Salsman
    Free Radical Biology and Aging Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA
    Antioxid Redox Signal 7:1078-88. 2005
    ..Taken together, these data suggest that not only H2O2, but also a variety of redox-active metabolites and hemes can oxidatively inactivate PTPs with potentially profound implications for signal transduction...
  51. ncbi request reprint Distinct patterns of gene expression in hepatocellular carcinomas and adjacent non-cancerous, cirrhotic liver tissues in rats fed a choline-deficient, L-amino acid-defined diet
    Fumiyuki Uematsu
    Department of Pathology, Sasaki Institute, Sasaki Foundation, Chiyoda ku, Tokyo, Japan
    Cancer Sci 96:414-24. 2005
    ....
  52. ncbi request reprint DNA cytosine methylation profile in various cancer-related genes is altered in cultured rat hepatocyte cell lines as compared with primary hepatocytes
    Kiyoshi Asada
    Third Department of Internal Medicine, Nara Medical University, Kashihara, Nara 634 8521, Japan
    Oncol Rep 15:1241-8. 2006
    ..This study suggests that a cautious approach is required when cell lines are utilized to study methylation-related carcinogenic, metastatic or tumoricidal mechanisms...

Research Grants2

  1. OMRF MRI SYSTEM
    ROBERT FLOYD; Fiscal Year: 2004
    ..Additionally, new MRI technology will be developed for assessing tissue localization of specific flee radicals with a focus on nitric oxide intermediates, and tissue-specific contrast enhancement. ..
  2. FREE RADICALS AND CHOLINE DEFICIENT LIVER CARCINOGENESIS
    ROBERT FLOYD; Fiscal Year: 2005
    ..C) We will determine if PBN (or its metabolite 4-OH-PBN) inhibits CD-mediated HCC development and ascertain if these compounds increase apoptosis in preneoplastic cells in this model. ..