Matthew T Flowers

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Physiol Genomics 33:361-72. 2008
  2. ncbi Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Biochim Biophys Acta 1791:85-91. 2009
  3. ncbi Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19734. 2011
  4. ncbi Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:19961-73. 2009
  5. ncbi Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate
    Xueqing Liu
    Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Arterioscler Thromb Vasc Biol 30:31-8. 2010
  6. ncbi Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Nutr Rev 65:S35-8. 2007
  7. ncbi Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    Novartis Found Symp 286:47-53; discussion 54-7, 162-3, 196-203. 2007
  8. ncbi Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
  9. ncbi Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433, Babcock Drive, Madison, WI 53706, USA
    Biochem Biophys Res Commun 380:818-22. 2009
  10. ncbi Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    Jessica B Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 537606, USA
    Diabetes 56:1228-39. 2007

Collaborators

Detail Information

Publications16

  1. ncbi Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Physiol Genomics 33:361-72. 2008
    ....
  2. ncbi Stearoyl-CoA desaturase and its relation to high-carbohydrate diets and obesity
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin, 433 Babcock Drive, Madison, Wisconsin 53706, USA
    Biochim Biophys Acta 1791:85-91. 2009
    ..In this review, we address the association of high-carbohydrate diets with increased SCD activity and summarize the current literature on the subject of SCD1 and body weight regulation...
  3. ncbi Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin, United States of America
    PLoS ONE 6:e19734. 2011
    ..These results highlight the importance of monounsaturated fatty acid synthesis for maintaining retinol homeostasis and point to disturbed retinol metabolism as a novel contributor to the Scd1 deficiency-induced skin phenotype...
  4. ncbi Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity
    Harini Sampath
    Department of Nutritional Sciences, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Biol Chem 284:19961-73. 2009
    ..This results in up-regulation of thermogenic processes for temperature maintenance at the expense of fuel economy, illustrating cross-talk between the skin and peripheral tissues in maintaining energy homeostasis...
  5. ncbi Loss of Stearoyl-CoA desaturase-1 attenuates adipocyte inflammation: effects of adipocyte-derived oleate
    Xueqing Liu
    Department of Biochemistry, University of Wisconsin, Madison, 433 Babcock Dr, Madison, WI 53706, USA
    Arterioscler Thromb Vasc Biol 30:31-8. 2010
    ..This study aimed at identify the effects of stearoyl-CoA desaturase-1 (SCD1) on the inflammatory response of a paracrine network involving adipocytes, macrophages, and endothelial cells...
  6. ncbi Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706 1544, USA
    Nutr Rev 65:S35-8. 2007
    ..We also found that the Scd1(-/-) mice on a normal chow diet had dramatically improved insulin sensitivity. However, leptin(ob/ob) Scd1(-/-) mice had worse diabetes than leptin(ob/ob) Scd1(wt/wt) mice...
  7. ncbi Stearoyl-CoA desaturase deficiency, hypercholesterolaemia, cholestasis and diabetes
    Alan D Attie
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    Novartis Found Symp 286:47-53; discussion 54-7, 162-3, 196-203. 2007
    ..But, surprisingly, leptin(ob/ob) Scd1(-/-) mice had worse diabetes than leptin(ob/ob) Scd1(wt/wt) mice. Thus, despite its effects on insulin sensitivity, Scdl deficiency worsens diabetes in leptin-deficient obese mice...
  8. ncbi Cholestasis and hypercholesterolemia in SCD1-deficient mice fed a low-fat, high-carbohydrate diet
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin Madison, Madison, WI, USA
    J Lipid Res 47:2668-80. 2006
    ..Therefore, endogenous MUFA synthesis is essential during dietary unsaturated fat insufficiency and influences the dietary requirement of PUFA...
  9. ncbi Stearoyl-CoA desaturase-1 deficiency attenuates obesity and insulin resistance in leptin-resistant obese mice
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433, Babcock Drive, Madison, WI 53706, USA
    Biochem Biophys Res Commun 380:818-22. 2009
    ..These data uncouple the effects of SCD1 deficiency on weight loss from those on insulin sensitivity and suggest a beneficial effect of SCD1 inhibition on insulin sensitivity in obese mice that express a functional leptin gene...
  10. ncbi Loss of stearoyl-CoA desaturase-1 improves insulin sensitivity in lean mice but worsens diabetes in leptin-deficient obese mice
    Jessica B Flowers
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 537606, USA
    Diabetes 56:1228-39. 2007
    ..Therefore, although loss of Scd1 has beneficial effects on adiposity, this benefit may come at the expense of beta-cells, resulting in an increased risk of diabetes...
  11. ncbi Hepatic stearoyl-CoA desaturase-1 deficiency protects mice from carbohydrate-induced adiposity and hepatic steatosis
    Makoto Miyazaki
    Department of Biochemistry, University of Wisconsin Madison, 433 Babcock Drive, Madison, WI 53706, USA
    Cell Metab 6:484-96. 2007
    ....
  12. ncbi Combined deletion of SCD1 from adipose tissue and liver does not protect mice from obesity
    Matthew T Flowers
    Department of Biochemistry University of Wisconsin Madison, Madison, WI 53706, USA
    J Lipid Res 53:1646-53. 2012
    ..The current study suggests that SCD1 deletion from adipose and/or liver is insufficient to elicit protection from obesity, but it supports the existence of extensive lipid cross-talk between liver and adipose tissue...
  13. ncbi Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism
    Matthew T Flowers
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin 53706, USA
    Curr Opin Lipidol 19:248-56. 2008
    ..This review evaluates the latest advances in our understanding of the pivotal role of stearoyl-coenzyme A desaturase 1 in health and disease...
  14. ncbi Probing the role of stearoyl-CoA desaturase-1 in hepatic insulin resistance
    Matthew T Flowers
    Department of Nutritional Sciences, University of Wisconsin - Madison, Madison, Wisconsin 53706, USA
    J Clin Invest 116:1478-81. 2006
    ....
  15. ncbi Combined expression trait correlations and expression quantitative trait locus mapping
    Hong Lan
    Department of Biochemistry, University of Wisconsin, Madison, Wisconsin, USA
    PLoS Genet 2:e6. 2006
    ..The combined analysis is more sensitive compared with linkage mapping alone...
  16. ncbi Positional cloning of Sorcs1, a type 2 diabetes quantitative trait locus
    Susanne M Clee
    Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    Nat Genet 38:688-93. 2006
    ..Our identification of the Sorcs1 gene provides insight into the pathway underlying the pathophysiology of obesity-induced type 2 diabetes mellitus...