T R Flotte

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309 USA
    Mol Pain 1:9. 2005
  2. ncbi request reprint Recombinant adeno-associated virus vectors for cystic fibrosis gene therapy
    T R Flotte
    Powell Gene Therapy Center, University of Florida, Gainesville 32610 0266, USA
    Curr Opin Mol Ther 3:497-502. 2001
  3. pmc Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice
    K Goudy
    Department of Pathology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 98:13913-8. 2001
  4. ncbi request reprint Gene therapy for cystic fibrosis
    T R Flotte
    University of Florida Genetics Institute, JHMHSC, Gainesville 32610 0266, USA
    Curr Opin Mol Ther 1:510-6. 1999
  5. ncbi request reprint Gene therapy in cystic fibrosis
    T R Flotte
    Powell Gene Therapy Center, University of Florida Genetics Institute, Gainesville, FL, USA
    Chest 120:124S-131S. 2001
  6. pmc Size does matter: overcoming the adeno-associated virus packaging limit
    T R Flotte
    Powell Gene Therapy Center, University of Florida, Gainesville, Florida 32610 0266, USA
    Respir Res 1:16-8. 2000
  7. pmc Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle
    S Song
    Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 98:4084-8. 2001
  8. ncbi request reprint Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors
    T R Flotte
    Department of Pediatrics and the Powell Gene Therapy Center, University of Florida, Gainesville, FL, USA
    Gene Ther 11:805-10. 2004
  9. ncbi request reprint Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice
    S Song
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Gene Ther 11:181-6. 2004
  10. ncbi request reprint Approaches and limitations to gene therapy for mitochondrial diseases
    R Owen
    Powell Gene Therapy Center, University of Florida Genetics Institute, Gainesville 32610-0266, USA
    Antioxid Redox Signal 3:451-60. 2001

Collaborators

  • M Campbell-Thompson
  • M A Atkinson
  • J Wang
  • B L Laube
  • S Song
  • K Goudy
  • Erin D Milligan
  • M Scott-Jorgensen
  • T M Ellis
  • J M Crawford
  • C Wasserfall
  • R Owen
  • Steven F Maier
  • Evan M Sloane
  • Leslie A Leinwand
  • Pedro E Cruz
  • Raymond Chavez
  • John R Forsayeth
  • Leah Spataro
  • Stephen J Langer
  • Julie Wieseler-Frank
  • Marucia Chacur
  • Sayamwong E Hammack
  • Linda R Watkins
  • Q Tang
  • M Kapturczak
  • Y C Zhang
  • K I Berns
  • M Powers
  • P J Laipis
  • A Muir

Detail Information

Publications10

  1. pmc Controlling neuropathic pain by adeno-associated virus driven production of the anti-inflammatory cytokine, interleukin-10
    Erin D Milligan
    Department of Psychology and the Center for Neuroscience, University of CO at Boulder, Boulder, CO 80309 USA
    Mol Pain 1:9. 2005
    ..Taken together, these data provide initial support that intrathecal gene therapy to drive the production of IL-10 may prove to be an efficacious treatment for neuropathic pain...
  2. ncbi request reprint Recombinant adeno-associated virus vectors for cystic fibrosis gene therapy
    T R Flotte
    Powell Gene Therapy Center, University of Florida, Gainesville 32610 0266, USA
    Curr Opin Mol Ther 3:497-502. 2001
    ....
  3. pmc Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice
    K Goudy
    Department of Pathology, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 98:13913-8. 2001
    ....
  4. ncbi request reprint Gene therapy for cystic fibrosis
    T R Flotte
    University of Florida Genetics Institute, JHMHSC, Gainesville 32610 0266, USA
    Curr Opin Mol Ther 1:510-6. 1999
    ..In this review, the relevant aspects of airway biology, the pathophysiological CF lung disease, and the characteristics of the currently available vector systems are discussed...
  5. ncbi request reprint Gene therapy in cystic fibrosis
    T R Flotte
    Powell Gene Therapy Center, University of Florida Genetics Institute, Gainesville, FL, USA
    Chest 120:124S-131S. 2001
    ..These findings could lead to more efficient and targeted lung delivery of aerosolized gene vectors in the future...
  6. pmc Size does matter: overcoming the adeno-associated virus packaging limit
    T R Flotte
    Powell Gene Therapy Center, University of Florida, Gainesville, Florida 32610 0266, USA
    Respir Res 1:16-8. 2000
    ..This technology could improve the chances for successful gene therapy of diseases like cystic fibrosis or Duchenne muscular dystrophy that lead to significant pulmonary morbidity...
  7. pmc Effect of DNA-dependent protein kinase on the molecular fate of the rAAV2 genome in skeletal muscle
    S Song
    Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL 32610, USA
    Proc Natl Acad Sci U S A 98:4084-8. 2001
    ..These results indicate that DNA-PK is involved in the formation of circular rAAV episomes...
  8. ncbi request reprint Gene therapy progress and prospects: recombinant adeno-associated virus (rAAV) vectors
    T R Flotte
    Department of Pediatrics and the Powell Gene Therapy Center, University of Florida, Gainesville, FL, USA
    Gene Ther 11:805-10. 2004
  9. ncbi request reprint Recombinant adeno-associated virus-mediated alpha-1 antitrypsin gene therapy prevents type I diabetes in NOD mice
    S Song
    Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
    Gene Ther 11:181-6. 2004
    ..This study suggests a potential therapeutic role for AAT in preventing type I diabetes as well as the ability of AAV gene therapy-based approaches to ameliorate disease effectively...
  10. ncbi request reprint Approaches and limitations to gene therapy for mitochondrial diseases
    R Owen
    Powell Gene Therapy Center, University of Florida Genetics Institute, Gainesville 32610-0266, USA
    Antioxid Redox Signal 3:451-60. 2001
    ..Therefore, gene therapy must be considered as a possible alternative. In this review, we will discuss the possibilities and the problems associated with gene therapy for mitochondrial disorders...