J D Flory

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi request reprint Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults
    J D Flory
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15620, USA
    Am J Med Genet 96:707-11. 2000
  2. ncbi request reprint Retest reliability of prolactin response to dl-fenfluramine challenge in adults
    Janine D Flory
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 26:269-72. 2002
  3. ncbi request reprint Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism
    J D Flory
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    Mol Psychiatry 4:93-6. 1999
  4. ncbi request reprint A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
    S B Manuck
    Department of Psychology, Behavioral Physiology Laboratory, University of Pittsburgh, PA 15260, USA
    Psychiatry Res 95:9-23. 2000
  5. ncbi request reprint Effects of short-term suppression of ovarian hormones on cardiovascular and neuroendocrine reactivity to stress in women
    K A Matthews
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychoneuroendocrinology 23:307-22. 1998
  6. ncbi request reprint Inverse relationship between fenfluramine-induced prolactin release and blood pressure in humans
    M F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Penn 15260, USA
    Hypertension 32:972-5. 1998
  7. ncbi request reprint Do the daily experiences of healthy men and women vary according to occupational prestige and work strain?
    K A Matthews
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychosom Med 62:346-53. 2000
  8. ncbi request reprint A convergent-divergent approach to context processing, general intellectual functioning, and the genetic liability to schizophrenia
    Angus W MacDonald
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    Neuropsychology 19:814-21. 2005
  9. ncbi request reprint Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, 3943 O Hara Street, Pittsburgh, PA 15260, USA
    Psychosom Med 68:895-903. 2006
  10. ncbi request reprint Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder
    Janine D Flory
    Department of Psychology, Queens College, City University of New York, 65 30 Kissena Boulevard, SB 318 Flushing, NY 11367, USA
    Br J Psychiatry 190:410-4. 2007

Detail Information

Publications30

  1. ncbi request reprint Memory performance and the apolipoprotein E polymorphism in a community sample of middle-aged adults
    J D Flory
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15620, USA
    Am J Med Genet 96:707-11. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:707-711, 2000...
  2. ncbi request reprint Retest reliability of prolactin response to dl-fenfluramine challenge in adults
    Janine D Flory
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Neuropsychopharmacology 26:269-72. 2002
    ..57 for PRL "area under the curve," p <.0001). These findings are consistent with speculation that variability in indices of central serotonergic function reflects a temporally stable dimension of individual differences...
  3. ncbi request reprint Neuroticism is not associated with the serotonin transporter (5-HTTLPR) polymorphism
    J D Flory
    Department of Psychology, University of Pittsburgh, PA 15260, USA
    Mol Psychiatry 4:93-6. 1999
    ..The contradictory findings suggest the need for a replication attempt in a large, normative sample that is stratified by ethnicity and sex...
  4. ncbi request reprint A regulatory polymorphism of the monoamine oxidase-A gene may be associated with variability in aggression, impulsivity, and central nervous system serotonergic responsivity
    S B Manuck
    Department of Psychology, Behavioral Physiology Laboratory, University of Pittsburgh, PA 15260, USA
    Psychiatry Res 95:9-23. 2000
    ..We conclude that the MAOA-uVNTR regulatory polymorphism may contribute, in part, to individual differences in both CNS serotonergic responsivity and personality traits germane to impulse control and antagonistic behavior...
  5. ncbi request reprint Effects of short-term suppression of ovarian hormones on cardiovascular and neuroendocrine reactivity to stress in women
    K A Matthews
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychoneuroendocrinology 23:307-22. 1998
    ..This study did not test the effects of current estrogen exposure or of long term suppression of ovarian hormones upon cardiovascular and neuroendocrine responses...
  6. ncbi request reprint Inverse relationship between fenfluramine-induced prolactin release and blood pressure in humans
    M F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh School of Medicine, Penn 15260, USA
    Hypertension 32:972-5. 1998
    ..These data reveal that in white but not black adults, fenfluramine-induced prolactin release correlates inversely with BP and may indicate a role of central serotonergic activity in the pathogenesis of hypertension...
  7. ncbi request reprint Do the daily experiences of healthy men and women vary according to occupational prestige and work strain?
    K A Matthews
    Department of Psychiatry, University of Pittsburgh, PA 15213, USA
    Psychosom Med 62:346-53. 2000
    ..This study evaluated the influence of occupational prestige and work strain on mood, the occurrence of interpersonal conflict, and ambulatory blood pressure and heart rate...
  8. ncbi request reprint A convergent-divergent approach to context processing, general intellectual functioning, and the genetic liability to schizophrenia
    Angus W MacDonald
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    Neuropsychology 19:814-21. 2005
    ....
  9. ncbi request reprint Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers
    Anna L Marsland
    Behavioral Immunology Laboratory, Department of Psychology, 3943 O Hara Street, Pittsburgh, PA 15260, USA
    Psychosom Med 68:895-903. 2006
    ..The current investigation extends the study of relationships between plasma IL-6 and cognitive performance to healthy middle-aged adults and to an examination of more specific cognitive domains...
  10. ncbi request reprint Serotonergic function in children with attention-deficit hyperactivity disorder: relationship to later antisocial personality disorder
    Janine D Flory
    Department of Psychology, Queens College, City University of New York, 65 30 Kissena Boulevard, SB 318 Flushing, NY 11367, USA
    Br J Psychiatry 190:410-4. 2007
    ..Impulsive aggression in adulthood is associated with disturbances in serotonergic function. In contrast, research examining this association in childhood has yielded inconsistent results...
  11. ncbi request reprint COMT val158Met and executive control: a test of the benefit of specific deficits to translational research
    Angus W MacDonald
    Department of Psychology, University of Pittsburgh, USA
    J Abnorm Psychol 116:306-12. 2007
    ..These data suggest that the interpretability gained by including task manipulations to uncover specific deficits can enhance associations between cognitive and genetic levels of analysis...
  12. ncbi request reprint Lower central serotonergic responsivity is associated with preclinical carotid artery atherosclerosis
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pittsburgh, PA 15260, USA
    Stroke 38:2228-33. 2007
    ..This investigation tested a hypothesized association between central serotonergic functioning and preclinical atherosclerosis...
  13. ncbi request reprint High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism
    Sarah M Conklin
    Department of Psychology, Allegheny College, 520 North Main Street, Meadville, PA 16335 3902, USA
    Psychosom Med 69:932-4. 2007
    ..Previously we reported that the relative concentrations of omega-3 and omega-6 polyunsaturated fatty acids in serum covary with depressive symptomatology and neuroticism in hypercholesterolemic adults...
  14. ncbi request reprint The metabolic syndrome is associated with reduced central serotonergic responsivity in healthy community volunteers
    Matthew F Muldoon
    Division of Clinical Pharmacology, Departments of Medicine and Epidemiology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    J Clin Endocrinol Metab 91:718-21. 2006
    ..The pathobiology of the metabolic syndrome remains unclear. The central nervous system is likely to be involved via regulation of eating, physical activity, blood pressure, and metabolism...
  15. ncbi request reprint The socio-economic status of communities predicts variation in brain serotonergic responsivity
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA 15260, USA
    Psychol Med 35:519-28. 2005
    ..Here we examine whether serotonergic responsivity covaries similarly with the SES of communities, as indexed by US Census data in the same study sample...
  16. ncbi request reprint Randomized trial of the effects of simvastatin on cognitive functioning in hypercholesterolemic adults
    Matthew F Muldoon
    Center for Clinical Pharmacology, University of Pittsburgh, Pennsylvania 15260, USA
    Am J Med 117:823-9. 2004
    ..The current study was designed to confirm and extend those findings...
  17. ncbi request reprint Central nervous system serotonergic responsivity and aggressive disposition in men
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, PA, USA
    Physiol Behav 77:705-9. 2002
    ..This finding suggests that association of the MAO-A promoter polymorphism with this behavioral phenotype may be mediated, in part, by allele-specific variation in central serotonergic responsivity...
  18. ncbi request reprint Low central nervous system serotonergic responsivity is associated with the metabolic syndrome and physical inactivity
    Matthew F Muldoon
    Divisions of Clinical Pharmacology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260, USA
    J Clin Endocrinol Metab 89:266-71. 2004
    ..These findings reveal a heretofore unrecognized association between reduced central serotonergic responsivity and the metabolic syndrome...
  19. ncbi request reprint A comparison of d, l-fenfluramine and citalopram challenges in healthy adults
    Janine D Flory
    Behavioral Physiology Laboratory 506 OEH, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychopharmacology (Berl) 174:376-80. 2004
    ..49, P's< or =0.02). The magnitude of the correlations is notable given the length of time between challenges. The results support the use of citalopram as an alternate neuroendocrine challenge to index CNS serotonergic responsivity...
  20. ncbi request reprint Socio-economic status covaries with central nervous system serotonergic responsivity as a function of allelic variation in the serotonin transporter gene-linked polymorphic region
    Stephen B Manuck
    Behavioral Physiology Laboratory, Department of Psychology, University of Pittsburgh, 506 EH, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychoneuroendocrinology 29:651-68. 2004
    ..We conclude that allelic variation at 5-HTTLPR moderates the influence of social position on CNS serotonergic responsivity...
  21. pmc Self-reported sleep duration is associated with the metabolic syndrome in midlife adults
    Martica H Hall
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Sleep 31:635-43. 2008
    ..In the present study, we evaluated the relationship between sleep duration and presence of the metabolic syndrome, which is a cluster of physiologically interrelated risk factors for cardiometabolic disease...
  22. ncbi request reprint Serotonergic function in the central nervous system is associated with daily ratings of positive mood
    Janine D Flory
    Department of Psychology, University of Pittsburgh, 4015 O Hara Street, Pittsburgh, PA 15260, USA
    Psychiatry Res 129:11-9. 2004
    ..e., Neuroticism). These results suggest that deficiencies in serotonergic function may reflect the relative absence of positive mood...
  23. ncbi request reprint Catechol-O-methyltransferase Val158Met genotype variation is associated with prefrontal-dependent task performance in schizotypal personality disorder patients and comparison groups
    Michael J Minzenberg
    Bronx Veterans Affairs Medical Center, Bronx, New York, 14068, USA
    Psychiatr Genet 16:117-24. 2006
    ..We evaluated the relationship of the COMT genotype with diagnostic status and cognitive performance in schizotypal personality disorder...
  24. ncbi request reprint Dispositional impulsivity in normal and abnormal samples
    Janine D Flory
    Department of Psychiatry, Box 1230, One Gustave Levy Place, Mount Sinai School of Medicine, New York, NY 10029, United States
    J Psychiatr Res 40:438-47. 2006
    ..Results from these analyses also lend support to a large body of work that demonstrates that normal and abnormal personality features are related...
  25. ncbi request reprint Neurobiologic function and temperament in subjects with personality disorders
    Vivian Mitropoulou
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    CNS Spectr 8:725-30. 2003
    ....
  26. ncbi request reprint Human choline transporter gene variation is associated with corticolimbic reactivity and autonomic-cholinergic function
    Serina A Neumann
    Department of Psychiatry and Behavioral Sciences, Eastern Virginia Medical School, 825 Fairfax Avenue, Norfolk, VA 23501
    Biol Psychiatry 60:1155-62. 2006
    ..Here, functional magnetic resonance imaging (fMRI) was used to examine the relation between a single nucleotide polymorphism (SNP) in CHT1 on regional brain reactivity relevant to autonomic (cholinergic) function...
  27. ncbi request reprint Irritable assault and variation in the COMT gene
    Janine D Flory
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
    Psychiatr Genet 17:344-6. 2007
    ..These findings provide limited support for a role of COMT in modulating aggressive behavior, and are extended to people with personality disorders...
  28. doi request reprint Trait negative affect: toward an integrated model of understanding psychological risk for impairment in cardiac autonomic function
    Maria E Bleil
    Department of Psychiatry, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94143 0848, USA
    Psychosom Med 70:328-37. 2008
    ..g., autonomic nervous system [ANS] dysfunction), the degree to which a general tendency to experience negative emotions may account for these relations is not known...
  29. doi request reprint Context processing in schizotypal personality disorder: evidence of specificity of impairment to the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, New York 10468, USA
    J Abnorm Psychol 117:342-54. 2008
    ..These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology...
  30. ncbi request reprint Developing an agenda for translational studies of resilience and vulnerability following trauma exposure
    Rachel Yehuda
    Bronx VA OOMH, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Ann N Y Acad Sci 1071:379-96. 2006
    ..Understanding why this is so will provide clues for the development of therapeutic interventions for those people who do develop stress-related psychopathology, or even for the prevention of adverse outcomes...