D F Florescu

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. doi request reprint The complex link between influenza and severe sepsis
    Diana F Florescu
    Infectious Diseases Division Internal Medicine Department University of Nebraska Medical Center Omaha, NE USA
    Virulence 5:137-42. 2014
  2. doi request reprint Adenovirus infections in heart transplantation
    Diana F Florescu
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Cardiol Rev 21:203-6. 2013
  3. doi request reprint Opportunistic viral infections in intestinal transplantation
    Diana F Florescu
    Division of Infectious Diseases, Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Expert Rev Anti Infect Ther 11:367-81. 2013
  4. doi request reprint Bloodstream infections during the first year after pediatric small bowel transplantation
    Diana F Florescu
    Infectious Diseases Section, Biostatistics Department, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Infect Dis J 31:700-4. 2012
  5. doi request reprint Incidence, risk factors, and outcomes associated with cytomegalovirus disease in small bowel transplant recipients
    D F Florescu
    Infectious Diseases Division, Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Transplant 16:294-301. 2012
  6. pmc Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis?
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA
    Crit Care 15:138. 2011
  7. doi request reprint Staphylococcus aureus infections after liver transplantation
    D F Florescu
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha, USA
    Infection 40:263-9. 2012
  8. pmc Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients
    Diana F Florescu
    Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Lincoln, Nebraska 68198 5400, USA
    Biol Blood Marrow Transplant 18:731-8. 2012
  9. doi request reprint Should multivisceral transplantation be considered in patients colonized with multidrug-resistant Pseudomonas aeruginosa?
    Diana F Florescu
    Transplant Infectious Diseases Program, Infectious Diseases Division, University of Nebraska Medical Center, Omaha, Nebraska NE 68198 5400, USA
    Microb Drug Resist 18:74-8. 2012
  10. doi request reprint What is the efficacy and safety of colistin for the treatment of ventilator-associated pneumonia? A systematic review and meta-regression
    Diana F Florescu
    Infectious Diseases Division, Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Clin Infect Dis 54:670-80. 2012

Detail Information

Publications28

  1. doi request reprint The complex link between influenza and severe sepsis
    Diana F Florescu
    Infectious Diseases Division Internal Medicine Department University of Nebraska Medical Center Omaha, NE USA
    Virulence 5:137-42. 2014
    ..This manuscript aims to provide a pathophysiological and clinical update on the link between influenza and severe sepsis. ..
  2. doi request reprint Adenovirus infections in heart transplantation
    Diana F Florescu
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Cardiol Rev 21:203-6. 2013
    ..Cidofovir is currently considered the standard of treatment for adenovirus disease not responding to reduction of immunosuppression...
  3. doi request reprint Opportunistic viral infections in intestinal transplantation
    Diana F Florescu
    Division of Infectious Diseases, Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Expert Rev Anti Infect Ther 11:367-81. 2013
    ..5, 58.2 and 47%, respectively. IT restores organ functions, but it is associated with complications, with infections representing the major cause of morbidity and mortality in this population...
  4. doi request reprint Bloodstream infections during the first year after pediatric small bowel transplantation
    Diana F Florescu
    Infectious Diseases Section, Biostatistics Department, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Infect Dis J 31:700-4. 2012
    ..Little information regarding bloodstream infections (BSIs) in small bowel transplantation has been published...
  5. doi request reprint Incidence, risk factors, and outcomes associated with cytomegalovirus disease in small bowel transplant recipients
    D F Florescu
    Infectious Diseases Division, Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Transplant 16:294-301. 2012
    ..001). CMV disease in SBT recipients was associated with an 11-fold mortality increase and a fourfold faster time-to-death. Time-to-death was significantly shorter with CMV enteritis...
  6. pmc Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis?
    Andre C Kalil
    Department of Internal Medicine, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA
    Crit Care 15:138. 2011
    ..Our updated meta-analysis with approximately 1,000 patients shows that active CMV infection continues to be associated with a significant 81% higher mortality rate than that in critically ill patients without active CMV infection...
  7. doi request reprint Staphylococcus aureus infections after liver transplantation
    D F Florescu
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha, USA
    Infection 40:263-9. 2012
    ..More data on the risk factors and outcomes after Staphylococcus aureus infections in liver transplantation are needed...
  8. pmc Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patients
    Diana F Florescu
    Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Lincoln, Nebraska 68198 5400, USA
    Biol Blood Marrow Transplant 18:731-8. 2012
    ..5 days; P = .04). No serious adverse events were attributed to CMX001 during therapy. CMX001 may be a promising therapeutic option for the treatment of severe adenovirus disease in immunocompromised patients...
  9. doi request reprint Should multivisceral transplantation be considered in patients colonized with multidrug-resistant Pseudomonas aeruginosa?
    Diana F Florescu
    Transplant Infectious Diseases Program, Infectious Diseases Division, University of Nebraska Medical Center, Omaha, Nebraska NE 68198 5400, USA
    Microb Drug Resist 18:74-8. 2012
    ..We discuss the dilemma concerning the transplantation of patients colonized with multidrug-resistant Pseudomonas spp., its potential consequences, and the peri and postoperative management of these patients...
  10. doi request reprint What is the efficacy and safety of colistin for the treatment of ventilator-associated pneumonia? A systematic review and meta-regression
    Diana F Florescu
    Infectious Diseases Division, Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Clin Infect Dis 54:670-80. 2012
    ..We aimed to assess the safety and efficacy of colistin for the treatment of VAP...
  11. doi request reprint Risk factors for systemic Candida infections in pediatric small bowel transplant recipients
    Diana F Florescu
    Division of Infectious Diseases, Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Infect Dis J 31:120-3. 2012
    ..Fungal infections are an important cause of morbidity and mortality after small bowel transplantation (SBT). Little information about risk factors for Candida infections in pediatric SBT is available...
  12. doi request reprint Risk factors and outcomes of Staphylococcus aureus infections after small bowel and multivisceral transplantation
    Diana F Florescu
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Infect Dis J 31:25-9. 2012
    ..No studies have evaluated the risk factors and outcomes of Staphylococcus aureus (SA) infections in small bowel (SBT) and multivisceral (including small bowel) transplantation (MVT)...
  13. ncbi request reprint Cytomegalovirus infections in non-immunocompromised and immunocompromised patients in the intensive care unit
    Diana F Florescu
    Internal Medicine Department, Infectious Diseases Division, University of Nebraska Medical Center, Nebraska, Omaha, USA
    Infect Disord Drug Targets 11:354-64. 2011
    ..Ganciclovir and valganciclovir are the first-line antiviral therapies for the treatment of immunocompromised patients, while foscarnet and cidofovir are reserved mainly for treatment of ganciclovir-resistant cytomegalovirus infections...
  14. doi request reprint Clostridium difficile and cytomegalovirus colitis co-infection: search for the hidden 'bug'
    D F Florescu
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Transpl Infect Dis 13:411-5. 2011
    ..We describe 2 cases of CMV and C. difficile colitis, and review 7 previously published reports. We aim to raise awareness of possible CMV-C. difficile co-infection, especially in refractory cases of C. difficile colitis...
  15. doi request reprint Cerebral aspergillosis caused by Aspergillus ustus following orthotopic heart transplantation: case report and review of the literature
    Diana F Florescu
    Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Clin Transplant 23:116-20. 2009
    ..The utility of molecular analysis for the identification of unusual fungal pathogens is also described. The refractory nature of A. ustus to treatment is similar to other Aspergillus species and treatment options are reviewed...
  16. doi request reprint Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and review
    Diana Florescu
    Immunocompromised Host Infectious Diseases Program, Microbiology University of Nebraska Medical Center, Omaha, NE, USA
    Pediatr Infect Dis J 27:1013-9. 2008
    ..This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and compares these cases with those previously reported in the literature...
  17. doi request reprint Effects of prolonged use of azithromycin in patients with cystic fibrosis: a meta-analysis
    D F Florescu
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha 68198 5400, NE, USA
    Pulm Pharmacol Ther 22:467-72. 2009
    ..12, 95% CI 1.10, 4.08, p=0.02). Azithromycin improves lung function of CF patients, especially in the subgroup colonized with Pseudomonas. However, nausea and diarrhea are significantly more frequent with azythromycin...
  18. doi request reprint Adenovirus infections in pediatric small bowel transplant recipients
    Diana F Florescu
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Transplantation 90:198-204. 2010
    ..Adenovirus is commonly isolated from pediatric small bowel transplant recipients, but its clinical consequences remain poorly understood...
  19. doi request reprint Incidence and outcome of fungal infections in pediatric small bowel transplant recipients
    D F Florescu
    Department of Internal Medicine, Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Transpl Infect Dis 12:497-504. 2010
    ..Data on the incidence, timing, and outcome of fungal infections in pediatric small bowel transplantation (SBT) are lacking...
  20. doi request reprint Is there a role for oral human immunoglobulin in the treatment for norovirus enteritis in immunocompromised patients?
    Diana F Florescu
    Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Transplant 15:718-21. 2011
    ..32, OR = 1.0). We show a potential role of OHIG treatment for NVE. Resolution of diarrhea and decreased stool output were observed at seven days; no benefit was found for length of hospital stay or hospital cost...
  21. doi request reprint Two cases of Norwalk virus enteritis following small bowel transplantation treated with oral human serum immunoglobulin
    Diana F Florescu
    Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
    Pediatr Transplant 12:372-5. 2008
    ..Protracted diarrhea is a challenging problem after small bowel transplantation. We report two patients who developed Norwalk virus enteritis after small bowel transplantation. Both received oral HSIG with resolution of diarrhea within 48 h...
  22. pmc IMPACT trial results should not change current standard of care of 100 days for cytomegalovirus prophylaxis
    A C Kalil
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE, USA
    Am J Transplant 11:18-21. 2011
    ..Further, based on all available evidence, we consider that another clinical trial to test 200-day CMV prophylaxis is not necessary...
  23. doi request reprint The importance of detecting cytomegalovirus infections in studies evaluating new therapies for severe sepsis
    Andre C Kalil
    Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Crit Care Med 38:S663-7. 2010
    ..Even randomized trials could have a much higher probability of false-negative rates for a new therapy than designed. Future severe sepsis trials should consider including active cytomegalovirus infection as a prospective covariate...
  24. doi request reprint Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unit
    Andre C Kalil
    University of Nebraska Medical Center, Omaha, NE, USA
    Crit Care Med 37:2350-8. 2009
    ..Cytomegalovirus is the most common viral opportunistic infection in immunocompromised patients. However, recent studies have demonstrated active cytomegalovirus infection in nonimmunosuppressed intensive care unit patients...
  25. doi request reprint Effectiveness of valganciclovir 900 mg versus 450 mg for cytomegalovirus prophylaxis in transplantation: direct and indirect treatment comparison meta-analysis
    Andre C Kalil
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
    Clin Infect Dis 52:313-21. 2011
    ..valganciclovir (VGC) 900 mg is approved for CMV prophylaxis, but it has been associated with 10%-40% leucopenia rate. We hypothesize that VGC 450 mg daily may be as effective as and safer than 900 mg daily...
  26. pmc Recommendations for the assessment and reporting of multivariable logistic regression in transplantation literature
    A C Kalil
    University of Nebraska Medical Center, Omaha, USA
    Am J Transplant 10:1686-94. 2010
    ....
  27. doi request reprint What is the impact of hypogammaglobulinemia on the rate of infections and survival in solid organ transplantation? A meta-analysis
    D F Florescu
    Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE Transplant Surgery Division, University of Nebraska Medical Center, Omaha, NE
    Am J Transplant 13:2601-10. 2013
    ..55; p = 0.005; I(2) = 0%). Severe hypogammaglobulinemia during the first year posttransplantation significantly increased the risk of CMV, fungal and respiratory infections, and was associated with higher 1-year all-cause mortality...
  28. doi request reprint Enterococcus pneumonia complicated with empyema and lung abscess in an HIV-positive patient. Case report and review of the literature
    T Vanschooneveld
    Infectious Diseases Section, University of Nebraska Medical Center, Omaha, NE, USA
    Int J STD AIDS 20:659-61. 2009
    ..Our case highlights the rarity of this entity and reviews the risk factors for Enterococcus pleuro-pulmonary infections...