Research Topics
| D F FlorescuSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
Bloodstream infections during the first year after pediatric small bowel transplantationDiana F Florescu
Infectious Diseases Section, Biostatistics Department, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Pediatr Infect Dis J 31:700-4. 2012..Little information regarding bloodstream infections (BSIs) in small bowel transplantation has been published...- Incidence, risk factors, and outcomes associated with cytomegalovirus disease in small bowel transplant recipientsD F Florescu
Infectious Diseases Division, Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Pediatr Transplant 16:294-301. 2012..001). CMV disease in SBT recipients was associated with an 11-fold mortality increase and a fourfold faster time-to-death. Time-to-death was significantly shorter with CMV enteritis... 
Is cytomegalovirus reactivation increasing the mortality of patients with severe sepsis?Andre C Kalil
Department of Internal Medicine, University of Nebraska Medical Center, 985400 Nebraska Medical Center, Omaha, NE 68198, USA
Crit Care 15:138. 2011..Our updated meta-analysis with approximately 1,000 patients shows that active CMV infection continues to be associated with a significant 81% higher mortality rate than that in critically ill patients without active CMV infection...- Staphylococcus aureus infections after liver transplantationD F Florescu
Infectious Diseases Section, University of Nebraska Medical Center, Omaha, USA
Infection 40:263-9. 2012..More data on the risk factors and outcomes after Staphylococcus aureus infections in liver transplantation are needed... - Safety and efficacy of CMX001 as salvage therapy for severe adenovirus infections in immunocompromised patientsDiana F Florescu
Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Lincoln, Nebraska 68198 5400, USA
Biol Blood Marrow Transplant 18:731-8. 2012..5 days; P = .04). No serious adverse events were attributed to CMX001 during therapy. CMX001 may be a promising therapeutic option for the treatment of severe adenovirus disease in immunocompromised patients... - Should multivisceral transplantation be considered in patients colonized with multidrug-resistant Pseudomonas aeruginosa?Diana F Florescu
Transplant Infectious Diseases Program, Infectious Diseases Division, University of Nebraska Medical Center, Omaha, Nebraska NE 68198 5400, USA
Microb Drug Resist 18:74-8. 2012..We discuss the dilemma concerning the transplantation of patients colonized with multidrug-resistant Pseudomonas spp., its potential consequences, and the peri and postoperative management of these patients... - What is the efficacy and safety of colistin for the treatment of ventilator-associated pneumonia? A systematic review and meta-regressionDiana F Florescu
Infectious Diseases Division, Nebraska Medical Center, Omaha, NE 68198 5400, USA
Clin Infect Dis 54:670-80. 2012..We aimed to assess the safety and efficacy of colistin for the treatment of VAP... - Risk factors for systemic Candida infections in pediatric small bowel transplant recipientsDiana F Florescu
Division of Infectious Diseases, Transplant Infectious Diseases Program, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Pediatr Infect Dis J 31:120-3. 2012..Fungal infections are an important cause of morbidity and mortality after small bowel transplantation (SBT). Little information about risk factors for Candida infections in pediatric SBT is available... - Risk factors and outcomes of Staphylococcus aureus infections after small bowel and multivisceral transplantationDiana F Florescu
Infectious Diseases Section, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Pediatr Infect Dis J 31:25-9. 2012..No studies have evaluated the risk factors and outcomes of Staphylococcus aureus (SA) infections in small bowel (SBT) and multivisceral (including small bowel) transplantation (MVT)... 
Cytomegalovirus infections in non-immunocompromised and immunocompromised patients in the intensive care unitDiana F Florescu
Internal Medicine Department, Infectious Diseases Division, University of Nebraska Medical Center, Nebraska, Omaha, USA
Infect Disord Drug Targets 11:354-64. 2011..Ganciclovir and valganciclovir are the first-line antiviral therapies for the treatment of immunocompromised patients, while foscarnet and cidofovir are reserved mainly for treatment of ganciclovir-resistant cytomegalovirus infections...- Is there a role for oral human immunoglobulin in the treatment for norovirus enteritis in immunocompromised patients?Diana F Florescu
Division of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Pediatr Transplant 15:718-21. 2011..32, OR = 1.0). We show a potential role of OHIG treatment for NVE. Resolution of diarrhea and decreased stool output were observed at seven days; no benefit was found for length of hospital stay or hospital cost... - Clostridium difficile and cytomegalovirus colitis co-infection: search for the hidden 'bug'D F Florescu
Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
Transpl Infect Dis 13:411-5. 2011..We describe 2 cases of CMV and C. difficile colitis, and review 7 previously published reports. We aim to raise awareness of possible CMV-C. difficile co-infection, especially in refractory cases of C. difficile colitis... - Two cases of Norwalk virus enteritis following small bowel transplantation treated with oral human serum immunoglobulinDiana F Florescu
Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Pediatr Transplant 12:372-5. 2008..Protracted diarrhea is a challenging problem after small bowel transplantation. We report two patients who developed Norwalk virus enteritis after small bowel transplantation. Both received oral HSIG with resolution of diarrhea within 48 h... - Cerebral aspergillosis caused by Aspergillus ustus following orthotopic heart transplantation: case report and review of the literatureDiana F Florescu
Section of Infectious Diseases, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Clin Transplant 23:116-20. 2009..The utility of molecular analysis for the identification of unusual fungal pathogens is also described. The refractory nature of A. ustus to treatment is similar to other Aspergillus species and treatment options are reviewed... - Leuconostoc bacteremia in pediatric patients with short bowel syndrome: case series and reviewDiana Florescu
Immunocompromised Host Infectious Diseases Program, Microbiology University of Nebraska Medical Center, Omaha, NE, USA
Pediatr Infect Dis J 27:1013-9. 2008..This article presents 6 new cases of pediatric patients with short bowel syndrome who developed Leuconostoc bacteremia, and compares these cases with those previously reported in the literature... - Effects of prolonged use of azithromycin in patients with cystic fibrosis: a meta-analysisD F Florescu
Infectious Diseases Section, University of Nebraska Medical Center, Omaha 68198 5400, NE, USA
Pulm Pharmacol Ther 22:467-72. 2009..12, 95% CI 1.10, 4.08, p=0.02). Azithromycin improves lung function of CF patients, especially in the subgroup colonized with Pseudomonas. However, nausea and diarrhea are significantly more frequent with azythromycin... - Incidence and outcome of fungal infections in pediatric small bowel transplant recipientsD F Florescu
Department of Internal Medicine, Transplant Infectious Diseases Program, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
Transpl Infect Dis 12:497-504. 2010..Data on the incidence, timing, and outcome of fungal infections in pediatric small bowel transplantation (SBT) are lacking... - Adenovirus infections in pediatric small bowel transplant recipientsDiana F Florescu
Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE 68198 5400, USA
Transplantation 90:198-204. 2010..Adenovirus is commonly isolated from pediatric small bowel transplant recipients, but its clinical consequences remain poorly understood... - IMPACT trial results should not change current standard of care of 100 days for cytomegalovirus prophylaxisA C Kalil
Infectious Diseases Division, University of Nebraska Medical Center, Omaha, NE, USA
Am J Transplant 11:18-21. 2011..Further, based on all available evidence, we consider that another clinical trial to test 200-day CMV prophylaxis is not necessary... - Prevalence and mortality associated with cytomegalovirus infection in nonimmunosuppressed patients in the intensive care unitAndre C Kalil
University of Nebraska Medical Center, Omaha, NE, USA
Crit Care Med 37:2350-8. 2009..Cytomegalovirus is the most common viral opportunistic infection in immunocompromised patients. However, recent studies have demonstrated active cytomegalovirus infection in nonimmunosuppressed intensive care unit patients... - The importance of detecting cytomegalovirus infections in studies evaluating new therapies for severe sepsisAndre C Kalil
Department of Medicine, University of Nebraska Medical Center, Omaha, NE, USA
Crit Care Med 38:S663-7. 2010..Even randomized trials could have a much higher probability of false-negative rates for a new therapy than designed. Future severe sepsis trials should consider including active cytomegalovirus infection as a prospective covariate... - Effectiveness of valganciclovir 900 mg versus 450 mg for cytomegalovirus prophylaxis in transplantation: direct and indirect treatment comparison meta-analysisAndre C Kalil
Infectious Diseases Division, University of Nebraska Medical Center, Omaha, Nebraska 68198 5400, USA
Clin Infect Dis 52:313-21. 2011..valganciclovir (VGC) 900 mg is approved for CMV prophylaxis, but it has been associated with 10%-40% leucopenia rate. We hypothesize that VGC 450 mg daily may be as effective as and safer than 900 mg daily... - Recommendations for the assessment and reporting of multivariable logistic regression in transplantation literatureA C Kalil
University of Nebraska Medical Center, Omaha, USA
Am J Transplant 10:1686-94. 2010.... - Enterococcus pneumonia complicated with empyema and lung abscess in an HIV-positive patient. Case report and review of the literatureT Vanschooneveld
Infectious Diseases Section, University of Nebraska Medical Center, Omaha, NE, USA
Int J STD AIDS 20:659-61. 2009..Our case highlights the rarity of this entity and reviews the risk factors for Enterococcus pleuro-pulmonary infections...