Melanie S Flint

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. doi request reprint Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, Pittsburgh, PA 15213, United States
    Psychoneuroendocrinology 34:1533-41. 2009
  2. doi request reprint Restraint stress and stress hormones significantly impact T lymphocyte migration and function through specific alterations of the actin cytoskeleton
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Behav Immun 25:1187-96. 2011
  3. ncbi request reprint Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes
    Melanie S Flint
    University of Pittsburgh Cancer Institute and Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neuroimmunol 167:34-44. 2005
  4. doi request reprint Proteomic analysis of the murine liver in response to a combined exposure to psychological stress and 7,12-dimethylbenz(a)anthracene
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, Cancer Biomarkers Facility Mass Spectrometry Platform, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    J Proteome Res 9:509-20. 2010
  5. ncbi request reprint Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones
    Melanie S Flint
    Department of Psychology, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Psychoneuroendocrinology 32:470-9. 2007
  6. doi request reprint Defining central themes in breast cancer biology by differential proteomics: conserved regulation of cell spreading and focal adhesion kinase
    Nicholas W Bateman
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Proteome Res 9:5311-24. 2010
  7. pmc Chronic exposure to stress hormones promotes transformation and tumorigenicity of 3T3 mouse fibroblasts
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15237, USA
    Stress 16:114-21. 2013
  8. doi request reprint Assessment of buffer systems for harvesting proteins from tissue interstitial fluid for proteomic analysis
    Pang Ning Teng
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA
    J Proteome Res 9:4161-9. 2010
  9. pmc Proteomic analysis of laser microdissected melanoma cells from skin organ cultures
    Brian L Hood
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    J Proteome Res 9:3656-63. 2010
  10. ncbi request reprint CD161B:ClrB interactions mediate activation of enhanced lysis of tumor target cells following NK cell:DC co-culture
    Tianbing Yang
    University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213 1863, USA
    Immunol Res 36:43-50. 2006

Collaborators

Detail Information

Publications13

  1. doi request reprint Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathway
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, Pittsburgh, PA 15213, United States
    Psychoneuroendocrinology 34:1533-41. 2009
    ..These data demonstrate that stress hormones interfere with paclitaxel efficacy and contribute significantly to drug resistance...
  2. doi request reprint Restraint stress and stress hormones significantly impact T lymphocyte migration and function through specific alterations of the actin cytoskeleton
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Behav Immun 25:1187-96. 2011
    ..In conclusion, we have defined a novel molecular mechanism whereby stress hormones negatively impact T cell activation and migration through regulation of key cytoskeletal and plasma membrane factors...
  3. ncbi request reprint Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes
    Melanie S Flint
    University of Pittsburgh Cancer Institute and Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Neuroimmunol 167:34-44. 2005
    ..These data suggest that, at the molecular level, stress activates genes responsible for priming the T cell to either undergo apoptosis or proliferation...
  4. doi request reprint Proteomic analysis of the murine liver in response to a combined exposure to psychological stress and 7,12-dimethylbenz(a)anthracene
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, Cancer Biomarkers Facility Mass Spectrometry Platform, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
    J Proteome Res 9:509-20. 2010
    ..These data support the hypothesis that psychological stress modulates DMBA-induced regulation of drug metabolizing proteins in the liver...
  5. ncbi request reprint Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormones
    Melanie S Flint
    Department of Psychology, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Psychoneuroendocrinology 32:470-9. 2007
    ..Taken together, these data show that stress hormones can increase DNA damage and transformation and alter transcriptional regulation of the cell cycle...
  6. doi request reprint Defining central themes in breast cancer biology by differential proteomics: conserved regulation of cell spreading and focal adhesion kinase
    Nicholas W Bateman
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Proteome Res 9:5311-24. 2010
    ..These analyses provide insights into conservation of protein expression across breast cancer cell subtypes, a subset of which warrants further investigation for their roles in the regulation of cell spreading and FAK in breast cancer...
  7. pmc Chronic exposure to stress hormones promotes transformation and tumorigenicity of 3T3 mouse fibroblasts
    Melanie S Flint
    Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15237, USA
    Stress 16:114-21. 2013
    ....
  8. doi request reprint Assessment of buffer systems for harvesting proteins from tissue interstitial fluid for proteomic analysis
    Pang Ning Teng
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA
    J Proteome Res 9:4161-9. 2010
    ..These data support that PBS is a suitable and convenient solution for harvesting TIF proteins for MS-based proteomics...
  9. pmc Proteomic analysis of laser microdissected melanoma cells from skin organ cultures
    Brian L Hood
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    J Proteome Res 9:3656-63. 2010
    ..This concordance demonstrates the value of SOCs for conducting proteomic investigations of the melanoma microenvironment...
  10. ncbi request reprint CD161B:ClrB interactions mediate activation of enhanced lysis of tumor target cells following NK cell:DC co-culture
    Tianbing Yang
    University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213 1863, USA
    Immunol Res 36:43-50. 2006
    ..This is the first report of NK receptors responsible for interaction with DCs having a role in mediating enhanced lytic function following NK:DC interactions...
  11. ncbi request reprint Differential regulation of sensitizer-induced inflammation and immunity by acute restraint stress in allergic contact dermatitis
    Melanie S Flint
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    J Neuroimmunol 140:28-40. 2003
    ....
  12. ncbi request reprint Acute stress modulates the irritant component of sensitizers in allergic contact dermatitis: implications for exposure assessment
    Melanie S Flint
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Toxicol Appl Pharmacol 188:50-8. 2003
    ....
  13. ncbi request reprint Restraint stress and corticotropin releasing hormone modulation of murine cutaneous POMC mRNA
    Melanie S Flint
    Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Stress 6:59-62. 2003
    ....