Research Topics
| Melanie S FlintSummaryAffiliation: University of Pittsburgh Country: USA Publications
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Detail Information
Publications
Stress hormones mediate drug resistance to paclitaxel in human breast cancer cells through a CDK-1-dependent pathwayMelanie S Flint
Department of Pharmacology and Chemical Biology, Pittsburgh, PA 15213, United States
Psychoneuroendocrinology 34:1533-41. 2009..These data demonstrate that stress hormones interfere with paclitaxel efficacy and contribute significantly to drug resistance...- Restraint stress and stress hormones significantly impact T lymphocyte migration and function through specific alterations of the actin cytoskeletonMelanie S Flint
Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
Brain Behav Immun 25:1187-96. 2011..In conclusion, we have defined a novel molecular mechanism whereby stress hormones negatively impact T cell activation and migration through regulation of key cytoskeletal and plasma membrane factors... 
Genomic profiling of restraint stress-induced alterations in mouse T lymphocytesMelanie S Flint
University of Pittsburgh Cancer Institute and Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
J Neuroimmunol 167:34-44. 2005..These data suggest that, at the molecular level, stress activates genes responsible for priming the T cell to either undergo apoptosis or proliferation...- Proteomic analysis of the murine liver in response to a combined exposure to psychological stress and 7,12-dimethylbenz(a)anthraceneMelanie S Flint
Department of Pharmacology and Chemical Biology, Cancer Biomarkers Facility Mass Spectrometry Platform, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, USA
J Proteome Res 9:509-20. 2010..These data support the hypothesis that psychological stress modulates DMBA-induced regulation of drug metabolizing proteins in the liver... - Induction of DNA damage, alteration of DNA repair and transcriptional activation by stress hormonesMelanie S Flint
Department of Psychology, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
Psychoneuroendocrinology 32:470-9. 2007..Taken together, these data show that stress hormones can increase DNA damage and transformation and alter transcriptional regulation of the cell cycle... - Defining central themes in breast cancer biology by differential proteomics: conserved regulation of cell spreading and focal adhesion kinaseNicholas W Bateman
Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
J Proteome Res 9:5311-24. 2010..These analyses provide insights into conservation of protein expression across breast cancer cell subtypes, a subset of which warrants further investigation for their roles in the regulation of cell spreading and FAK in breast cancer... - Assessment of buffer systems for harvesting proteins from tissue interstitial fluid for proteomic analysisPang Ning Teng
Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA
J Proteome Res 9:4161-9. 2010..These data support that PBS is a suitable and convenient solution for harvesting TIF proteins for MS-based proteomics... - Proteomic analysis of laser microdissected melanoma cells from skin organ culturesBrian L Hood
Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
J Proteome Res 9:3656-63. 2010..This concordance demonstrates the value of SOCs for conducting proteomic investigations of the melanoma microenvironment... - Chronic exposure to stress hormones promotes transformation and tumorigenicity of 3T3 mouse fibroblastsMelanie S Flint
Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15237, USA
Stress 16:114-21. 2013.... - CD161B:ClrB interactions mediate activation of enhanced lysis of tumor target cells following NK cell:DC co-cultureTianbing Yang
University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA 15213-1863, USA
Immunol Res 36:43-50. 2006..This is the first report of NK receptors responsible for interaction with DCs having a role in mediating enhanced lytic function following NK:DC interactions... - Differential regulation of sensitizer-induced inflammation and immunity by acute restraint stress in allergic contact dermatitisMelanie S Flint
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
J Neuroimmunol 140:28-40. 2003.... - Acute stress modulates the irritant component of sensitizers in allergic contact dermatitis: implications for exposure assessmentMelanie S Flint
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Toxicol Appl Pharmacol 188:50-8. 2003.... - Restraint stress and corticotropin releasing hormone modulation of murine cutaneous POMC mRNAMelanie S Flint
Toxicology and Molecular Biology Branch, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
Stress 6:59-62. 2003....