P Thomas Fletcher

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism
    P Thomas Fletcher
    School of Computing, University of Utah, Salt Lake City, UT, USA
    Neuroimage 51:1117-25. 2010
  2. pmc The geometric median on Riemannian manifolds with application to robust atlas estimation
    P Thomas Fletcher
    University of Utah, Salt Lake City, Utah, USA
    Neuroimage 45:S143-52. 2009
  3. pmc scMRI reveals large-scale brain network abnormalities in autism
    Brandon A Zielinski
    Departments of Pediatrics and Neurology, University of Utah, Salt Lake City, UT, USA
    PLoS ONE 7:e49172. 2012
  4. pmc Group statistics of DTI fiber bundles using spatial functions of tensor measures
    Casey B Goodlett
    School of Computing, University of Utah, USA
    Med Image Comput Comput Assist Interv 11:1068-75. 2008
  5. pmc Particle-based shape analysis of multi-object complexes
    Joshua Cates
    Scientific Computing and Imaging Institute, Univ Utah, Salt Lake City, UT, USA
    Med Image Comput Comput Assist Interv 11:477-85. 2008
  6. ncbi request reprint Interactive visualization of volumetric white matter connectivity in DT-MRI using a parallel-hardware Hamilton-Jacobi solver
    Won Ki Jeong
    Scientific Computing and Imaging Instiutte, School of Computing, University of Utah, Salt Lake City 84112, USA
    IEEE Trans Vis Comput Graph 13:1480-7. 2007
  7. pmc Particle based shape regression of open surfaces with applications to developmental neuroimaging
    Manasi Datar
    Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, USA
    Med Image Comput Comput Assist Interv 12:167-74. 2009
  8. pmc Axon tracking in serial block-face scanning electron microscopy
    Elizabeth Jurrus
    Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA
    Med Image Anal 13:180-8. 2009
  9. ncbi request reprint Neuropsychological investigation of motor impairments in autism
    Tyler C Duffield
    a Department of Psychology, Brigham Young University, Provo, UT, USA
    J Clin Exp Neuropsychol 35:867-81. 2013
  10. ncbi request reprint Longitudinal changes in cortical thickness in autism and typical development
    Brandon A Zielinski
    1 Department of Pediatrics, University of Utah, Salt Lake City, UT, USA2 Department of Neurology, University of Utah, Salt Lake City, UT, USA3 Primary Children s Medical Centre, Salt Lake City, UT, USA
    Brain 137:1799-812. 2014

Collaborators

Detail Information

Publications25

  1. pmc Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism
    P Thomas Fletcher
    School of Computing, University of Utah, Salt Lake City, UT, USA
    Neuroimage 51:1117-25. 2010
    ....
  2. pmc The geometric median on Riemannian manifolds with application to robust atlas estimation
    P Thomas Fletcher
    University of Utah, Salt Lake City, Utah, USA
    Neuroimage 45:S143-52. 2009
    ..Using this approach, we also present a robust brain atlas estimation technique based on the geometric median in the space of deformable images...
  3. pmc scMRI reveals large-scale brain network abnormalities in autism
    Brandon A Zielinski
    Departments of Pediatrics and Neurology, University of Utah, Salt Lake City, UT, USA
    PLoS ONE 7:e49172. 2012
    ..Moreover, we provide evidence of specific abnormalities in brain network architecture underlying autism that are quantifiable using standard clinical MRI...
  4. pmc Group statistics of DTI fiber bundles using spatial functions of tensor measures
    Casey B Goodlett
    School of Computing, University of Utah, USA
    Med Image Comput Comput Assist Interv 11:1068-75. 2008
    ..Plots of the discrimination direction provide a clinical interpretation of the group differences. The methodology is tested on a pediatric study of subjects aged one and two years...
  5. pmc Particle-based shape analysis of multi-object complexes
    Joshua Cates
    Scientific Computing and Imaging Institute, Univ Utah, Salt Lake City, UT, USA
    Med Image Comput Comput Assist Interv 11:477-85. 2008
    ..We also consider statistical analysis of object poses. The modeling and analysis methods are illustrated on brain structure complexes from an ongoing clinical study of pediatric autism...
  6. ncbi request reprint Interactive visualization of volumetric white matter connectivity in DT-MRI using a parallel-hardware Hamilton-Jacobi solver
    Won Ki Jeong
    Scientific Computing and Imaging Instiutte, School of Computing, University of Utah, Salt Lake City 84112, USA
    IEEE Trans Vis Comput Graph 13:1480-7. 2007
    ..We demonstrate the proposed method on some synthetic and real DT-MRI datasets and compare the performance with existing methods...
  7. pmc Particle based shape regression of open surfaces with applications to developmental neuroimaging
    Manasi Datar
    Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah, USA
    Med Image Comput Comput Assist Interv 12:167-74. 2009
    ..We demonstrate the method on synthetic data and provide a new results on clinical MRI data related to early development of the human head...
  8. pmc Axon tracking in serial block-face scanning electron microscopy
    Elizabeth Jurrus
    Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA
    Med Image Anal 13:180-8. 2009
    ..Validation results indicate that this algorithm can significantly speed up the task of manual axon tracking...
  9. ncbi request reprint Neuropsychological investigation of motor impairments in autism
    Tyler C Duffield
    a Department of Psychology, Brigham Young University, Provo, UT, USA
    J Clin Exp Neuropsychol 35:867-81. 2013
    ..The results suggest a hierarchical motor disruption in ASD, with difficulties evident only in more complex tasks as well as a potential anomalous size-function relation in motor cortex in ASD. ..
  10. ncbi request reprint Longitudinal changes in cortical thickness in autism and typical development
    Brandon A Zielinski
    1 Department of Pediatrics, University of Utah, Salt Lake City, UT, USA2 Department of Neurology, University of Utah, Salt Lake City, UT, USA3 Primary Children s Medical Centre, Salt Lake City, UT, USA
    Brain 137:1799-812. 2014
    ..Moreover, cortical thickness abnormalities in autism spectrum disorders are region-specific, vary with age, and may remain dynamic well into adulthood. ..
  11. pmc Longitudinal Heschl's gyrus growth during childhood and adolescence in typical development and autism
    Molly D Prigge
    Department of Psychiatry, School of Medicine, University of Utah, Salt Lake City, UT 84108, USA
    Autism Res 6:78-90. 2013
    ..Our longitudinal analyses revealed dynamic gray and white matter changes in Heschl's gyrus throughout childhood and adolescence in both typical development and autism...
  12. pmc Group analysis of resting-state fMRI by hierarchical Markov random fields
    Wei Liu
    Scientific Computing and Imaging Institute, University of Utah, USA
    Med Image Comput Comput Assist Interv 15:189-96. 2012
    ..We show that our method is able to estimate more consistent subject label maps, as well as a stable group label map...
  13. pmc Functional connectivity magnetic resonance imaging classification of autism
    Jeffrey S Anderson
    Department of Neuroradiology, University of Utah, 1A71 School of Medicine, Salt Lake City, UT 84132, USA
    Brain 134:3742-54. 2011
    ..These findings indicate feasibility of a functional connectivity magnetic resonance imaging diagnostic assay for autism...
  14. ncbi request reprint Spatial regularization of functional connectivity using high-dimensional Markov random fields
    Wei Liu
    Scientific Computing and Imaging Institute, University of Utah, USA
    Med Image Comput Comput Assist Interv 13:363-70. 2010
    ..We present an efficient, highly parallelized algorithm on the Graphics Processing Unit (GPU). We validate our approach on a synthetically generated example as well as real data from a resting state fMRI study...
  15. ncbi request reprint Genetic, structural and functional imaging biomarkers for early detection of conversion from MCI to AD
    Nikhil Singh
    University of Utah, Salt Lake City, UT, USA
    Med Image Comput Comput Assist Interv 15:132-40. 2012
    ..We evaluate the proposed methodology on the Alzheimer's Disease Neuroimaging Initiative (ADNI) database to predict conversion of individuals with mild cognitive impairment (MCI) to AD, only using information available at baseline...
  16. doi request reprint Realizing the potential of positron emission tomography with 18F-fluorodeoxyglucose to improve the treatment of Alzheimer's disease
    Norman L Foster
    Center for Alzheimer s Care, Imaging and Research, Department of Neurology, University of Utah, Salt Lake City, UT, USA
    Alzheimers Dement 4:S29-36. 2008
    ..The judicious use of FDG-PET is needed to accelerate the evaluation of promising new drugs and more rationally target treatments for dementing diseases...
  17. pmc Shape modeling and analysis with entropy-based particle systems
    Joshua Cates
    School of Computing, University of Utah, Salt Lake City UT, USA
    Inf Process Med Imaging 20:333-45. 2007
    ..This paper presents the formulation; several synthetic examples in two and three dimensions; and an application to the statistical shape analysis of the caudate and hippocampus brain structures from two clinical studies...
  18. ncbi request reprint Multivariate statistical analysis of deformation momenta relating anatomical shape to neuropsychological measures
    Nikhil Singh
    University of Utah, Salt Lake City, UT, USA
    Med Image Comput Comput Assist Interv 13:529-37. 2010
    ..We report the results of this analysis on 313 subjects from the Mild Cognitive Impairment group in the Alzheimer's Disease Neuroimaging Initiative (ADNI)...
  19. pmc Group analysis of DTI fiber tract statistics with application to neurodevelopment
    Casey B Goodlett
    Scientific Computing and Imaging Institute, School of Computing, University of Utah, Salt Lake City, Utah 84112, USA
    Neuroimage 45:S133-42. 2009
    ..Significant differences in neonates were found in the splenium tract between controls and subjects with isolated mild ventriculomegaly (MVM) demonstrating the potential of this method for clinical studies...
  20. ncbi request reprint A volumetric approach to quantifying region-to-region white matter connectivity in diffusion tensor MRI
    P Thomas Fletcher
    School of Computing, University of Utah, Salt Lake City, UT, USA
    Inf Process Med Imaging 20:346-58. 2007
    ..In this way we can obtain volumetric measures on white-matter tracts between regions without any explicit integration of tracts. We demonstrate the proposed method on several fiber tracts from DT-MRI data of the normal human brain...
  21. pmc Regional characterization of longitudinal DT-MRI to study white matter maturation of the early developing brain
    Neda Sadeghi
    Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT 84112, USA
    Neuroimage 68:236-47. 2013
    ..This will eventually lead to a prediction of white matter diffusion properties and associated cognitive development at later stages given imaging data at early stages...
  22. ncbi request reprint Quantifying metabolic asymmetry modulo structure in Alzheimer's disease
    P Thomas Fletcher
    School of Computing, University of Utah, Salt Lake City, UT, USA
    Inf Process Med Imaging 20:446-57. 2007
    ..We present results from applying the methodology to images from the Alzheimer's Disease Neuroimaging Initiative (ADNI)...
  23. pmc Adaptive Riemannian metrics for improved geodesic tracking of white matter
    Xiang Hao
    Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA
    Inf Process Med Imaging 22:13-24. 2011
    ..We demonstrate that the proposed method results in improved geodesics using both synthetic and real DTI data...
  24. ncbi request reprint 4D MAP image reconstruction incorporating organ motion
    Jacob Hinkle
    Scientific Computing and Imaging Institute, University of Utah Salt Lake City, Utah, USA
    Inf Process Med Imaging 21:676-87. 2009
    ..An example of applying this algorithm to real patient image data is also presented, demonstrating the utility of the algorithm in reducing artifacts...
  25. doi request reprint Improved segmentation of white matter tracts with adaptive Riemannian metrics
    Xiang Hao
    School of Computing, University of Utah, Salt Lake City, UT, United States Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, United States Electronic address
    Med Image Anal 18:161-75. 2014
    ..We also compare our method with tractography methods and geodesic approaches using other Riemannian metrics and demonstrate that the proposed method results in improved geodesics and segmentations using both synthetic and real DTI data. ..