DANIEL FLETCHER

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells
    Ovijit Chaudhuri
    University of California San Francisco and Berkeley Joint Graduate Group in Bioengineering and Department of Bioengineering, University of California Berkeley, Berkeley, California, USA
    Nat Methods 6:383-7. 2009
  2. pmc An AFM-based stiffness clamp for dynamic control of rigidity
    Kevin D Webster
    Biophysics Graduate Group, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e17807. 2011
  3. pmc Mobile phone based clinical microscopy for global health applications
    David N Breslauer
    UCSF UC Berkeley Bioengineering Graduate Group, University of California Berkeley, Berkeley, CA, USA
    PLoS ONE 4:e6320. 2009
  4. pmc Tonic shock induces detachment of Giardia lamblia
    Wendy R Hansen
    Biophysics Graduate Group, University of California, Berkeley, California, USA
    PLoS Negl Trop Dis 2:e169. 2008
  5. pmc To model or not to model?
    Daniel A Fletcher
    University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 22:909-10. 2011
  6. pmc Cell mechanics and the cytoskeleton
    Daniel A Fletcher
    Bioengineering and Biophysics, University of California, Berkeley, California 94720, USA
    Nature 463:485-92. 2010
  7. pmc Active biological materials
    Daniel A Fletcher
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Annu Rev Phys Chem 60:469-86. 2009
  8. ncbi request reprint Intravascular drug delivery with a pulsed liquid microjet
    Daniel A Fletcher
    Department of Bioengineering, University of California, Berkeley, 459 Evans Hall, Room 1762, Berkeley, CA 94720 1762, USA
    Arch Ophthalmol 120:1206-8. 2002
  9. ncbi request reprint Spiroplasma swim by a processive change in body helicity
    Joshua W Shaevitz
    Department of Integrative Biology, University of California, Berkeley, 459 Evans Hall, Berkeley, California 94720, USA
    Cell 122:941-5. 2005
  10. pmc Slow stress propagation in adherent cells
    Michael J Rosenbluth
    Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Biophys J 95:6052-9. 2008

Research Grants

  1. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2005
  2. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2006
  3. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2007
  4. Mechanical Regulation of Actin Networks
    DANIEL FLETCHER; Fiscal Year: 2009
  5. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2009
  6. Mechanical Regulation of Actin Networks
    Daniel A Fletcher; Fiscal Year: 2010
  7. Mechanical Regulation of Actin Networks
    Daniel A Fletcher; Fiscal Year: 2010

Collaborators

Detail Information

Publications20

  1. pmc Combined atomic force microscopy and side-view optical imaging for mechanical studies of cells
    Ovijit Chaudhuri
    University of California San Francisco and Berkeley Joint Graduate Group in Bioengineering and Department of Bioengineering, University of California Berkeley, Berkeley, California, USA
    Nat Methods 6:383-7. 2009
    ..This instrument can be a useful tool for understanding the role of mechanics in biological processes...
  2. pmc An AFM-based stiffness clamp for dynamic control of rigidity
    Kevin D Webster
    Biophysics Graduate Group, University of California, Berkeley, California, United States of America
    PLoS ONE 6:e17807. 2011
    ....
  3. pmc Mobile phone based clinical microscopy for global health applications
    David N Breslauer
    UCSF UC Berkeley Bioengineering Graduate Group, University of California Berkeley, Berkeley, CA, USA
    PLoS ONE 4:e6320. 2009
    ....
  4. pmc Tonic shock induces detachment of Giardia lamblia
    Wendy R Hansen
    Biophysics Graduate Group, University of California, Berkeley, California, USA
    PLoS Negl Trop Dis 2:e169. 2008
    ..Giardia cells are known to regulate their volume when exposed to changes in osmolality, but the short-timescale effects of osmolality and pH on parasite attachment are not known...
  5. pmc To model or not to model?
    Daniel A Fletcher
    University of California, Berkeley, Berkeley, CA 94720, USA
    Mol Biol Cell 22:909-10. 2011
    ..To provide perspective on the question of whether and when to combine modeling and experiments, a panel of experts at the 2010 ASCB Annual Meeting shared their personal experiences and advice on how to use modeling effectively...
  6. pmc Cell mechanics and the cytoskeleton
    Daniel A Fletcher
    Bioengineering and Biophysics, University of California, Berkeley, California 94720, USA
    Nature 463:485-92. 2010
    ..An important insight emerging from this work is that long-lived cytoskeletal structures may act as epigenetic determinants of cell shape, function and fate...
  7. pmc Active biological materials
    Daniel A Fletcher
    Department of Bioengineering, University of California, Berkeley, California 94720, USA
    Annu Rev Phys Chem 60:469-86. 2009
    ..This review discusses the basic characteristics of these active biological materials that set them apart from conventional materials and that create a rich array of unique behaviors...
  8. ncbi request reprint Intravascular drug delivery with a pulsed liquid microjet
    Daniel A Fletcher
    Department of Bioengineering, University of California, Berkeley, 459 Evans Hall, Room 1762, Berkeley, CA 94720 1762, USA
    Arch Ophthalmol 120:1206-8. 2002
    ..Perforation of the wall of the blood vessel did not extend beyond the jet diameter...
  9. ncbi request reprint Spiroplasma swim by a processive change in body helicity
    Joshua W Shaevitz
    Department of Integrative Biology, University of California, Berkeley, 459 Evans Hall, Berkeley, California 94720, USA
    Cell 122:941-5. 2005
    ..A processive change in the helicity of the body creates these waves and enables directional movement...
  10. pmc Slow stress propagation in adherent cells
    Michael J Rosenbluth
    Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Biophys J 95:6052-9. 2008
    ....
  11. doi request reprint Analyzing cell mechanics in hematologic diseases with microfluidic biophysical flow cytometry
    Michael J Rosenbluth
    Department of Bioengineering, 608B Stanley Hall, Berkeley, CA 94720 3220, USA
    Lab Chip 8:1062-70. 2008
    ..Biophysical flow cytometry offers a low-cost and high-throughput diagnostic and drug discovery platform for hematologic diseases that affect microcirculatory flow...
  12. ncbi request reprint Loading history determines the velocity of actin-network growth
    Sapun H Parekh
    UCSF UC Berkeley Joint Graduate Group in Bioengineering, University of California at Berkeley, CA 94720, USA
    Nat Cell Biol 7:1219-23. 2005
    ....
  13. pmc Large-scale simulations of fluctuating biological membranes
    Andrea Pasqua
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Chem Phys 132:154107. 2010
    ..We illustrate the model's versatility and realism by characterizing a membrane's response to a prodding nanorod...
  14. pmc Actin polymerization serves as a membrane domain switch in model lipid bilayers
    Allen P Liu
    Biophysics Program, University of California, Berkeley, CA 94720, USA
    Biophys J 91:4064-70. 2006
    ..These results show that dynamic, membrane-bound actin networks alone can control when and where membrane domains form and may actively contribute to membrane organization during cell signaling...
  15. pmc Reversible stress softening of actin networks
    Ovijit Chaudhuri
    UC San Francisco UC Berkeley Joint Graduate Group in Bioengineering and Department of Bioengineering, University of California at Berkeley, Berkeley, California 94720, USA
    Nature 445:295-8. 2007
    ..The observation of both stress stiffening and softening suggests a complex interplay between entropic and enthalpic elasticity in determining the mechanical properties of actin networks...
  16. ncbi request reprint Piezoelectric control of needle-free transdermal drug delivery
    Jeanne C Stachowiak
    University of California, Berkeley, Department of Mechanical Engineering, Berkeley, CA 94720, USA
    J Control Release 124:88-97. 2007
    ..Finally, we discuss how electronically-controlled jet injectors may enable the decoupling of injection parameters such as penetration depth and dose, improving the reliability of needle-free transdermal drug delivery...
  17. doi request reprint Dynamic control of needle-free jet injection
    Jeanne C Stachowiak
    University of California, Berkeley, Department of Mechanical Engineering, Berkeley, CA 94720, USA
    J Control Release 135:104-12. 2009
    ..This dynamic control of jet velocity creates the potential for better control of needle-free injections, as demonstrated through injection studies on whole ex vivo human skin samples...
  18. pmc Unilamellar vesicle formation and encapsulation by microfluidic jetting
    Jeanne C Stachowiak
    Department of Mechanical Engineering, Biophysics Graduate Group, and Department of Bioengineering, University of California, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 105:4697-702. 2008
    ..The ability of microfluidic jetting to controllably encapsulate solutions inside of GUVs creates new opportunities for the study and use of compartmentalized biomolecular systems in science, industry, and medicine...
  19. pmc Limits of filopodium stability
    Sander Pronk
    Department of Bioengineering, University of California Berkeley, Berkeley, California 94720, USA
    Phys Rev Lett 100:258102. 2008
    ..We discuss several in vitro experiments where this kind of stability has already been observed. Furthermore, we predict that the filaments in long, stable filopodia adopt a helical shape...

Research Grants9

  1. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2005
    ..The resulting instrument will be made available to researchers interested in quantifying spatial and temporal coordination of cell movements. ..
  2. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2006
    ..The resulting instrument will be made available to researchers interested in quantifying spatial and temporal coordination of cell movements. ..
  3. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2007
    ..The resulting instrument will be made available to researchers interested in quantifying spatial and temporal coordination of cell movements. ..
  4. Mechanical Regulation of Actin Networks
    DANIEL FLETCHER; Fiscal Year: 2009
    ....
  5. Differential Force Microscopy
    DANIEL FLETCHER; Fiscal Year: 2009
    ..The resulting instrument will be made available to researchers interested in quantifying spatial and temporal coordination of cell movements. ..
  6. Mechanical Regulation of Actin Networks
    Daniel A Fletcher; Fiscal Year: 2010
    ....
  7. Mechanical Regulation of Actin Networks
    Daniel A Fletcher; Fiscal Year: 2010
    ....