Research Topics
Species | Monika R FleshnerSummaryAffiliation: University of Colorado Country: USA Publications
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Publications
Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasomeMonika Fleshner
Department of Integrative Physiology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0354, United States Electronic address
Brain Behav Immun 27:1-7. 2013....
Interleukin-1 beta: a potential link between stress and the development of visceral obesityKristin J Speaker
Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
BMC Physiol 12:8. 2012....
Acute stressor exposure facilitates innate immunity more in physically active than in sedentary ratsMonika Fleshner
Department of Kinesiology and Applied Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
Am J Physiol Regul Integr Comp Physiol 282:R1680-6. 2002..Thus physical activity status facilitates the positive effect of acute stress on innate immunity...- Endogenous extra-cellular heat shock protein 72: releasing signal(s) and functionM Fleshner
Department of Integrative Physiology, University of Colorado Bouler, CO 80309 0354, USA
Int J Hyperthermia 21:457-71. 2005.... - Physical activity and stress resistance: sympathetic nervous system adaptations prevent stress-induced immunosuppressionMonika Fleshner
Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, CO 80309, USA
Exerc Sport Sci Rev 33:120-6. 2005..The current review develops the hypothesis that physical activity may prevent stress-induced suppression of the immune system and suggests an immunophysiological mechanism (sympathetic nervous system constraint) for this effect... - Translational research using in vivo measures of primary antibody responsesMonika Fleshner
Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 354, Boulder, CO 80309-0354, USA
Brain Behav Immun 19:309-10. 2005 - Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormonesMonika Fleshner
Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
Psychoneuroendocrinology 29:1142-52. 2004..Both the intra- and extracellular Hsp72 responses were blocked or attenuated by ADX. This study demonstrates that cat exposure can stimulate the Hsp72 response and that adrenal hormones contribute to this response... - The neurobiology of the stress-resistant brainMonika Fleshner
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
Stress 14:498-502. 2011..Summaries of each presentation, supporting publications, and overall take-home messages from the session are presented... - Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissuesJay Campisi
Department of Kinesiology and Applied Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
Am J Physiol Regul Integr Comp Physiol 284:R520-30. 2003..Facilitated induction of HSP72 may contribute to the increased stress resistance previously reported in physically active organisms... - Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nucleiBenjamin N Greenwood
Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309-0354, USA
Biol Psychiatry 57:559-68. 2005..The observed changes in mRNA regulation in a subset of raphe nuclei might contribute to the stress resistance produced by wheel running and the antidepressant and anxiolytic effects of physical activity... - Short-term treadmill running in the rat: what kind of stressor is it?David A Brown
Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309 0354, USA
J Appl Physiol 103:1979-85. 2007..These data indicate that in response to short-term treadmill running both male and female rats show signs of systemic stress, but that the pattern of changes occurs in a sex-specific manner... - Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neuronsBenjamin N Greenwood
Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309-0354, USA
J Neurosci 23:2889-98. 2003..An increase in 5-HT1A inhibitory autoreceptor expression may contribute to the attenuation of DRN 5-HT activity and the prevention of LH in physically active rats... - The consequences of uncontrollable stress are sensitive to duration of prior wheel runningBenjamin N Greenwood
Department of Integrative Physiology, University of Colorado, Boulder, 80309-0354, USA
Brain Res 1033:164-78. 2005..The potential role of the BNST in the prevention of LH by wheel running is discussed... - Exercise, learned helplessness, and the stress-resistant brainBenjamin N Greenwood
Department of Integrative Physiology, Center for Neuroscience, University of Colorado Boulder, Clare Small Building, Boulder, CO 80309 0354, USA
Neuromolecular Med 10:81-98. 2008.... - Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrusSerge Campeau
Department of Psychology and Neuroscience, University of Colorado, Boulder, USA
Brain Res 1323:109-18. 2010..Although the function of the alpha(1D) ADR in the dentate gyrus is not known, these data provide further evidence for a close interaction between stress and the noradrenergic system in the hippocampus... - Chronic voluntary wheel running facilitates corticosterone response habituation to repeated audiogenic stress exposure in male ratsSarah K Sasse
Department of Psychology, University of Colorado, Boulder, CO 80309, USA
Stress 11:425-37. 2008.... - The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 ratsPaul V Strong
Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, Clare Small Room 104, Campus Box 354, Boulder, CO 80309, USA
Psychopharmacology (Berl) 203:665-75. 2009..Blocking 5-HT(2C) receptors in the face of an increase in serotonin can alleviate anxiety behaviors in some animal models. However, specific 5-HT receptor subtypes involved in learned helplessness remain unknown... - Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exerciseBenjamin N Greenwood
Department of Integrative Physiology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA
Psychopharmacology (Berl) 199:209-22. 2008..Exercise is anxiolytic in humans, and wheel running prevents anxiety-like behavioral consequences of uncontrollable stress in rats, but the effects of exercise on acute fluoxetine-induced anxiety-like behaviors are unknown... - Lesions of the basolateral amygdala reverse the long-lasting interference with shuttle box escape produced by uncontrollable stressBenjamin N Greenwood
Department of Integrative Physiology and the Center for Neuroscience, University of Colorado Boulder, Campus Box 354, Boulder, CO 80309, United States
Behav Brain Res 211:71-6. 2010..Results have important implications for the mechanisms underlying learned helplessness phenomena... - 5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stressJohn P Christianson
Department of Psychology and Neuroscience, University of Colorado, Boulder, 80309, USA
Biol Psychiatry 67:339-45. 2010.... - A behavioral analysis of the impact of voluntary physical activity on hippocampus-dependent contextual conditioningBenjamin N Greenwood
Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, Boulder, CO 80309 0354, USA
Hippocampus 19:988-1001. 2009..Wheel running increased BDNF mRNA in the dentate gyrus, CA1, and the basolateral amygdala. Results are consistent with improved hippocampal function following physical activity... - Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preferenceRobert R Rozeske
University of Colorado Boulder, Department of Psychology and Neuroscience, Muenzinger Building, UCB 345, Boulder, CO 80309, USA
Behav Brain Res 219:378-81. 2011..Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP... - Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathwayBenjamin N Greenwood
Department of Integrative Physiology, Center for Neuroscience, University of Colorado, Boulder, CO, USA
Behav Brain Res 217:354-62. 2011.... - Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigueTeresa E Foley
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
Behav Brain Res 174:132-42. 2006..These data suggest that central serotonergic and dopaminergic systems may be involved in the mechanisms by which HCR have delayed onset of exercise-induced fatigue compared to LCR... - The 1- to 2-Hz oscillations in muscle force are exacerbated by stress, especially in older adultsEvangelos A Christou
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
J Appl Physiol 97:225-35. 2004.... - Acute stress decreases inflammation at the site of infection. A role for nitric oxideJay Campisi
Department of Kinesiology and Applied Physiology, University of Colorado-Boulder, Campus Box 354, Boulder, CO 80309-0354, USA
Physiol Behav 77:291-9. 2002..Thus, acute stress improved recovery from bacterially induced inflammation possibly due to local elevations in NO... - Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleusHeidi E W Day
Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
J Comp Neurol 474:364-78. 2004..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR... - Stressor exposure produces long-term reductions in antigen-specific T and B cell responsesLawrence S Gazda
Department of Psychology, University of Colorado at Boulder, CO 80309-0354, USA
Stress 6:259-67. 2003.... - Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escapeBenjamin N Greenwood
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
Behav Neurosci 121:992-1000. 2007..Results demonstrate a long-lasting interference with shuttle box escape that can be reversed by exercise in a duration-dependent fashion... - Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72John D Johnson
Center for Neuroscience, Dept of Integrative Physiology, Univ of Colorado at Boulder, Boulder, CO 80309 0354, USA
J Appl Physiol 99:1789-95. 2005..Understanding the signals involved in elevating extracellular Hsp72 could facilitate the use of extracellular Hsp72 to bolster immunity and perhaps prevent exacerbation of inflammatory diseases during stress... - Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune systemJay Campisi
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309-0354, USA
Cell Stress Chaperones 8:272-86. 2003..Thus, these results lend support to the hypothesis that intense stressor exposure increases eHsp72, which acts as a danger signal to potentiate the NO response to bacterial challenge and facilitate recovery from bacterial inflammation... - B-1 cell (CD5+/CD11b+) numbers and nIgM levels are elevated in physically active vs. sedentary ratsGwendolyn F Elphick
Department of Intergrative Phsiololgy, University of Colorado at Boulder, Boulder, CO 80309-0354, USA
J Appl Physiol 95:199-206. 2003..Because B-1 cells are important in host defense, these changes may contribute to the health benefits of exercise... - Elevated IL-1beta contributes to antibody suppression produced by stressAlbert Moraska
Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309, USA
J Appl Physiol 93:207-15. 2002..These data support the hypothesis that stress-induced increases in innate immunity (i.e., IL-1beta) may contribute to stress-induced suppression in acquired immunity (i.e., anti-KLH Ig)... - Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in menTaro P Smith
Department of Integrative Physiology, Campus Box 354, University of Colorado at Boulder, Boulder, CO 80309, USA
J Appl Physiol 97:491-8. 2004..In conclusion, regular physical activity in older men is associated with a more robust immune response to novel antigenic challenge... - Resting cellular and physiological effects of freewheel runningSarah L Kennedy
Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
Med Sci Sports Exerc 37:79-83. 2005..In conclusion, freewheel running provides sufficient exercise stimulus to produce some, but not all, training associated physiological adaptations... - Can exercise stress facilitate innate immunity? A functional role for stress-induced extracellular Hsp72Monika Fleshner
Department of Integrative Physiology, Center for Neuroscience, University of Colorado, Boulder, CO 80309 0354, USA
Exerc Immunol Rev 9:6-24. 2003 - Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72John D Johnson
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309-0354, USA
J Leukoc Biol 79:425-34. 2006..In addition, we present data that emphasize the importance of caution when conducting in vitro immunological tests of Hsp72 function... - The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adultsDanielle J Frey
Sleep and Chronobiology Laboratory, Department of Integrative Physiology, Center for Neuroscience, University of Colorado at Boulder, Clare Small, Room 114, Campus Box 354, Boulder, CO 80309, USA
Brain Behav Immun 21:1050-7. 2007..These findings suggest that one night of sleep loss triggers a stress response that includes stimulation of both pro- and anti-inflammatory proteins in the healthy young subjects tested under our experimental conditions... - Increased serum nIgM in voluntarily physically active rats: a potential role for B-1 cellsGwendolyn F Elphick
Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder 80309-0354, USA
J Appl Physiol 94:660-7. 2003..Because nIgM is important in multiple aspects of the immune response, an elevation in this innate humoral component could contribute to improved immunity in physically active organisms... - Neuroplasticity of dopamine circuits after exercise: implications for central fatigueTeresa E Foley
Department Integrative Physiology, Center for Neuroscience, Clare Small Building, University of Colorado Boulder, Boulder, CO 80309 0354, USA
Neuromolecular Med 10:67-80. 2008..Results from these studies are discussed in light of our understanding of the role of DA in the neurobiological mechanisms of central fatigue... - Physiological improvements and health benefits during an exercise-based comprehensive rehabilitation program in medically complex patientsTaro P Smith
Dept. of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
Exerc Immunol Rev 12:86-96. 2006..05), and hospitalizations (P < 0.05). CONCLUSION: Patients improve physical capacity, which result in improvements in health status with concurrent reductions in healthcare utilization during a comprehensive rehabilitation program... - Neurobiology of exerciseRod K Dishman
Department of Exercise Science, The University of Georgia, Ramsey Center, 330 River Road, Athens, GA 30602 6554, USA
Obesity (Silver Spring) 14:345-56. 2006....
Research Grants
- The Neurobiology of the Stress Resistant BrainMonika R Fleshner; Fiscal Year: 2010....
- Stress, Heat-Shock Proteins, and Innate ImmunityMonika Fleshner; Fiscal Year: 2007..abstract_text> ..
- The Neurobiology of the Stress Resistant BrainMonika Fleshner; Fiscal Year: 2007..Together, these changes may prevent the intense DRN 5HT activation during uncontrollable stress, and/or the subsequent development & expression of LH. ..
- EXERCISE, STRESS AND IMMUNITY--PHYSIOLOGICAL MECHANISMSMonika Fleshner; Fiscal Year: 2004....