Monika R Fleshner

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. doi request reprint Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome
    Monika Fleshner
    Department of Integrative Physiology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0354, United States
    Brain Behav Immun 27:1-7. 2013
  2. pmc Interleukin-1 beta: a potential link between stress and the development of visceral obesity
    Kristin J Speaker
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    BMC Physiol 12:8. 2012
  3. ncbi request reprint Acute stressor exposure facilitates innate immunity more in physically active than in sedentary rats
    Monika Fleshner
    Department of Kinesiology and Applied Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1680-6. 2002
  4. ncbi request reprint Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function
    M Fleshner
    Department of Integrative Physiology, University of Colorado Bouler, CO 80309 0354, USA
    Int J Hyperthermia 21:457-71. 2005
  5. ncbi request reprint Physical activity and stress resistance: sympathetic nervous system adaptations prevent stress-induced immunosuppression
    Monika Fleshner
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, CO 80309, USA
    Exerc Sport Sci Rev 33:120-6. 2005
  6. ncbi request reprint Translational research using in vivo measures of primary antibody responses
    Monika Fleshner
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 354, Boulder, CO 80309 0354, USA
    Brain Behav Immun 19:309-10. 2005
  7. ncbi request reprint Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones
    Monika Fleshner
    Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
    Psychoneuroendocrinology 29:1142-52. 2004
  8. pmc The neurobiology of the stress-resistant brain
    Monika Fleshner
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Stress 14:498-502. 2011
  9. ncbi request reprint Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues
    Jay Campisi
    Department of Kinesiology and Applied Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Am J Physiol Regul Integr Comp Physiol 284:R520-30. 2003
  10. ncbi request reprint Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei
    Benjamin N Greenwood
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    Biol Psychiatry 57:559-68. 2005

Research Grants

  1. The Neurobiology of the Stress Resistant Brain
    Monika R Fleshner; Fiscal Year: 2010
  2. Stress, Heat-Shock Proteins, and Innate Immunity
    Monika Fleshner; Fiscal Year: 2007
  3. The Neurobiology of the Stress Resistant Brain
    Monika Fleshner; Fiscal Year: 2007
  4. EXERCISE, STRESS AND IMMUNITY--PHYSIOLOGICAL MECHANISMS
    Monika Fleshner; Fiscal Year: 2004

Detail Information

Publications42

  1. doi request reprint Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome
    Monika Fleshner
    Department of Integrative Physiology, Center for Neuroscience, University of Colorado at Boulder, Boulder, CO 80309 0354, United States
    Brain Behav Immun 27:1-7. 2013
    ....
  2. pmc Interleukin-1 beta: a potential link between stress and the development of visceral obesity
    Kristin J Speaker
    Department of Integrative Physiology, University of Colorado at Boulder, 80309, USA
    BMC Physiol 12:8. 2012
    ....
  3. ncbi request reprint Acute stressor exposure facilitates innate immunity more in physically active than in sedentary rats
    Monika Fleshner
    Department of Kinesiology and Applied Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Am J Physiol Regul Integr Comp Physiol 282:R1680-6. 2002
    ..Thus physical activity status facilitates the positive effect of acute stress on innate immunity...
  4. ncbi request reprint Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function
    M Fleshner
    Department of Integrative Physiology, University of Colorado Bouler, CO 80309 0354, USA
    Int J Hyperthermia 21:457-71. 2005
    ....
  5. ncbi request reprint Physical activity and stress resistance: sympathetic nervous system adaptations prevent stress-induced immunosuppression
    Monika Fleshner
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, CO 80309, USA
    Exerc Sport Sci Rev 33:120-6. 2005
    ..The current review develops the hypothesis that physical activity may prevent stress-induced suppression of the immune system and suggests an immunophysiological mechanism (sympathetic nervous system constraint) for this effect...
  6. ncbi request reprint Translational research using in vivo measures of primary antibody responses
    Monika Fleshner
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado at Boulder, Campus Box 354, Boulder, CO 80309 0354, USA
    Brain Behav Immun 19:309-10. 2005
  7. ncbi request reprint Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones
    Monika Fleshner
    Department of Integrative Physiology, University of Colorado Boulder, Boulder, CO 80309, USA
    Psychoneuroendocrinology 29:1142-52. 2004
    ..Both the intra- and extracellular Hsp72 responses were blocked or attenuated by ADX. This study demonstrates that cat exposure can stimulate the Hsp72 response and that adrenal hormones contribute to this response...
  8. pmc The neurobiology of the stress-resistant brain
    Monika Fleshner
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Stress 14:498-502. 2011
    ..Summaries of each presentation, supporting publications, and overall take-home messages from the session are presented...
  9. ncbi request reprint Habitual physical activity facilitates stress-induced HSP72 induction in brain, peripheral, and immune tissues
    Jay Campisi
    Department of Kinesiology and Applied Physiology and the Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    Am J Physiol Regul Integr Comp Physiol 284:R520-30. 2003
    ..Facilitated induction of HSP72 may contribute to the increased stress resistance previously reported in physically active organisms...
  10. ncbi request reprint Wheel running alters serotonin (5-HT) transporter, 5-HT1A, 5-HT1B, and alpha 1b-adrenergic receptor mRNA in the rat raphe nuclei
    Benjamin N Greenwood
    Department of Integrative Physiology, University of Colorado, Boulder, Colorado 80309 0354, USA
    Biol Psychiatry 57:559-68. 2005
    ..In the current study, we investigated whether physical activity alters factors involved in the regulation of central 5-HT neural activity...
  11. ncbi request reprint Short-term treadmill running in the rat: what kind of stressor is it?
    David A Brown
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309 0354, USA
    J Appl Physiol 103:1979-85. 2007
    ..These data indicate that in response to short-term treadmill running both male and female rats show signs of systemic stress, but that the pattern of changes occurs in a sex-specific manner...
  12. ncbi request reprint Freewheel running prevents learned helplessness/behavioral depression: role of dorsal raphe serotonergic neurons
    Benjamin N Greenwood
    Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder, Colorado 80309 0354, USA
    J Neurosci 23:2889-98. 2003
    ..An increase in 5-HT1A inhibitory autoreceptor expression may contribute to the attenuation of DRN 5-HT activity and the prevention of LH in physically active rats...
  13. ncbi request reprint The consequences of uncontrollable stress are sensitive to duration of prior wheel running
    Benjamin N Greenwood
    Department of Integrative Physiology, University of Colorado, Boulder, 80309 0354, USA
    Brain Res 1033:164-78. 2005
    ..The potential role of the BNST in the prevention of LH by wheel running is discussed...
  14. doi request reprint Exercise, learned helplessness, and the stress-resistant brain
    Benjamin N Greenwood
    Department of Integrative Physiology, Center for Neuroscience, University of Colorado Boulder, Clare Small Building, Boulder, CO 80309 0354, USA
    Neuromolecular Med 10:81-98. 2008
    ....
  15. pmc Stress rapidly increases alpha 1d adrenergic receptor mRNA in the rat dentate gyrus
    Serge Campeau
    Department of Psychology and Neuroscience, University of Colorado, Boulder, USA
    Brain Res 1323:109-18. 2010
    ..Although the function of the alpha(1D) ADR in the dentate gyrus is not known, these data provide further evidence for a close interaction between stress and the noradrenergic system in the hippocampus...
  16. pmc Chronic voluntary wheel running facilitates corticosterone response habituation to repeated audiogenic stress exposure in male rats
    Sarah K Sasse
    Department of Psychology, University of Colorado, Boulder, CO 80309, USA
    Stress 11:425-37. 2008
    ....
  17. doi request reprint The effects of the selective 5-HT(2C) receptor antagonist SB 242084 on learned helplessness in male Fischer 344 rats
    Paul V Strong
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, Clare Small Room 104, Campus Box 354, Boulder, CO 80309, USA
    Psychopharmacology (Berl) 203:665-75. 2009
    ..Blocking 5-HT(2C) receptors in the face of an increase in serotonin can alleviate anxiety behaviors in some animal models. However, specific 5-HT receptor subtypes involved in learned helplessness remain unknown...
  18. doi request reprint Anxiety-like behaviors produced by acute fluoxetine administration in male Fischer 344 rats are prevented by prior exercise
    Benjamin N Greenwood
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA
    Psychopharmacology (Berl) 199:209-22. 2008
    ..Exercise is anxiolytic in humans, and wheel running prevents anxiety-like behavioral consequences of uncontrollable stress in rats, but the effects of exercise on acute fluoxetine-induced anxiety-like behaviors are unknown...
  19. pmc Lesions of the basolateral amygdala reverse the long-lasting interference with shuttle box escape produced by uncontrollable stress
    Benjamin N Greenwood
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado Boulder, Campus Box 354, Boulder, CO 80309, United States
    Behav Brain Res 211:71-6. 2010
    ..Results have important implications for the mechanisms underlying learned helplessness phenomena...
  20. pmc 5-hydroxytryptamine 2C receptors in the basolateral amygdala are involved in the expression of anxiety after uncontrollable traumatic stress
    John P Christianson
    Department of Psychology and Neuroscience, University of Colorado, Boulder, 80309, USA
    Biol Psychiatry 67:339-45. 2010
    ....
  21. pmc A behavioral analysis of the impact of voluntary physical activity on hippocampus-dependent contextual conditioning
    Benjamin N Greenwood
    Department of Integrative Physiology and the Center for Neuroscience, University of Colorado, Boulder, CO 80309 0354, USA
    Hippocampus 19:988-1001. 2009
    ..Wheel running increased BDNF mRNA in the dentate gyrus, CA1, and the basolateral amygdala. Results are consistent with improved hippocampal function following physical activity...
  22. pmc Voluntary wheel running produces resistance to inescapable stress-induced potentiation of morphine conditioned place preference
    Robert R Rozeske
    University of Colorado Boulder, Department of Psychology and Neuroscience, Muenzinger Building, UCB 345, Boulder, CO 80309, USA
    Behav Brain Res 219:378-81. 2011
    ..Six weeks of voluntary wheel running constrains activation of DRN 5-HT neurons during exposure to inescapable stress. Six weeks of voluntary wheel running before inescapable stress blocked stress-induced potentiation of morphine CPP...
  23. pmc Long-term voluntary wheel running is rewarding and produces plasticity in the mesolimbic reward pathway
    Benjamin N Greenwood
    Department of Integrative Physiology, Center for Neuroscience, University of Colorado, Boulder, CO, USA
    Behav Brain Res 217:354-62. 2011
    ....
  24. ncbi request reprint Elevated central monoamine receptor mRNA in rats bred for high endurance capacity: implications for central fatigue
    Teresa E Foley
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Behav Brain Res 174:132-42. 2006
    ..These data suggest that central serotonergic and dopaminergic systems may be involved in the mechanisms by which HCR have delayed onset of exercise-induced fatigue compared to LCR...
  25. ncbi request reprint The 1- to 2-Hz oscillations in muscle force are exacerbated by stress, especially in older adults
    Evangelos A Christou
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    J Appl Physiol 97:225-35. 2004
    ....
  26. ncbi request reprint Acute stress decreases inflammation at the site of infection. A role for nitric oxide
    Jay Campisi
    Department of Kinesiology and Applied Physiology, University of Colorado Boulder, Campus Box 354, Boulder, CO 80309 0354, USA
    Physiol Behav 77:291-9. 2002
    ..Thus, acute stress improved recovery from bacterially induced inflammation possibly due to local elevations in NO...
  27. pmc Differential expression of 5HT-1A, alpha 1b adrenergic, CRF-R1, and CRF-R2 receptor mRNA in serotonergic, gamma-aminobutyric acidergic, and catecholaminergic cells of the rat dorsal raphe nucleus
    Heidi E W Day
    Department of Psychology and Center for Neuroscience, University of Colorado, Boulder, Colorado 80309, USA
    J Comp Neurol 474:364-78. 2004
    ..The differential distribution of distinct neurochemical phenotypes lends support to the idea of functional differentiation of the DR...
  28. ncbi request reprint Stressor exposure produces long-term reductions in antigen-specific T and B cell responses
    Lawrence S Gazda
    Department of Psychology, University of Colorado at Boulder, CO 80309 0354, USA
    Stress 6:259-67. 2003
    ....
  29. ncbi request reprint Therapeutic effects of exercise: wheel running reverses stress-induced interference with shuttle box escape
    Benjamin N Greenwood
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Behav Neurosci 121:992-1000. 2007
    ..Results demonstrate a long-lasting interference with shuttle box escape that can be reversed by exercise in a duration-dependent fashion...
  30. ncbi request reprint Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72
    John D Johnson
    Center for Neuroscience, Dept of Integrative Physiology, Univ of Colorado at Boulder, Boulder, CO 80309 0354, USA
    J Appl Physiol 99:1789-95. 2005
    ..Understanding the signals involved in elevating extracellular Hsp72 could facilitate the use of extracellular Hsp72 to bolster immunity and perhaps prevent exacerbation of inflammatory diseases during stress...
  31. pmc Stress-induced extracellular Hsp72 is a functionally significant danger signal to the immune system
    Jay Campisi
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Cell Stress Chaperones 8:272-86. 2003
    ..Thus, these results lend support to the hypothesis that intense stressor exposure increases eHsp72, which acts as a danger signal to potentiate the NO response to bacterial challenge and facilitate recovery from bacterial inflammation...
  32. ncbi request reprint B-1 cell (CD5+/CD11b+) numbers and nIgM levels are elevated in physically active vs. sedentary rats
    Gwendolyn F Elphick
    Department of Intergrative Phsiololgy, University of Colorado at Boulder, Boulder, CO 80309 0354, USA
    J Appl Physiol 95:199-206. 2003
    ..Because B-1 cells are important in host defense, these changes may contribute to the health benefits of exercise...
  33. ncbi request reprint Elevated IL-1beta contributes to antibody suppression produced by stress
    Albert Moraska
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309, USA
    J Appl Physiol 93:207-15. 2002
    ..These data support the hypothesis that stress-induced increases in innate immunity (i.e., IL-1beta) may contribute to stress-induced suppression in acquired immunity (i.e., anti-KLH Ig)...
  34. ncbi request reprint Influence of age and physical activity on the primary in vivo antibody and T cell-mediated responses in men
    Taro P Smith
    Department of Integrative Physiology, Campus Box 354, University of Colorado at Boulder, Boulder, CO 80309, USA
    J Appl Physiol 97:491-8. 2004
    ..In conclusion, regular physical activity in older men is associated with a more robust immune response to novel antigenic challenge...
  35. ncbi request reprint Resting cellular and physiological effects of freewheel running
    Sarah L Kennedy
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Med Sci Sports Exerc 37:79-83. 2005
    ..Exercise modulates many aspects of physiology. The purpose of the current experiment was to characterize the impact of regular, moderate physical activity on resting, baseline measures of cellular immunity blood lipids, and muscle enzyme...
  36. ncbi request reprint Can exercise stress facilitate innate immunity? A functional role for stress-induced extracellular Hsp72
    Monika Fleshner
    Department of Integrative Physiology, Center for Neuroscience, University of Colorado, Boulder, CO 80309 0354, USA
    Exerc Immunol Rev 9:6-24. 2003
  37. ncbi request reprint Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72
    John D Johnson
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    J Leukoc Biol 79:425-34. 2006
    ..In addition, we present data that emphasize the importance of caution when conducting in vitro immunological tests of Hsp72 function...
  38. ncbi request reprint The effects of 40 hours of total sleep deprivation on inflammatory markers in healthy young adults
    Danielle J Frey
    Sleep and Chronobiology Laboratory, Department of Integrative Physiology, Center for Neuroscience, University of Colorado at Boulder, Clare Small, Room 114, Campus Box 354, Boulder, CO 80309, USA
    Brain Behav Immun 21:1050-7. 2007
    ..These findings suggest that one night of sleep loss triggers a stress response that includes stimulation of both pro- and anti-inflammatory proteins in the healthy young subjects tested under our experimental conditions...
  39. ncbi request reprint Increased serum nIgM in voluntarily physically active rats: a potential role for B-1 cells
    Gwendolyn F Elphick
    Department of Kinesiology and Applied Physiology, Center for Neuroscience, University of Colorado, Boulder 80309 0354, USA
    J Appl Physiol 94:660-7. 2003
    ..Because nIgM is important in multiple aspects of the immune response, an elevation in this innate humoral component could contribute to improved immunity in physically active organisms...
  40. doi request reprint Neuroplasticity of dopamine circuits after exercise: implications for central fatigue
    Teresa E Foley
    Department Integrative Physiology, Center for Neuroscience, Clare Small Building, University of Colorado Boulder, Boulder, CO 80309 0354, USA
    Neuromolecular Med 10:67-80. 2008
    ..Results from these studies are discussed in light of our understanding of the role of DA in the neurobiological mechanisms of central fatigue...
  41. ncbi request reprint Physiological improvements and health benefits during an exercise-based comprehensive rehabilitation program in medically complex patients
    Taro P Smith
    Dept of Integrative Physiology, University of Colorado at Boulder, Boulder, CO 80309, USA
    Exerc Immunol Rev 12:86-96. 2006
    ..To determine the effects of an exercise-based comprehensive rehabilitation program on the physiological, health, and cost benefit in medically complex patients...
  42. ncbi request reprint Neurobiology of exercise
    Rod K Dishman
    Department of Exercise Science, The University of Georgia, Ramsey Center, 330 River Road, Athens, GA 30602 6554, USA
    Obesity (Silver Spring) 14:345-56. 2006
    ....

Research Grants15

  1. The Neurobiology of the Stress Resistant Brain
    Monika R Fleshner; Fiscal Year: 2010
    ....
  2. Stress, Heat-Shock Proteins, and Innate Immunity
    Monika Fleshner; Fiscal Year: 2007
    ..abstract_text> ..
  3. The Neurobiology of the Stress Resistant Brain
    Monika Fleshner; Fiscal Year: 2007
    ..Together, these changes may prevent the intense DRN 5HT activation during uncontrollable stress, and/or the subsequent development & expression of LH. ..
  4. EXERCISE, STRESS AND IMMUNITY--PHYSIOLOGICAL MECHANISMS
    Monika Fleshner; Fiscal Year: 2004
    ....