M Fleshner

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response
    M Fleshner
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
    J Immunol 166:3813-9. 2001
  2. ncbi request reprint Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy
    M Fleshner
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    J Neuroimmunol 86:134-41. 1998
  3. ncbi request reprint Exercise and neuroendocrine regulation of antibody production: protective effect of physical activity on stress-induced suppression of the specific antibody response
    M Fleshner
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309 0354, USA
    Int J Sports Med 21:S14-9. 2000
  4. ncbi request reprint Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats
    M K Hansen
    Department of Psychology, University of Colorado at Boulder, 80309 0345, USA
    Auton Neurosci 85:119-26. 2000
  5. ncbi request reprint Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide
    M K Hansen
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Am J Physiol Regul Integr Comp Physiol 278:R331-6. 2000
  6. ncbi request reprint Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve
    R P Gaykema
    Department of Psychology, University of Colorado, Boulder, Colo, USA
    Neuroimmunomodulation 5:234-40. 1998
  7. ncbi request reprint Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor
    T Deak
    Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Res 847:211-20. 1999
  8. ncbi request reprint The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone
    E D Milligan
    Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Res 810:48-58. 1998
  9. ncbi request reprint Splenic norepinephrine depletion following acute stress suppresses in vivo antibody response
    S L Kennedy
    Department of Integrative Physiology, University of Colorado, Campus Box 354, Boulder, Colorado 80309 0354, USA
    J Neuroimmunol 165:150-60. 2005
  10. ncbi request reprint Sexual dimorphism of the intracellular heat shock protein 72 response
    M Nickerson
    Dept of IPHY, CB 354, Boulder, CO 80309, USA
    J Appl Physiol 101:566-75. 2006

Detail Information

Publications31

  1. ncbi request reprint Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody response
    M Fleshner
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
    J Immunol 166:3813-9. 2001
    ..Given that IFN-gamma is an important regulator of the IgM to IgG2a switch, it is possible that the small rise in GC found 4-7 days after KLH facilitates IgG2a isotype switching...
  2. ncbi request reprint Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy
    M Fleshner
    Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
    J Neuroimmunol 86:134-41. 1998
    ..v. administered cytokines. This effect was dose dependent. The results add support to the hypothesis that vagal afferents are involved in peripheral cytokine-to-brain communication...
  3. ncbi request reprint Exercise and neuroendocrine regulation of antibody production: protective effect of physical activity on stress-induced suppression of the specific antibody response
    M Fleshner
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309 0354, USA
    Int J Sports Med 21:S14-9. 2000
    ....
  4. ncbi request reprint Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in rats
    M K Hansen
    Department of Psychology, University of Colorado at Boulder, 80309 0345, USA
    Auton Neurosci 85:119-26. 2000
    ..Furthermore, these data indicate that, at the doses and times tested, subdiaphragmatic vagal afferents are not crucial for LPS-induced brain IL-1beta protein...
  5. ncbi request reprint Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharide
    M K Hansen
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    Am J Physiol Regul Integr Comp Physiol 278:R331-6. 2000
    ..In conclusion, vagotomy itself has no marked effect on circulating endotoxin levels or the production of IL-1beta, IL-6, or corticosterone in blood after an intraperitoneal injection of LPS...
  6. ncbi request reprint Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerve
    R P Gaykema
    Department of Psychology, University of Colorado, Boulder, Colo, USA
    Neuroimmunomodulation 5:234-40. 1998
    ..These findings implicate vagal afferents as a potential signaling pathway to brain regions that generate illness responses to pro-inflammatory mediators...
  7. ncbi request reprint Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressor
    T Deak
    Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Res 847:211-20. 1999
    ..These long-term changes in corticosteroid receptor activation, evident 24 h after IS exposure, may be responsible for some of the long-term neural, behavioral and immune changes observed following this acute stress procedure...
  8. ncbi request reprint The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormone
    E D Milligan
    Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
    Brain Res 810:48-58. 1998
    ..These data provide support for a specific mode of action for i.c.v. alpha-MSH(1-13), namely blockade of APRs with no impact on acute hyperthermia or increased levels of CORT produced during IS...
  9. ncbi request reprint Splenic norepinephrine depletion following acute stress suppresses in vivo antibody response
    S L Kennedy
    Department of Integrative Physiology, University of Colorado, Campus Box 354, Boulder, Colorado 80309 0354, USA
    J Neuroimmunol 165:150-60. 2005
    ..These data support the hypothesis that splenic NE depletion is necessary and sufficient for stress-induced suppression of antibody to a T-cell dependent antigen...
  10. ncbi request reprint Sexual dimorphism of the intracellular heat shock protein 72 response
    M Nickerson
    Dept of IPHY, CB 354, Boulder, CO 80309, USA
    J Appl Physiol 101:566-75. 2006
    ..The adrenal glands, spleen, and heart did not exhibit sexual dimorphism of the HSP72 response. The estrous cycle did not have a significant effect on basal or stress-induced HSP72 in females...
  11. ncbi request reprint Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines
    J D Johnson
    Department of Integrative Physiology and Center for Neuroscience, Clare Small Building, Room 114, University of Colorado, Boulder, CO 80309 0354, USA
    Neuroscience 135:1295-307. 2005
    ....
  12. ncbi request reprint Acute stress may facilitate recovery from a subcutaneous bacterial challenge
    T Deak
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Neuroimmunomodulation 6:344-54. 1999
    ..Furthermore, IS does not appear to alter the rat's ability to sequester bacteria in the subcutaneous space since no swelling of lymph nodes or chronic activation of the hypothalamic-pituitary-adrenal axis was observed...
  13. ncbi request reprint Physical activity alters the brain Hsp72 and IL-1beta responses to peripheral E. coli challenge
    M Nickerson
    Dept of Integrative Physiology, Neuroimmunophysiology Laboratory, Univ of Colorado, Boulder, CO 80309, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1665-74. 2005
    ....
  14. ncbi request reprint The role of the vagus nerve in cytokine-to-brain communication
    S F Maier
    Department of Psychology, University of Colorado, Boulder 80309, USA
    Ann N Y Acad Sci 840:289-300. 1998
    ..Data extending this analysis to TNF-alpha and intravenous routes will be described...
  15. ncbi request reprint Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation
    C R Pugh
    Department of Psychology, University of Colorado at Boulder, 80309 0345, USA
    Behav Brain Res 106:109-18. 1999
    ..These findings also add to the generality of the idea that stressors induce IL-1beta activity in the brain and that IL-1beta may play physiological roles in the uninjured brain...
  16. ncbi request reprint Role of extracellular HSP72 in acute stress-induced potentiation of innate immunity in active rats
    J Campisi
    Department of Kinesiology and Applied Physiology, and Center for Neuroscience, University of Colorado at Boulder, 80309 0354, USA
    J Appl Physiol 94:43-52. 2003
    ..Thus physically active rats both recover faster than sedentary rats after bacterial challenge + IS exposure and demonstrate potentiated cellular responses to eHSP72 activation that could be important for bacterial recovery...
  17. ncbi request reprint Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challenge
    J Campisi
    Department of Integrative Physiology, University of Colorado at Boulder, Boulder, Colorado 80309 0354, USA
    J Appl Physiol 95:1873-82. 2003
    ..Therefore, fever, activity reduction, and corticosterone elevation induced by E. coli infection may have been evoked by a neural, rather than a humoral, pathway from the periphery to the brain...
  18. ncbi request reprint Voluntary freewheel running selectively modulates catecholamine content in peripheral tissue and c-Fos expression in the central sympathetic circuit following exposure to uncontrollable stress in rats
    B N Greenwood
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
    Neuroscience 120:269-81. 2003
    ..The attenuation of sympathetic responses observed in this study may be one important mechanism for the protective effect of physical activity against stress-related illness and immunosuppression...
  19. doi request reprint Hypothalamic pituitary adrenal axis responses to low-intensity stressors are reduced after voluntary wheel running in rats
    S Campeau
    University of Colorado, Department of Psychology and Neuroscience, Muenzinger, Boulder, CO, USA
    J Neuroendocrinol 22:872-88. 2010
    ....
  20. ncbi request reprint Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppression
    A Moraska
    University of Colorado at Boulder, Department of Kinesiology and Applied Physiology, Boulder, CO 80309, USA
    Am J Physiol Regul Integr Comp Physiol 281:R484-9. 2001
    ..Anti-KLH IgG(1) was stress insensitive. These data suggest that physical activity can buffer the negative impact of stress on behavior and acquired immune function...
  21. pmc Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampus
    B N Greenwood
    Department of Integrative Physiology, Center for Neuroscience, University of Colorado, Clare Small Room 104, Campus Box 354, Boulder, CO 80309 0354, USA
    Neuroscience 144:1193-208. 2007
    ..Results also suggest that the prevention of stress-induced hippocampal BDNF suppression is not necessary for the protective effect of wheel running against learned helplessness...
  22. ncbi request reprint Endogenous extra-cellular heat shock protein 72: releasing signal(s) and function
    M Fleshner
    Department of Integrative Physiology, University of Colorado Bouler, CO 80309 0354, USA
    Int J Hyperthermia 21:457-71. 2005
    ....
  23. ncbi request reprint Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockade
    R S Mazzeo
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309, USA
    J Appl Physiol 91:2143-9. 2001
    ..In conclusion, the results indicate a role for alpha-adrenergic regulation of the IL-6 response to the stress of both short-term moderate-intensity exercise and hypoxia...
  24. pmc 5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behavior
    P V Strong
    Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
    Neuroscience 197:132-44. 2011
    ....
  25. ncbi request reprint The immune system and memory consolidation: a role for the cytokine IL-1beta
    C Rachal Pugh
    University of Colorado at Boulder, Department of Psychology, Campus Box 345, Boulder, CO 80310, USA
    Neurosci Biobehav Rev 25:29-41. 2001
    ....
  26. ncbi request reprint Combined effects of space flight factors and radiation on humans
    P Todd
    BioServe Space Technologies Center for Space Commercialization, Campus Box 429, University of Colorado, Boulder, CO, USA
    Mutat Res 430:211-9. 1999
    ..Best-case and worst-case scenarios are considered. In the worst case, a doubling of immune-function demand, accompanied by a halving of immune capacity, would reduce the endangering dose to a crew member to around 1 Gy...
  27. ncbi request reprint Activation of the arousal response can impair performance on a simple motor task
    J T Noteboom
    Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309-0354, USA
    J Appl Physiol 91:821-31. 2001
    ..Although women exhibited more of a reduction in steadiness than men, the effect was largely unrelated to the magnitude of the change in arousal...
  28. pmc Opioid activation of toll-like receptor 4 contributes to drug reinforcement
    M R Hutchinson
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309, USA
    J Neurosci 32:11187-200. 2012
    ....
  29. ncbi request reprint A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphine
    Ian N Johnston
    Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
    J Neurosci 24:7353-65. 2004
    ..Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates...
  30. pmc Cardiovascular exercise intervention improves the primary antibody response to keyhole limpet hemocyanin (KLH) in previously sedentary older adults
    R W Grant
    Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 906 South Goodwin Avenue, Urbana, IL 61801, USA
    Brain Behav Immun 22:923-32. 2008
    ..We have shown for the first time that cardiovascular training in previously sedentary elderly results in significantly higher primary IgG1 and IgM antibody responses, while having no effect on IgG2 production...
  31. ncbi request reprint Evidence that brief stress may induce the acute phase response in rats
    T Deak
    Department of Psychology, University of Colorado at Boulder 80309, USA
    Am J Physiol 273:R1998-2004. 1997
    ....