Research Topics
| M FleshnerSummaryAffiliation: University of Colorado Country: USA Publications
| Collaborators
|
Detail Information
Publications
Endogenous glucocorticoids play a positive regulatory role in the anti-keyhole limpet hemocyanin in vivo antibody responseM Fleshner
Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
J Immunol 166:3813-9. 2001..Given that IFN-gamma is an important regulator of the IgM to IgG2a switch, it is possible that the small rise in GC found 4-7 days after KLH facilitates IgG2a isotype switching...- Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomyM Fleshner
Department of Kinesiology and Applied Physiology, University of Colorado at Boulder, 80309 0354, USA
J Neuroimmunol 86:134-41. 1998..v. administered cytokines. This effect was dose dependent. The results add support to the hypothesis that vagal afferents are involved in peripheral cytokine-to-brain communication... - Exercise and neuroendocrine regulation of antibody production: protective effect of physical activity on stress-induced suppression of the specific antibody responseM Fleshner
Department of Kinesiology and Applied Physiology, University of Colorado, Boulder 80309 0354, USA
Int J Sports Med 21:S14-9. 2000.... - Effects of vagotomy on lipopolysaccharide-induced brain interleukin-1beta protein in ratsM K Hansen
Department of Psychology, University of Colorado at Boulder, 80309 0345, USA
Auton Neurosci 85:119-26. 2000..Furthermore, these data indicate that, at the doses and times tested, subdiaphragmatic vagal afferents are not crucial for LPS-induced brain IL-1beta protein... - Effects of vagotomy on serum endotoxin, cytokines, and corticosterone after intraperitoneal lipopolysaccharideM K Hansen
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
Am J Physiol Regul Integr Comp Physiol 278:R331-6. 2000..In conclusion, vagotomy itself has no marked effect on circulating endotoxin levels or the production of IL-1beta, IL-6, or corticosterone in blood after an intraperitoneal injection of LPS... - Bacterial endotoxin induces fos immunoreactivity in primary afferent neurons of the vagus nerveR P Gaykema
Department of Psychology, University of Colorado, Boulder, Colo, USA
Neuroimmunomodulation 5:234-40. 1998..These findings implicate vagal afferents as a potential signaling pathway to brain regions that generate illness responses to pro-inflammatory mediators... - Long-term changes in mineralocorticoid and glucocorticoid receptor occupancy following exposure to an acute stressorT Deak
Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Brain Res 847:211-20. 1999..These long-term changes in corticosteroid receptor activation, evident 24 h after IS exposure, may be responsible for some of the long-term neural, behavioral and immune changes observed following this acute stress procedure... - The long term acute phase-like responses that follow acute stressor exposure are blocked by alpha-melanocyte stimulating hormoneE D Milligan
Department of Psychology, Campus Box 345, University of Colorado at Boulder, Boulder, CO 80309 0345, USA
Brain Res 810:48-58. 1998..These data provide support for a specific mode of action for i.c.v. alpha-MSH(1-13), namely blockade of APRs with no impact on acute hyperthermia or increased levels of CORT produced during IS... - Splenic norepinephrine depletion following acute stress suppresses in vivo antibody responseS L Kennedy
Department of Integrative Physiology, University of Colorado, Campus Box 354, Boulder, Colorado 80309-0354, USA
J Neuroimmunol 165:150-60. 2005..These data support the hypothesis that splenic NE depletion is necessary and sufficient for stress-induced suppression of antibody to a T-cell dependent antigen... - Sexual dimorphism of the intracellular heat shock protein 72 responseM Nickerson
Dept of IPHY, CB 354, Boulder, CO 80309, USA
J Appl Physiol 101:566-75. 2006..The adrenal glands, spleen, and heart did not exhibit sexual dimorphism of the HSP72 response. The estrous cycle did not have a significant effect on basal or stress-induced HSP72 in females... - Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokinesJ D Johnson
Department of Integrative Physiology and Center for Neuroscience, Clare Small Building, Room 114, University of Colorado, Boulder, CO 80309 0354, USA
Neuroscience 135:1295-307. 2005.... - Acute stress may facilitate recovery from a subcutaneous bacterial challengeT Deak
Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
Neuroimmunomodulation 6:344-54. 1999..Furthermore, IS does not appear to alter the rat's ability to sequester bacteria in the subcutaneous space since no swelling of lymph nodes or chronic activation of the hypothalamic-pituitary-adrenal axis was observed... - Physical activity alters the brain Hsp72 and IL-1beta responses to peripheral E. coli challengeM Nickerson
Dept of Integrative Physiology, Neuroimmunophysiology Laboratory, Univ of Colorado, Boulder, CO 80309, USA
Am J Physiol Regul Integr Comp Physiol 289:R1665-74. 2005.... - The role of the vagus nerve in cytokine-to-brain communicationS F Maier
Department of Psychology, University of Colorado, Boulder 80309, USA
Ann N Y Acad Sci 840:289-300. 1998..Data extending this analysis to TNF-alpha and intravenous routes will be described... - Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolationC R Pugh
Department of Psychology, University of Colorado at Boulder, 80309 0345, USA
Behav Brain Res 106:109-18. 1999..These findings also add to the generality of the idea that stressors induce IL-1beta activity in the brain and that IL-1beta may play physiological roles in the uninjured brain... - Role of extracellular HSP72 in acute stress-induced potentiation of innate immunity in active ratsJ Campisi
Department of Kinesiology and Applied Physiology, and Center for Neuroscience, University of Colorado at Boulder, 80309-0354, USA
J Appl Physiol 94:43-52. 2003..Thus physically active rats both recover faster than sedentary rats after bacterial challenge + IS exposure and demonstrate potentiated cellular responses to eHSP72 activation that could be important for bacterial recovery... - Circulating cytokines and endotoxin are not necessary for the activation of the sickness or corticosterone response produced by peripheral E. coli challengeJ Campisi
Department of Integrative Physiology, University of Colorado at Boulder, Boulder, Colorado 80309-0354, USA
J Appl Physiol 95:1873-82. 2003..Therefore, fever, activity reduction, and corticosterone elevation induced by E. coli infection may have been evoked by a neural, rather than a humoral, pathway from the periphery to the brain... - Voluntary freewheel running selectively modulates catecholamine content in peripheral tissue and c-Fos expression in the central sympathetic circuit following exposure to uncontrollable stress in ratsB N Greenwood
Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, CO 80309, USA
Neuroscience 120:269-81. 2003..The attenuation of sympathetic responses observed in this study may be one important mechanism for the protective effect of physical activity against stress-related illness and immunosuppression... 
Hypothalamic pituitary adrenal axis responses to low-intensity stressors are reduced after voluntary wheel running in ratsS Campeau
University of Colorado, Department of Psychology and Neuroscience, Muenzinger, Boulder, CO, USA
J Neuroendocrinol 22:872-88. 2010....- Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppressionA Moraska
University of Colorado at Boulder, Department of Kinesiology and Applied Physiology, Boulder, CO 80309, USA
Am J Physiol Regul Integr Comp Physiol 281:R484-9. 2001..Anti-KLH IgG(1) was stress insensitive. These data suggest that physical activity can buffer the negative impact of stress on behavior and acquired immune function... 
Learned helplessness is independent of levels of brain-derived neurotrophic factor in the hippocampusB N Greenwood
Department of Integrative Physiology, Center for Neuroscience, University of Colorado, Clare Small Room 104, Campus Box 354, Boulder, CO 80309 0354, USA
Neuroscience 144:1193-208. 2007..Results also suggest that the prevention of stress-induced hippocampal BDNF suppression is not necessary for the protective effect of wheel running against learned helplessness...- Endogenous extra-cellular heat shock protein 72: releasing signal(s) and functionM Fleshner
Department of Integrative Physiology, University of Colorado Bouler, CO 80309 0354, USA
Int J Hyperthermia 21:457-71. 2005.... - Interleukin-6 response to exercise and high-altitude exposure: influence of alpha-adrenergic blockadeR S Mazzeo
Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309, USA
J Appl Physiol 91:2143-9. 2001..In conclusion, the results indicate a role for alpha-adrenergic regulation of the IL-6 response to the stress of both short-term moderate-intensity exercise and hypoxia... - 5-hydroxytryptamine 2C receptors in the dorsal striatum mediate stress-induced interference with negatively reinforced instrumental escape behaviorP V Strong
Department of Integrative Physiology, University of Colorado, Boulder, CO 80309 0354, USA
Neuroscience 197:132-44. 2011.... - The immune system and memory consolidation: a role for the cytokine IL-1betaC Rachal Pugh
University of Colorado at Boulder, Department of Psychology, Campus Box 345, Boulder, CO 80310, USA
Neurosci Biobehav Rev 25:29-41. 2001.... - Combined effects of space flight factors and radiation on humansP Todd
BioServe Space Technologies Center for Space Commercialization, Campus Box 429, University of Colorado, Boulder, CO, USA
Mutat Res 430:211-9. 1999..Best-case and worst-case scenarios are considered. In the worst case, a doubling of immune-function demand, accompanied by a halving of immune capacity, would reduce the endangering dose to a crew member to around 1 Gy... - Activation of the arousal response can impair performance on a simple motor taskJ T Noteboom
Department of Kinesiology and Applied Physiology, University of Colorado, Boulder, Colorado 80309-0354, USA
J Appl Physiol 91:821-31. 2001..Although women exhibited more of a reduction in steadiness than men, the effect was largely unrelated to the magnitude of the change in arousal... - Opioid activation of toll-like receptor 4 contributes to drug reinforcementM R Hutchinson
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado 80309, USA
J Neurosci 32:11187-200. 2012.... - A role for proinflammatory cytokines and fractalkine in analgesia, tolerance, and subsequent pain facilitation induced by chronic intrathecal morphineIan N Johnston
Department of Psychology, University of Colorado, Boulder, Colorado 80309, USA
J Neurosci 24:7353-65. 2004..Taken together, these results suggest that IL-1 and fractalkine are endogenous regulators of morphine analgesia and are involved in the increases in pain sensitivity that occur after chronic opiates... - Cardiovascular exercise intervention improves the primary antibody response to keyhole limpet hemocyanin (KLH) in previously sedentary older adultsR W Grant
Division of Nutritional Sciences, University of Illinois at Urbana Champaign, 906 South Goodwin Avenue, Urbana, IL 61801, USA
Brain Behav Immun 22:923-32. 2008..We have shown for the first time that cardiovascular training in previously sedentary elderly results in significantly higher primary IgG1 and IgM antibody responses, while having no effect on IgG2 production... - Evidence that brief stress may induce the acute phase response in ratsT Deak
Department of Psychology, University of Colorado at Boulder 80309, USA
Am J Physiol 273:R1998-2004. 1997....