Jason B Fleming

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Inactivation of tumor suppressor genes by promoter methylation is important in the pathogenesis of pancreatic cancer
    Jason B Fleming
    Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    Cancer Biol Ther 1:297-9. 2002
  2. ncbi request reprint Functional imaging of angiogenesis in an orthotopic model of pancreatic cancer
    Jason B Fleming
    The Hamon Center for Therapeutic Oncology Research and the Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    J Cell Biochem 90:492-501. 2003
  3. ncbi request reprint Superficial femoral vein as a conduit for portal vein reconstruction during pancreaticoduodenectomy
    Jason B Fleming
    Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Arch Surg 140:698-701. 2005
  4. pmc Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice
    Carlton C Barnett
    Department of Surgery, University of Colorado at Denver, Denver Health Medical Center, Denver, Colorado 80204 0206, USA
    Cancer 116:3862-74. 2010
  5. doi request reprint Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Cancer Res 68:4340-6. 2008
  6. ncbi request reprint Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts
    Shane E Holloway
    Department of Surgery, Division of Surgical Oncology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 8593, USA
    Ann Surg Oncol 13:1145-55. 2006
  7. ncbi request reprint Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature
    Grzegorz Korpanty
    Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
    Clin Cancer Res 13:323-30. 2007
  8. ncbi request reprint Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy
    Jason B Fleming
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Mol Cancer Res 3:413-23. 2005
  9. ncbi request reprint Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice
    Adam W Beck
    Simmons Comprehensive Cancer Center and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 118:2639-43. 2006
  10. ncbi request reprint Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer
    Shane E Holloway
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Am Coll Surg 200:371-7. 2005

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Inactivation of tumor suppressor genes by promoter methylation is important in the pathogenesis of pancreatic cancer
    Jason B Fleming
    Department of Surgery, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd, Dallas, TX 75390 8593, USA
    Cancer Biol Ther 1:297-9. 2002
  2. ncbi request reprint Functional imaging of angiogenesis in an orthotopic model of pancreatic cancer
    Jason B Fleming
    The Hamon Center for Therapeutic Oncology Research and the Department of Surgery, University of Texas, Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    J Cell Biochem 90:492-501. 2003
    ..In this review, we will use the example of orthotopic mouse models of pancreatic cancer as a tool to survey the challenges and possibilities of functional imaging of angiogenesis, a critical determinant of metastasis...
  3. ncbi request reprint Superficial femoral vein as a conduit for portal vein reconstruction during pancreaticoduodenectomy
    Jason B Fleming
    Division of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Arch Surg 140:698-701. 2005
  4. pmc Intravenous delivery of the plasma fraction of stored packed erythrocytes promotes pancreatic cancer growth in immunocompetent mice
    Carlton C Barnett
    Department of Surgery, University of Colorado at Denver, Denver Health Medical Center, Denver, Colorado 80204 0206, USA
    Cancer 116:3862-74. 2010
    ....
  5. doi request reprint Vascular endothelial growth factor receptor 2 mediates macrophage infiltration into orthotopic pancreatic tumors in mice
    Sean P Dineen
    Division of Surgical Oncology, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Cancer Res 68:4340-6. 2008
    ..Our results show an underappreciated mechanism of action that may directly contribute to the antitumor activity of angiogenesis inhibitors that block the VEGFR2 pathway...
  6. ncbi request reprint Selective blockade of vascular endothelial growth factor receptor 2 with an antibody against tumor-derived vascular endothelial growth factor controls the growth of human pancreatic adenocarcinoma xenografts
    Shane E Holloway
    Department of Surgery, Division of Surgical Oncology, Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, Texas 75390 8593, USA
    Ann Surg Oncol 13:1145-55. 2006
    ..In this study, we evaluated the efficacy of 2C3, an antibody that inhibits VEGF receptor 2 activation by human VEGF, to inhibit the growth of human pancreatic adenocarcinoma in mice...
  7. ncbi request reprint Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature
    Grzegorz Korpanty
    Hamon Center for Therapeutic Oncology Research and Department of Surgery, University of Texas Southwestern Medical Center, Dallas 75390 8593, USA
    Clin Cancer Res 13:323-30. 2007
    ..We investigated the use of targeted microbubbles to follow vascular response of therapy in a mouse model of pancreatic adenocarcinoma...
  8. ncbi request reprint Molecular consequences of silencing mutant K-ras in pancreatic cancer cells: justification for K-ras-directed therapy
    Jason B Fleming
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390 8593, USA
    Mol Cancer Res 3:413-23. 2005
    ..We have found that silencing mutant K-ras through RNAi results in alteration of tumor cell behavior in vitro and suggests that targeting mutant K-ras specifically might be effective against pancreatic cancer in vivo...
  9. ncbi request reprint Combination of a monoclonal anti-phosphatidylserine antibody with gemcitabine strongly inhibits the growth and metastasis of orthotopic pancreatic tumors in mice
    Adam W Beck
    Simmons Comprehensive Cancer Center and Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    Int J Cancer 118:2639-43. 2006
    ..In conclusion, 3G4 enhanced the anti-tumor and anti-metastatic activity of gemcitabine without contributing to toxicity...
  10. ncbi request reprint Increased expression of Cyr61 (CCN1) identified in peritoneal metastases from human pancreatic cancer
    Shane E Holloway
    Division of Surgical Oncology, Department of Surgery, Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, TX 75390 8593, USA
    J Am Coll Surg 200:371-7. 2005
    ..We hypothesized that comparison of ECM-associated gene expression in primary and metastatic pancreatic tumors would identify ECM proteins associated with pancreatic metastasis...
  11. doi request reprint Treatment sequencing for resectable pancreatic cancer: influence of early metastases and surgical complications on multimodality therapy completion and survival
    Ching Wei D Tzeng
    Department of Surgery, University of Kentucky, Lexington, KY, USA
    J Gastrointest Surg 18:16-25. 2014
    ..NT sequencing is a practical treatment strategy, particularly for patients at high biological or perioperative risk. ..
  12. doi request reprint The cost-effectiveness of neoadjuvant chemoradiation is superior to a surgery-first approach in the treatment of pancreatic head adenocarcinoma
    Daniel E Abbott
    Department of Surgery, University of Cincinnati School of Medicine, Cincinnati, OH, USA
    Ann Surg Oncol 20:S500-8. 2013
    ..The objective of this study was to compare cost and outcomes between a surgery-first approach versus neoadjuvant chemoradiation followed by surgery for resectable pancreatic head cancer...
  13. doi request reprint Cost-effectiveness of treatment strategies for pancreatic head adenocarcinoma and potential opportunities for improvement
    Daniel E Abbott
    Department of Surgery, University of Cincinnati, Cincinnati, OH, USA
    Ann Surg Oncol 19:3659-67. 2012
    ..Our objective was to compare the cost-effectiveness of various treatment strategies for resectable pancreatic head adenocarcinoma, and to identify opportunities for improved cost effectiveness...
  14. pmc Serum CA 19-9 as a marker of resectability and survival in patients with potentially resectable pancreatic cancer treated with neoadjuvant chemoradiation
    Matthew H G Katz
    Department of Surgery, The University of California, Orange, CA, USA
    Ann Surg Oncol 17:1794-801. 2010
    ..We evaluated CA 19-9 as a marker of therapeutic response, completion of therapy, and survival in patients enrolled on two recently reported clinical trials...
  15. ncbi request reprint Surgical therapy of peptic ulcers in the 21st century: more common than you think
    George A Sarosi
    Department of Surgery, North Texas Veterans Administration Medical Center, 4500 S Lancaster Rd, Dallas, TX 75216, USA
    Am J Surg 190:775-9. 2005
    ..The purpose of this study was to characterize the Veteran patients undergoing surgery for peptic ulcer disease in a modern series and to examine the effect of H. pylori status on surgical outcome and recurrence of PUD...
  16. pmc Resection of at-risk mesenteric lymph nodes is associated with improved survival in patients with small bowel neuroendocrine tumors
    Christine S Landry
    Department of Surgical Oncology, Baylor University Medical Center, 3410 Worth Street, Suite 235, Dallas, TX 75246, USA
    World J Surg 37:1695-700. 2013
    ..We hypothesized that the extent of lymphadenectomy reported in a large administrative database would be associated with overall survival for jejunal and ileal neuroendocrine tumors...
  17. doi request reprint Borderline resectable pancreatic cancer: the importance of this emerging stage of disease
    Matthew H G Katz
    Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77230 1402, USA
    J Am Coll Surg 206:833-46; discussion 846-8. 2008
    ..There is no optimal treatment schema for this distinct stage of disease, so the role of surgery is undefined...
  18. pmc LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
    Davide Melisi
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Mol Cancer Ther 7:829-40. 2008
    ..Targeting TbetaRI/II kinase activity on pancreatic cancer cells or the cells of the liver microenvironment represents a novel therapeutic approach to prevent pancreatic cancer metastasis...
  19. doi request reprint Development of an integrated biospecimen bank and multidisciplinary clinical database for pancreatic cancer
    Rosa F Hwang
    Department of Surgical Oncology, Unit 444, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Ann Surg Oncol 15:1356-66. 2008
    ..We describe the development of an integrated pancreatic tissue bank (PTB) and clinical database for patients with pancreatic cancer and other pancreatic disorders...
  20. ncbi request reprint Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells
    Bailu Peng
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Clin Cancer Res 8:3628-38. 2002
    ..We seek to determine the role of Smad4/DPC4 in the suppression of tumor cell growth and in the regulation of TGF-beta-mediated expression of cell-cycle regulatory genes p15(ink4b) and p21(waf1)...
  21. doi request reprint Current diagnosis and management of unusual pancreatic tumors
    Melinda M Mortenson
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Am J Surg 196:100-13. 2008
    ....
  22. doi request reprint Diagnosis and management of cystic neoplasms of the pancreas: an evidence-based approach
    Matthew H G Katz
    Department of Surgical Oncology, The University of Texas, MD Anderson Cancer Center, Houston, TX 77030, USA
    J Am Coll Surg 207:106-20. 2008
  23. doi request reprint Tumor-node-metastasis staging of pancreatic adenocarcinoma
    Matthew H G Katz
    Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA
    CA Cancer J Clin 58:111-25. 2008
    ....
  24. ncbi request reprint Distal pancreatectomy for isolated metastasis of endometrial carcinoma to the pancreas
    Dan G Blazer
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77230 1402, USA
    JOP 9:56-60. 2008
    ..Herein, we report what to our knowledge is the first description of pancreatic resection of metastatic endometrial carcinoma...
  25. ncbi request reprint Focal adhesions and associated proteins in medullary thyroid carcinoma cells
    Lawrence T Kim
    Surgical Service, Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Surg Res 111:177-84. 2003
    ..We hypothesized that adhesion-dependent signaling might be deranged in MTC cells...