Adam S Fleisher

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment
    Adam Fleisher
    Department of Neurosciences, University of California San Diego, La Jolla, Calif, USA
    Arch Neurol 62:953-7. 2005
  2. ncbi request reprint Identification of Alzheimer disease risk by functional magnetic resonance imaging
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    Arch Neurol 62:1881-8. 2005
  3. pmc Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
    Adam S Fleisher
    University of California, San Diego, La Jolla, CA 92037, USA
    Arch Neurol 65:1031-8. 2008
  4. pmc Cerebral perfusion and oxygenation differences in Alzheimer's disease risk
    Adam S Fleisher
    University of California at San Diego, Department of Neuroscience, La Jolla, CA 92037 0949, United States
    Neurobiol Aging 30:1737-48. 2009
  5. ncbi request reprint Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment
    A S Fleisher
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neurology 70:191-9. 2008
  6. ncbi request reprint Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment
    A S Fleisher
    Alzheimer s Disease Cooperative Study, La Jolla, CA 92037, USA
    Neurology 68:1588-95. 2007
  7. pmc Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment
    Danielle C Whitehair
    Department of Neurosciences, University of California, San Diego, CA, USA
    Alzheimers Dement 6:412-9. 2010
  8. pmc Structural MRI biomarkers for preclinical and mild Alzheimer's disease
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0841, USA
    Hum Brain Mapp 30:3238-53. 2009
  9. pmc Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation
    Beau M Ances
    Department of Neurosciences, University of California, San Diego, USA
    Hum Brain Mapp 30:1120-32. 2009
  10. pmc Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response
    S Duke Han
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
    Neurobiol Aging 28:238-47. 2007

Research Grants

Detail Information

Publications24

  1. ncbi request reprint Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairment
    Adam Fleisher
    Department of Neurosciences, University of California San Diego, La Jolla, Calif, USA
    Arch Neurol 62:953-7. 2005
    ..The presence of the apolipoprotein E epsilon4 (APOE*E4) allele has been associated with greater hippocampal atrophy in women than in men with Alzheimer disease. This relationship has not been demonstrated in MCI...
  2. ncbi request reprint Identification of Alzheimer disease risk by functional magnetic resonance imaging
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, La Jolla 92037, USA
    Arch Neurol 62:1881-8. 2005
    ..Functional magnetic resonance imaging plays a promising role in the preclinical characterization of Alzheimer disease (AD) for use in early diagnosis and in preventive drug trials...
  3. pmc Phase 2 safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer disease
    Adam S Fleisher
    University of California, San Diego, La Jolla, CA 92037, USA
    Arch Neurol 65:1031-8. 2008
    ..To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in Alzheimer disease...
  4. pmc Cerebral perfusion and oxygenation differences in Alzheimer's disease risk
    Adam S Fleisher
    University of California at San Diego, Department of Neuroscience, La Jolla, CA 92037 0949, United States
    Neurobiol Aging 30:1737-48. 2009
    ..BOLD activations should be interpreted with caution, and do not necessarily reflect differences in neuronal activation...
  5. ncbi request reprint Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment
    A S Fleisher
    Department of Neurosciences, University of California, San Diego, CA, USA
    Neurology 70:191-9. 2008
    ..To compare volumetric MRI of whole brain and medial temporal lobe structures to clinical measures for predicting progression from amnestic mild cognitive impairment (MCI) to Alzheimer disease (AD)...
  6. ncbi request reprint Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment
    A S Fleisher
    Alzheimer s Disease Cooperative Study, La Jolla, CA 92037, USA
    Neurology 68:1588-95. 2007
    ..To investigate the neurocognitive measures that best predict progression from amnestic mild cognitive impairment (aMCI) to Alzheimer disease (AD)...
  7. pmc Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment
    Danielle C Whitehair
    Department of Neurosciences, University of California, San Diego, CA, USA
    Alzheimers Dement 6:412-9. 2010
    ..We examine the prospective association of APOE varepsilon4 allele status on measures of cognitive and functional decline in subjects with amnestic MCI (aMCI)...
  8. pmc Structural MRI biomarkers for preclinical and mild Alzheimer's disease
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0841, USA
    Hum Brain Mapp 30:3238-53. 2009
    ..These methods will enable a more complete longitudinal characterization and allow us to identify changes that are predictive of conversion to AD...
  9. pmc Effects of aging on cerebral blood flow, oxygen metabolism, and blood oxygenation level dependent responses to visual stimulation
    Beau M Ances
    Department of Neurosciences, University of California, San Diego, USA
    Hum Brain Mapp 30:1120-32. 2009
    ..A calibrated approach provides a more quantitative reflection of underlying metabolic changes than the BOLD response alone...
  10. pmc Verbal paired-associate learning by APOE genotype in non-demented older adults: fMRI evidence of a right hemispheric compensatory response
    S Duke Han
    University of California San Diego, Department of Psychiatry, La Jolla, CA 92093 0603, United States
    Neurobiol Aging 28:238-47. 2007
    ....
  11. pmc Episodic memory loss is related to hippocampal-mediated beta-amyloid deposition in elderly subjects
    E C Mormino
    Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA
    Brain 132:1310-23. 2009
    ..This pattern suggests that declining EM in older individuals may be caused by Abeta-induced hippocampus atrophy...
  12. ncbi request reprint Potential impact of amyloid imaging on diagnosis and intended management in patients with progressive cognitive decline
    Michael Grundman
    Department of Neurosciences, University of California, San Diego, CA, USA
    Alzheimer Dis Assoc Disord 27:4-15. 2013
    ..8% (95% CI, 25.0%-41.6%). In summary, amyloid imaging results altered physician's diagnostic thinking, intended testing, and management of patients undergoing evaluation for cognitive decline...
  13. ncbi request reprint Applications of neuroimaging to disease-modification trials in Alzheimer's disease
    Adam S Fleisher
    Department of Neurosciences, University of California, San Diego, USA
    Behav Neurol 21:129-36. 2009
    ..This review discusses recently presented data from the ADNI dataset, and the importance of imaging in the future of drug development in AD...
  14. ncbi request reprint Neuropsychiatric symptoms and regional neocortical atrophy in mild cognitive impairment and Alzheimer's disease
    Michael S Rafii
    1Department of Neurosciences, University of California, San Diego, CA, USA
    Am J Alzheimers Dis Other Demen 29:159-65. 2014
    ..To assess the relationship between regional neocortical atrophy and psychotic symptoms in adults with mild cognitive impairment (MCI) and Alzheimer's disease (AD)...
  15. pmc Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study
    Adam S Fleisher
    Banner Alzheimer s Institute, Phoenix, AZ, USA
    Lancet Neurol 11:1057-65. 2012
    ..We sought to characterise the age-related accumulation of Aβ deposition in presenilin 1 (PSEN1) E280A mutation carriers across the spectrum of preclinical disease...
  16. ncbi request reprint Continuous peripheral nerve blocks: is local anesthetic dose the only factor, or do concentration and volume influence infusion effects as well?
    Brian M Ilfeld
    Department of Anesthesiology, University of California San Diego, UCSD Center for Pain Medicine, 9300 Campus Point Drive, La Jolla, California 92037 7651, USA
    Anesthesiology 112:347-54. 2010
    ..The main determinant of continuous peripheral nerve block effects--local anesthetic concentration and volume or simply total drug dose--remains unknown...
  17. pmc High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
    Paul S Aisen
    Department of Neurosciences, University of California, San Diego, 9500 Gilman Dr, M C 0949, La Jolla, CA 92093, USA
    JAMA 300:1774-83. 2008
    ..Prior studies of B vitamins to reduce homocysteine in AD have not had sufficient size or duration to assess their effect on cognitive decline...
  18. doi request reprint A phase1 study of stereotactic gene delivery of AAV2-NGF for Alzheimer's disease
    Michael S Rafii
    Department of Neurosciences, University of California, San Diego, CA, USA
    Alzheimers Dement . 2014
    ....
  19. ncbi request reprint Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease
    Adam S Fleisher
    The Banner Alzheimer s Institute, Phoenix, AZ, USA
    Neurobiol Aging 34:1-12. 2013
    ..Investigate apolipoprotein E ε4 (APOE4) gene and aging effects on florbetapir F18 positron emission tomography (PET) in normal aging and Alzheimer's disease (AD)...
  20. ncbi request reprint Neurodegenerative disorders with diffuse cortical Lewy bodies
    Adam S Fleisher
    Department of Neuroscience, UCSD Department of Neurosciences, University of California, San Diego, La Jolla, California, USA
    Adv Neurol 96:148-65. 2005
  21. pmc Subregional neuroanatomical change as a biomarker for Alzheimer's disease
    Dominic Holland
    Department of Neurosciences, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    Proc Natl Acad Sci U S A 106:20954-9. 2009
    ..The findings indicate that regional temporal lobe cortical changes would have great utility as outcome measures in clinical trials and may also have utility in clinical practice for aiding early diagnosis of neurodegenerative disease...
  22. pmc 3D characterization of brain atrophy in Alzheimer's disease and mild cognitive impairment using tensor-based morphometry
    Xue Hua
    Laboratory of Neuro Imaging, Department of Neurology, UCLA School of Medicine, Neuroscience Research Building 225E, Los Angeles, CA 90095 1769, USA
    Neuroimage 41:19-34. 2008
    ..In the future, TBM may help to (1) identify factors that resist or accelerate the disease process, and (2) measure disease burden in treatment trials...
  23. pmc The Alzheimer's Disease Neuroimaging Initiative (ADNI): MRI methods
    Clifford R Jack
    Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 27:685-91. 2008
    ..The approach taken in ADNI to standardization across sites and platforms of the MRI protocol, postacquisition corrections, and phantom-based monitoring of all scanners could be used as a model for other multisite trials...
  24. pmc Longitudinal stability of MRI for mapping brain change using tensor-based morphometry
    Alex D Leow
    Laboratory of Neuro Imaging, Brain Mapping Division, Department of Neurology and Semel Institute of Neuroscience, UCLA School of Medicine, 635 Charles E Young Drive South, Suite 225E, Los Angeles, CA 90095 7332, USA
    Neuroimage 31:627-40. 2006
    ..No strong evidence favored B0 correction. Although SPGR/FLASH images showed least deviation here, pulse sequence selection for the ADNI project was based on multiple additional image analyses, to be reported elsewhere...

Research Grants2

  1. BOLD and Perfusion fMRI of Alzheimer's Disease Risk
    Adam Fleisher; Fiscal Year: 2007
    ....
  2. BOLD and Perfusion fMRI of Alzheimer's Disease Risk
    Adam Fleisher; Fiscal Year: 2008
    ....