D E Fleck

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. pmc Functional MRI of sustained attention in bipolar mania
    D E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0583, USA
    Mol Psychiatry 17:325-36. 2012
  2. doi request reprint Morphometric magnetic resonance imaging in psychiatry
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Top Magn Reson Imaging 19:131-42. 2008
  3. doi request reprint Wisconsin Card Sorting Test performance in bipolar disorder: effects of mood state and early course
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Bipolar Disord 10:539-45. 2008
  4. ncbi request reprint Processing efficiency and directed forgetting in bipolar disorder
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Int Neuropsychol Soc 11:871-80. 2005
  5. ncbi request reprint Directed forgetting deficits in patients with temporal lobe epilepsy: an information processing perspective
    D E Fleck
    University of Cincinnati, Department of Psychiatry, OH 45267 0559, USA
    J Int Neuropsychol Soc 5:549-55. 1999
  6. ncbi request reprint Processing efficiency and sustained attention in bipolar disorder
    David E Fleck
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Int Neuropsychol Soc 11:49-57. 2005
  7. ncbi request reprint Verbal memory in mania: effects of clinical state and task requirements
    David E Fleck
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 5:375-80. 2003
  8. ncbi request reprint Differential prescription of maintenance antipsychotics to African American and white patients with new-onset bipolar disorder
    David E Fleck
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 63:658-64. 2002
  9. ncbi request reprint Reaction time measures of sustained attention differentiate bipolar disorder from schizophrenia
    D E Fleck
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Schizophr Res 52:251-9. 2001
  10. ncbi request reprint Ethnicity and diagnosis in patients with affective disorders
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Psychiatry 64:747-54. 2003

Research Grants

Detail Information

Publications35

  1. pmc Functional MRI of sustained attention in bipolar mania
    D E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0583, USA
    Mol Psychiatry 17:325-36. 2012
    ..Differential striatal and thalamic deactivation in bipolar disorder is interpreted as a loss of amygdala (emotional brain) modulation by the ventrolateral prefrontal-subcortical circuit, which interferes with attentional maintenance...
  2. doi request reprint Morphometric magnetic resonance imaging in psychiatry
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45267 0559, USA
    Top Magn Reson Imaging 19:131-42. 2008
    ..However, advances in outcome and treatment monitoring show considerably more promise for rapid application in psychiatry...
  3. doi request reprint Wisconsin Card Sorting Test performance in bipolar disorder: effects of mood state and early course
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Bipolar Disord 10:539-45. 2008
    ..However, it is unclear to what extent executive dysfunction exists (i) during syndromal remission, when mood symptoms are attenuated, and (ii) during the early course of bipolar disorder...
  4. ncbi request reprint Processing efficiency and directed forgetting in bipolar disorder
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Int Neuropsychol Soc 11:871-80. 2005
    ..Problems with processing efficiency are viewed as trait characteristics of bipolar disorder that may be overlooked by traditional error-based assessments...
  5. ncbi request reprint Directed forgetting deficits in patients with temporal lobe epilepsy: an information processing perspective
    D E Fleck
    University of Cincinnati, Department of Psychiatry, OH 45267 0559, USA
    J Int Neuropsychol Soc 5:549-55. 1999
    ..The results suggest that interictal memory performance in temporal lobe epilepsy may be disrupted in part because of a deficit in the differential processing of task relevant and task irrelevant information, particularly at retrieval...
  6. ncbi request reprint Processing efficiency and sustained attention in bipolar disorder
    David E Fleck
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Int Neuropsychol Soc 11:49-57. 2005
    ..Problems with processing efficiency are viewed as trait characteristics of bipolar disorder that may be overlooked by traditional error-based assessments...
  7. ncbi request reprint Verbal memory in mania: effects of clinical state and task requirements
    David E Fleck
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 5:375-80. 2003
    ..Manic patients exhibit impaired verbal learning and memory, particularly following longstanding illness. However, it is unclear whether recognition and recall performance are differentially influenced by a manic mood state...
  8. ncbi request reprint Differential prescription of maintenance antipsychotics to African American and white patients with new-onset bipolar disorder
    David E Fleck
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 63:658-64. 2002
    ..African American patients may be at increased risk because excess antipsychotic prescription appears to be common in this population, although this issue has not been longitudinally studied in bipolar disorder...
  9. ncbi request reprint Reaction time measures of sustained attention differentiate bipolar disorder from schizophrenia
    D E Fleck
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Schizophr Res 52:251-9. 2001
    ..By incorporating reaction time measures into CPT assessments, discriminant ability may be enhanced...
  10. ncbi request reprint Ethnicity and diagnosis in patients with affective disorders
    Stephen M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Clin Psychiatry 64:747-54. 2003
    ..Why this occurs is unknown. Extending prior work, the authors hypothesized that first-rank symptoms distract clinicians so that they fail to identify affective disorders in African Americans...
  11. ncbi request reprint Persistent attentional dysfunction in remitted bipolar disorder
    K E Wilder-Willis
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267-0559, USA
    Bipolar Disord 3:58-62. 2001
    ..Performance decrements on attentional tasks may be in part reflective of motor impairments in patients with BPD...
  12. ncbi request reprint Is impaired outcome following a first manic episode due to mood-incongruent psychosis?
    S M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 45267 0559, Cincinnati, OH, USA
    J Affect Disord 61:87-94. 2000
    ..Mood-incongruent psychosis during the course of bipolar disorder has been associated with poor outcome. However, it remains unknown whether this is secondary to persistent affective or psychotic symptoms or both...
  13. ncbi request reprint Eight-month functional outcome from mania following a first psychiatric hospitalization
    S M Strakowski
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Psychiatr Res 34:193-200. 2000
    ..Further clarification of recovery of these different areas of function may lead to better integrated treatments that maximize functional improvement early in the course of bipolar disorder...
  14. ncbi request reprint Frequency and severity of religious delusions in Christian patients with psychosis
    G E Getz
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Psychiatry Res 103:87-91. 2001
    ..Religious affiliation may influence the frequency of religious delusions, particularly in Protestant individuals, but religious affiliation appears to be independent of religious delusion severity...
  15. ncbi request reprint Rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder
    Drew H Barzman
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati, OH 45229 3039, USA
    Bipolar Disord 9:339-44. 2007
    ..To examine the rates, types, and psychosocial correlates of legal charges in adolescents with newly diagnosed bipolar disorder (BD)...
  16. ncbi request reprint Outcome following a first manic episode: cross-national US and Taiwan comparison
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:820-7. 2007
    ..Therefore, the aim of this study was to identify differential and shared outcome predictors in first-episode manic bipolar patients in Cincinnati, OH, USA and Taipei, Taiwan...
  17. doi request reprint Post-traumatic stress symptoms and trauma exposure in youth with first episode bipolar disorder
    Jeffrey R Strawn
    Department of Psychiatry, University of Cincinnati, College of Medicine, Cincinnati, OH 45267 0559, USA
    Early Interv Psychiatry 4:169-73. 2010
    ..To examine the prevalence of trauma exposure as well as the rates and effects of post-traumatic stress disorder (PTSD) in adolescents with bipolar disorder following a first manic episode...
  18. pmc Impulsivity across the course of bipolar disorder
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0583, Cincinnati, OH 45267 0583, USA
    Bipolar Disord 12:285-97. 2010
    ..To determine whether abnormalities of impulse control persist across the course of bipolar disorder, thereby representing potential state markers and endophenotypes...
  19. pmc Inhibition and attention in adolescents with nonmanic mood disorders and a high risk for developing mania
    Manpreet K Singh
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati, Cincinnati, OH, USA
    J Clin Exp Neuropsychol 31:1-7. 2009
    ..75), and color naming speed (d = 0.88). The results indicate that MD participants exhibit psychomotor disinhibition, marginal cognitive slowing and cautious response biases, but no formal deficits in sustained or selective attention...
  20. doi request reprint Cigarette smoking in the early course of bipolar disorder: association with ages-at-onset of alcohol and marijuana use
    Jaimee L Heffner
    Tri State Tobacco and Alcohol Research Center, University of Cincinnati Genome Research Institute, Cincinnati, OH 45237, USA
    Bipolar Disord 10:838-45. 2008
    ..e., three or more times per week for a month or more)...
  21. pmc Characterizing impulsivity in mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Universtiy of Cincinnati College of Medicine, Cincinnati, OH, USA
    Bipolar Disord 11:41-51. 2009
    ....
  22. ncbi request reprint Twelve-month outcome of adolescents with bipolar disorder following first hospitalization for a manic or mixed episode
    Melissa P DelBello
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Am J Psychiatry 164:582-90. 2007
    ..The aim of this study was to examine the 12-month outcome of bipolar adolescents following an initial hospitalization for a manic or mixed episode...
  23. ncbi request reprint Safety and tolerability of quetiapine in the treatment of acute mania in bipolar disorder
    Caleb M Adler
    Center for Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Affect Disord 100:S15-22. 2007
    ..To review the safety/tolerability of quetiapine in four placebo-controlled studies in patients with bipolar I disorder experiencing acute mania...
  24. ncbi request reprint Effects of co-occurring cannabis use disorders on the course of bipolar disorder after a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 2341 Albert Sabin Way, Cincinnati, OH 45267, USA
    Arch Gen Psychiatry 64:57-64. 2007
    ..Cannabis use disorders commonly co-occur in bipolar disorder; however, the effects of cannabis abuse on outcome have been minimally studied...
  25. ncbi request reprint Neuroanatomic characterization of schizoaffective disorder using MRI: a pilot study
    Glen E Getz
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Schizophr Res 55:55-9. 2002
    ..Patients diagnosed with SCA exhibited regional abnormalities on the striatum that resemble those seen in BPD. This study suggests that SCA has some neuroanatomical characteristics similar to BPD...
  26. ncbi request reprint Ethnicity and first-rank symptoms in patients with psychosis
    Lesley M Arnold
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Schizophr Res 67:207-12. 2004
    ..These findings indicate that psychotic symptom presentation should be evaluated in the context of other symptoms (e.g., affective symptoms) in diagnostic assessments in order to prevent misdiagnoses of schizophrenia...
  27. ncbi request reprint Inhibitory control in Obsessive-Compulsive Disorder
    Robert Krikorian
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Brain Cogn 54:257-9. 2004
    ..It was speculated, however, that emotional stimulation might negatively affect performance and that this might be studied in subsequent research...
  28. ncbi request reprint Sex, ethnicity, and antipsychotic medication use in patients with psychosis
    Lesley M Arnold
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Schizophr Res 66:169-75. 2004
    ..There were no ethnic or sex differences in the dosing of antipsychotics for the treatment of schizophrenia spectrum disorders. There were also no ethnic or sex differences in the use of second-generation antipsychotics...
  29. ncbi request reprint Factors associated with medication adherence in African American and white patients with bipolar disorder
    David E Fleck
    Center for Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:646-52. 2005
    ..The purpose of this study was to examine rates of medication nonadherence, self-perceived reasons for nonadherence, and attitudes associated with non-adherence in these ethnic groups...
  30. ncbi request reprint Concurrent tracking of alcohol use and bipolar disorder symptoms
    David E Fleck
    Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 8:338-44. 2006
    ..The primary aim of this analysis was to examine concurrent symptom tracking and how the relative onsets of AUD and BD influence the concurrent tracking of symptoms...
  31. ncbi request reprint Effects of co-occurring alcohol abuse on the course of bipolar disorder following a first hospitalization for mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 231 Albert Sabin Way ML0559, PO Box 670559, Cincinnati, OH 45267 0559, USA
    Arch Gen Psychiatry 62:851-8. 2005
    ..Alcohol-use disorders are common co-occurring conditions affecting bipolar patients, and this co-occurrence is negatively associated with outcome...
  32. ncbi request reprint The effectiveness and tolerability of aripiprazole for pediatric bipolar disorders: a retrospective chart review
    Drew H Barzman
    Bipolar and Psychotic Disorders Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    J Child Adolesc Psychopharmacol 14:593-600. 2004
    ..The aim of this retrospective chart review was to evaluate the effectiveness and tolerability of aripiprazole for the treatment of children and adolescents with bipolar disorders...
  33. ncbi request reprint The influence of religious affiliation on time to first treatment and hospitalization
    Q Moss
    The Division of Bipolar Disorders Research, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Schizophr Res 84:421-6. 2006
    ..To date, there have been no studies to evaluate religion's effect on DUP. In this study, we evaluated the effect of certain religious affiliations and degree of religious practice on the DUP...
  34. doi request reprint The role of complex emotions in inconsistent diagnoses of schizophrenia
    Michael A Gara
    Department of Psychiatry, UMDNJ University Behavioral HealthCare and Robert Wood Johnson Medical School, Piscataway, NJ 08855 1392, USA
    J Nerv Ment Dis 198:609-13. 2010
    ..e., age of patient, gender, or ethnicity. In particular, complex emotion patterns were associated with greater disagreement between experts and trained lay interviewers than were simpler patterns...
  35. ncbi request reprint Selective attention in schizoaffective disorder: pilot data
    David E Fleck
    Schizophr Res 68:109-10. 2004

Research Grants1

  1. Manic Distractibility and Frontosubcortical Processing
    DAVID FLECK; Fiscal Year: 2007
    ..abstract_text> ..