Lisa A Flanagan

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Neurite branching on deformable substrates
    Lisa A Flanagan
    Division of Experimental Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroreport 13:2411-5. 2002
  2. ncbi request reprint Unique dielectric properties distinguish stem cells and their differentiated progeny
    Lisa A Flanagan
    Department of Pathology and Laboratory Medicine, Medical Sciences I, D 440, University of California Irvine School of Medicine, Irvine, California 92697 4800, USA
    Stem Cells 26:656-65. 2008
  3. ncbi request reprint Advancing practical usage of microtechnology: a study of the functional consequences of dielectrophoresis on neural stem cells
    Jente Lu
    Department of Biomedical Engineering, University of California at Irvine, 3020 Gross Hall, 845 Health Sciences Road, Irvine, CA 92697, USA
    Integr Biol (Camb) 4:1223-36. 2012
  4. pmc Regulation of human neural precursor cells by laminin and integrins
    Lisa A Flanagan
    Pathology Department, School of Medicine, University of California Irvine, California 92697 4800, USA
    J Neurosci Res 83:845-56. 2006
  5. doi request reprint Dual frequency dielectrophoresis with interdigitated sidewall electrodes for microfluidic flow-through separation of beads and cells
    Lisen Wang
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    Electrophoresis 30:782-91. 2009
  6. pmc Engineering microscale cellular niches for three-dimensional multicellular co-cultures
    Carlos P Huang
    Department of Biomedical Engineering, University of California, 3410 Natural Sciences II, Irvine, CA 92697 2715, USA
    Lab Chip 9:1740-8. 2009
  7. pmc Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry
    Lisen Wang
    Department of Biomedical Engineering, 3120 Nature Science II, Irvine, CA 92697, USA
    Lab Chip 7:1114-20. 2007
  8. pmc Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels
    Yo El Ju
    Division of Experimental Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biomaterials 28:2097-108. 2007
  9. doi request reprint Frequency discretization in dielectrophoretic assisted cell sorting arrays to isolate neural cells
    Javier L Prieto
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    Lab Chip 12:2182-9. 2012
  10. pmc Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation
    Kelli G Sharp
    Reeve Irvine Research Center and Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA 92697 1705, USA
    Exp Neurol 235:345-56. 2012

Research Grants

  1. Regulation of neural stem cells by Lhx2
    Lisa Flanagan; Fiscal Year: 2007

Collaborators

Detail Information

Publications14

  1. pmc Neurite branching on deformable substrates
    Lisa A Flanagan
    Division of Experimental Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neuroreport 13:2411-5. 2002
    ..These results show that mechanical properties of the substrate specifically direct the formation of neurite branches, which are critical for appropriate synaptic connections during development and regeneration...
  2. ncbi request reprint Unique dielectric properties distinguish stem cells and their differentiated progeny
    Lisa A Flanagan
    Department of Pathology and Laboratory Medicine, Medical Sciences I, D 440, University of California Irvine School of Medicine, Irvine, California 92697 4800, USA
    Stem Cells 26:656-65. 2008
    ..These findings provide evidence for a whole cell property that reflects stem cell fate bias and establish DEP as a tool with unique capabilities for interrogating, characterizing, and sorting stem cells...
  3. ncbi request reprint Advancing practical usage of microtechnology: a study of the functional consequences of dielectrophoresis on neural stem cells
    Jente Lu
    Department of Biomedical Engineering, University of California at Irvine, 3020 Gross Hall, 845 Health Sciences Road, Irvine, CA 92697, USA
    Integr Biol (Camb) 4:1223-36. 2012
    ..We find DEP electric fields are not harmful to stem cells in suspension at short exposure times, thus providing a basis for developing DEP-based applications for stem cells...
  4. pmc Regulation of human neural precursor cells by laminin and integrins
    Lisa A Flanagan
    Pathology Department, School of Medicine, University of California Irvine, California 92697 4800, USA
    J Neurosci Res 83:845-56. 2006
    ..These results define laminin and its integrin receptors as key regulators of human NSPCs...
  5. doi request reprint Dual frequency dielectrophoresis with interdigitated sidewall electrodes for microfluidic flow-through separation of beads and cells
    Lisen Wang
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    Electrophoresis 30:782-91. 2009
    ..As a result, populations of cells can be separated simultaneously instead of one by one to enable high-throughput sorting microfluidic devices...
  6. pmc Engineering microscale cellular niches for three-dimensional multicellular co-cultures
    Carlos P Huang
    Department of Biomedical Engineering, University of California, 3410 Natural Sciences II, Irvine, CA 92697 2715, USA
    Lab Chip 9:1740-8. 2009
    ..These studies demonstrate the versatility and potential of this new microfluidic platform to engineer 3D microscale architectures to investigate cell-cell and cell-matrix interactions...
  7. pmc Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry
    Lisen Wang
    Department of Biomedical Engineering, 3120 Nature Science II, Irvine, CA 92697, USA
    Lab Chip 7:1114-20. 2007
    ..This novel particle switching technique can be integrated with other particle detection components to enable microfluidic flow cytometry systems...
  8. pmc Enhanced neurite growth from mammalian neurons in three-dimensional salmon fibrin gels
    Yo El Ju
    Division of Experimental Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Biomaterials 28:2097-108. 2007
    ..These data demonstrate that salmon fibrin encourages the growth of neurites from mammalian neurons and suggest that salmon fibrin may be a beneficial scaffold for neuronal regrowth after CNS injury...
  9. doi request reprint Frequency discretization in dielectrophoretic assisted cell sorting arrays to isolate neural cells
    Javier L Prieto
    Department of Biomedical Engineering, University of California, Irvine, CA 92697, USA
    Lab Chip 12:2182-9. 2012
    ..With this characterization and the MC simulation we choose the optimal parameters for neuronal sorting. Cell sorting experiments presented achieve a 1.4-fold neuronal enrichment as predicted by our model...
  10. pmc Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation
    Kelli G Sharp
    Reeve Irvine Research Center and Department of Anatomy and Neurobiology, University of California Irvine, Irvine, CA 92697 1705, USA
    Exp Neurol 235:345-56. 2012
    ..Salmon fibrin clearly has properties distinct from those of mammalian fibrin and is a beneficial injectable scaffold for treatment of spinal cord injury...
  11. pmc Complex and dynamic landscape of RNA polyadenylation revealed by PAS-Seq
    Peter J Shepard
    Department of Microbiology and Molecular Genetics, University of California at Irvine, Irvine, California 92697, USA
    RNA 17:761-72. 2011
    ..Together, our PAS-Seq analyses revealed a complex landscape of RNA polyadenylation in mammalian cells and the dynamic regulation of APA during stem cell differentiation...
  12. pmc Co-factors of LIM domains (Clims/Ldb/Nli) regulate corneal homeostasis and maintenance of hair follicle stem cells
    Xiaoman Xu
    Department of Medicine, Division of Endocrinology, Sprague Hall, Room 206, University of California, Irvine, Irvine, CA 92697 4030, USA
    Dev Biol 312:484-500. 2007
    ..Together, these data indicate that Clim proteins play important roles in the homeostasis of corneal epithelium and hair follicles...
  13. ncbi request reprint Human neural stem cell growth and differentiation in a gradient-generating microfluidic device
    Bong Geun Chung
    Department of Biomedical Engineering, Henry Samueli School of Engineering, University of California Irvine, CA 92697 2715, USA
    Lab Chip 5:401-6. 2005
    ..This gradient-generating microfluidic platform should be useful for a wide range of basic and applied studies on cultured cells, including SCs...
  14. ncbi request reprint Effects of substrate stiffness on cell morphology, cytoskeletal structure, and adhesion
    Tony Yeung
    Institute for Medicine and Engineering, University of Pennsylvania, PA 19104, USA
    Cell Motil Cytoskeleton 60:24-34. 2005
    ..These results support the hypothesis that mechanical factors impact different cell types in fundamentally different ways, and can trigger specific changes similar to those stimulated by soluble ligands...

Research Grants2

  1. Regulation of neural stem cells by Lhx2
    Lisa Flanagan; Fiscal Year: 2007
    ..She is pursuing her research at UC Irvine, which has outstanding resources that will aid her in her career development and goals. ..