Frank A Fitzpatrick

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi Inflammation, carcinogenesis and cancer
    F A Fitzpatrick
    Huntsman Cancer Institute, University of Utah, Salt Lake City 84112 5550, USA
    Int Immunopharmacol 1:1651-67. 2001
  2. ncbi The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related agents
    F A Fitzpatrick
    Department of Oncological Science, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84103, USA
    Int Immunopharmacol 3:1699-714. 2003
  3. ncbi Cyclooxygenase enzymes: regulation and function
    F A Fitzpatrick
    Department of Oncological Sciences and Department of Medicinal Chemistry, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112 0555, USA
    Curr Pharm Des 10:577-88. 2004
  4. ncbi Curcumin impairs tumor suppressor p53 function in colon cancer cells
    Philip J Moos
    Department of Oncological Sciences and Department of Medicinal Chemistry, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
    Carcinogenesis 25:1611-7. 2004
  5. ncbi Fiberoptic resonance Raman spectroscopy to measure carotenoid oxidative breakdown in live tissues
    Brandon G Bentz
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Cancer Prev Res (Phila) 3:529-38. 2010
  6. ncbi Oxidation of 2-Cys-peroxiredoxins by arachidonic acid peroxide metabolites of lipoxygenases and cyclooxygenase-2
    Pauline Cordray
    Department of Pharmacology and Toxicology, and Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    J Biol Chem 282:32623-9. 2007
  7. ncbi Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity
    Sheryl M Verbitski
    Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Skaggs Hall, Room 307, Salt Lake City, UT 84112, USA
    J Med Chem 47:2062-70. 2004

Research Grants

  1. TRANSCELLULAR LEUKOTRIENE BIOSYNTHESIS AND INFLAMMATION
    Frank Fitzpatrick; Fiscal Year: 1999
  2. Leukotriene Biosynthesis: Inflammation and Cancer
    Frank Fitzpatrick; Fiscal Year: 2004

Collaborators

Detail Information

Publications7

  1. ncbi Inflammation, carcinogenesis and cancer
    F A Fitzpatrick
    Huntsman Cancer Institute, University of Utah, Salt Lake City 84112 5550, USA
    Int Immunopharmacol 1:1651-67. 2001
    ..Simultaneously, the results from the anti-oxidant trials draw attention to an alternate hypothesis, favoring epigenetic inactivation of key tumor suppressors, such as p53, and the consequent liability this places on genomic integrity...
  2. ncbi The immunopharmacology of paclitaxel (Taxol), docetaxel (Taxotere), and related agents
    F A Fitzpatrick
    Department of Oncological Science, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84103, USA
    Int Immunopharmacol 3:1699-714. 2003
    ..Lastly, we discuss the immunopharmacological traits of paclitaxel and docetaxel in terms of their relevance to human clinical pharmacology and toxicology and their activity in animal models of autoimmune disorders...
  3. ncbi Cyclooxygenase enzymes: regulation and function
    F A Fitzpatrick
    Department of Oncological Sciences and Department of Medicinal Chemistry, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112 0555, USA
    Curr Pharm Des 10:577-88. 2004
    ..e. aspirin) and create new ones that still seek to achieve Hoffman's original goal...
  4. ncbi Curcumin impairs tumor suppressor p53 function in colon cancer cells
    Philip J Moos
    Department of Oncological Sciences and Department of Medicinal Chemistry, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT 84112, USA
    Carcinogenesis 25:1611-7. 2004
    ..It disrupts the conformation of the p53 protein required for its serine phosphorylation, its binding to DNA, its transactivation of p53-responsive genes and p53-mediated cell cycle arrest...
  5. ncbi Fiberoptic resonance Raman spectroscopy to measure carotenoid oxidative breakdown in live tissues
    Brandon G Bentz
    Division of Otolaryngology Head and Neck Surgery, Department of Surgery, University of Utah School of Medicine, 50 North Medical Drive, Salt Lake City, UT 84132, USA
    Cancer Prev Res (Phila) 3:529-38. 2010
    ..This proof-of-concept study provides the foundation to justify future validation of our Raman prototype...
  6. ncbi Oxidation of 2-Cys-peroxiredoxins by arachidonic acid peroxide metabolites of lipoxygenases and cyclooxygenase-2
    Pauline Cordray
    Department of Pharmacology and Toxicology, and Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112, USA
    J Biol Chem 282:32623-9. 2007
    ..A., Poole, L. B, and Karplus P. A. (2003) Science 300, 600-653). Peroxiredoxin-dependent mechanisms may modulate the receptor-dependent actions of autocoids derived from cellular lipoxygenase and cyclooxygenase catalysis...
  7. ncbi Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity
    Sheryl M Verbitski
    Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Skaggs Hall, Room 307, Salt Lake City, UT 84112, USA
    J Med Chem 47:2062-70. 2004
    ..These newly characterized proteasome inhibitors may represent a new chemical class of cancer therapeutics...

Research Grants5

  1. TRANSCELLULAR LEUKOTRIENE BIOSYNTHESIS AND INFLAMMATION
    Frank Fitzpatrick; Fiscal Year: 1999
    ....
  2. Leukotriene Biosynthesis: Inflammation and Cancer
    Frank Fitzpatrick; Fiscal Year: 2004
    ..We anticipate that our investigations will identify a novel molecular process associated with elevated risks of cancer and a novel role for eicosanoids in the modulation of genomic stability...