Research Topics
Genomes and GenesSpecies | Annette FitzpatrickSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Using photovoice to understand cardiovascular health awareness in Asian eldersAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, Washington 98115, USA
Health Promot Pract 13:48-54. 2012..Photovoice provided insight into perceptions of cardiovascular health that is vital for developing health promotion and education interventions in limited-English-speaking communities...
Association between insulin resistance and c-reactive protein among Peruvian adultsBizu Gelaye
University of Washington, Multidisciplinary International Research Training Program, Seattle, WA, USA
Diabetol Metab Syndr 2:30. 2010..We sought to evaluate the relationship between serum C-reactive protein (CRP), a marker of systemic inflammation, and prevalence of IR among Peruvian adults...- The relationship of bottle feeding and other sucking behaviors with speech disorder in Patagonian preschoolersClarita Barbosa
Corporacion de Rehabilitacion Club De Leones Cruz Del Sur, Punta Arenas, Chile
BMC Pediatr 9:66. 2009..However, these findings were inconsistent. We investigated associations between use of bottles, pacifiers, and other sucking behaviors with speech disorders in children attending three preschools in Punta Arenas (Patagonia), Chile... 
Leukocyte telomere length and cardiovascular disease in the cardiovascular health studyAnnette L Fitzpatrick
Department of Epidemiology, School of Public Health and Community Medicine, Collaborative Health Studies Coordinating Center, University of Washington, Seattle, WA 98115, USA
Am J Epidemiol 165:14-21. 2007..22, 95% confidence interval: 1.29, 8.02). These results support the hypotheses that telomere attrition may be related to diseases of aging through mechanisms involving oxidative stress, inflammation, and progression to CVD...- Survival following dementia onset: Alzheimer's disease and vascular dementiaAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, WA 98115, USA
J Neurol Sci 229:43-9. 2005..4 years for mixed dementia, and 11.0 years for matched controls with normal cognition. While persons with VaD died primarily from cerebrovascular disease, those with AD/mixed dementia died more frequently from dementia/failure to thrive... - The association between prolonged fatigue and cardiovascular disease in World War II veteran twinsAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, Washington 98115, USA
Twin Res 7:571-7. 2004..9-4.0). These data corroborate the association of fatigue with CVD and suggest that it is not influenced by a common genetic factor. Further studies are needed to clarify the relationship and to better understand the biologic mechanisms... - Midlife and late-life obesity and the risk of dementia: cardiovascular health studyAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Collaborative Health Studies Coordinating Center, Seattle, 98115, USA
Arch Neurol 66:336-42. 2009..While high adiposity in middle age appears to be related to greater dementia risk, studies exploring this association in the elderly are conflicting... - Leukocyte telomere length and mortality in the Cardiovascular Health StudyAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Collaborative Health Studies Coordinating Center, Building 29, Suite 310, 6200 NE 74th Street, Seattle, WA 98115, USA
J Gerontol A Biol Sci Med Sci 66:421-9. 2011..Leukocyte telomere length (LTL) is related to diseases of aging, but studies of mortality have been inconsistent... - Associations of gait speed and other measures of physical function with cognition in a healthy cohort of elderly personsAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, NE, Seattle, WA 98115, USA
J Gerontol A Biol Sci Med Sci 62:1244-51. 2007..Recent evidence suggests that physical decline and slower gait may be associated with early signs of dementia, but more information on healthy older adults is needed... - Incidence and prevalence of dementia in the Cardiovascular Health StudyAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, Washington 98115, USA
J Am Geriatr Soc 52:195-204. 2004..To estimate the incidence and prevalence of dementia, Alzheimer's disease (AD), and vascular dementia (VaD) in the Cardiovascular Health Study (CHS) cohort... - Recruitment of the elderly into a pharmacologic prevention trial: the Ginkgo Evaluation of Memory Study experienceAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, WA 98115, USA
Contemp Clin Trials 27:541-53. 2006..Information on the experience of the GEM Study recruitment may be helpful to other clinical trials attempting to randomize older adults into prevention trials... - Modifications to the Healthy Eating Index and its ability to predict obesity: the Multi-Ethnic Study of AtherosclerosisSue K Gao
Department of Epidemiology, University of Washington, Seattle, WA, USA
Am J Clin Nutr 88:64-9. 2008..The Healthy Eating Index (HEI) is a measure of diet quality developed based on the Dietary Guidelines for Americans (DGA)... - Does Ginkgo biloba reduce the risk of cardiovascular events?Lewis H Kuller
Department of Epidemiology, University of Pittsburgh, 130 N Bellefield Ave, Room 550, Pittsburgh, PA 15213, USA
Circ Cardiovasc Qual Outcomes 3:41-7. 2010..Cardiovascular disease (CVD) was a preplanned secondary outcome of the Ginkgo Evaluation of Memory Study. The trial previously reported that Ginkgo biloba had no effect on the primary outcome, incident dementia... - Using telephone and informant assessments to estimate missing Modified Mini-Mental State Exam scores and rates of cognitive decline. The cardiovascular health studyAlice M Arnold
Department of Biostatistics, University of Washington, Seattle, WA, USA
Neuroepidemiology 33:55-65. 2009..To estimate an equivalent to the Modified Mini-Mental State Exam (3MSE), and to compare changes in the 3MSE with and without the estimated scores... - Risk factors for dementia in the cardiovascular health cognition studyLewis H Kuller
Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, PA 15261, USA
Neuroepidemiology 22:13-22. 2003..The Cardiovascular Health Cognition Study has evaluated the determinants of dementia among 3,608 participants that had a magnetic resonance imaging (MRI) of the brain in 1991 and were followed to 1998-1999... - Race/ethnicity and telomere length in the Multi-Ethnic Study of AtherosclerosisAna V Diez Roux
Department of Epidemiology, Center for Integrative Approaches to Health Disparities, University of Michigan, Ann Arbor, MI 48109, USA
Aging Cell 8:251-7. 2009..Race/ethnic differences in LTL may reflect the cumulative burden of differential exposure to oxidative stress (and its predictors) over the lifecourse... - Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition StudyStephen L Seliger
Division of Nephrology, University of Washington, Seattle, Washington 98195, USA
J Am Soc Nephrol 15:1904-11. 2004..Strategies to prevent or delay the onset of dementia in patients with moderate renal impairment are needed... - Weight, mortality, years of healthy life, and active life expectancy in older adultsPaula Diehr
Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
J Am Geriatr Soc 56:76-83. 2008..To determine whether weight categories predict subsequent mortality and morbidity in older adults... - C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and olderBrandon L Pierce
Institute for Public Health Genetics, University of Washington, Seattle, WA, USA
Cancer Causes Control 20:1193-203. 2009..21). Our results suggest that circulating CRP and IL-6 do not influence PCa risk. SNPs at the CRP locus are not associated with PCa risk in this cohort, while the association between rs1800795 and PCa risk warrants further investigation... - Carrying the burdens of poverty, parenting, and addiction: depression symptoms and self-silencing among ethnically diverse womenTherese M Grant
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 180 Nickerson Street, Seattle, WA 98109 1631, USA
Community Ment Health J 47:90-8. 2011..03; P = .001). Differences in depressive symptomatology by ethnic groups were accounted for by their differences in self-silencing... - Ginkgo biloba and risk of cancer: secondary analysis of the Ginkgo Evaluation of Memory (GEM) StudyMary L Biggs
Department of Biostatistics, University of Washington, Seattle, WA 98115, USA
Pharmacoepidemiol Drug Saf 19:694-8. 2010..We analyzed cancer as a secondary endpoint in the Ginkgo Evaluation of Memory (GEM) Study, the largest randomized, double-blind, placebo-controlled clinical trial of Ginkgo supplementation to date... - Secondary prevention of myocardial infarction with nonpharmacologic strategies in a Medicaid cohortErica B Oberg
Department of Health Services, University of Washington, Seattle, WA 98195 7660, USA
Prev Chronic Dis 6:A52. 2009..We identified gaps between secondary prevention guidelines and ambulatory care received by Medicaid enrollees after an MI... - Genetic Susceptibility to Prostate Cancer: Prostate-specific Antigen and its Interaction with the Androgen Receptor (United States)Weiva Sieh
Division of Medical Genetics, Department of Medicine, University of Washington, Box 357720, Seattle, WA, 98195 7720, USA
Cancer Causes Control 17:187-97. 2006..To determine whether directly observed prostate-specific antigen (PSA) promoter diploid haplotype, either alone or in conjunction with androgen receptor (AR) genotype, is associated with prostate cancer risk... - Phenotype harmonization and cross-study collaboration in GWAS consortia: the GENEVA experienceSiiri N Bennett
Collaborative Health Studies Coordinating Center, Department of Biostatistics, University of Washington, Seattle, Washington 98115, USA
Genet Epidemiol 35:159-73. 2011..GENEVA's harmonization efforts and policy of promoting data sharing and collaboration, not only within GENEVA but also with outside collaborations, can provide important guidance to ongoing and new consortia... - Supplement use contributes to meeting recommended dietary intakes for calcium, magnesium, and vitamin C in four ethnicities of middle-aged and older Americans: the Multi-Ethnic Study of AtherosclerosisAndrea N Burnett-Hartman
Fred Hutchinson Cancer Research Center, and Department of Epidemiology, University of Washington, Seattle, WA, USA
J Am Diet Assoc 109:422-9. 2009..We also assessed the prevalence of intakes above Tolerable Upper Intake Levels (ULs)... - Anger expression, negative life events and violent behaviour among male college students in EthiopiaBizu Gelaye
Department of Epidemiology, Multidisciplinary International Research Training Program, University of Washington School of Public Health and Community Medicine, Seattle, Washington 98195, USA
Scand J Public Health 36:538-45. 2008..To assess the prevalence of violent behaviour and to identify risk factors associated with violent behaviour among male college students in Ethiopia... - Knowledge of cardiovascular health among Chinese, Korean and Vietnamese immigrants to the USThanh G N Ton
Department of Neurology, University of Washington, Seattle, WA, USA
J Immigr Minor Health 13:127-39. 2011..All participants desired more information, and identified barriers to effective communication with healthcare providers. A deeper understanding of beliefs and barriers faced by Asian immigrants can help guide health promotion efforts... - Education, cognitive test scores, and black-white differences in dementia riskMarie Florence Shadlen
Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington Harborview Medical Center, 325 9th Avenue, Seattle, WA 98104, USA
J Am Geriatr Soc 54:898-905. 2006..To compare dementia risks of elderly black and white subjects and to determine whether differences in education and cognitive test scores contribute to the inconsistency in reported differences between these groups... - Dementia and Alzheimer's disease incidence in relationship to cardiovascular disease in the Cardiovascular Health Study cohortAnne B Newman
Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
J Am Geriatr Soc 53:1101-7. 2005..To determine whether coronary artery disease, peripheral arterial disease (PAD), or noninvasive markers of cardiovascular disease (CVD) predict the onset of dementia and Alzheimer's disease (AD)... - Statin use and the risk of incident dementia: the Cardiovascular Health StudyThomas D Rea
Department of Medicine, University of Washington, Seattle 98101, USA
Arch Neurol 62:1047-51. 2005..Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) reduce cardiovascular risk through mechanisms that might affect the development of dementia... - Type 2 diabetes and impaired glucose tolerance among cardiac patientsDaniel A Enquobahrie
Multidisciplinary International Research Training Program, University of Washington School of Public Health and Community Medicine, Seattle, Washington, 98101, USA
Acta Cardiol 62:439-44. 2007..T2D and IGT prevalence and their relation to other risk factors were investigated among cardiac patients... - A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology ConsortiumAnne B Newman
Department of Epidemiology, Graduate School of Public Health, 130 North Bellefield Avenue, Suite 500, University of Pittsburgh, Pittsburgh, PA 15213, USA
J Gerontol A Biol Sci Med Sci 65:478-87. 2010..Genome-wide association studies (GWAS) may yield insights into longevity... - Prostate carcinoma incidence in relation to prediagnostic circulating levels of insulin-like growth factor I, insulin-like growth factor binding protein 3, and insulinChu Chen
Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
Cancer 103:76-84. 2005..To examine this issue further, the authors conducted a nested case-control study within the Cardiovascular Health Study cohort... - Survival in HIV-1-positve adults practicing psychological or spiritual activities for one yearAnnette L Fitzpatrick
Department of Epidemiology, University of Washington, Seattle, USA
Altern Ther Health Med 13:18-20, 22-4. 2007..To investigate associations between survival and use of psychological and spiritual activities practiced over 1 year in HIV-positive (HIV+) patients... - Barriers to health care access among the elderly and who perceives themAnnette L Fitzpatrick
CHS Coordinating Center, Building 29, Suite 310, University of Washington, 6200 NE 74th Street, Seattle, WA 98115, USA
Am J Public Health 94:1788-94. 2004..Race was not significant after adjustment for other factors. CONCLUSIONS: Psychological and physical barriers affect access to care among the elderly; these may be influenced by poverty more than by race... - Depression and type 2 diabetes mellitus: the multiethnic study of atherosclerosisSherita Hill Golden
Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
Psychosom Med 69:529-36. 2007..To assess the cross-sectional association between depression and glucose tolerance status... - Albuminuria and dementia in the elderly: a community studyJoshua I Barzilay
Kaiser Permanente of Georgia, Tucker, GA 30084, USA
Am J Kidney Dis 52:216-26. 2008..In this study, we examine whether cognitive status (normal cognition, mild cognitive impairment, and dementia) is associated with albuminuria, a microvascular disorder of the kidney... - Prevalence of neuropsychiatric symptoms in dementia and mild cognitive impairment: results from the cardiovascular health studyConstantine G Lyketsos
Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD, USA
JAMA 288:1475-83. 2002..Dementia and MCI are associated with neuropsychiatric symptoms in clinical samples. Only 2 population-based studies exist of the prevalence of these symptoms in dementia, and none exist for MCI... - Enhanced risk for Alzheimer disease in persons with type 2 diabetes and APOE epsilon4: the Cardiovascular Health Study Cognition StudyFumiko Irie
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, 7201 Wisconsin Ave, Bethesda, MD, USA
Arch Neurol 65:89-93. 2008..Diabetes and the apolipoprotein E epsilon4 allele (APOE epsilon4) increase the risk for Alzheimer disease (AD). We hypothesize that APOE epsilon4 may modify the risk for AD in individuals with diabetes... - Regional and racial differences in the prevalence of physician-diagnosed essential tremor in the United StatesElan D Louis
College of Physicians and Surgeons, Columbia University, New York, New York 10032, USA
Mov Disord 18:1035-40. 2003..Caucasians were five times more likely to have physician-diagnosed ET than were African Americans. This study does not provide an explanation for this difference, which deserves further study... - Prospective study of alcohol consumption and risk of dementia in older adultsKenneth J Mukamal
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, 330 Brookline Ave, RO 114, Boston, Mass 02215, USA
JAMA 289:1405-13. 2003..Alcohol consumption has been associated with complex changes in cerebral vasculature and structure in older adults. How alcohol consumption affects the incidence of dementia is less clear... - Use of herbal medicine and other dietary supplements in community-dwelling older people: Baseline data from the ginkgo evaluation of memory studyRichard L Nahin
National Center for Complementary and Alternative Medicine, National Institutes of Health, Bethesda, Maryland 20892, USA
J Am Geriatr Soc 54:1725-35. 2006..To analyze baseline data from the Ginkgo Evaluation of Memory (GEM) study, in which information was collected on the use of all dietary supplements... - Association between screening for osteoporosis and the incidence of hip fractureLisa M Kern
Robert Wood Johnson Clinical Scholars Program, Johns Hopkins School of Medicine, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Ann Intern Med 142:173-81. 2005..Because direct evidence for the effectiveness of screening is lacking, guidelines disagree on whether people should be screened for osteoporosis... - Quantity versus quality of life: how do we decide?Annette L Fitzpatrick
J Am Geriatr Soc 52:314-5. 2004
Research Grants
- Telomere Attrition and Cardiovascular DiseaseAnnette Fitzpatrick; Fiscal Year: 2007..Results of this study will enhance the understanding of the relationships between telomere dynamics and cardiovascular morbidity and mortality providing new insights into the biology of human aging...
- Survival and Comorbidities after DementiaAnnette Fitzpatrick; Fiscal Year: 2003..This application will support continued analyses of an important database designed to provide valuable research for the prevention and impact of dementia in this country. ..
- Use of Herbs and Dietary Supplements in Four EthnicitiesAnnette Fitzpatrick; Fiscal Year: 2005..It may also be possible to test associations of specific herb/supplement use with specific clinical/subclinical conditions should adequate power be available. ..