Research Topics
Genomes and Genes
| Katherine A FitzgeraldSummaryAffiliation: University of Massachusetts Medical School Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Detecting microRNA activity from gene expression dataStephen F Madden
School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
BMC Bioinformatics 11:257. 2010..In this study we used predicted miRNA-gene interactions to analyse mRNA gene expression microarray data to predict miRNAs associated with particular diseases or conditions...
Immunology. The shape of things to comeKatherine A Fitzgerald
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Science 316:1574-6. 2007- Sorting out Toll signalsKatherine A Fitzgerald
Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 125:834-6. 2006..This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism... - The interferon inducible gene: ViperinKatherine A Fitzgerald
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Interferon Cytokine Res 31:131-5. 2011..Viperin is also induced by nonviral microbial products such as lipopolysaccharide (LPS) and by a wide range of bacteria, suggesting a broader role in innate antimicrobial defenses... 
Integr-ating IL-1 alpha in antiviral host defensesKatherine A Fitzgerald
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Immunity 31:7-9. 2009..In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity...- The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signalingAnnett Schoenemeyer
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 280:17005-12. 2005..IRF5 and IRF7, therefore, emerge from these studies as critical mediators of TLR7 signaling... - Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expressionFranz G Bauernfeind
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 183:787-91. 2009..Signals provided by NF-kappaB activators are necessary but not sufficient for NLRP3 activation, and a second stimulus such as ATP or crystal-induced damage is required for NLRP3 activation... - The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA virusesVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 11:395-402. 2010..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity... - Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activationNicole Cusson-Hermance
Departments of Cancer Biology and Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 280:36560-6. 2005..These studies suggest that Rip1 uses a similar, ubiquitin-dependent mechanism to activate IkappaB kinase-beta in response to TNF-alpha and TLR3 ligands... - The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-ISimon Rothenfusser
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 175:5260-8. 2005..We propose that Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering dsRNA from RIG-I... - LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIFKatherine A Fitzgerald
Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
J Exp Med 198:1043-55. 2003..These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS... - NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsPeter Duewell
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 464:1357-61. 2010..These findings provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for the therapy of this disease... - Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genomeShruti Sharma
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
Immunity 35:194-207. 2011..Collectively, these observations implicate AT-rich DNA sensing via STING, TBK1 and IRF3-IRF7 in P. falciparum malaria... - The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transductionDaniel C Rowe
Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 103:6299-304. 2006.... - Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasomeXianbao He
Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
J Immunol 184:5743-54. 2010..pneumoniae directly activates the NLRP3/ASC inflammasome, leading to the release of biologically active IL-1beta, and that concurrent IL-1 signaling is required for optimal host defense against acute bacterial pneumonia... - Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoproteinNadege Goutagny
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 184:1168-79. 2010..Collectively, these data reveal differential mechanisms of sensing for two closely related viruses, which operate in cell type-specific manners... - Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1Martina Severa
Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 281:26188-95. 2006..Collectively, these studies identify Viperin as a tightly regulated ISGF3 target gene, which is counter-regulated by PRDI-BF1... - Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infectionShenghua Zhou
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Virol 86:11254-65. 2012.... - TLR4 is a negative regulator in noninfectious lung inflammationHang Zhao
Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
J Immunol 184:5308-14. 2010..These data provide a molecular level explanation for the function of TLR4 in LMW HA (200 kDa)-induced lung inflammation, as inhibition of the beta form of pro-IL-1 promotes an anti-inflammatory response... - Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin KYu Sun
Department of Medicine, Columbia University, New York, NY 10032, USA
Circ Res 104:455-65. 2009.... - TLR9 signals after translocating from the ER to CpG DNA in the lysosomeEicke Latz
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building 308, 364 Plantation Street, Worcester, MA 01605, USA
Nat Immunol 5:190-8. 2004..Our data indicate a previously unknown mechanism of cellular activation involving the recruitment of TLR9 from the ER to sites of CpG DNA uptake, where signal transduction is initiated... - Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in miceJennifer L Ather
Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
J Immunol 187:64-73. 2011.... - A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signalingKamalpreet Nagpal
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 284:25742-8. 2009..Genotyping of Mal D96N in three different cohorts suggested that it is a rare mutation. We, thus, describe a rare variant in Mal that exerts its effect via its inability to bind MyD88... - Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilizationVeit Hornung
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:847-56. 2008..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal... - Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virusShenghua Zhou
Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
J Virol 84:9452-62. 2010..These virus-host interactions may play important roles in the pathogeneses of LCMV and other human arenavirus diseases... - TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNAMarie Charrel-Dennis
Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell Host Microbe 4:543-54. 2008..Thus, activation of IFN-alpha/-beta production during infection with GBS, commonly considered an extracellular pathogen, appears to result from the interaction of GBS DNA with a putative intracellular DNA sensor or receptor... - The NLRP12 inflammasome recognizes Yersinia pestisGregory I Vladimer
Division of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA 01605, USA
Immunity 37:96-107. 2012..These studies reveal a role for NLRP12 in host resistance against pathogens. Minimizing NLRP12 inflammasome activation may have been a central factor in evolution of the high virulence of Y. pestis... - TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteriaVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Cell 150:606-19. 2012..The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection... - AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASCVeit Hornung
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nature 458:514-8. 2009..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1... - NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosisAmit K Pandey
Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
PLoS Pathog 5:e1000500. 2009.... - Inflammasomes and anti-viral immunityVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
J Clin Immunol 30:632-7. 2010..In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity... - Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1βBibhuti B Mishra
Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 14:52-60. 2013..Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections... - Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signalingNicholas Paquette
Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Proc Natl Acad Sci U S A 109:12710-5. 2012..In addition, studies in mammalian cells show similar modification and inhibition of hTAK1. These data present evidence that TAK1 is a target for YopJ-mediated inhibition... - Cytosolic surveillance and antiviral immunityVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, MA, USA
Curr Opin Virol 1:455-62. 2011..Here, we review this expanding area of innate immunity by focusing on the molecular mechanisms of cytosolic host-defenses... - Endotoxin recognition and signal transduction by the TLR4/MD2-complexKatherine A Fitzgerald
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, LRB, Room 308, 364 Plantation Street, Worcester, MA 01605, USA
Microbes Infect 6:1361-7. 2004.... - The NALP3 inflammasome is involved in the innate immune response to amyloid-betaAnnett Halle
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Nat Immunol 9:857-65. 2008..Our findings suggest that activation of the NALP3 inflammasome is important for inflammation and tissue damage in Alzheimer's disease... - Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signallingConnie W Woo
Department of Medicine, Columbia University, New York, NY 10032, USA
Nat Cell Biol 11:1473-80. 2009..We speculate that this mechanism evolved to promote survival of TLR-expressing cells that experience prolonged levels of physiological ER stress in the course of the host response to invading pathogens... - Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infectionShenghua Zhou
Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
J Immunol 178:5173-81. 2007..We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host... - Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5Weijun Chen
Department of Biochemistry and Molecular Pharmacology, 364 Plantation Street, Worcester, Massachusetts 01605, USA
Nat Struct Mol Biol 15:1213-20. 2008..Thus, phosphorylation is likely to activate IRF5 and other family members by triggering conformational rearrangements that switch the C-terminal segment from an autoinihibitory to a dimerization role... - Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent mannerLukas Bossaller
Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
J Immunol 189:5508-12. 2012..Hence, Fas controls a novel noncanonical IL-1β activation pathway in myeloid cells, which could play an essential role in inflammatory processes, tumor surveillance, and control of infectious diseases... - IKKepsilon and TBK1 are essential components of the IRF3 signaling pathwayKatherine A Fitzgerald
Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
Nat Immunol 4:491-6. 2003..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response... - Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteinsDonghai Wang
Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
J Biol Chem 288:4594-601. 2013.... - Regulation of inflammasome signalingVijay A K Rathinam
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
Nat Immunol 13:333-2. 2012..Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance... - Pattern recognition receptors and the innate immune response to viral infectionMikayla R Thompson
Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Viruses 3:920-40. 2011..By highlighting recent progress in these areas, we hope to convey a greater understanding of how viruses activate PRR signaling and how this interaction shapes the anti-viral immune response... - Innate immune sensing of DNA virusesVijay A K Rathinam
Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
Virology 411:153-62. 2011..In this review, we discuss the recent advances in the innate immune sensing of DNA viruses and focus on the recognition mechanisms involved... - The PYHIN protein family as mediators of host defensesStefan A Schattgen
Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
Immunol Rev 243:109-18. 2011..Here, we review these discoveries and highlight the emerging role of the PYHIN protein family in mammalian host defenses... - Defective pro-IL-1β responses in macrophages from aged miceAlejandro Ramirez
Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, S6 862, 55 Lake Avenue North, Worcester, MA, 01655, USA
Immun Ageing 9:27. 2012..abstract:.. - Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complexHyung S Youn
Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California, Davis, CA 95616, USA
J Immunol 175:3339-46. 2005..The results raise the possibility that certain dietary phytochemicals can modulate TLR-derived signaling and inflammatory target gene expression and can alter susceptibility to microbial infection and chronic inflammatory diseases... - Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signalingAnne F McGettrick
School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
Proc Natl Acad Sci U S A 103:9196-201. 2006..We have therefore uncovered a key process in Toll-like receptor 4 signaling, identifying TRAM as the target for PKCepsilon... - Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulenceJulianne Stack
Department of Biochemistry, Trinity College, Dublin 2, Ireland
J Exp Med 201:1007-18. 2005..Importantly, VV lacking the A46R gene was attenuated in a murine intranasal model, demonstrating the importance of A46R for VV virulence... - Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 inductionElizabeth K Brint
Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
J Biol Chem 277:49205-11. 2002.... - The Toll-IL-1 receptor adaptor family grows to five membersLuke A J O'Neill
Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
Trends Immunol 24:286-90. 2003..It is probable that differential use of adaptors will help explain the distinct pathways activated by TLRs during host defence... - TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expressionStefanie N Vogel
Departments of Microbiology and Immunology and Medicine, University of Maryland, Baltimore, MD, USA
Mol Interv 3:466-77. 2003..Given the rapidity with which such interactions have been described, we have attempted to summarize our current understanding of the adapters that are so essential for TLR signaling and provide a working model for future studies... - Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1Joo Y Lee
Western Human Nutrition Research Center, The Agricultural Research Service United States Department of Agriculture, and Department of Nutrition, University of California Davis, Davis, California 95616, USA
J Biol Chem 279:16971-9. 2004..These results also suggest that inflammatory responses induced by the activation of TLRs can be differentially modulated by types of dietary fatty acids... - Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptorsGary DiPerna
Viral Immune Evasion Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
J Biol Chem 279:36570-8. 2004..Furthermore, N1L inhibited IRF3 signaling, which is also regulated by TBK1. These studies define a role for N1L as an immunomodulator of innate immunity by targeting components of NF-kappaB and IRF3 signaling pathways... - TOLLing away in BrazilJane A Mitchell
Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
Nat Immunol 7:675-9. 2006 - The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascadesHarry Bjorkbacka
Lipid Metabolism Unit, Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
Physiol Genomics 19:319-30. 2004.... - Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signallingFelix Geeraedts
Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
PLoS Pathog 4:e1000138. 2008.... - NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1Sinead M Miggin
School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
Proc Natl Acad Sci U S A 104:3372-7. 2007..This functional interaction reveals an important aspect of the coordination between TLRs and caspase-1 during the innate response to pathogens... - Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAMAmy G Hise
Center for Global Health and Diseases and Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
J Immunol 178:1068-76. 2007..These results establish that the innate inflammatory pathways activated by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal... - Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune responseNicole T Liberati
Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
Proc Natl Acad Sci U S A 101:6593-8. 2004..These data reveal the involvement of a previously uncharacterized, evolutionarily conserved TIR domain protein in innate immunity that is functionally distinct from other known TIR domain signaling adapters... - Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and TrifPamela Cook
Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
Immunology 122:222-9. 2007..In contrast to wild type bone marrow derived macrophages (BMDM), Tram(-/-) and Trif(-/-) BMDM proliferate in response to Salmonella infection...
Research Grants
- Regulation of Type I Interferon Gene Expression in the Innate Immune ResponseKatherine Fitzgerald; Fiscal Year: 2007....
- Regulation of Type I Interferon Gene Expression in the Innate Immune ResponseKatherine A Fitzgerald; Fiscal Year: 2010..abstract_text> ..
- Role of PISA; a PYHIN Family Member in Intracellular DNA RecognitionEicke Latz; Fiscal Year: 2010..Elucidation of molecular details of PISA activation could lead to novel strategies of pharmacological interference for diseases based on intracellular DNA recognition. ..