Katherine A Fitzgerald

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc Detecting microRNA activity from gene expression data
    Stephen F Madden
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
    BMC Bioinformatics 11:257. 2010
  2. pmc The interferon inducible gene: Viperin
    Katherine A Fitzgerald
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Interferon Cytokine Res 31:131-5. 2011
  3. doi request reprint Integr-ating IL-1 alpha in antiviral host defenses
    Katherine A Fitzgerald
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Immunity 31:7-9. 2009
  4. ncbi request reprint Immunology. The shape of things to come
    Katherine A Fitzgerald
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 316:1574-6. 2007
  5. ncbi request reprint Sorting out Toll signals
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 125:834-6. 2006
  6. ncbi request reprint The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
    Annett Schoenemeyer
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:17005-12. 2005
  7. pmc Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    Franz G Bauernfeind
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 183:787-91. 2009
  8. pmc The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 11:395-402. 2010
  9. ncbi request reprint Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
    Nicole Cusson-Hermance
    Departments of Cancer Biology and Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:36560-6. 2005
  10. ncbi request reprint The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
    Simon Rothenfusser
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 175:5260-8. 2005

Detail Information

Publications70

  1. pmc Detecting microRNA activity from gene expression data
    Stephen F Madden
    School of Medicine and Medical Science, Conway Institute, University College Dublin, Dublin, Ireland
    BMC Bioinformatics 11:257. 2010
    ..In this study we used predicted miRNA-gene interactions to analyse mRNA gene expression microarray data to predict miRNAs associated with particular diseases or conditions...
  2. pmc The interferon inducible gene: Viperin
    Katherine A Fitzgerald
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Interferon Cytokine Res 31:131-5. 2011
    ..Viperin is also induced by nonviral microbial products such as lipopolysaccharide (LPS) and by a wide range of bacteria, suggesting a broader role in innate antimicrobial defenses...
  3. doi request reprint Integr-ating IL-1 alpha in antiviral host defenses
    Katherine A Fitzgerald
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Immunity 31:7-9. 2009
    ..In this issue of Immunity, Di Paolo et al. (2009) implicate interleukin-1 alpha (IL- 1 alpha) in virus-induced inflammation and identify the beta 3 integrin as the key receptor regulating IL-1 alpha activity...
  4. ncbi request reprint Immunology. The shape of things to come
    Katherine A Fitzgerald
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 316:1574-6. 2007
  5. ncbi request reprint Sorting out Toll signals
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 125:834-6. 2006
    ..This binding recruits a key adaptor MyD88 to TLR4, suggesting that there is crosstalk between the TLR signaling pathway and phospholipid metabolism...
  6. ncbi request reprint The interferon regulatory factor, IRF5, is a central mediator of toll-like receptor 7 signaling
    Annett Schoenemeyer
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:17005-12. 2005
    ..IRF5 and IRF7, therefore, emerge from these studies as critical mediators of TLR7 signaling...
  7. pmc Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
    Franz G Bauernfeind
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 183:787-91. 2009
    ..Signals provided by NF-kappaB activators are necessary but not sufficient for NLRP3 activation, and a second stimulus such as ATP or crystal-induced damage is required for NLRP3 activation...
  8. pmc The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 11:395-402. 2010
    ..Collectively, our observations demonstrate the importance of AIM2 in the sensing of both bacterial and viral pathogens and in triggering innate immunity...
  9. ncbi request reprint Rip1 mediates the Trif-dependent toll-like receptor 3- and 4-induced NF-{kappa}B activation but does not contribute to interferon regulatory factor 3 activation
    Nicole Cusson-Hermance
    Departments of Cancer Biology and Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 280:36560-6. 2005
    ..These studies suggest that Rip1 uses a similar, ubiquitin-dependent mechanism to activate IkappaB kinase-beta in response to TNF-alpha and TLR3 ligands...
  10. ncbi request reprint The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I
    Simon Rothenfusser
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 175:5260-8. 2005
    ..We propose that Lgp2 acts as a negative feedback regulator of antiviral signaling by sequestering dsRNA from RIG-I...
  11. pmc LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Exp Med 198:1043-55. 2003
    ..These studies suggest that TRIF and TRAM both function in LPS-TLR4 signaling to regulate the MyD88-independent pathway during the innate immune response to LPS...
  12. pmc NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    Peter Duewell
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 464:1357-61. 2010
    ..These findings provide new insights into the pathogenesis of atherosclerosis and indicate new potential molecular targets for the therapy of this disease...
  13. pmc Innate immune recognition of an AT-rich stem-loop DNA motif in the Plasmodium falciparum genome
    Shruti Sharma
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    Immunity 35:194-207. 2011
    ..Collectively, these observations implicate AT-rich DNA sensing via STING, TBK1 and IRF3-IRF7 in P. falciparum malaria...
  14. pmc The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction
    Daniel C Rowe
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 103:6299-304. 2006
    ....
  15. pmc Inflammation and fibrosis during Chlamydia pneumoniae infection is regulated by IL-1 and the NLRP3/ASC inflammasome
    Xianbao He
    Section of Infectious Diseases, Department of Medicine, Boston Medical Center, Boston University School of Medicine, Boston, MA 02118, USA
    J Immunol 184:5743-54. 2010
    ..pneumoniae directly activates the NLRP3/ASC inflammasome, leading to the release of biologically active IL-1beta, and that concurrent IL-1 signaling is required for optimal host defense against acute bacterial pneumonia...
  16. pmc Cell type-specific recognition of human metapneumoviruses (HMPVs) by retinoic acid-inducible gene I (RIG-I) and TLR7 and viral interference of RIG-I ligand recognition by HMPV-B1 phosphoprotein
    Nadege Goutagny
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 184:1168-79. 2010
    ..Collectively, these data reveal differential mechanisms of sensing for two closely related viruses, which operate in cell type-specific manners...
  17. pmc Cutting edge: FAS (CD95) mediates noncanonical IL-1β and IL-18 maturation via caspase-8 in an RIP3-independent manner
    Lukas Bossaller
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 189:5508-12. 2012
    ..Hence, Fas controls a novel noncanonical IL-1β activation pathway in myeloid cells, which could play an essential role in inflammatory processes, tumor surveillance, and control of infectious diseases...
  18. ncbi request reprint Toll-like receptor-dependent and -independent viperin gene expression and counter-regulation by PRDI-binding factor-1/BLIMP1
    Martina Severa
    Division of Infectious Disease and Immunology, Department of Medicine, The University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 281:26188-95. 2006
    ..Collectively, these studies identify Viperin as a tightly regulated ISGF3 target gene, which is counter-regulated by PRDI-BF1...
  19. pmc Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation
    John J Kaminski
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605
    J Immunol 191:3876-83. 2013
    ..Collectively, these findings reveal a new route by which suppressive ODNs modulate the immune system and unveil novel applications for suppressive ODNs in the treatment of infectious and autoimmune diseases. ..
  20. pmc Role of interferon regulatory factor 7 in T cell responses during acute lymphocytic choriomeningitis virus infection
    Shenghua Zhou
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 86:11254-65. 2012
    ....
  21. pmc Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K
    Yu Sun
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Circ Res 104:455-65. 2009
    ....
  22. doi request reprint TLR4 is a negative regulator in noninfectious lung inflammation
    Hang Zhao
    Pulmonary and Critical Care Unit, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Immunol 184:5308-14. 2010
    ..These data provide a molecular level explanation for the function of TLR4 in LMW HA (200 kDa)-induced lung inflammation, as inhibition of the beta form of pro-IL-1 promotes an anti-inflammatory response...
  23. ncbi request reprint TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    Eicke Latz
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building 308, 364 Plantation Street, Worcester, MA 01605, USA
    Nat Immunol 5:190-8. 2004
    ..Our data indicate a previously unknown mechanism of cellular activation involving the recruitment of TLR9 from the ER to sites of CpG DNA uptake, where signal transduction is initiated...
  24. doi request reprint A long noncoding RNA mediates both activation and repression of immune response genes
    Susan Carpenter
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 341:789-92. 2013
    ..Collectively, these studies unveil a central role of lincRNA-Cox2 as a broad-acting regulatory component of the circuit that controls the inflammatory response. ..
  25. pmc Serum amyloid A activates the NLRP3 inflammasome and promotes Th17 allergic asthma in mice
    Jennifer L Ather
    Vermont Lung Center, Division of Pulmonary Disease and Critical Care, Department of Medicine, University of Vermont, Burlington, VT 05405, USA
    J Immunol 187:64-73. 2011
    ....
  26. pmc Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    Veit Hornung
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 9:847-56. 2008
    ..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal...
  27. pmc Induction and inhibition of type I interferon responses by distinct components of lymphocytic choriomeningitis virus
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Virol 84:9452-62. 2010
    ..These virus-host interactions may play important roles in the pathogeneses of LCMV and other human arenavirus diseases...
  28. pmc TLR-independent type I interferon induction in response to an extracellular bacterial pathogen via intracellular recognition of its DNA
    Marie Charrel-Dennis
    Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Host Microbe 4:543-54. 2008
    ..Thus, activation of IFN-alpha/-beta production during infection with GBS, commonly considered an extracellular pathogen, appears to result from the interaction of GBS DNA with a putative intracellular DNA sensor or receptor...
  29. pmc A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling
    Kamalpreet Nagpal
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 284:25742-8. 2009
    ..Genotyping of Mal D96N in three different cohorts suggested that it is a rare mutation. We, thus, describe a rare variant in Mal that exerts its effect via its inability to bind MyD88...
  30. doi request reprint Dual Engagement of the NLRP3 and AIM2 Inflammasomes by Plasmodium-Derived Hemozoin and DNA during Malaria
    Parisa Kalantari
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 6:196-210. 2014
    ..Finally, infected erythrocytes activated both the NLRP3 and AIM2 inflammasomes. These observations suggest that Hz and DNA work together to induce systemic inflammation during malaria. ..
  31. pmc Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid
    Joseph Conlon
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 190:5216-25. 2013
    ..Collectively, these findings detail an unexpected species-specific role for STING as a receptor for an anticancer drug and uncover important insights that may explain the failure of DMXAA in clinical trials for human cancer...
  32. pmc Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β
    Bibhuti B Mishra
    Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 14:52-60. 2013
    ..Our data indicate that the NO produced as a result of adaptive immunity is indispensable in modulating the destructive innate inflammatory responses elicited during persistent infections...
  33. pmc Inflammation in mice ectopically expressing human Pyogenic Arthritis, Pyoderma Gangrenosum, and Acne (PAPA) Syndrome-associated PSTPIP1 A230T mutant proteins
    Donghai Wang
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 288:4594-601. 2013
    ....
  34. pmc The NLRP12 inflammasome recognizes Yersinia pestis
    Gregory I Vladimer
    Division of Infectious Diseases and Immunology, UMass Medical School, Worcester, MA 01605, USA
    Immunity 37:96-107. 2012
    ..These studies reveal a role for NLRP12 in host resistance against pathogens. Minimizing NLRP12 inflammasome activation may have been a central factor in evolution of the high virulence of Y. pestis...
  35. pmc TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 150:606-19. 2012
    ..The identification of TRIF as a regulator of caspase-11 underscores the importance of TLRs as master regulators of inflammasomes during Gram-negative bacterial infection...
  36. pmc AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
    Veit Hornung
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nature 458:514-8. 2009
    ..Collectively, these observations identify AIM2 as a new receptor for cytoplasmic DNA, which forms an inflammasome with the ligand and ASC to activate caspase-1...
  37. doi request reprint Inflammasomes and anti-viral immunity
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Clin Immunol 30:632-7. 2010
    ..In this review, we provide an overview of how caspase-1-activating inflammasomes participate during viral infections and their role in regulating anti-viral immunity...
  38. pmc NOD2, RIP2 and IRF5 play a critical role in the type I interferon response to Mycobacterium tuberculosis
    Amit K Pandey
    Department of Molecular Genetics and Microbiology, University of Massachusetts Medical School, Worcester, MA, USA
    PLoS Pathog 5:e1000500. 2009
    ....
  39. pmc STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
    Jan Petrasek
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605
    Proc Natl Acad Sci U S A 110:16544-9. 2013
    ..The pathogenic role of IRF3 in ALD was independent of inflammation or Type-I interferons. Thus, STING and IRF3 are key determinants of ALD, linking ER stress signaling with the mitochondrial pathway of hepatocyte apoptosis. ..
  40. doi request reprint Overexpression of membrane-bound fas ligand (CD95L) exacerbates autoimmune disease and renal pathology in pristane-induced lupus
    Lukas Bossaller
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 191:2104-14. 2013
    ..These results demonstrate that FasL promotes inflammation in TMPD-induced autoimmunity, and its cleavage limits FasL proinflammatory activity. ..
  41. pmc CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
    Frederick J Sheedy
    Department of Medicine, Marc and Ruti Bell Program for Vascular Biology and Disease, The Leon H Charney Division of Cardiology, New York University School of Medicine, New York, New York, USA
    Nat Immunol 14:812-20. 2013
    ..Collectively, our findings highlight the importance of CD36 in the accrual and nucleation of NLRP3 ligands from within the macrophage and position CD36 as a central regulator of inflammasome activation in sterile inflammation. ..
  42. pmc Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5
    Weijun Chen
    Department of Biochemistry and Molecular Pharmacology, 364 Plantation Street, Worcester, Massachusetts 01605, USA
    Nat Struct Mol Biol 15:1213-20. 2008
    ..Thus, phosphorylation is likely to activate IRF5 and other family members by triggering conformational rearrangements that switch the C-terminal segment from an autoinihibitory to a dimerization role...
  43. pmc Serine/threonine acetylation of TGFβ-activated kinase (TAK1) by Yersinia pestis YopJ inhibits innate immune signaling
    Nicholas Paquette
    Division of Infectious Disease, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Proc Natl Acad Sci U S A 109:12710-5. 2012
    ..In addition, studies in mammalian cells show similar modification and inhibition of hTAK1. These data present evidence that TAK1 is a target for YopJ-mediated inhibition...
  44. pmc Cytosolic surveillance and antiviral immunity
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, MA, USA
    Curr Opin Virol 1:455-62. 2011
    ..Here, we review this expanding area of innate immunity by focusing on the molecular mechanisms of cytosolic host-defenses...
  45. pmc The NALP3 inflammasome is involved in the innate immune response to amyloid-beta
    Annett Halle
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 9:857-65. 2008
    ..Our findings suggest that activation of the NALP3 inflammasome is important for inflammation and tissue damage in Alzheimer's disease...
  46. ncbi request reprint Role of MyD88 in route-dependent susceptibility to vesicular stomatitis virus infection
    Shenghua Zhou
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605, USA
    J Immunol 178:5173-81. 2007
    ..We believe that these results explain how the route of infection, probably by virtue of activating different cell populations, can lead to entirely different outcomes of infection based on the underlying genetics of the host...
  47. ncbi request reprint Endotoxin recognition and signal transduction by the TLR4/MD2-complex
    Katherine A Fitzgerald
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, LRB, Room 308, 364 Plantation Street, Worcester, MA 01605, USA
    Microbes Infect 6:1361-7. 2004
    ....
  48. pmc Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling
    Connie W Woo
    Department of Medicine, Columbia University, New York, NY 10032, USA
    Nat Cell Biol 11:1473-80. 2009
    ..We speculate that this mechanism evolved to promote survival of TLR-expressing cells that experience prolonged levels of physiological ER stress in the course of the host response to invading pathogens...
  49. pmc Molecular basis of DNA recognition in the immune system
    Maninjay K Atianand
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    J Immunol 190:1911-8. 2013
    ..In this review, we discuss a rapidly evolving view of how cytosolic DNA-sensing machineries coordinate antimicrobial immunity and, if unchecked, lead to autoimmune disease...
  50. ncbi request reprint IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
    Katherine A Fitzgerald
    Division of Infectious Disease and Immunology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Nat Immunol 4:491-6. 2003
    ..Thus, IKKepsilon and TBK1 have a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response...
  51. pmc Regulation of inflammasome signaling
    Vijay A K Rathinam
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Nat Immunol 13:333-2. 2012
    ..Here we discuss the various regulatory mechanisms that have evolved to keep inflammasome signaling in check to maintain immunological balance...
  52. pmc Pattern recognition receptors and the innate immune response to viral infection
    Mikayla R Thompson
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Viruses 3:920-40. 2011
    ..By highlighting recent progress in these areas, we hope to convey a greater understanding of how viruses activate PRR signaling and how this interaction shapes the anti-viral immune response...
  53. doi request reprint The PYHIN protein family as mediators of host defenses
    Stefan A Schattgen
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Immunol Rev 243:109-18. 2011
    ..Here, we review these discoveries and highlight the emerging role of the PYHIN protein family in mammalian host defenses...
  54. pmc Innate immune sensing of DNA viruses
    Vijay A K Rathinam
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Virology 411:153-62. 2011
    ..In this review, we discuss the recent advances in the innate immune sensing of DNA viruses and focus on the recognition mechanisms involved...
  55. pmc Defective pro-IL-1β responses in macrophages from aged mice
    Alejandro Ramirez
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, S6 862, 55 Lake Avenue North, Worcester, MA, 01655, USA
    Immun Ageing 9:27. 2012
    ..abstract:..
  56. ncbi request reprint The Toll-IL-1 receptor adaptor family grows to five members
    Luke A J O'Neill
    Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin, Ireland
    Trends Immunol 24:286-90. 2003
    ..It is probable that differential use of adaptors will help explain the distinct pathways activated by TLRs during host defence...
  57. ncbi request reprint Characterization of signaling pathways activated by the interleukin 1 (IL-1) receptor homologue T1/ST2. A role for Jun N-terminal kinase in IL-4 induction
    Elizabeth K Brint
    Cytokine Research Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 277:49205-11. 2002
    ....
  58. ncbi request reprint TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression
    Stefanie N Vogel
    Departments of Microbiology and Immunology and Medicine, University of Maryland, Baltimore, MD, USA
    Mol Interv 3:466-77. 2003
    ..Given the rapidity with which such interactions have been described, we have attempted to summarize our current understanding of the adapters that are so essential for TLR signaling and provide a working model for future studies...
  59. pmc Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence
    Julianne Stack
    Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Exp Med 201:1007-18. 2005
    ..Importantly, VV lacking the A46R gene was attenuated in a murine intranasal model, demonstrating the importance of A46R for VV virulence...
  60. pmc Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling
    Anne F McGettrick
    School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 103:9196-201. 2006
    ..We have therefore uncovered a key process in Toll-like receptor 4 signaling, identifying TRAM as the target for PKCepsilon...
  61. ncbi request reprint Specific inhibition of MyD88-independent signaling pathways of TLR3 and TLR4 by resveratrol: molecular targets are TBK1 and RIP1 in TRIF complex
    Hyung S Youn
    Western Human Nutrition Research Center, Agricultural Research Service, US Department of Agriculture, University of California, Davis, CA 95616, USA
    J Immunol 175:3339-46. 2005
    ..The results raise the possibility that certain dietary phytochemicals can modulate TLR-derived signaling and inflammatory target gene expression and can alter susceptibility to microbial infection and chronic inflammatory diseases...
  62. pmc Superior immunogenicity of inactivated whole virus H5N1 influenza vaccine is primarily controlled by Toll-like receptor signalling
    Felix Geeraedts
    Department of Medical Microbiology, Molecular Virology Section, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    PLoS Pathog 4:e1000138. 2008
    ....
  63. ncbi request reprint TOLLing away in Brazil
    Jane A Mitchell
    Cardiothoracic Pharmacology, Unit of Critical Care Medicine, National Heart and Lung Institute, Imperial College, Dovehouse Street, London SW3 6LY, UK
    Nat Immunol 7:675-9. 2006
  64. ncbi request reprint Poxvirus protein N1L targets the I-kappaB kinase complex, inhibits signaling to NF-kappaB by the tumor necrosis factor superfamily of receptors, and inhibits NF-kappaB and IRF3 signaling by toll-like receptors
    Gary DiPerna
    Viral Immune Evasion Group, Department of Biochemistry, Trinity College, Dublin 2, Ireland
    J Biol Chem 279:36570-8. 2004
    ..Furthermore, N1L inhibited IRF3 signaling, which is also regulated by TBK1. These studies define a role for N1L as an immunomodulator of innate immunity by targeting components of NF-kappaB and IRF3 signaling pathways...
  65. pmc Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response
    Nicole T Liberati
    Department of Genetics, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 101:6593-8. 2004
    ..These data reveal the involvement of a previously uncharacterized, evolutionarily conserved TIR domain protein in innate immunity that is functionally distinct from other known TIR domain signaling adapters...
  66. ncbi request reprint Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1
    Joo Y Lee
    Western Human Nutrition Research Center, The Agricultural Research Service United States Department of Agriculture, and Department of Nutrition, University of California Davis, Davis, California 95616, USA
    J Biol Chem 279:16971-9. 2004
    ..These results also suggest that inflammatory responses induced by the activation of TLRs can be differentially modulated by types of dietary fatty acids...
  67. ncbi request reprint Innate immune responses to endosymbiotic Wolbachia bacteria in Brugia malayi and Onchocerca volvulus are dependent on TLR2, TLR6, MyD88, and Mal, but not TLR4, TRIF, or TRAM
    Amy G Hise
    Center for Global Health and Diseases and Department of Ophthalmology, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    J Immunol 178:1068-76. 2007
    ..These results establish that the innate inflammatory pathways activated by endosymbiotic Wolbachia in B. malayi and O. volvulus filaria are dependent on TLR2-TLR6 interactions and are mediated by adaptor molecules MyD88 and TIRAP/Mal...
  68. pmc NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1
    Sinead M Miggin
    School of Biochemistry and Immunology, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 104:3372-7. 2007
    ..This functional interaction reveals an important aspect of the coordination between TLRs and caspase-1 during the innate response to pathogens...
  69. pmc Salmonella-induced SipB-independent cell death requires Toll-like receptor-4 signalling via the adapter proteins Tram and Trif
    Pamela Cook
    Centre for Veterinary Science, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK
    Immunology 122:222-9. 2007
    ..In contrast to wild type bone marrow derived macrophages (BMDM), Tram(-/-) and Trif(-/-) BMDM proliferate in response to Salmonella infection...
  70. ncbi request reprint The induction of macrophage gene expression by LPS predominantly utilizes Myd88-independent signaling cascades
    Harry Bjorkbacka
    Lipid Metabolism Unit, Department of Molecular Biology, Massachusetts General Hospital, Boston 02114, USA
    Physiol Genomics 19:319-30. 2004
    ....

Research Grants7

  1. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine A Fitzgerald; Fiscal Year: 2010
    ..abstract_text> ..
  2. Regulation of Type I Interferon Gene Expression in the Innate Immune Response
    Katherine Fitzgerald; Fiscal Year: 2007
    ....
  3. Role of PISA; a PYHIN Family Member in Intracellular DNA Recognition
    Eicke Latz; Fiscal Year: 2010
    ..Elucidation of molecular details of PISA activation could lead to novel strategies of pharmacological interference for diseases based on intracellular DNA recognition. ..