Research Topics
| P S FishmanSummaryAffiliation: University of Maryland Country: USA Publications
Research Grants
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Detail Information
Publications
Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c))P S Fishman
Neurology Service, Baltimore VA Medical Center and the Department of Neurology, University of Maryland, School of Medicine, Baltimore, USA
Nat Toxins 7:151-6. 1999..Atoxic tetanus proteins containing additional molecular domains as well as H(c) may be more suitable vectors for linkage with therapeutic proteins and delivery to neurons...- Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxinPaul S Fishman
Research Service, Veterans Affairs Health Care System, Baltimore, Maryland, USA
J Neurosci Res 83:1540-3. 2006..Uptake of TTC by nerve terminals from an intramuscular depot is an avid and rapid process and is not blocked by vaccination associated with protection from tetanus toxin... - Paradoxical aspects of parkinsonian tremorPaul S Fishman
Department of Neurology, University of Maryland, School of Medicine and The Baltimore VAMC, Baltimore, Maryland 21201, USA
Mov Disord 23:168-73. 2008.... 
Localized tetanus in immunized micePaul S Fishman
Research Services, Maryland VAHCS, 10 N Greene Street, Baltimore, MD 21201, United States
Neurotoxicology 30:697-701. 2009..This study in uniformly vaccinated animals also illustrates the potential difficulties in determining an appropriate dose of toxin in a human population with variable degrees of immunity...- A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in miceKristin E Larsen
Columbia University, Department of Neurology, New York, NY 10032, and Cecil B. Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
Brain Res 1120:1-12. 2006..These results indicate that TTC can serve as a non-viral vehicle to substantially improve the delivery of functionally active growth factors to motor neurons in the mammalian CNS... - Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation. Requirement for cytosolic distributionC C Matthews
Department of Neurology, University of Maryland, School of Medicine, and Veteran s Affairs Medical Center, Baltimore, MD, 21201, USA
J Mol Neurosci 14:155-66. 2000..Access to the site where toxic superoxides are generated or their targets may be necessary for the protective function of SOD1... - IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS miceRu Ju Chian
Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
Brain Res 1287:1-19. 2009..IGF-1:TTC may prove to be neuroprotective in other animal models of CNS disease or injury known to be responsive to unmodified IGF-1... - Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNSJianhong Li
Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Biochem Biophys Res Commun 390:947-51. 2009..These studies indicate that insect cell-derived GDNF:TTC retains its bi-functional activity in mammalian CNS in vivo and improves delivery of GDNF to spinal cord following intramuscular- or intrathecal administration... - Interaction of mitochondrial respiratory inhibitors and excitotoxins potentiates cell death in hippocampal slice culturesRosemary A Schuh
Research Service, Maryland VA Healthcare System, Baltimore, Maryland 21201, USA
J Neurosci Res 86:3306-13. 2008.... - The evolution of disability in Parkinson diseaseLisa M Shulman
Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Mov Disord 23:790-6. 2008..Better understanding of the stages of disability may facilitate the development of novel outcome measures in clinical trials in PD... - The clinically important difference on the unified Parkinson's disease rating scaleLisa M Shulman
Departments of Neurology, University of Maryland Schoolof Medicine, Baltimore, MD 21201, USA
Arch Neurol 67:64-70. 2010..To determine the estimates of minimal, moderate, and large clinically important differences (CIDs) for the Unified Parkinson's Disease Rating Scale (UPDRS)... - Impact of psychogenic movement disorders versus Parkinson's on disability, quality of life, and psychopathologyKaren E Anderson
Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Mov Disord 22:2204-9. 2007..Quality of life and mental health implications of PMD were also evident. PMD impacts several aspects of patient function and daily life... - A comparative study of physical performance measures in Parkinson's diseaseHaruko Tanji
Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
Mov Disord 23:1897-905. 2008..The results of this study will facilitate choosing performance measures for clinical care and clinical trials in PD... - Glutamate decarboxylase protects neurons against excitotoxic injuryChristopher C Matthews
Research Service, Maryland VA Healthcare System, Baltimore, Maryland 21201, USA
J Neurosci Res 85:855-9. 2007..Targeting of this enzyme to the interior of synaptic vesicles may enhance its potency as a neuroprotectant against excitotoxicity... - Racial and socioeconomic disparities in parkinsonismJ Patrick Hemming
Department of Neurology, School of Medicine, University of Maryland, Baltimore, 21201, USA
Arch Neurol 68:498-503. 2011..To assess potential racial and socioeconomic disparities in patients with parkinsonism treated at a tertiary Movement Disorders Center... - Optical coherence tomography in the diagnosis and treatment of neurological disordersM Samir Jafri
Baltimore VA Medical Center, University of Maryland School of Medicine, Department of Neurology, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
J Biomed Opt 10:051603. 2005..TSE include diseases such as Mad Cow disease and Creutzfeldt-Jakob disease (CJD) in humans. OCT performed on the brain from a woman who died of CJD was able to detect clearly the pathological vacuoles... - Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: a potential vector for delivering heterologous proteins to neuronsJ W Francis
Cecil B Day Center for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Neurochem 74:2528-36. 2000..These results suggest that a catalytically inactive form of DAB(389)TTC may be useful as a nonviral vehicle to deliver exogenous proteins to the cytosolic compartment of neurons... - Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in miceSusanna C Benn
Cecil B. Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Neurochem 95:1118-31. 2005..These results indicate that TTC may serve as a useful prototype for development as a non-viral vehicle for improving delivery of therapeutic proteins to the CNS... - Mutuality of the marital relationship in Parkinson's diseaseHaruko Tanji
Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Mov Disord 23:1843-9. 2008..PD severity, especially gait, balance, urinary incontinence and motor fluctuations are particular stressors on the marital relationship... 
Environmental neurotoxin-induced progressive model of parkinsonism in ratsWei Bin Shen
Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA
Ann Neurol 68:70-80. 2010....- Hematopoietic progenitors express neural genesJames Goolsby
Department of Neurology, University of Maryland School of Medicine, and Multiple Sclerosis Center of Excellence, Veterans Affairs Medical Center, Baltimore, MD 21201, USA
Proc Natl Acad Sci U S A 100:14926-31. 2003..The fact that these CD34+ cells also express transcription factors (Rex-1 and Oct-4) that are found in early development elicits the hypothesis that they may be pluripotent embryonic-like stem cells... - Glutamate-pyruvate transaminase protects against glutamate toxicity in hippocampal slicesC C Matthews
Research Service, Veteran s Affairs Medical Center, 10 N Greene St, Baltimore, MD 21201, USA
Brain Res 978:59-64. 2003..GPT is an effective neuroprotectant against glutamate excitotoxicity. When exposure is limited to endogenously released glutamate, neuroprotection by GPT is not dependent on added pyruvate... - When do patients with Parkinson disease disclose their diagnosis?S Haines
Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Neurology 67:488-90. 2006..Patients who delayed disclosure were more likely male, younger, and employed. There is considerable variability among patients with PD in the time to disclose their diagnosis... - Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cellsJianhong Li
Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
Biochem Biophys Res Commun 385:380-4. 2009..These results support further testing of recombinant GDNF:TTC as a non-viral vector to improve delivery of GDNF to brain and spinal cord in vivo... - A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neuronsJonathan W Francis
Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
Brain Res 995:84-96. 2004..While these studies indicate that SDT may not be useful for SMA therapy, the use of the TTC:DTx fusion construct to deliver other passenger proteins to the neuronal cytosol should not be ruled out... - A multi-domain protein system based on the HC fragment of tetanus toxin for targeting DNA to neuronal cellsMichael Box
Department of Biological Sciences, Imperial College of Science, Technology and Medicine, Exhibition Road SW7 2AY London, UK
J Drug Target 11:333-43. 2003..The demonstration that this multi-domain protein can target genes specifically to neuronal cells is a first step in the development of novel vectors for the delivery of genes with therapeutic potential to diseased neuronal tissues... - Development of a delivery vehicle for intracellular transport of botulinum neurotoxin antagonistsMichael C Goodnough
Department of Food Microbiology, Food Research Institute, University of Wisconsin, 1925 Willow Dr, Madison, WI 53706, USA
FEBS Lett 513:163-8. 2002..The HC of BoNT/A thus offers promise as a selective carrier to deliver BoNT antagonists to the nerve terminal cytoplasm for inhibiting the proteolytic activity of internalized BoNT/A LC...
Research Grants
- Motor Neuron Protection through Glutamate DegradationPaul Fishman; Fiscal Year: 2002....