P S Fishman

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c))
    P S Fishman
    Neurology Service, Baltimore VA Medical Center and the Department of Neurology, University of Maryland, School of Medicine, Baltimore, USA
    Nat Toxins 7:151-6. 1999
  2. ncbi request reprint Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxin
    Paul S Fishman
    Research Service, Veterans Affairs Health Care System, Baltimore, Maryland, USA
    J Neurosci Res 83:1540-3. 2006
  3. ncbi request reprint Paradoxical aspects of parkinsonian tremor
    Paul S Fishman
    Department of Neurology, University of Maryland, School of Medicine and The Baltimore VAMC, Baltimore, Maryland 21201, USA
    Mov Disord 23:168-73. 2008
  4. doi request reprint Localized tetanus in immunized mice
    Paul S Fishman
    Research Services, Maryland VAHCS, 10 N Greene Street, Baltimore, MD 21201, United States
    Neurotoxicology 30:697-701. 2009
  5. ncbi request reprint A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice
    Kristin E Larsen
    Columbia University, Department of Neurology, New York, NY 10032, and Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
    Brain Res 1120:1-12. 2006
  6. ncbi request reprint Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation. Requirement for cytosolic distribution
    C C Matthews
    Department of Neurology, University of Maryland, School of Medicine, and Veteran s Affairs Medical Center, Baltimore, MD, 21201, USA
    J Mol Neurosci 14:155-66. 2000
  7. doi request reprint IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice
    Ru Ju Chian
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
    Brain Res 1287:1-19. 2009
  8. doi request reprint Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS
    Jianhong Li
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 390:947-51. 2009
  9. doi request reprint Interaction of mitochondrial respiratory inhibitors and excitotoxins potentiates cell death in hippocampal slice cultures
    Rosemary A Schuh
    Research Service, Maryland VA Healthcare System, Baltimore, Maryland 21201, USA
    J Neurosci Res 86:3306-13. 2008
  10. doi request reprint The evolution of disability in Parkinson disease
    Lisa M Shulman
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Mov Disord 23:790-6. 2008

Research Grants

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Neuronal binding of tetanus toxin compared to its ganglioside binding fragment (H(c))
    P S Fishman
    Neurology Service, Baltimore VA Medical Center and the Department of Neurology, University of Maryland, School of Medicine, Baltimore, USA
    Nat Toxins 7:151-6. 1999
    ..Atoxic tetanus proteins containing additional molecular domains as well as H(c) may be more suitable vectors for linkage with therapeutic proteins and delivery to neurons...
  2. ncbi request reprint Immunization does not interfere with uptake and transport by motor neurons of the binding fragment of tetanus toxin
    Paul S Fishman
    Research Service, Veterans Affairs Health Care System, Baltimore, Maryland, USA
    J Neurosci Res 83:1540-3. 2006
    ..Uptake of TTC by nerve terminals from an intramuscular depot is an avid and rapid process and is not blocked by vaccination associated with protection from tetanus toxin...
  3. ncbi request reprint Paradoxical aspects of parkinsonian tremor
    Paul S Fishman
    Department of Neurology, University of Maryland, School of Medicine and The Baltimore VAMC, Baltimore, Maryland 21201, USA
    Mov Disord 23:168-73. 2008
    ....
  4. doi request reprint Localized tetanus in immunized mice
    Paul S Fishman
    Research Services, Maryland VAHCS, 10 N Greene Street, Baltimore, MD 21201, United States
    Neurotoxicology 30:697-701. 2009
    ..This study in uniformly vaccinated animals also illustrates the potential difficulties in determining an appropriate dose of toxin in a human population with variable degrees of immunity...
  5. ncbi request reprint A glial cell line-derived neurotrophic factor (GDNF):tetanus toxin fragment C protein conjugate improves delivery of GDNF to spinal cord motor neurons in mice
    Kristin E Larsen
    Columbia University, Department of Neurology, New York, NY 10032, and Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Charlestown 02129, USA
    Brain Res 1120:1-12. 2006
    ..These results indicate that TTC can serve as a non-viral vehicle to substantially improve the delivery of functionally active growth factors to motor neurons in the mammalian CNS...
  6. ncbi request reprint Protective effect of supplemental superoxide dismutase on survival of neuronal cells during starvation. Requirement for cytosolic distribution
    C C Matthews
    Department of Neurology, University of Maryland, School of Medicine, and Veteran s Affairs Medical Center, Baltimore, MD, 21201, USA
    J Mol Neurosci 14:155-66. 2000
    ..Access to the site where toxic superoxides are generated or their targets may be necessary for the protective function of SOD1...
  7. doi request reprint IGF-1:tetanus toxin fragment C fusion protein improves delivery of IGF-1 to spinal cord but fails to prolong survival of ALS mice
    Ru Ju Chian
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
    Brain Res 1287:1-19. 2009
    ..IGF-1:TTC may prove to be neuroprotective in other animal models of CNS disease or injury known to be responsive to unmodified IGF-1...
  8. doi request reprint Insect GDNF:TTC fusion protein improves delivery of GDNF to mouse CNS
    Jianhong Li
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 390:947-51. 2009
    ..These studies indicate that insect cell-derived GDNF:TTC retains its bi-functional activity in mammalian CNS in vivo and improves delivery of GDNF to spinal cord following intramuscular- or intrathecal administration...
  9. doi request reprint Interaction of mitochondrial respiratory inhibitors and excitotoxins potentiates cell death in hippocampal slice cultures
    Rosemary A Schuh
    Research Service, Maryland VA Healthcare System, Baltimore, Maryland 21201, USA
    J Neurosci Res 86:3306-13. 2008
    ....
  10. doi request reprint The evolution of disability in Parkinson disease
    Lisa M Shulman
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Mov Disord 23:790-6. 2008
    ..Better understanding of the stages of disability may facilitate the development of novel outcome measures in clinical trials in PD...
  11. doi request reprint The clinically important difference on the unified Parkinson's disease rating scale
    Lisa M Shulman
    Departments of Neurology, University of Maryland Schoolof Medicine, Baltimore, MD 21201, USA
    Arch Neurol 67:64-70. 2010
    ..To determine the estimates of minimal, moderate, and large clinically important differences (CIDs) for the Unified Parkinson's Disease Rating Scale (UPDRS)...
  12. ncbi request reprint Impact of psychogenic movement disorders versus Parkinson's on disability, quality of life, and psychopathology
    Karen E Anderson
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Mov Disord 22:2204-9. 2007
    ..Quality of life and mental health implications of PMD were also evident. PMD impacts several aspects of patient function and daily life...
  13. doi request reprint A comparative study of physical performance measures in Parkinson's disease
    Haruko Tanji
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Mov Disord 23:1897-905. 2008
    ..Disability in PD is commonly assessed by patient self-report, which may be limited by patient insight...
  14. ncbi request reprint Glutamate decarboxylase protects neurons against excitotoxic injury
    Christopher C Matthews
    Research Service, Maryland VA Healthcare System, Baltimore, Maryland 21201, USA
    J Neurosci Res 85:855-9. 2007
    ..Targeting of this enzyme to the interior of synaptic vesicles may enhance its potency as a neuroprotectant against excitotoxicity...
  15. doi request reprint Racial and socioeconomic disparities in parkinsonism
    J Patrick Hemming
    Department of Neurology, School of Medicine, University of Maryland, Baltimore, 21201, USA
    Arch Neurol 68:498-503. 2011
    ..To assess potential racial and socioeconomic disparities in patients with parkinsonism treated at a tertiary Movement Disorders Center...
  16. ncbi request reprint Optical coherence tomography in the diagnosis and treatment of neurological disorders
    M Samir Jafri
    Baltimore VA Medical Center, University of Maryland School of Medicine, Department of Neurology, 655 West Baltimore Street, Baltimore, Maryland 21201, USA
    J Biomed Opt 10:051603. 2005
    ..TSE include diseases such as Mad Cow disease and Creutzfeldt-Jakob disease (CJD) in humans. OCT performed on the brain from a woman who died of CJD was able to detect clearly the pathological vacuoles...
  17. ncbi request reprint Enhancement of diphtheria toxin potency by replacement of the receptor binding domain with tetanus toxin C-fragment: a potential vector for delivering heterologous proteins to neurons
    J W Francis
    Cecil B Day Center for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Neurochem 74:2528-36. 2000
    ..These results suggest that a catalytically inactive form of DAB(389)TTC may be useful as a nonviral vehicle to deliver exogenous proteins to the cytosolic compartment of neurons...
  18. ncbi request reprint Tetanus toxin fragment C fusion facilitates protein delivery to CNS neurons from cerebrospinal fluid in mice
    Susanna C Benn
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
    J Neurochem 95:1118-31. 2005
    ..These results indicate that TTC may serve as a useful prototype for development as a non-viral vehicle for improving delivery of therapeutic proteins to the CNS...
  19. doi request reprint Mutuality of the marital relationship in Parkinson's disease
    Haruko Tanji
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mov Disord 23:1843-9. 2008
    ..PD severity, especially gait, balance, urinary incontinence and motor fluctuations are particular stressors on the marital relationship...
  20. pmc Environmental neurotoxin-induced progressive model of parkinsonism in rats
    Wei Bin Shen
    Department of Pharmacology and Experimental Therapeutics, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201, USA
    Ann Neurol 68:70-80. 2010
    ....
  21. pmc Hematopoietic progenitors express neural genes
    James Goolsby
    Department of Neurology, University of Maryland School of Medicine, and Multiple Sclerosis Center of Excellence, Veterans Affairs Medical Center, Baltimore, MD 21201, USA
    Proc Natl Acad Sci U S A 100:14926-31. 2003
    ..The fact that these CD34+ cells also express transcription factors (Rex-1 and Oct-4) that are found in early development elicits the hypothesis that they may be pluripotent embryonic-like stem cells...
  22. ncbi request reprint Glutamate-pyruvate transaminase protects against glutamate toxicity in hippocampal slices
    C C Matthews
    Research Service, Veteran s Affairs Medical Center, 10 N Greene St, Baltimore, MD 21201, USA
    Brain Res 978:59-64. 2003
    ..GPT is an effective neuroprotectant against glutamate excitotoxicity. When exposure is limited to endogenously released glutamate, neuroprotection by GPT is not dependent on added pyruvate...
  23. ncbi request reprint When do patients with Parkinson disease disclose their diagnosis?
    S Haines
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neurology 67:488-90. 2006
    ..Patients who delayed disclosure were more likely male, younger, and employed. There is considerable variability among patients with PD in the time to disclose their diagnosis...
  24. doi request reprint Recombinant GDNF: tetanus toxin fragment C fusion protein produced from insect cells
    Jianhong Li
    Cecil B Day Laboratory for Neuromuscular Research, Department of Neurology, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Biochem Biophys Res Commun 385:380-4. 2009
    ..These results support further testing of recombinant GDNF:TTC as a non-viral vector to improve delivery of GDNF to brain and spinal cord in vivo...
  25. ncbi request reprint A survival motor neuron:tetanus toxin fragment C fusion protein for the targeted delivery of SMN protein to neurons
    Jonathan W Francis
    Cecil B Day Laboratory for Neuromuscular Research, Massachusetts General Hospital, Building 114, 16th Street, Room 3003, Charlestown, MA 02129, USA
    Brain Res 995:84-96. 2004
    ..While these studies indicate that SDT may not be useful for SMA therapy, the use of the TTC:DTx fusion construct to deliver other passenger proteins to the neuronal cytosol should not be ruled out...
  26. ncbi request reprint A multi-domain protein system based on the HC fragment of tetanus toxin for targeting DNA to neuronal cells
    Michael Box
    Department of Biological Sciences, Imperial College of Science, Technology and Medicine, Exhibition Road SW7 2AY London, UK
    J Drug Target 11:333-43. 2003
    ..The demonstration that this multi-domain protein can target genes specifically to neuronal cells is a first step in the development of novel vectors for the delivery of genes with therapeutic potential to diseased neuronal tissues...
  27. ncbi request reprint Development of a delivery vehicle for intracellular transport of botulinum neurotoxin antagonists
    Michael C Goodnough
    Department of Food Microbiology, Food Research Institute, University of Wisconsin, 1925 Willow Dr, Madison, WI 53706, USA
    FEBS Lett 513:163-8. 2002
    ..The HC of BoNT/A thus offers promise as a selective carrier to deliver BoNT antagonists to the nerve terminal cytoplasm for inhibiting the proteolytic activity of internalized BoNT/A LC...

Research Grants1